4th Biennial International Ocular Regenerative Symposium

4th Biennial International

Ocular Regenerative Symposium From Bench to Bedside October 5, 2023 | Boston, MA

Harvard Medical School Department of Ophthalmology

Organizing Committee CONFERENCE CO-CHAIRS Demetrios G. Vavvas, MD, PhD Solman and Libe Friedman Professor of Ophthalmology, Harvard Medical School Co-director, Ocular Regenerative Medicine Institute, Harvard Ophthalmology Director, Retina Service, Mass Eye and Ear

Michael J. Young, PhD Associate Professor of Ophthalmology, Harvard Medical School Co-Director, Ocular Regenerative Medicine Institute, Harvard Ophthalmology Director, Minda de Gunzburg Center for Retinal Regeneration , Harvard Ophthalmology Associate Scientist, Schepens Eye Research Institute of Mass Eye and Ear

DEPARTMENT CHAIR Joan W. Miller, MD David Glendenning Cogan Professor of Ophthalmology, Harvard Medical School Chair, Department of Ophthalmology, Harvard Medical School Chair of Ophthalmology, Mass Eye and Ear and Massachusetts General Hospital Ophthalmologist-in-Chief, Brigham and Women’s Hospital

Massachusetts Eye and Ear • Massachusetts General Hospital • Boston Children’s Hospital Beetham Eye Institute at the Joslin Diabetes Center • Brigham and Women’s Hospital • Beth Israel Deaconess Medical Center Cambridge Health Alliance • VA Boston Healthcare System • VA Maine Healthcare System

eye.hms.harvard.edu

4th Biennial International Ocular Regenerative Symposium

4th Biennial International

Ocular Regenerative Symposium From Bench to Bedside

Thursday, October 5, 2023 - Starr Center, 185 Cambridge Street, Boston, MA 7:00 - 8:00 AM

Breakfast

8:00 - 8:05 AM

Welcome & Introduction Demetrios G. Vavvas, MD, PhD and Michael J. Young, PhD - Conference Co-chairs

SESSION 1 - POSTERIOR SEGMENT MACULA / GEOGRAPHIC ATROPHY / RPE DISEASES

8:10 - 8:30 AM

Developing a Phase I/IIa Clinical Trial to Test Safety and Efficiacy of an Autologous iPS Cellderived RPE Patch in AMD Patients Kapil Bharti, PhD - Scientific Director and Senior Investigator, Ocular and Stem Cell Translational Research Section, National Eye Insitute, National Institutes of Health

8:30 - 8:50 AM

Self-organization, Quality Control, and Preclinical Studies of Human iPSC-derived Retinal Sheets for Tissue-transplantation Therapy Atsushi Kuwahara, PhD - Director, Regenerative Ophthalmology Group, Sumitomo Pharma Co.

8:50 - 9:10 AM

Stem Cells in the Adult RPE and Their Therapeutic Applications Sally Temple, PhD - Research Professor, School of Public Health, University of Albany/SUNY and Scientific Director and Co-founder, Neural Stem Cell Institute

9:10 - 9:55 AM

Panel Discussion Moderator: Jeffrey Stern, PhD, MD - Board Chair, Director of Translational Research and Co-Founder, Neural Stem Cell Institute

9:55 - 10:15 AM

Break

SESSION 2 - POSTERIOR SEGMENT PHOTORECEPTOR DISEASES / AMD 10:15 - 10:35 AM

A Clinical Study of Retinal Organoid Transplantation Yasuhiko Hirami, MD, PhD - Vice President, Kobe City Eye Hospital and Director of Ophthalmology, Kobe City Medical Center

10:35 - 10:55 AM

Retinal Progenitor Cells for the Treatment of Blinding Disease Michael J. Young, PhD - Associate Professor of Ophthalmology and Co-Director, Ocular Regenerative Medical Institute, Harvard Medical School

10:55 - 11:15 AM

Tissue Engineering a Retinal Patch Using Stem Cell-derived Photoreceptors Professor Jane Sowden, PhD - Professor of Developmental Biology & Genetics, Great Ormond Street Institute of Child Health, University College of London

11:15 - 12:00 PM

Panel Discussion Moderator: Jason Comander MD, PhD - Associate Professor of Ophthalmology, Harvard Medical School

12:00 - 1:00 PM

Lunch

1:00 - 1:05 PM

Keynote Lecture Introduction Demetrios Vavvas, MD, PhD - Solman and Libe Friedman Professor of Ophthalmology and Co-Director, Ocular Regenerative Medical Institute, Harvard Medical School

1:05 - 2:00 PM

Keynote Lecture: Towards Accelerated Medical Innovation Jeffrey M. Karp, PhD - Professor of Anesthesia, Harvard Medical School, Distinguished Chair in Clinical Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital; and Principal Faculty Member, Harvard Stem Cell Institute

Harvard Medical School Department of Ophthalmology

Thursday, October 5, 2023 - Continued SESSION 3 - OPTIC NERVE / RETINA GANGLION CELL DISEASES 2:00 - 2:20 PM

Neuroprotection Bench to Clinic Jeffrey Goldberg, MD, PhD - Professor and Chair of Ophthalmology, Stanford University

2:20 - 2:40 PM

Retinal Ganglion Cell Transplantation: The Role of the Microenvironment Engineering Petr Baranov, MD, PhD - Assistant Professor of Ophthalmology Harvard Medical School

2:40 - 3:00 PM

Divergent Regulation of Retinal Regeneration at Tissue and Cellular Scales Jeffrey S. Mumm, PhD - Associate Professor of Ophthalmology and Helen Larson & Charles Glenn Grover Chair in Ophthalmology, Johns Hopkins University, School of Medicine

3:00 - 3:45 PM

Panel Discussion Moderator: Dong Feng Chen, PhD - Associate Professor of Ophthalmology, Harvard Medical School

3:45 - 4:05 PM

Break

SESSION 4 - CORNEA / ANTERIOR SEGMENT DISEASES 4:05 - 4:25 PM

Cultivated Autologous Limbal Epithelial Cell Transplantation: Stem Cells Meet FDA Ula V. Jurkunas, MD - Associate Professor of Ophthalmology and Co-director, Cornea Center of Excellence, Harvard Medical School

4:25 - 4:45 PM

Translating Corneal Regeneration - Keeping Pace with Research May Griffith, PhD - Professor, Department of Ophthalmology, Faculty of Medicine, Université de Montréal

4:45 - 5:05 PM

Toward Corneal Regenerative Medicine Shigeru Kinoshita, MD, PhD - Professor and Chairman of Ophthalmology, Kyoto Prefectural University of Medicine

5:05 - 5:50 PM

Panel Discussion Moderator: Darlene A. Dartt, PhD - Professor of Ophthalmology, Harvard Medical School

5:50 - 5:55 PM

Closing Remarks & Adjourn Demetrios G. Vavvas, MD, PhD and Michael J. Young, PhD - Conference Co-chairs

6:05 - 7:30 PM

Reception & Networking

Notes

4th Biennial International Ocular Regenerative Symposium

Funding for this conference was made posible by an 1R13 EY 031922-01 grant from the National Eye Insitute

Travel Award Winners Dheeraj Agrohia Graduate Student University of Massachusetts Amherst Amherst, MA

Anneliese Ceisel Graduate Student Johns Hopkins School of Medicine Baltimore, MD

Blake Archer Medical Student University of Houston College of Medicine Houston, TX

Julian Garcia-Sanchez Postdoctoral Scholar Byers Eye Institute, Stanford University Stanford, CA

Josy Augustine Visiting Postdoctoral Research Fellow Mass Eye and Ear, Harvard Medical School Belfast, UK

Mitzi Swift Research Coordinator University of Alabama at Birmingham Birmingham, GA

Soumaya Belhadj Postdoctoral Fellow University of Rochester Rochester, NY

Brianna Watson Medical Student Howard University College of Medicine Washington, DC

Brionna Bennett Medical Student University of South Carolina School of Medicine Greenville, SC

Huanhuan Xiao Postdoctoral Fellow Johns Hopkins School of Medicine Baltimore, MD

Andrea Campbell Graduate Student University of Rochester Rochester, NY

Harvard Medical School Department of Ophthalmology Advertiserments

Platinum Level

4th Biennial International Ocular Regenerative Symposium Advertiserments

Gold Level

Silver Level

Bronze Level

THANK YOU TO OUR GENEROUS SUPPORTERS Promotional Sponsors Platinum

Sumitomo Pharma Gold

Boehringer Ingelheim Silver

Astellas Pharma Bronze

Virscio Educational Grants

Genentech Regeneron

National Eye Institute