What's The Difference Between Sativa And Indica? If you visit a dispensary, you will most likely see three prevalent types of cannabis: Indica, Sativa, and Hybrid. If you have been a cannabis consumer for quite some time, you probably know the general difference between Indica and Sativa. However, if you are into the science of cannabis, you know that the dichotomy between Indica and Sativa doesn’t truly exist in the way it is oftentimes presented.