4th Biennial International Ocular Regenerative Symposium

Organizing Committee

CONFERENCE CO-CHAIRS

Demetrios G. Vavvas, MD, PhD

Solman and Libe Friedman Professor of Ophthalmology, Harvard Medical School

Co-director, Ocular Regenerative Medicine Institute, Harvard Ophthalmology Director, Retina Service, Mass Eye and Ear

Michael J. Young, PhD

Associate Professor of Ophthalmology, Harvard Medical School

Co-Director, Ocular Regenerative Medicine Institute, Harvard Ophthalmology

Director, Minda de Gunzburg Center for Retinal Regeneration , Harvard Ophthalmology Associate Scientist, Schepens Eye Research Institute of Mass Eye and Ear

DEPARTMENT CHAIR

Joan W. Miller, MD

David Glendenning Cogan Professor of Ophthalmology, Harvard Medical School

Chair, Department of Ophthalmology, Harvard Medical School

Chair of Ophthalmology, Mass Eye and Ear and Massachusetts General Hospital

Ophthalmologist-in-Chief, Brigham and Women’s Hospital

4th Biennial International Ocular Regenerative Symposium

4th Biennial International Ocular Regenerative Symposium

From Bench to Bedside

Thursday, October 5, 2023 - Starr Center, 185 Cambridge Street, Boston, MA

7:00 - 8:00 AM Breakfast

8:00 - 8:05 AM

Welcome & Introduction

Demetrios G. Vavvas, MD, PhD and Michael J. Young, PhD - Conference Co-chairs

Developing a Phase I/IIa Clinical Trial to Test Safety and Efficiacy of an Autologous iPS Cellderived RPE Patch in AMD Patients

8:10 - 8:30 AM

Kapil Bharti, PhD - Scientific Director and Senior Investigator, Ocular and Stem Cell Translational Research Section, National Eye Insitute, National Institutes of Health

8:30 - 8:50 AM

Self-organization, Quality Control, and Preclinical Studies of Human iPSC-derived Retinal Sheets for Tissue-transplantation Therapy

Atsushi Kuwahara, PhD - Director, Regenerative Ophthalmology Group, Sumitomo Pharma Co.

Stem Cells in the Adult RPE and Their Therapeutic Applications

8:50 - 9:10 AM

Sally Temple, PhD - Research Professor, School of Public Health, University of Albany/SUNY and Scientific Director and Co-founder, Neural Stem Cell Institute

Panel Discussion

Moderator: Jeffrey Stern, PhD, MD - Board Chair, Director of Translational Research and Co-Founder, Neural Stem Cell Institute 9:55 -

9:10 - 9:55 AM

AM

A Clinical Study of Retinal Organoid Transplantation

10:15 - 10:35 AM

Yasuhiko Hirami, MD, PhD - Vice President, Kobe City Eye Hospital and Director of Ophthalmology, Kobe City Medical Center

Retinal Progenitor Cells for the Treatment of Blinding Disease

10:35 - 10:55 AM

Michael J. Young, PhD - Associate Professor of Ophthalmology and Co-Director, Ocular Regenerative Medical Institute, Harvard Medical School

Tissue Engineering a Retinal Patch Using Stem Cell-derived Photoreceptors

10:55 - 11:15 AM

11:15 - 12:00 PM

12:00 - 1:00 PM

1:00 - 1:05 PM

Professor Jane Sowden, PhD - Professor of Developmental Biology & Genetics, Great Ormond Street Institute of Child Health, University College of London

Panel Discussion

Moderator: Jason Comander MD, PhD - Associate Professor of Ophthalmology, Harvard Medical School

Keynote Lecture Introduction

Demetrios Vavvas, MD, PhD - Solman and Libe Friedman Professor of Ophthalmology and Co-Director, Ocular Regenerative Medical Institute, Harvard Medical School

Keynote Lecture: Towards Accelerated Medical Innovation

1:05 - 2:00 PM

Jeffrey M. Karp, PhD - Professor of Anesthesia, Harvard Medical School, Distinguished Chair in Clinical Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital; and Principal Faculty Member, Harvard Stem Cell Institute

Harvard Medical School Department of Ophthalmology

Thursday, October 5, 2023 - Continued

Neuroprotection Bench to Clinic

2:00 - 2:20 PM

2:20 - 2:40 PM

2:40 - 3:00 PM

3:00 - 3:45 PM

3:45 -

Jeffrey Goldberg, MD, PhD - Professor and Chair of Ophthalmology, Stanford University

Retinal Ganglion Cell Transplantation: The Role of the Microenvironment Engineering

Petr Baranov, MD, PhD - Assistant Professor of Ophthalmology Harvard Medical School

Divergent Regulation of Retinal Regeneration at Tissue and Cellular Scales

Jeffrey S. Mumm, PhD - Associate Professor of Ophthalmology and Helen Larson & Charles Glenn Grover Chair in Ophthalmology, Johns Hopkins University, School of Medicine

Panel Discussion

Moderator: Dong Feng Chen, PhD - Associate Professor of Ophthalmology, Harvard Medical School

4:05 - 4:25 PM

4:25 - 4:45 PM

4:45 - 5:05 PM

5:05 - 5:50 PM

5:50 - 5:55 PM

Cultivated Autologous Limbal Epithelial Cell Transplantation: Stem Cells Meet FDA

Ula V. Jurkunas, MD - Associate Professor of Ophthalmology and Co-director, Cornea Center of Excellence, Harvard Medical School

Translating Corneal Regeneration - Keeping Pace with Research

May Griffith, PhD - Professor, Department of Ophthalmology, Faculty of Medicine, Université de Montréal

Toward Corneal Regenerative Medicine

Shigeru Kinoshita, MD, PhD - Professor and Chairman of Ophthalmology, Kyoto Prefectural University of Medicine

Panel Discussion

Moderator: Darlene A. Dartt, PhD - Professor of Ophthalmology, Harvard Medical School

Closing Remarks & Adjourn

Demetrios G. Vavvas, MD, PhD and Michael J. Young, PhD - Conference Co-chairs

6:05 - 7:30 PM Reception & Networking

Notes

4th Biennial International Ocular Regenerative Symposium

Funding for this conference was made posible by an 1R13 EY 031922-01 grant from the National Eye Insitute

Travel Award Winners

Dheeraj Agrohia Graduate Student

University of Massachusetts Amherst

Amherst, MA

Blake Archer Medical Student

University of Houston College of Medicine

Houston, TX

Josy Augustine Visiting Postdoctoral Research Fellow

Mass Eye and Ear, Harvard Medical School

Belfast, UK

Soumaya Belhadj Postdoctoral Fellow

University of Rochester

Rochester, NY

Brionna Bennett Medical Student

University of South Carolina School of Medicine

Greenville, SC

Andrea Campbell Graduate Student

University of Rochester

Rochester, NY

Anneliese Ceisel Graduate Student

Johns Hopkins School of Medicine

Baltimore, MD

Julian Garcia-Sanchez Postdoctoral Scholar

Byers Eye Institute, Stanford University

Stanford, CA

Mitzi Swift Research Coordinator

University of Alabama at Birmingham

Birmingham, GA

Brianna Watson Medical Student

Howard University College of Medicine

Washington, DC

Huanhuan Xiao Postdoctoral Fellow

Johns Hopkins School of Medicine

Baltimore, MD

Platinum Level

Gold Level

Silver Level

Bronze Level

Promotional

Platinum

Gold Boehringer

Silver

Bronze

Virscio

Educational Grants

National Eye Institute