HumanPr i mar yCel l s
Pr i mar yhumancel l sar ecel l st hathavebeent akenoutofhumant i ssuesl i kebonemar r ow and bl ood.Theyar er ecogni sedasacr uci alt oolf ordevel opi ngi nvi vomodel s,suchasxenogr af tor humani sedmi ce,orf ori nvi t r ocel l basedt est s.
Benef i t sofPr i mar yCel l s I n vi t r o cel l based exper i ment s have l ong empl oyed i mmor t al i sed cel ll i nes. However , r esear cher sadmi tt hatbi ol ogi calal t er at i onsbr oughtonbycel ll i nesbei ngcont i nuousl yused may compr omi se t hei rphysi ol ogi calr el evance i nr esear ch.Dat a gai ned f r om cel lcul t ur e syst ems ar e mor e physi ol ogi cal l yr el evantwhen human pr i mar y cel l s ar e used,and t hei r si gni f i cancei nt hest udyofbi ol ogi calpr ocesses,di seasepr ogr essi on,andmedi cat i ondi scover y i sgr owi ng.
Advant agesofPr i mar yCel l s Pr i mar ycel l sover comeet hi calar gument sagai nstusi ngani mal si nbi omedi calr esear ch andper mi tt heuseofhumant i ssuei nexper i ment s.
I nst eadofempl oyi ngcel ll i nes,pr i mar ycel l sar emor er el evantt osci ent i f i cr esear ch.An excel l entsyst em t o exami ne bi ochemi calsi gnal l i ng i n vi vo car ef ul l yi s pr escr eened pr i mar ycel l s.
Pr i mar y cel l s make r esear ch mor e af f or dabl e by l ower i ng t he costofusi ng ani mal model s.
Pr i mar ycel l svsCel ll i nes Compar ed t o pr i mar ycel l s,cont i nuouscel ll i nesar et ypi cal l ymor e dur abl e and manageabl e. They ar e a qui ck, si mpl e appr oach t o acqui r i ng f undament al knowl edgeandhavel i mi t l essgr owt hpot ent i al .Wor ki ngwi t hcont i nuouscel ll i nes has some downsi des,i ncl udi ng t he possi bi l i t y ofal t er ed physi ol ogi calf eat ur es t hatdo notaccur at el yr ef l ectt he i n vi vo st at e due t o genet i c modi f i cat i on or t r ansf or mat i on,whi chmi ghtchangeovert i mewi t hr epeat edpassagi ng.
Appl i cat i onsofPr i mar yCel l s I n cel l ul ar and mol ecul ar bi ol ogy , pr i mar y cel lcul t ur ei s bei ng used mor e f r equent l yasakeyt ool .I tof f er sexcel l entmodelsyst emsf orst udyi ngt het ypi cal physi ol ogyandbi ochemi st r yofcel l s( suchasmet abol i cst udi es,agei ng,si gnal l i ng st udi es) ,t heef f ect sofdr ugsandt oxi csubst ancesont hecel l s,andmut agenesi s and car ci nogenesi s.Addi t i onal l y ,i ti s empl oyed f ort he cr eat i on ofbi ol ogi cal mol ecul esandmedi cat i onscr eeni ng.
Dr ugScr eeni ng
3D Cul t ur e
CancerResear ch
Toxi col ogy
Vacci ne Pr oduct i on
Regener at i ve Medi ci ne
Genet i c Engi neer i ng
Or gan Repl acement