2022 Moffitt Scientific Symposium

PROGRAM AGENDA Day 1 – Tuesday, May 10th, 2022 SRB Ted Couch Auditorium 4:00-5:00 PM

W. Jack Pledger Researcher of the Year lecture: Jose Conejo-Garcia, Ph.D. “It takes a village: Concurrent innate and adaptive T cell responses cooperate with humoral immunity to spontaneously exert immune pressure against human ovarian cancer progression”

5:00-6:00 PM

Reception in SRB Murphy

Day 2 – Wednesday, May 11th, 2022 USF Marshall Student Center 8:00-9:00 AM

Registration, Breakfast & Poster Viewing in the Ballroom

9:00-9:10 AM

Welcome, Patrick Hwu, MD, Moffitt President & CEO (Plaza Room)

9:10-9:35 AM

Featured Poster Presentations (Plaza Room) Moderator: Dr. Zena Jameel Dr. Hayley Ackerman “Changes to the tumor microenvironment with loss of TAp73 in lung adenocarcinoma” Dr. Ammoren Dohm “Stereotactic radiosurgery and anti-PD-1 + CTLA-4 therapy, antiPD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors, BRAF inhibitor, or conventional chemotherapy for the management of melanoma brain metastases” Dr. Min Jeong Yang “What happens when you smoke a cigarette mindfully?: A qualitative study” Dr. Dipesh Niraula “A Decision Support Software for AI-assisted decision-making in Response-Adaptive Radiotherapy--An Evaluation Study” Dr. Rana Falahat “In vivo demethylation-mediated reversal of tumor cell-intrinsic cGAS silencing improves the efficacy of STING agonist therapy” Sarah Bazargan “Targeting Myeloid-Derived Suppressor Cells (MDSCs) in Bladder Cancer to Enhance Efficacy of Adoptive Cell Therapy (ACT)” Dr. Menal Bhandari “Role of Adjuvant Regional Nodal Irradiation Resected Melanoma: A Secondary Analysis of SWOG S1404” Dr. Mohammad Zahid “Modeling Post-Surgical Recurrence and Survival of Clear Cell Renal Cell Carcinoma Patients with Genomic and Immune Signatures”

9:35-10:25 AM

Oral Presentations (Plaza Room) Moderators: Dr. Katarzyna Rejniak & Dr. Vani Simmons Emma Adhikari “Brain met-associated fibroblasts drive breast cancer invasive capacity by secreting fucosylated PVR/CD155 to alter adhesion and motility”

Dr. Danielle DePalo “Over 20 Years of Treatment of Genital Melanomas, a Single Institution’s Experience” Dr. Mariana Arevalo “Human papillomavirus vaccine uptake among Hispanic/Latino young and mid-age adults in the United States” Dr. Sandhya Prabhakaran “Distinct spatiotemporal tumor-immune ecologies define therapeutic response in NSCLC patients” Dr. Nick Chakiryan “Geospatial characterization of immune cell distributions and dynamics across the microenvironment in renal cell carcinoma” 10:30-12:00 PM

Poster Session #1 (Ballroom) Odd numbered Posters

11:30- 12:30 PM Lunch (Ballroom) 12:00-1:30 PM

Poster Session #2 (Ballroom) Even Numbered Posters

1:45-2:10 PM

Featured Poster Presentations (Plaza Room) Moderator: Dr. Evan Wuthrick Nicol Mecozzi “Genetic tools for the stable overexpression of circular RNAs in melanoma” Dr. Traci Kruer “XPO1 over-expression is a mechanism of resistance for eprenetapopt and 5-azacitidine therapy that can be therapeutically exploited to improve the treatment of TP53 mutated myeloid malignancies” Dr. Ibrahim Oraiqat “In Vivo Demonstration of Three Dimensional Dosimetry and Radiation Beam Localization via Ionizing Radiation Acoustics Imaging (iRAI) in Rabbits” Dr. Marco Napoli “DeltaNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer” Dr. Andrew Sinnamon “Simultaneous Hepatic and Visceral Resection: Preoperative Risk Stratification and Implications on Return to Intended Oncologic Therapy” Niveditha Nerlakanti “Regulation of SLC17A7 tumor suppressor gene expression in osteosarcoma”

2:10-3:00 PM

Oral Presentations (Plaza Room) Moderators: Dr. John Mullinax & Dr. Lixin Wan Dr. Stanislav Drapela “HIRA is a master regulator of the proliferation-to-dormancy switch in breast cancer” Dr. Ismail Elbaz Younes “Mutation Burden Comparison Between Chronic Myelomonocytic Leukemia with Progression to Acute Myeloid Leukemia and De Novo Acute Myeloid Leukemia M4/M5” Dr. Jessica Rivera Rivera “Genetic counseling and testing among Black men with prostate cancer” Dr. Rafael Renatino Canevarolo “Functional Genomic Landscape of Multiple Myeloma Identifies Novel Therapeutic Strategies” Dr. Marilena Tauro “Dual epigenetic/autophagy inhibition as a novel strategy to tackle Triple Negative Breast Cancer”

3:00-3:15 PM

Awards and Closing Remarks, Dr. Odion Binitie & Dr. Jong Park (Plaza Room)

TRANSPORTATION A Moffitt shuttle bus will be running a continuous route between Moffitt and the USF Marshall Center on Wednesday, May 11th from 7:30AM-4:00PM. You may also choose to walk or drive your personal vehicle if you have an appropriate USF parking permit.

Please see map below for exact shuttle stop locations Shuttle stop =

POSTER MAP USF Marshall Student Center Ballroom

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FEATURED POSTERS Presenter Hayley Ackerman Sarah Bazargan

Nicol Mecozzi Marco Napoli Niveditha Nerlakanti Ammoren Dohm

Menal Bhandari

Traci Kruer

Andrew Sinnamon

Min-Jeong Yang Dipesh Niraula

Mohammad Zahid

Ibrahim Oraiqat

Rana Falahat

Title (mentor) Changes to the tumor microenvironment with loss of TAp73 in lung adenocarcinoma (Flores) Targeting Myeloid-Derived Suppressor Cells (MDSCs) in Bladder Cancer to Enhance Efficacy of Adoptive Cell Therapy (ACT) (Pilon-Thomas) Genetic tools for the stable overexpression of circular RNAs in melanoma (Karreth) DeltaNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer (Flores) Regulation of SLC17A7 tumor suppressor gene expression in osteosarcoma (Lynch) Stereotactic radiosurgery and anti-PD-1 + CTLA-4 therapy, anti-PD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors, BRAF inhibitor, or conventional chemotherapy for the management of melanoma brain metastases (Ahmed) Role of Adjuvant Regional Nodal Irradiation Resected Melanoma: A Secondary Analysis of SWOG S1404 (Wuthrick) XPO1 over-expression is a mechanism of resistance for eprenetapopt and 5-azacitidine therapy that can be therapeutically exploited to improve the treatment of TP53 mutated myeloid malignancies (Padron) Simultaneous Hepatic and Visceral Resection: Preoperative Risk Stratification and Implications on Return to Intended Oncologic Therapy (Anaya) What happens when you smoke a cigarette mindfully?: A qualitative study (Vinci) A Decision Support Software for AI-assisted decisionmaking in Response-Adaptive Radiotherapy--An Evaluation Study (El Naqa) Modeling Post-Surgical Recurrence and Survival of Clear Cell Renal Cell Carcinoma Patients with Genomic and Immune Signatures (Enderling) In Vivo Demonstration of Three Dimensional Dosimetry and Radiation Beam Localization via Ionizing Radiation Acoustics Imaging (iRAI) in Rabbits (El Naqa) In vivo demethylation-mediated reversal of tumor cellintrinsic cGAS silencing improves the efficacy of STING agonist therapy (Mulé)

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BASIC SCIENCE POSTERS Listed alphabetically by last name Presenter Suehelay Acevedo Acevedo Mohammed Alkhouli

Martial Boutchueng Djidjou

Holly Branthoover

Daiana Celias Janine DeBlasi Ou Deng Avani Deshpande Aya Elmarsafwai Jeremy Frieling

Wael Gamal Yifeng Gao Maria Gonzalez- Rodriguez Kay Hänggi

Qianqian Hu

Mohammad Ibrahim

Pietro Irrera

Title (mentor) Determining the role of ΔNp63 in lung adenocarcinoma progression (Flores) Ex vivo expansion of tumor infiltrating lymphocytes (TIL) from human renal cell carcinoma (RCC) tumors (PilonThomas) Fibroblasts target the tumor ROS intrinsic pathways to drive the resistance in proximal RTK-mutant cancer cells (Haura) Identification and enrichment of neoantigen-reactive T cells to optimize adoptive cell transfer with tumorinfiltrating lymphocytes (TIL) (Pilon-Thomas) Investigating the mechanism of extracellular DNA uptake by dendritic cells (Ruffell) Distinct NRF2 signaling thresholds mediate lung tumor initiation and progression (DeNicola) Mechanisms of resistance to BRAF-directed treatment in BRAF-mutant melanoma brain metastasis (Rix) Investigating the putative tumor suppressive role of TROLL-9 in breast cancer (Flores) Regulation and Roles of Polyamines in CD8+ T-cell Fate and Functions (Cleveland) Dissecting the interplay between gamma delta CAR T cells and mesenchymal stem cells in the context of the bone metastatic prostate cancer microenvironment (Lynch) Metabolic Abnormalities Associated with T-cell Exhaustion in Chronic Lymphocytic Leukemia (Pinilla-Ibarz) Regulations Between ADAR1 and p53 Family Members in Human Breast Cancer (Flores) Inhibiting Bromodomain and Extra-Terminal domain proteins as a therapeutic approach for NF2 (Kissil) Necroptosis in tumors induced CXCL1 production intrinsically through the necrosome and via TLR4 on live neighboring tumor cells to activate CXCL1/CXCR2 axis mediated immunosuppression to promote tumor growth (Ruffell) Differential Chemoproteomics Reveals MARK2/3 as Cell Migration-Relevant Targets of the ALK Inhibitor Brigatinib (Rix) Sotorasib, a selective G12C K-RAS inhibitor, modulates the tumor microenvironment to promote TNFα and IFNγ signaling and augment checkpoint inhibitor and adoptive T cell therapy response (Beg) Optimization of intraperitoneal delivery of iopamidol in orthotopic pancreatic tumor model for CEST-MRI pH imaging (Gillies)

Poster # 114 081

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Neel Jasani Chang Jiang Hossein Kashfi

Jie Li

Xiaobo Li

Yi Liao Qian Liu

John Lockhart

Anurima Majumder Angelie Matar Sumit Mehta

Mostafa Nasr Thales Nepomuceno

Saheed Oseni

Nicolas Prieto Devesh Raizada Rafael Renatino Canevarolo Lily Rix Alyssa Shepard Aidan Snell

Joanne Tejero

PHGDH - A therapeutic vulnerability in melanoma (Karreth) SOD2 Deletion Sensitizes Cells to Beta-Lapachone Cytotoxicity (DeNicola) Quinolinic acid phosphoribosyl transferase (QPRT) is an important metabolic liability of non-small cell lung cancer (Gomes) Cholesterol metabolism in macrophages as a potential regulator of breast cancer resistance to hormone therapy (Ruffell) TAp63 regulated oncogenic long non-coding RNA-8 (TROLL-8) promotes human breast cancer progression through CPT1A mediated fatty acid oxidation (Flores) Ligandable target discovery by using fully functionalized fragment-like probes and chemical proteomics (Rix) Delineating the crucial role of fucosyltransferase 4 in mediating androgen-driven metastatic spread in melanoma (Lau) Analyzing tumor progression and heterogeneity in lung adenocarcinoma using machine learning and spatial multiomics (Flores) CTNNB1 mutation can mediate resistance to EGFR, ALK and KRAS targeted therapies (Haura) Synthesis of ACK1 Inhibitors as Therapeutic Cancer Agents (Lawrence) Lymphocyte infiltration in histologic subtypes of epithelial ovarian carcinoma and its effect on survival (ConejoGarcia) MMP-2 facilitates prostate cancer entry into and exit from dormancy (Lynch) Use of functional assays to classify veriants of uncertain clinical significance: portability of results to AfricanAmerican ancestry (Monteiro) The immunological signatures of African American prostate cancer as biological determinants of disease disparity (Adeegbe) Electron transport chain inhibition induces NRF2 degradation in KEAP1MUT NSCLC (DeNicola) Age-induced chronic accumulation of cortisol drives chemotherapy resistance in lung cancer (Gomes) Multiple myeloma evolution is characterized by dynamic epigenetic landscapes (Silva) Targeting POU2F3 transcription factor-driven small cell lung cancer (Rix) Investigating the Tumor Resistance of the Naked Mole-Rat (Kissil) HOIP-mediated linear ubiquitination of p31comet disables spindle assembly checkpoint to bridge the cytokine response with chromosome instability (Wan) The Role of Methylmalonic Acid in Promoting Clonal Hematopoiesis (Gomes)

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Laura Torrente Benito Traversa

Kaizhen Wang Nate Ward Sang Jun Yoon

Investigating the therapeutic potential of copper modulation in NRF2 hyperactive lung tumors (DeNicola) How Stress Changes You: Chronic Cortisol Exposure Triggers Epigenetic Remodeling in Non-Small Cell Lung Cancer (Gomes) MYBL2 promotes melanoma aggressiveness and represent a melanoma vulnerability (Karreth) Mitochondrial Function Antagonizes NSCLC Viability Under Therapeutic Cysteine Deprivation (DeNicola) In vivo stable isotope tracing in genetically engineered cancer models to evaluate the source and fate of cysteine (DeNicola)

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CLINICAL SCIENCE POSTERS Listed alphabetically by last name Presenter Julieta Abraham- Miranda

Luis Aguirre

Adam Alayli Mahogany Ambrose John Michael Bryant

Alberto Crimi

Ruben Cruz-Chamorro

Abhishek Dhawan

Kelly Elleson Austin Ellis

Erik Feldtmann Beth Green Emre Guvenli

Bing Han Heather Huelster Lee Hugar

Title (mentor) CAR T cells manufactured from frozen peripheral blood mononuclear cells (PBMCs) have similar phenotype and function, but reduced cell expansion, compared to those from fresh PBMCs (Locke) Characterization of Clinical and Molecular Features in Indolent Chronic Myelomonocytic Leukemia Phenotypes (Komrokji) Durability and safety of radiolucent carbon fibers pedicle screws for stabilization in spinal metastatic disease (Tran) Incidental Avid Breast Lesions Detected on Whole Body 68 Ga-DOTATATE PET/CT (Falcon) Pathological outcomes of pancreatic adenocarcinoma (PA) after pre-operative high biological effective dose (BED) magnetic resonance image-guided radiation therapy (MRgRT) (Frakes) Chondrosarcoma of the pelvis, survival and outcome of 35 patients treated with hemipelvectomy with navigation (Joyce) Real World Rates and Predictive Factors of Pneumonitis in Advanced, Non-resectable NSCLC Treated with Concurrent Chemoradiation and Durvalumab (Dilling) HSC depletion and Granulocyte macrophage progenitor expansion are clinically relevant features of disease progression in Chronic Myelomonocytic Leukemia (Padron) Breast conservation surgery in the elderly: Are we undertreating? (Lee) Clinicopathologic Distinction Between Acute Myeloid Leukemia with Mutated NPM1 and Acute Myeloid Leukemia with Myelodysplasia-Related Changes in Cases with Multilineage Dysplasia (Tashkandi, Zhang) Expandable Endoprosthesis in Pediatric Patients Following Resection of Malignant Bone Tumors (Binitie) Complications, Recovery, and Patient-Reported Quality of Life after Radical Cystectomy (Gilbert) Evaluation of Molecular Determinants Related to Outcomes in Recurrent High Grade Glioma Treated with Hypofractionated Stereotactic Radiotherapy (HFSRT) and Immune Checkpoint Blockade (Grass) Skin Lesions of the Breast Diagnosed by Punch Biopsy (Rosa) Novel Use of ctDNA to Identify Locally Advanced and Metastatic Upper Tract Urothelial Carcinoma (Li) Exploring knowledge, perspectives, and misperceptions of palliative care: a mixed methods analysis of patients with

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Denis Imbody Akriti Jain

Shirley Jiang

Grace Johnson

Hruday Kalagotla

Kyle Kemmerling Mariam Khaled

Casey Liveringhouse Gavin Lockard

Jennifer Logue Sylea Lowery John Lynes Kara Madey

Nicholas Manguso

Julian Marin-Acevedo

Shauna McVorran

Matthew Mills

Nour Nasser

stage II or greater bladder cancer and their caregivers (Gilbert) Mechanisms of acquired resistance to KRAS G12C inhibitors (Haura) Outcomes of Patients Treated with CPX-351 as First Line Therapy for AML based on their Antecedent History of Myeloid Malignancy (Sweet) Characterization of immune infiltrates associated with radiation necrosis in the setting of brain metastases immunotherapy (Yu) The effect of race, employment, and poverty on outcomes in chimeric antigen receptor therapy for DLBCL patients (Blue) Events of Radiation Necrosis in Melanoma Brain Metastases Treated with Stereotactic Radiosurgery and anti-PD-1 + CTLA-4 therapy, anti-PD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors, BRAF inhibitor, or conventional chemotherapy (Ahmed) Second Opinion in Pancreatobiliary Cytopathology at a Tertiary Care Academic Institution (Centeno) Single-cell and multi-omics analysis uncovers immune and metabolic remodeling of CSF environment in leptomeningeal lymphoma (Smalley) Neoadjuvant Simultaneous Integrated Boost Radiotherapy Improves Outcome for Retroperitoneal Sarcoma (Naghavi) Diffusion Tensor Imaging Tractography to Improve Surgical Outcomes for Intramedullary Spinal Cord Tumor Resection (Tran) Cytopenia and infection early after standard of care idecabtagene vicleucel in multiple myeloma (Hansen) Understanding Patient and Provider Perspectives on Vaccine Based Treatment Trials (Vadaparampil) Pattern of Leptomeningeal Disease in Melanoma: Analysis of Moffitt Database (Liu) Adaptive Stereotactic Body Radiation Therapy (SBRT) on an MRI linear accelerator for patients with pancreatic cancer: Does treatment time efficiency improve by therapy completion? (Hoffe) Surgical Training in a Cancer Center during COVID: Informing the Hybrid Learning Model of the Future (Dineen) Efficacy of Cetuximab After Immunotherapy (IO) in Advanced Cutaneous Squamous Cell Carcinoma (CSCC) (Khushalani) Outcomes and Patterns of Failure in Early-Stage, High-Risk Histology Endometrial Cancer treated with Vaginal Cuff Brachytherapy (Montejo) Predictors of Leptomeningeal Disease following Stereotactic Radiation for Patients with Breast Cancer Brain Metastases (Ahmed) Evaluation of initial and online adapted plan quality in Ethos for head and neck patients (Redler)

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Alexander Netzley

Anupam Rishi

Kyle Rose

Sebastian Rubino Julia Selfridge Heather Sinner

William Paul Skelton IV

Marian Smallin Yaakov Stern Sean Stokes

Elaine Tan

Gerald Wallace

Caroline Ward Junmin Whiting Anthony Wood

Xing Zhao

Trimodal Therapy Utilizing a Magnetic Resonance Imageguided Radiotherapy (MRgRT) Partial Bladder Tumor Boost in Muscle Invasive Bladder Cancer (Grass) Immune Cell Infiltrates of the Tumor Microenvironment and Radiosensitivity of Recurrent Glioblastomas and their Association with Outcome (Ahmed) Surgical Management of Clinically Localized Urachal Carcinoma: Supporting the Role of Lymphadenectomy as Standard of Care (Sexton) Pituitary Metastases: The Moffitt Cancer Center Experience (Tran) Effect of microporous polysaccharide particles in patients undergoing mastectomy (Lee) Surgical Management of the Axilla in Invasive Lobular Carcinoma in the Z1071 Era: A Propensity-Score Matched Analysis of the National Cancer Database (Laronga) Development of a mathematical model to predict outcomes in patients with metastatic urothelial carcinoma (mUC) on immunotherapy (IO) who progressed post platinum-based chemotherapy (Jain) C19MC MicroRNA 520G Impacts Melanin Production and Restores the SP100 Antiviral Gene at RNA Level (Brohl) Emerging vulnerability to CDK12/13 inhibitors in KRASiresistant NSCLC (Haura) Establishing a Prospective Registry of Gastrointestinal Oncology Acute Care Surgery Patients: A Quality Improvement Project (Dineen) BRAF V600E mutation and decreased survival in metastatic mismatch repair deficient colorectal cancer patients (Sahin) Changing recognition of breast cancer related leptomeningeal disease and response to therapy: a retrospective single institution review (Forsyth) Assessing the efficacy of imiquimod use in patients with persistent locally advanced melanoma in situ (Zager) A Predictive Avastin Gene Signature in Late-Stage Colorectal Cancer (Chen) Evaluation of tumor DNA sequencing results in patients with gastric and gastroesophageal junction adenocarcinoma stratified by TP53 mutation status (Mehta) Assessing Rapid On-Site Evaluation (ROSE) for Adequacy of Endobronchial Ultrasound Transbronchial Needle Aspiration (EBUS-TBNA) Procedures Compared to A Directto-Cellblock Approach As a Response to COVID-19 Pandemic (Bui)

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POPULATION SCIENCE POSTERS Listed alphabetically by last name Presenter Rania Abdulla

Rossybelle Amorrotu Amanda Bloomer Cherell Cottrell-Daniels

Lisa Gudenkauf

Cassandra Hathaway

Shelly Li Ursula Martinez Ebin Mathew Kerri Murphy Samantha Reese Awatef Riahi Nathanael Stanley

Danielle Tometich

Honor Woodward Brent Xia

Yayi Zhao

Title (mentor) Resource Utilization and Cost Assessment: Design of a Tracking Tool for a Colorectal Cancer Screening and Hepatitis C Virus Educational Intervention Trial (Christy) History of keratinocyte carcinoma associated with survival following a subsequent primary malignancy (Rollison) Age Variations in COVID-19 Associated Fears among Cancer Patients (Siegel) Associations among experiences with racial discrimination, religiosity/spirituality, and cigarette smoking among African American adults: The Jackson Heart Study (Vidrine) Feasibility and Acceptability of a Group-Based and eHealth-Delivered Psychosocial Intervention for Young Adult Cancer Survivors: A Pilot Trial (Oswald) Effects of the COVID-19 Vaccination on Social Isolation Among Patients with Cancer During the COVID-19 Pandemic (Tworoger) Risk Factors of Chemotherapy-Induced Nausea and Health Care Utilization among Older Adults with Cancer (Jim) Motivating a Spectrum of Cancer Patients to Quit Smoking: Intervention Development (Brandon) Investigating the Accuracy and Effectiveness of Hepatitis C Virus Informational Materials (Vadaparampil) Feasibility of Augmented Reality for Smoking Cessation (Simmons) COVID-19 Vaccine Uptake among Adolescent and Young Adult (AYA) Cancer Patients (Donovan) Racial and ethnic differences in germline variants in African patients with hereditary breast cancer (Monteiro) 2021 COEE Outreach Retreat: Preparing Outreach Teams to Utilize Location Intelligence in Strategic Planning (Vadaparampil) Objectively assessed physical activity and sleep during and after chemotherapy for gynecologic malignancies: A controlled comparison (Jim) Adapting a Smoking Cessation Treatment Manual for Lung Cancer Patients (Simmons) Patient-caregiver dyads in pancreatic cancer: Identification of patient and caregiver factors associated with caregiver well-being (Hodul) Survival trends among patients diagnosed with both melanoma and chronic lymphocytic leukemia (Rollison)

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QUANTITATIVE SCIENCE POSTERS Listed alphabetically by last name Presenter Ari Barnett Roldan Renee Brady-Nicholls

Rafael Bravo Anuraag Bukkuri Biwei Cao Samuel Coleman Scott Cukras Thomas Dombrowski

Ryan Fogarty Jill Gallaher Chandler Gatenbee Anjun Hu Briley Humphrey Alexandria Johnson Anna Miller

Tatiana Miti Thanh Nguyen Maureiq Ojwang

Oscar Ospina

Meagan Read

Title (mentor) Predictive capability for personalized patient response in NSCLC utilizing tumor dynamics (Enderling) Using Patient-Reported Outcome Dynamics to Predict Response to Immunotherapy in Non-Small Cell Lung Cancer (Enderling) Normal tissue density shapes tumor growth and evolution in a 3D whole-organ model of lung cancer (Anderson) Eco-Evolutionary Dynamics of Poly-Aneuploid Cancer Cells: A Life History Model (Brown) Cancer Gene Prognostic Atlas: an interactive portal for prognostic gene discovery across human cancers (Wang) Systematic evaluation of predictive gene signatures of immune checkpoint inhibitors in melanoma patients (Tan) iscTrack, an interactive single-cell tool to track emerging transcriptional states over time in tumors (Chen) Tumor-immune ecosystem dynamics define an individual Radiation Immune Score to predict pan-cancer radiocurability (Enderling) Discriminating malignancy of prostate glands with Deep Learning (Balagurunathan) Coupling PSA and testosterone dynamics to better classify tumor resistance in prostate cancer (Anderson) VALIS: Virtual Alignment of pathoLogy Image Series (Anderson) LinG3D: An In-Silico Tool for Visualizing the SpatioTemporal Dynamics of Clonal Evolution (Rejniak) Synthesis of JAK2 Inhibitors and PROTACs as Potential Cancer Therapeutics (Lawrence) Comparing Prostate Specific Antigen Dynamics Between Black Patients and White Patients (Enderling) The evolution of refractory multiple myeloma: uncoupling the role of the bone microenvironment and intrinsic resistance using an integrated approach (Basanta) Developing a Spatial Analysis Pipeline to Quantify the Drug-Sheltering Effects of Stroma in NSCLC (Basanta) ISCVAM - Interactive Single Cell Visual Analytics for Multiomics (Chen) Reconstructing the metabolic landscape from histology images of solid cancers for phenotype quantification (Rejniak) Detection of spatial patterns within the tumor microenvironment of leptomeningeal metastatic melanomas via gene pathway analysis (Fridley) Management of Malignant Small Bowel Obstruction – Is Intestinal Bypass Effective Palliation? (Dineen)

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Ryan Schenck

Alex Soupir

Maximilian Strobl

Virginia Turati

Malgorzata Tyczynska Zhouping Wei Jeffrey West

Joseph Weygand Mengyu Xie

Leveraging fluctuating methylation clocks to diagnose clonal hematopoiesis and provide tissue level insights (Anderson) Spatial clustering of immune cells in diffuse large B-cell lymphoma show association with CAR-T therapy response (Fridley) Learning to adapt: Using mathematical modeling and deep learning to improve adaptive therapy scheduling (Anderson) An integrated approach to understanding the clonal dynamics of childhood acute lymphoblastic leukemia from diagnosis to relapse (Anderson) Understanding Evolution of Resistance to Targeted Therapies using Agent-Based Modeling (Basanta) Imaging Biomarkers in CAR-T (Balagurunathan) Disulfiram re-sensitizes ER+ breast cancer cell lines resistant to paclitaxel through an evolutionary double-bind (Anderson) Feasibility of Diffusion Weight Imaging at the MRI-guided Linear Accelerator (Redler) A digital histopathology spatial feature extraction and machine learning pipeline to predict patient outcome from multiplex Immunofluorescence slides (Tan)

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TRANSLATIONAL SCIENCE POSTERS Listed alphabetically by last name Presenter Gustavo Borjas Andrew Chang

Bina Desai Asmaa Elkenawi

Michael Emmons

MacLean Hall

Katelyn Handley

Bruna Victorasso Jardim-Perassi Tony Kurian

Samuele Lodovichi Kimberly Luddy Sarah Lulu Renata Ariza Marques Rossetti

Sathyanarayana Neelature Sriramareddy

Nina Obertopp

Stefano Pasetto

Misty Shields

Title (mentor) Changes in Tertiary Lymphoid Structures Following Oncolytic Virus + αPD-1 (Li) Proteogenomic, epigenetic and clinical implications of recurrent aberrant splice variants in clear cell renal cell carcinoma (Manley) Impact of stromal protection in response to ALK targeted therapies in NSCLC (Marusyk) Identifying novel regulators of macrophage tumor cell metabolic interactions in prostate cancer of African American men (Yamoah) Deacetylation of EP300 by HDAC8 regulates the formation of a stress resistant neural crest-like invasive state in melanoma (Smalley) An investigation into the role of CD4+ tumor-infiltrating lymphocytes (TIL) in metastatic melanoma patients with a complete response to adoptive cell therapy (Pilon-Thomas) Utilization of immortalized B cells to identify SDCBP as a novel therapeutic target in ovarian carcinoma (Conejo-Garcia) Targeting acidosis to improve immunotherapy in pancreatic ductal adenocarcinoma model (Gillies) Evaluating CD83 Expression on Organ-Specific Normal Tissues to Anticipate Potential Toxicity of Novel Human CD83-targeted Chimeric Antigen Receptor (CAR) T Cell (Davila) SART1 as a novel therapeutic target to improve efficacy of PARP-inhibitors (Monteiro) Evolutionary selection identifies critical immune relevant genes in lung cancer subtypes (Gatenby) Glioblastoma CAR-T Gene Targets: Using RNA-seq to screen for “AND” gating pairs (Hwu) Stimulation of tumor infiltrating B-cells improves exvivo TIL expansion for melanoma immunotherapy (Abate Daga) To define how the uvel melanoma-liver environment crosstalk shapes metastasis growth and therapeutic response (Smalley) Comparing different culturing conditions in ex vivo expansion of TIL from murine HPV+ head and neck tumors (Pilon-Thomas) Breast cancer patient-specific reaction-diffusion from spectral analysis of immunohistochemistry slides (Enderling) Reactivation of p53 in Small Cell Lung Cancer with APR246 (Shafique)

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Yumeng Zhang

Hong Zheng

The impact of pre-treatment plasma sex hormones on the immune checkpoint inhibitors response in patients with metastatic non-small cell lung cancer (Robinson) Oncolytic adenovirus encoding transgenes for IFN and recombinant CD40 ligand promotes conventional dendritic cell activation and trafficking with enhanced tumor infiltrating lymphocytes for effective cancer immunotherapy (Beg)

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MOFFITT SCIENTIFIC SYMPOSIUM COMMITTEE Dr. Odion Binitie (Co-Chair) Dr. Jong Park (Co-Chair) Dr Yoga Balagurunathan Dr. John Bryant Dr. Leidy Isenalumhe Dr. Zena Jameel Dr. John Mullinax Dr. Katarzyna Rejniak Dr. Michael Shafique Dr. Vani Simmons Dr. Luxin Sun Dr. Lixin Wan Dr. Iman Washington Dr. Evan Wuthrick

EVENT COORDINATORS Angela Reagan Sarah Riordan Kassie Selbert