TheRol eofKer at i nocyt es
Whatar eKer at i nocyt es? Wi t hover90% oft hecel l soft heepi der mi s,t het opl ayeroft heski n,bei ngker at i nocyt es,t hi s cel lt ype domi nat est he epi der mi s.Theybegi ni nt he st r at um basal e,t he epi der mi s'deepest l ayer ,andadvancet ot hest r at um cor neum,t heski n' st opbar r i erl ayer .Squamouscel l swi t ha hi ghdegr eeofker at i ni zat i onandnonucl eusar ewhatar eknownasker at i nocyt es.
Di f f er ent i at i on I nt heepi der mi sbasall ayer ,ker at i nocyt esmul t i pl yandbegi nt ogr adual l ydi f f er ent i at east hey move t owar dt he sur f ace.They under go a si gni f i cantmor phol ogi calchange t hr oughoutt hi s pr ocess and begi nt o make ker at i n,cyt oki nes,gr owt hf act or s,i nt er l euki ns,and compl ement f act or s.Numer ousenvi r onment aland epi genet i cr egul at or ymechani smscont r olker at i nocyt e di f f er ent i at i on.
Funct i onsofKer at i nocyt es Ker at i nocyt eshaveaver yspeci f i cf unct i on.Someoft hecommonf unct i onsofker at i nocyt es i ncl ude: Asat i ghtbar r i ert hatl i mi t st heescapeofmoi st ur e,heat ,andot herel ement swhi l e pr event i ngt heent r yofot hersubst ances,t heypl ayacr uci alr ol ei npr ot ect i on. Addi t i onal l y ,t hesecel l shaveast r uct ur alf unct i onbymaki ngcl oseconnect i onswi t h t heot herepi der malcel l sandhol di ngt hosecel l si npl ace. Fur t her mor e,af t erski ndamage,ker at i nocyt esser veasi mmunomodul at or s.