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2016 Harold Honickman Lecturer in Prostate Health: Dr. Patrick Walsh

AUA 2016 in San Diego The annual AUA meeting was held in San Diego from May 5 through May 10. Our faculty and residents participated in a variety of plenary sessions, educational programs, and podium and poster presentations. Here is a recap of Jefferson Urology at the event. Hands-On Urologic AUA Ultrasound Course – Edouard Trabulsi, MD MP02-08: Trabulsi E, Tripathi S, Calvaresi A, Solomides C, Gomella L, Thakur M: VPAC1 in shed urinary cellsa potential genitourinary cancer biomarker (PODIUM) (Presented by Dr. Trabulsi) AUA Urologic Oncology Research Symposium “Targeting DNA Repair-hormone Crosstalk in Advanced Prostate Cancer,” Dr. Karen Knudsen V1-05: Lewandoski P, Raval A, Pridjian A, Figueroa T, Zeltser I: Intraperitoneal robotic assisted laparoscopic excision of an upper pole ureterocele and Cohen cross trigonal ureteral reimplantation of a duplicated system (VIDEO) (Presented by Dr. Lewandoski)

Dr. Patrick Walsh (pictured fourth from left) is this year’s distinguished lecturer of the annual Harold Honickman Lecture in Prostate Health. Pictured with Dr. Walsh are (left to right): Dr. Edouard Trabulsi, Dr. Kevin Kelly, Dr. Kenneth Brownstein, Dr. Walsh, Dr. Leonard Gomella, Steve Smith (senior vice president of the Office of Institutional Advancement), and Jonathan Agree (senior director of development, clinical programs). Dr. Walsh had a pre-lecture meeting to learn more about our SKCC prostate cancer program.

was skillfully designed for the diverse audience of providers, students, patients and members of the Jefferson Health community. The Harold Honickman Lecture in Prostate Health was established in honor of Mr. Honickman through a generous gift from his sister, Claire Reichlin, and her partner, D. Walter Cohen, DDS. Mr. Honickman and his wife, Lynne, are recognized for their many philanthropic contributions to the Delaware Valley. They are longtime friends and supporters of Jefferson, where Mr. Honickman serves on the Board of Trustees of Thomas Jefferson University Hospital. The fund supports an annual lecture in Thomas Jefferson University’s Department of Urology to promote prostate health.

S&T39-Tanimoto R, Hubosky SG, Healy KA, Birbe R, Bibbo M, Bagley DH: Concordance of ureteroscopic biopsy grade to radical nephroureterectomy grade and stage based on the 1973 and 2004 WHO classification systems for upper tract urothelial carcinoma (POSTER) (Presented by Dr. Tanimoto)

SUFU Meeting-Panel Discussion with Difficult Case Presentation: Optimal Treatment of DSE in the Male Patient (Sphincter stents; Neurotoxins; Neurostimulation/ Neuromodualtion; Suprapubic Tube). Panelists: Jerry Blavis, Graham Creasey, Patrick Shenot, Christopher Smith

“Laser Enucleation of the Prostate” AUA Technology Theater – Akhil Das, MD

MP 19:Imaging/Radiology/UroRadiology III, Moderator: Edouard J. Trabulsi, MD

MP43-18: Shah M, Barthold J, Xie L, Bani-Hani A: Does Varicocele Repair improve Total Motile Sperm Count (TMSC) in Adolescents? A Pilot Study (Presented by Dr. Shah)

AUA New Member Event Panel– Anne Calvaresi, NP Plenary II-Crossfire: Controversies in UrologyMalignant Radical Prostatectomy is Better than Radiotherapy for High Risk Prostate Cancer Moderator: Leonard G. Gomella, MD

MP40-Prostate Cancer:Localized:Surgical Therapy I. Moderators: Scott Eggener, MD; Leonard G. Gomella, MD

“Ho:LEP-An update in Technique, Instruments & Strategies for Tissue Removal” – Akhil Das, MD

“History of Urology” – Urology Forum II- FRII-08- Scotland KB, Lewandoski P, Raval A, Murphy A: American Women in Urology: A Fascinating History (Presented by Dr. Scotland) Bard Fellow Breakfast-Drs. Brownstein, Bagley, Lallas, Healy, Hubosky, Tanimoto, Molly Gerber (Dr. Tanimoto presented his research to the group) Highlights: Society of Urologic Oncology Program: Plenary I Presenter: Leonard G. Gomella, MD MP61-13: Buraschi S, Xu S-Q, Stefanello M, Moskalev I, Morcavallo A, Genua M, Tanimoto R, Neill T, Peiper SC, Gomella LG, Belfiore A, Black P, Iozzo RV and Morrione A: Progranulin targeting in urothelial cancer cells inhibits motility, anchorage-independent growth, tumor formation in vivo and sensitizes cells to cisplatin (Poster) (Presented by Morrione) 068PG: Advanced Ureteroscopy: Overcoming Challenging Problems. Director: Michael Grasso, III, MD Faculty: Demetrius H. Bagley, MD, Olivier Traxer, MD, Scott G. Hubosky, MD Session 3 - “Hot Controversies in Stone Disease” – Rock Society Moderators: Nicole L. Miller, MD and Demetrius H. Bagley, MD

MP51-12: Fascelli M, Hubosky SG, Healy KA, Shah M, Bagley DH: Cost Savings Associated with Selective Guidewire Use During Retrograde Ureteral Access (Moderated Poster) (Presented by Dr. Fascelli)

Recent Publications Ross NA, Truong H, Keller MS, Mulholland JK, Lee JB, Sahu J: Follicular Lymphomatoid Papulosis: An EosinophilcRich Follicular Subtype Masquerading as Folliculitis Clinically and Histologically. Am J Dermatophatol 38(1), Jan 2016; e1-e10. PMID:26730698 Freedland SJ, Choeurng V, Howard L, DeHoedt A, duPlessis M, Yousefi K, Lam LL, Buerki C, Ra S, Robbins B, Trabulsi EJ, Shah NL, Abdollah F, Feng FY, Davicioni E, Dicker AP, Karnes RJ, Den RB: Utilization of a Genomic Classifier for Prediction of Metastasis following Salvage Radiation Therapy after Radical Prostatectomy. Eur Urol, Jan 2016. PMID:26806658 Tripathi S, Trabulsi EJ, Gomella L, Kim S, McCue P, Intenzo C, Birbe R, Gandhe A, Kumar P, Thakur M: VPAC1 Targeted 64Cu-TP3805 PET Imaging of Prostate Cancer: Preliminary Evaluation in Man. Urology 2016, Feb 2016; 88:111-8. PMID: 26519886 Hubosky SG, Healy KA, Raval AJ, Lallas CD, FilickoOhara J, Bagley DH: Incidental Lymphoma Discovered during Surveillance for Low-Grade Upper Tract Urothelial Carcinoma treated Ureteroscopically: A Case Report Series. J Endourol Case Reports, Vol. 2 (1): 14-17, February 2016 Lallas CD: Robotic VR stimulation to measure competency: A step in the right direction (Commentary). Can J Urol, Feb 2016; 23(1):8167. PMID: 26892059 Mata R, Palladino C, Nicoloski ML, LoPresi AN, Malaguarnera R, Ragusa M, Sciortino D, Morrione A, Maggiolini M, Vella V, Belfiore A: IGF-I Induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway. Oncotarget 2016, 16 Feb 2016; 7(7):7683-700. PMID: 26655502 Gomella LG: Commentary - Genetic Variants in Cell Cycle Control Pathway Confer Susceptibility to Aggressive Prostate Carcinoma Kibel, A et al. Prostate 76:479–490, 2016. Commentary-Urology Practice Update, March 2016. Scotland KB, Lallas CD, Trabulsi EJ, Calvaresi A, Schaeffer D, Shaw C, Gomella LG: Clinical Influences in the Multidisciplinary Management of Small Renal Masses in a Tertiary Referral Center. Urology Practice (in press). Tanimoto R, Cleary RC, Bagley DH, Hubosky SG: Ureteral Avulsion associated with Ureteroscopy: Insights from the MAUDE database. J Endourol, 2016 March; 30(3): 257-61. PMID:26507706 Fizazi K, Chi KN, de Bono JS, Gomella LG, Miller K, Rathkopf DE, Ryan CJ, Scher HI, Shore ND, De Porre P, Londhe A, McGowan T, Pelhivanov N, Charnas R, Todd MB, Montgomery B: Low Incidence of Corticosteroidassociated Adverse Events on Long-term Exposure to Low-

dose Prednisone Given with Abiraterone Acetate to Patients with Metastatic Castration-resistant Prostate Cancer. Eur Urol., 2016 Mar 7. pii: S0302-2838(16)00213-X. doi: 10.1016/j. eururo.2016.02.035. [Epub ahead of print] PMID: 26965562 Syed A, Raval A, Pridjian A, Birbe R, Trabulsi EJ: Radiographic Kinetics of Sarcomatoid Renal Cell Carcinoma. Urology, March 2016 (Epub ahead of print) PMID:27041470 Gomella LG: Editorial - TV Drug Commercials: Keeping Physicians Informed. Can J Urol April 2016; 23(2): 8188. PMID:27085820 Gomella LG: Editorial Comment - Clinical Relevance of Incidental Prostatic Lesions on FDG-Positron Emission Tomography/Computerized Tomography: Should Patients Receive Further Evaluation? Urology Practice Update 2016 (in press) Das A, Lewandoski P, Laganosky D, Walton J, Shenot PJ: Ureteroarterial Fistula: A Review of the Literature-Review Article. Vascular 2016. April; 24(2):203-7. PMID:25972027 Giri VN, Gross L, Gomella LG, Hyatt C: How I Do It: Genetic Counseling and Genetic Testing for Inherited Prostate Cancer. Can J Urol, April 2016; 23 (2): 8247-53. PMID: 27085833 Sidana A, Walton-Diaz A, Truong H, Siddiqui MM, Miao N, Shih J, Manes A, Bratslavsky G, Linehan WM, Metwalli AR: Postoperative evaluation in creatine kinase and its impact on renal function in patients underoing complex partial nephrectomy. Int Urol Nephrol. Published online April 19, 2016. PMID:27093966 Ross AE, Den RB, Yousefi K, Trock BJ, Tosoian J, Davicioni E, Thompson DJ, Choeurng V, Haddad Z, Tran PT, Trabulsi EJ, Gomella LG, Lallas CD, Abdollah F, Feng FY, Klein EA, Dicker AP, Freedland SJ, Karnes RJ, Schaeffer EM: Efficacy of post-operative radiation in a prostatectomy cohort adjusted for clinical and genomic risk. Prostate Cancer Prostatic Dis. May 3, 2016. doi: 10.1038/ pcan.2016.15. [Epub ahead of print] PMID:27136742 Buraschi S, Xu S-Q, Stefanello M, Moskalev I, Morcavallo A, Genua M, Tanimoto R, Mata’ R, Peiper S, Gomella L, Belfiore A, Black P, Iozzo R and Morrione A: Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. Oncotarget, May 2016. Pages 1-16. PMID:27220888 Gomella LG: Prostate HIFU Comes to the U.S. Urology Times Perspective, June 2016 Gomella LG: Commentary - Blue Light Cystoscopy Should be Used Routinely for Bladder Cancer Detection: Pro. Practice Update for Urologists, June 9, 2016

Amirian M: My Surgical Mission to Kumasi, Ghana with IVUmed. AUA News, May 2016, pgs. 29-30. Dan TD, Doyle L, Raval AJ, Pridjian A, Gomella LG, Den RB: “How I Do It” - Dosing, Administration and Safety of Radium-223. Canadian J Urol, June 2016; 23(3): 83018305.PMID:27347625 Figler BD: REPLY: Limited Panniculectomy for Adult Buried Penis Repair. Plastic Reconstr Surg, June 2016; 137(6): 1065e-6e. PMID: 26895592 Raman JD, Lin YK, Shariat SF, Krabbe LM, Margulis V, Arnouk A, Lallas CD, Trabulsi EJ, Drouin SJ, Rouprêt M, Bozzini G, Colin P, Peyronnet B, Bensalah K, Bailey K, Canes D, Klatte T: Preoperative nomogram to predict likelihood of complications following radical nephroureterectomy. BJU Int, June 20, 2016. (Epub ahead of print) PMID:27322735

UrologyUpdate Editorial Directors: Dolores Shupp Byrne Trish Shea Layout and Design: Trish Shea Contributors: Dolores Shupp Byrne, Leonard Gomella, Scott Bowes, Edouard Trabulsi, Jean Hoffman Censits. For more Departmental information and newsletters archives visit: www.jefferson.edu/university/jmc/ departments/urology/newsletters This issue and recent newsletters are also available at: issuu.com/jeffersonurology

New England Journal of Medicine and for 25 years was the editor-in-chief of Campbell’s Textbook of Urology, which has been renamed Campbell Walsh in his honor. In 1996, Dr. Walsh received the Charles F. Kettering Medal from the General Motors Cancer Research Foundation for “the most outstanding recent contributions to the diagnosis and treatment of cancer.” He has received many other high honors over his career at Hopkins. Prior to the lecture, Dr. Walsh participated in a “meet and greet” with leaders from the SKCC prostate cancer program and several members of Jefferson’s leadership team. Dr. Elizabeth Dale, Executive Vice President and Chief Development Officer, Office of Institutional Advancement, and Dr. Stephen K. Klasko, president and CEO Thomas Jefferson University and Jefferson Health, welcomed the audience and provided the background of the annual Honickman lectureship. Dr. Leonard Gomella formally introduced Dr. Walsh who presented: “Prostate Cancer: Where have we been, where are we and where are we going?” The talk

PD13-07: Truong H, Hegarty S, Hubosky S, Healy K, Hoffman-Censits J, Giri VN: Characterization of Upper Tract Urothelial Carcinoma in Patients with Clinical Suspicion of Lynch Syndrome (Presented by Dr. Truong)

Urologic Care for the Allied Health Professional. Faculty: Anne Calvaresi, NP “Hormone Resistant Prostate Cancer”

JEFFERSON UROLOGY UPDATE

The annual Harold Honickman Lecture in Prostate Health was held on Monday, April 18, in the Connelly Auditorium. This year’s distinguished lecturer was Patrick C. Walsh, MD, University Distinguished Service Professor of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital and the Department of Urology, The Johns Hopkins University School of Medicine in Baltimore. Dr. Walsh is renowned for his pioneering work in all aspects of prostate cancer, specifically in the development of the anatomic approach to radical prostatectomy. For 15 years, he served on the editorial board of the

Pictured left to right: Dr. Walter Cohen, Dr. Elizabeth Dale, Claire Reichlin, Harold Honickman, Lynn Honickman, Dr. Steve Klasko, Peg Walsh, Dr. Pat Walsh, Dr. Leonard Gomella, and Steve Smith.

PD13-05: Mann M, Cleary R, Gomella L, Hubosky S, McCue P, Bagley D, Lallas C, Trabulsi E: Fluorescence In Situ Hybridization (FISH) in the Diagnosis of Bladder and Upper Tract Urothelial Carcinoma: A single-institution experience (Presented by Dr. Mann)