7.3
3.0
87.5
146.0
23.5
144.6
88.5
7.3
3.0
87.5
146.0
23.5
144.6
88.5
ONE DOSE, CONTROLS PARASITES UP TO
150 DAYS.1
WORTH ITS WEIGHT IN
POUNDS.
Extended-Release Injectable Parasiticide 5% Sterile Solution For the Treatment and Control of Internal and External Parasites of Cattle on Pasture with Persistent Effectiveness Not for use in female dairy cattle 20 months of age or older, including dry dairy cows. Not for use in calves to be processed for veal. Not for use in breeding bulls, or in calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive rotational grazing. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. INDICATIONS FOR USE LONGRANGE, when administered at the recommended dose volume of 1 mL per 110 lb (50 kg) body weight, is effective in the treatment and control of the following internal and external parasites of cattle: Gastrointestinal Roundworms Lungworms Bunostomum phlebotomum – Adults Lungworms and L4 Dictyocaulus viviparus – Adults Gastrointestinal Roundworms oncophora Bunostomum phlebotomumCooperia – Adults and L4 – Adults and L4 Cooperia punctata – Adults and L4 Cooperia oncophora – Adults and L4 Dictyocaulus viviparus – Adults Cooperia surnabada – Adults and L4 Cooperia punctata – AdultsHaemonchus and L4 placei – Adults Grubs Cooperia surnabada – Adults and L4 Oesophagostomum radiatum – AdultsGrubs Hypoderma bovis Haemonchus placei – AdultsOstertagia lyrata – Adults Mites Hypoderma bovis Oesophagostomum radiatum – Adults Ostertagia ostertagi – Adults, L4, and Sarcoptes scabiei var. bovis Ostertagia lyrata – Adults inhibited L4 Mites Trichostrongylus axei – Adults and L 4 Ostertagia ostertagi – Adults, L4 and inhibited L4 Trichostrongylus colubriformis – Adults Trichostrongylus axei – Adults and L4 Sarcoptes scabiei var. bovis Persistent Activity Trichostrongylus colubriformis – Adults the following parasites for the indicated amounts of time following treatment:
Parasites
Parasites
Gastrointestinal Roundworms Gastrointestinal Roundworms Bunostomum phlebotomum Bunostomum phlebotomum Cooperia oncophora Cooperia oncophora Cooperia punctata Cooperia punctata Haemonchus placei Haemonchus placei Oesophagostomum radiatum Oesophagostomum radiatum Ostertagia lyrata Ostertagia lyrata Ostertagia ostertagi Ostertagia ostertagi Trichostrongylus axei Trichostrongylus axei Lungworms Lungworms Dictyocaulus viviparus Dictyocaulus viviparus
Durations of of Persistent Durations Effectiveness 150 days 150 days 100 days 100 days 100 days 100 days 120 days 120 days 120 days 120 days 120 days 120 days 120 days 120 days 100 days 100 days 150 days
150 days
DOSAGE AND ADMINISTRATION DOSAGE AND ADMINISTRATION Body Weight (lb) Dose Volume (mL) LONGRANGE® LONGRANGE® (eprinomectin) should (eprinomectin) be given only by 110 1 by subcutaneous injection inshould frontbeofgiven theonly shoulder at the 220 2 subcutaneous injection in front of recommended dosage level of 1 mg eprinomectin per kg body 330 3 shoulder at the recommended weight (1 mL per 110 lb bodythe weight). Each mL of LONGRANGE 440 4 dosage level of 1 mg eprinomectin contains 50 mg of eprinomectin, sufficient to treat lb (50 550 5 per kg body weight (1 110 mL per 110kg) lb body weight. Divide doses greater than 10 mL between two 660 6 body weight). injection sites to reduce occasional or site reaction. Each mLdiscomfort of LONGRANGE contains 770 7 880 8 Do not underdose. Ensure each animal receives a complete treat 110Underdosing lb (50 kg) body weight. 990 9 dose based on a current bodytoweight. may result Divide doses greater than 10 mL 1100 10 in ineffective treatment, andbetween encourage the development of two injection sites to LONGRANGE is to be given parasite resistance. reduce occasional discomfort or site subcutaneously only.only. Animals LONGRANGE is to be givenreaction. subcutaneously Animals should be appropriately restrained should be appropriately restrained to achieve the proper to achieve the proper route ofroute of administration. Inject under the loose skin in front the shoulder administration. Injectofunder the (see illustration) using a 16 or 18 gauge, to ¾ofinch loose skin in½front theneedle. shoulder illustration) using adisinfectant. 16 or 18 Sanitize the injection site by(see applying a suitable gauge, ½ to ¾ inch needle. Clean, properly disinfected needles be used Sanitize should the injection sitetobyreduce the potential for injection siteapplying infections. a suitable disinfectant. Extended-Release Injectable Parasiticide Clean, properlyPeriods disinfected be used to reduce the potential 5% Sterile Solution Withdrawal and needles Residueshould Warnings for injection site infections. For the Treatment and Control of Internal and External Animals intended for human consumption must not be slaughtered within 48 days of the 50 mL bottle size: Use only polypropylene syringes. Not for use with Parasites of Cattle on Pasture with Persistent Effectivenesslast treatment. This drug product is not approved for use in female dairy cattle 20 months polycarbonate syringe material. If syringe material is not known, contact the Not for use in female dairy cattle 20 months of age or older, including dry dry dairy cows. Useprior in these may cause drug in 3 months syringe manufacturer to usecattle for identification. Do notresidues use beyond dairy cows. Not for use in calves to be processed for veal. of age or older, including milk and/or in calves born to these cows. A withdrawal period has not been for after stopper has been punctured. Discard bottle after 15established stopper punctures. Not for use in breeding bulls, or in calves less than 3 months of age. pre-ruminating Do not use in to be processed for veal. mL and 500calves mL bottle sizes: Use only automatic syringe equipment Not for use in cattle managed in feedlots or under intensive rotational calves.250 provided by Merial. To obtain compatible equipment, contact Merial at 1-888grazing. Animal Safety Warnings and Precautions 637-4251 or your veterinarian. LONGRANGE should not be stored in automatic CAUTION: Federal law restricts this drug to use by or on the order of a The product is likely to causesyringe tissue equipment. damage at Automatic the site ofsyringe injection, including possible granulomas and equipment should be thoroughly cleaned licensed veterinarian. necrosis. These reactions haveafter disappeared treatment. Local tissuepuncture reactionwith maydraw-off result inspike. trim loss each use.without Discard bottle after one stopper of edible tissue at slaughter. Alternatively, a 50-mL polypropylene repeater syringe compatible with DESCRIPTION may be used. To obtainarea list of compatible contact This LONGRANGE® (eprinomectin) is a ready-to-use, sterile Observe injectablecattle preparation for injection siteLONGRANGE reactions. If injection site reactions suspected, consultequipment, your veterinarian. Merial at 1-888-637-4251. When using from a repeater do not use beyond containing eprinomectin, a member of the macrocyclicproduct lactone isclass notoffor intravenous or intramuscular use. Protect product light.syringe, LONGRANGE® (eprinomectin) 3 months after stopper has been punctured. Discard bottle after 15 punctures. antiparasitics. Each mL of LONGRANGE contains 50 mg of eprinomectin in a has been developed specifically for use in cattle only. This product should not be used in other animal species. LONGRANGE should not be stored in the repeater syringe. co-solvent system of N-methyl-2-pyrrolidone (30% v/v) and triacetin (qs), along When to Treatthat Cattle with Grubs No special handling or protective clothing is necessary. with 50 mg of poly-lactide-co-glycolic-acid 75:25 (PLGA), a polymer allows a slow release of eprinomectin from the formulation, thereby maintaining a LONGRANGE effectively controls all stages of cattle grubs. However, proper timing of treatment is WARNINGS ANDcattle PRECAUTIONS prolonged duration of product effectiveness. Butylatedimportant. hydroxytoluene (0.2 most mg/ effective For the results, should be treated as soon as possible after the end mL) acts as an antioxidant in the formulation. of the heel fly (warble fly) season. Withdrawal Periods and Residue Warnings The chemical name of eprinomectin is 4”-deoxy-4”-epiacetylamino-avermectin Environmental Hazards Animals intended for human consumption must not be slaughtered B1. It is a semi-synthetic member Not for use in cattle managed within in feedlots ortheunder intensive rotational grazing because the 48 days of last treatment. of the avermectin family of Thisevaluated drug product not approved for use in female dairy cattle 20 environmental impact has not been foristhese scenarios. compounds consisting of a mixture months age or older, including dry dairyand cows. in these cattle for most of two homologous components, Other Warnings: Parasite resistance mayofdevelop to any dewormer, hasUsebeen reported may cause drug residues in milk and/or in calves born to these cows. B1a and B1b, which differ by a single classes of dewormers. A withdrawal period has not been established for pre-ruminating methylene group at C26. Treatment with a dewormer used incalves. conjunction with parasite management practices appropriate to the Do not use in calves to be processed for veal. INDICATIONS FOR USE geographic area and the animal(s) to be treated may slow the development of parasite resistance. User Safety Warnings LONGRANGE, when administered Fecal examinations or otherNot diagnostic tests and parasite management history should be used to for Use in Humans. Keep this and all drugs out of the reach of children. at the recommended dose volume of 1 mL per 110 lb (50 kg) body weight, is the product is appropriate forsafety the herd/flock, to contains the use of anydetailed dewormer. Following the The material data sheet prior (MSDS) more occupational effective in the treatment and control of the followingdetermine internal andifexternal use of any dewormer, effectiveness treatmentToshould monitored example, with the use of a fecal safety of information. reportbe adverse effects,(for to obtain an MSDS, or for parasites of cattle: egg count reduction test or another appropriate method). assistance, contact Merial at 1-888-637-4251. For additional information about Gastrointestinal Roundworms Lungworms adverseover drugtime experience reporting for animal drugs,reduction contact FDA at 1-888-FDAA decrease in a drug’ s effectiveness as calculated by fecal egg count tests may indicate Bunostomum phlebotomum – Adults and L4 Dictyocaulus viviparus – Adults or dewormer http://www.fda.gov/AnimalVeterinary. the development of resistanceVETS, to the administered. Your parasite management plan should be Cooperia oncophora – Adults and L4 adjusted accordingly based onAnimal regularSafety monitoring. Warnings and Precautions LONGRANGE (EPRINOMECTIN) IMPORTANT SAFETY INFORMATION: Do not treat within Cooperia punctata – Adults and L4 Macrocyclic lactones provide The prolonged that may increase pressure for resistant product drug is likelyexposure to cause tissue damage at the selection site of injection, including Cooperia surnabada – Adults and L4 possible granulomasinand necrosis. These reactions have disappeared without 48 days of slaughter. Not for use in female dairy cattle 20 months of age or older, including parasites. This effect may be more pronounced extended-release formulations. Haemonchus placei – Adults Grubs treatment. Local tissue reaction may result in trim loss of edible tissue at slaughter. TARGET ANIMAL SAFETY dry dairy cows, or in veal calves. Post-injection site damage (e.g., granulomas, necrosis) can radiatum – Adults Hypoderma Observe cattle for injection site reactions. If injection site reactions are bovis Oesophagostomum Clinical studies have demonstrated the wide margin of safety of This LONGRANGE® (eprinomectin). suspected, consult your veterinarian. product is not for intravenousOverdosing or Ostertagia lyrata – Adults at 3 to 5 times the recommended dose resulted in a statistically reduction(eprinomectin) in average weight occur. These reactions have disappeared without treatment. Not for use in breeding bulls, or in intramuscular use. Protect product fromsignificant light. LONGRANGE® has Ostertagia ostertagi – Adults, L4, and gain when compared to the group tested at label dose.for Treatment-related observed in not most been developed specifically use in cattle only.lesions This product should becattle inhibited L4 calves less than 3 months of age. Not for use in cattle managed in feedlots or under intensive used in swelling, other animal species. or necrosis in the subcutaneous tissue of the administered the product included hyperemia, Trichostrongylus axei – Adults and L4 Mites skin. The administration of LONGRANGE at 3 times the recommended therapeutic dose had no adverse rotational grazing. When to Treat with Grubs Trichostrongylus colubriformis – Adults Sarcoptes scabiei var. effects bovis on beef cows reproductive at all stagesCattle of breeding or pregnancy or on their calves. LONGRANGE effectively controls all stages of cattle grubs. However, proper Persistent Activity Not for use in bulls, as reproductive safety testing has not conducted in males intended timing of treatment is important. For been the most effective results, cattle should for 1 LONGRANGElabel. has been proven to effectively protect cattle from reinfection with Dependent upon parasite species, as referenced in FOI summary and LONGRANGE product breeding or actively breeding.beNot for use in calves less than months safety treated as soon as possible after3the end ofoftheage heelbecause fly (warble fly) testing season. has the following parasites for the indicated amounts of time following treatment: Hypoderma larvae (cattle grubs) at the period when these grubs not been conducted in calvesDestruction less than 3ofmonths of age. are in vital areas may cause undesirable host-parasite reactions, including the Durations of STORAGE Parasites possibility of fatalities. Killing Hypoderma lineatum when it is in the tissue Persistent Store atEffectiveness 77° F (25° C) with excursions between 59° and(gullet) 86° Fmay (15°cause and 30° C). Protect fromkilling light. surrounding the esophagus salivation and bloat;
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Gastrointestinal Roundworms Bunostomum phlebotomum
oncophora LONGRANGE® and the Cattle Head Logo® are registered trademarksCooperia of Boehringer punctata Ingelheim Animal Health USA Inc. ©2022 Boehringer Ingelheim AnimalCooperia Health USA Inc., Haemonchus placei Duluth, GA. All Rights Reserved. US-BOV-0055-2022C Oesophagostomum radiatum Ostertagia lyrata Ostertagia ostertagi Trichostrongylus axei Lungworms
acid (GABA).
H. bovis when it is in the vertebral canal may cause staggering or paralysis. Approved by FDA under NADA # 141-327 days Made150 in Canada. These reactions are not specific to treatment with LONGRANGE, but can occur Manufactured Health USAtreatment Inc., Duluth,ofGA 30096Cattle should be treated either before or 100 daysfor Boehringer Ingelheim withAnimal any successful grubs. ®The Cattle Head Logo and ®LONGRANGE registered of afterare these stagestrademarks of grub development. Consult your veterinarian concerning 100 days Boehringer Ingelheim Animal Healththe USAproper Inc. time for treatment. 120 days © 2019 Boehringer Ingelheim Animal Health USA Inc. All rights reserved. 120 daysRev. 01/2019, 8LON016E 1050-2889-08, US-BOV-0597-2021A Environmental Hazards 120 days 120 days 100 days
Studies indicate that when eprinomectin comes in contact with soil, it readily and tightly binds to the soil and becomes inactive over time. Free eprinomectin may adversely affect fish and certain aquatic organisms. Do not contaminate water by direct application or by improper disposal of drug containers. Dispose
STORAGE