TheRol eofKer at i nocyt es
Whatar eKer at i nocyt es? Wi t hover90% oft hecel l soft heepi der mi s,t het opl ayeroft heski n,bei ngker at i nocyt es,t hi s cel lt ype domi nat est he epi der mi s.Theybegi ni nt he st r at um basal e,t he epi der mi s'deepest l ayer ,andadvancet ot hest r at um cor neum,t heski n' st opbar r i erl ayer .Squamouscel l swi t ha hi ghdegr eeofker at i ni zat i onandnonucl eusar ewhatar eknownasker at i nocyt es.
Di f f er ent i at i on I nt heepi der mi sbasall ayer ,ker at i nocyt esmul t i pl yandbegi nt ogr adual l ydi f f er ent i at east hey move t owar dt he sur f ace.They under go a si gni f i cantmor phol ogi calchange t hr oughoutt hi s pr ocess and begi nt o make ker at i n,cyt oki nes,gr owt hf act or s,i nt er l euki ns,and compl ement f act or s.Numer ousenvi r onment aland epi genet i cr egul at or ymechani smscont r olker at i nocyt e di f f er ent i at i on.
Funct i onsofKer at i nocyt es Ker at i nocyt eshaveaver yspeci f i cf unct i on.Someoft hecommonf unct i onsofker at i nocyt es i ncl ude: Asat i ghtbar r i ert hatl i mi t st heescapeofmoi st ur e,heat ,andot herel ement swhi l e pr event i ngt heent r yofot hersubst ances,t heypl ayacr uci alr ol ei npr ot ect i on. Addi t i onal l y ,t hesecel l shaveast r uct ur alf unct i onbymaki ngcl oseconnect i onswi t h t heot herepi der malcel l sandhol di ngt hosecel l si npl ace. Fur t her mor e,af t erski ndamage,ker at i nocyt esser veasi mmunomodul at or s.
Resear chAppl i cat i ons Ker at i nocyt escanbest udi edf ort hef ol l owi ngr easons:
Epi der mal
Dr ug
Ski n
Toxi col ogy
Cosmet i c
st udi es
devel opment
agei ng
st udi es
st udi es
Rel at i onshi pswi t hot herski ncel l s Rel at i onshi pswi t hot herski ncel l s Managi ng ski n homeost asi s and est abl i shi ng a heal t hy woundheal i ng pr ocess depends on t he i nt er act i on of ker at i nocyt es and f i br obl ast s. Thr oughpar acr i nesi gnal l i ngpr ocesses,t heset wocel lt ypescant al kt oone anot her .Chr oni cwoundsmayr esul tf r om t hedi sr upt i onoft hi scr osst al k.
Ker at i nocyt esandMel anocyt es Ther el at i onshi pbet weenker at i nocyt esandmel anocyt esi si mpor t antf ort he homeost asi soft heepi der mi s.