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Mount Sinai External Parties Resource Guide

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Innovation and Collaboration With Mount Sinai: Research Cores, Data, and Technology

Mount Sinai’s culture of innovation and collaboration has made it one of the country’s most prestigious research institutions. As one of New York City’s largest academic medical systems, with more than 9,000 physicians working across seven hospitals and more than 350 research labs, the Mount Sinai Health System provides an interdisciplinary environment for some of the world’s most talented researchers to do their work.

These experts are aided and supported by an outstanding complement of research cores— including the Dean’s Centers of Research Excellence (CoREs)—patient data resources, clinical trial capabilities, and advanced technologies.

The following is a list of the resources available to our external collaborators, which offer powerful tools for discovering and testing new drugs, large, diverse patient data and biobanks, robust clinical trials and advanced labs and imaging capabilities, and more. All share a single mission—to help solve the most complex problems in research and clinical care.

Click on the hyperlinks  for more information about specific programs.

For further information, please contact members of the Strategic Alliance and Program Management team within Mount Sinai Innovation Partners: Joy Dicker, Managing Director ( joy.dicker@mssm.edu ), and Irina Furman, Director ( irina.furman@mssm.edu ).

Analytical Services

Biomarkers in Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD) Program 

Develops biomarker-based tools for risk stratification and therapeutic monitoring in kidney disease for clinical research using electronic medical record data, biospecimens, and pathway analysis.

Flow Cytometry CoRE 

Provides instrumentation, expertise, and education required to incorporate flow cytometry and cell sorting into research.

Center for Advanced Genomics Technology 

A world-class next-generation sequencing, single-cell, and spatial -omics resource supporting diverse translational and basic research, led by expert scientific leadership and a multidisciplinary team. The Core has contributed to hundreds of high-impact publications and provides comprehensive wet-lab and highperformance computational capabilities to enable advanced genomic discoveries across a wide range of diseases and applications.

Human Immune Monitoring Center 

Integrates scientific expertise with leading-edge technologies to deliver comprehensive and longitudinal immune monitoring of patients during exposure to therapies.

Metabolomics CoRE 

Offers advanced mass spectrometry-based metabolomics assays.

Neurometabolomics and Neuroinformatics Co RE 

Provides mass spectrometry-based metabolomics and bioinformatics services, supporting projects from sample preparation to data interpretation across pathways, including carbon, lipid, short-chain fatty acids, and hormone metabolism.

Nuclear Magnetic Resonance (NMR) Facility/Liquid

Chromatography-Mass Spectrometry (LC-MS) Facility 

Provides advanced instrumentation and user training formolecular analysis, supporting diverse research needs from small molecules to biomacromolecules and intact proteins.

OCCAM-Immune 

Spin-off of the Human Immune Monitoring Center dedicated to industry collaborations to identify biomarkers of response and resistance to novel drug targets.

Zhang Bioinformatics Laboratory 

Provides integrated analytical services, including genomeand proteome-level analysis, clinical data integration, and training in computational tools to support research.

Biobanking and Repositories

BioMe BioBank 

Enables large-scale studies through an electronic medical record-linked biobank.

Biorepository and Pathology CoR 

Supports tissue and body fluid procurement, storage, and tracking.

Mount Sinai Million Health Discoveries Program 

Program aiming to sequence the genomes of 1 million diverse patients to advance precision medicine and integrate genetics into everyday care.

Neuropathology Brain Bank and Research CoRE 

Offers comprehensive neuropathological services, including advanced histology, tissue processing, and access to a well-curated brain tissue collection.

Clinical Trial and Data Services

Center for Vaccine Research and Pandemic Preparedness (C-VaRPP) 

Provides the framework for studying how the human immune system protects us from deadly viruses and uses this knowledge to generate diagnostics, vaccines and therapeutics. The Center conducts pragmatic observational studies, performs comprehensive characterizations of immune responses as well as viral pathogens and provides experimental services for pre clinical and post market studies using human derived biological materials.

Institute for Transformative Clinical Trials (ITCT) 

Offers expertise to design, conduct, and analyze innovative clinical trials.

International Center for Health Outcomes and Innovation Research (InCHOIR) 

Serves as an interdisciplinary clinical and data coordinating center.

Translational Transplant Research Center (TTRC) 

Supports translational and clinical transplantation studies with expertise in transplant immunobiology and offers preclinical services, including heart, trachea, liver, and kidney transplantation models.

Innovation and Collaboration With Mount Sinai: Research Cores, Data, and Technology

Vaccine and Cell Therapy Laboratory 

Facilitates phase I/II clinical trials with expert support and services, including current good manufacturing practice manufacturing, testing, biobanking, and immune analysis for cancer and other diseases.

Imaging Services

Cryo-EM CoRE 

Home to a Glacios 2 Cryo-TEM for image acquisition with near atomic resolution capabilities. The CoRE also provides consultation, training and education, sample preparation, imaging, and image analysis.

Microscopy and Advanced Bioimaging CoRE 

Offers open access to advanced imaging technologies, image analysis, education, custom solutions, and expert microscope support.

Mount Sinai BioMedical Engineering and Imaging Institute (BMEII) 

Provides advanced imaging and expert support for clinical and translational studies.

• Human Imaging Core  : Research-dedicated 3T/7T MRI, PET/MRI, and CT, with access to PET/CT, SPECT, DEXA, and ultrasound, to support clinical trials at all phases with established and custom imaging endpoints.

• Small Animal Imaging Core  : Micro MRI, micro-PET/ CT, micro ultrasound, bioluminescence/fluorescence, and radiochemistry to support early-phase and translational studies.

Lab Services

Center for Kidney Disease Innovation (CKDI) 

Advances kidney research through tissue engineering and model systems such as 3D bio-printed tubules and stem cell-derived organoids to drive discovery and therapeutic innovation.

Histology CoRE 

Provides complete histological services, including tissue processing, sectioning, advanced staining, molecular imaging, and histomorphometric analysis.

Human Islet and Adenovirus Co RE 

Supports human islet research by providing expert guidance, experimental tools, and viral vectors, while also offering rodent islet resources and specialized analyses to advance diabetes-related studies.

Neurophenotyping CoRE 

Provides state-of-the-art behavioral and stereotactic technologies to support optogenetic, chemogenetic, and CRISPR-based studies and comprehensive neurobehavioral and cognitive testing in murine models.

RNA and Nanoparticle Therapeutics Co RE 

Develops next-generation RNA therapeutics using lipid nanoparticle technology, offering custom RNA delivery systems and tools to accelerate genetic medicine research.

Skeletal and Metabolic Phenotyping CoRE 

Offers phenotyping and analytical services to evaluate skeletal and metabolic disease models, including body composition, bone density, biomarker analysis, and metabolic function testing.

Small Animal Surgery Co RE 

Performs surgery on small animals, mostly pertaining to cardiovascular models.

Stem Cell Engineering Co RE 

Provides human pluripotent stem cell (PSC) lines, lab space, reagents, and training, along with services such as induced pluripotent stem cell (iPSC) generation from somatic cells, characterization, long-term banking, and access to diverse, well-characterized iPSC lines with a focus on CRISPR-based gene editing and support for PSC differentiation protocols.

Transgenic and Genome Editing Co RE 

Offers a comprehensive suite of services for the generation and manipulation of mouse models.

Zebrafish Modeling CoRE 

Offers comprehensive zebrafish-based modeling of human diseases and in vivo therapeutic testing, with capabilities spanning genome editing, transgenesis, phenotypic assays, and compound screening.

Medical Devices

Mount Sinai BioDesign 

Multidisciplinary program that identifies unmet clinical needs by supporting the design, development, and translation of novel medical technologies, advancing innovations into successful venture-backed spinouts and commercial partnerships. Also partners with external medical technology companies to refine product strategy, support design and prototyping, generate preclinical evidence, and advance regulatory, commercialization, and clinical development through benchtop studies, in vivo testing, and first-in-human trials.

Mount Sinai Health System | One Gustave L. Levy Place | New York, NY 10029

For further information, please contact members of the Strategic Alliance and Program Management team within Mount Sinai Innovation Partners: Joy Dicker, Managing Director ( joy.dicker@mssm.edu ), and Irina Furman, Director ( irina.furman@mssm.edu ).

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