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Volume 32

Issue 3, 2013

ISSX President’s Message: See You in Toronto! By Bill J. Smith, ISSX President I’m keeping the President’s message for the newsletter short and sweet for this issue. Why you ask? Simply because I’m going to see you in Toronto in just a few weeks! ISSX has a great tradition of organizing an international meeting every three years with regional meetings in North America, Europe, and AsiaPacific in between. ISSX leadership felt that Toronto, Canada was a great location for the 10th International Meeting because 1) our 7th International Meeting in Vancouver, Canada in 2004 was the most attended ISSX meeting to date; 2) there is easy access to Toronto for international travelers; 3) our headquarters hotel, the Westin Harbour Castle, is a great hotel and conference center with great amenities; and 4) the superb support by Meeting Organizing Committee (MOC) Chair Denis Grant, at the University of Toronto along with his entire committee. By now you have reviewed the fantastic program Denis and his MOC created for this meeting. I hope you agree that the quality of the science that will be presented is reason enough to attend. But if it isn’t, our Wednesday, October 2 party at the Hockey Hall of Fame will probably be enough to

tip you over the edge. There are many things you can do to support ISSX, but your active participation in the meetings has the most impact. So if you haven’t yet registered please reconsider because I would love to see you in Toronto! Bill J. Smith ISSX President

Read all about the 10th International ISSX Meeting on page 3 International Toronto, Ontario, Canada • September 29 - October 3, 2013

IN THIS ISSUE 1

ISSX President’s Message

2 Upcoming Meetings

10 New Members

Book Review: Natural Products Isolation

a Colleague for the 5th 11 Nominate Asia Pacific ISSX Meeting Awards

10th International ISSX Meeting Announcement

Book Review NATURAL PRODUCTS ISOLATION Methods and Protocols Editors: Satyajit D. Sarker and Lutfun Nahar Humana Press, SpringerVerlag GmbH, Germany. 564pp, ISBN 978-1-61779-623-4, 2012

/ISSX Newsletter / Issue 3, 2013

The wealth of natural products available from our surroundings is phenomenal and, from a numerical standpoint, we have only just begun to rummage through this vast resource. The exploitation of natural products as materia medica for treatment of various disorders probably dates back to man’s origins and has been improved upon over the ensuing centuries, albeit with countless false claims made and countless false avenues pursued. Within our modern scientific age there has been a revival of interest in natural products with attention paid to their biological activity and its refinement by chemical modification. As declared in the introductory chapter, such natural products offer, “…templates for the development of novel scaffolds of drugs.” (page 1). Unfortunately, the separation of these desired products, as a starting point, from the biochemical matrices presented by living tissues is a major and unenviable task for the researcher. As the editors state in their preface, “Techniques for extraction and isolation of natural products… […]… have evolved over the years, and

particularly over the last couple of decades…” (page vii) and that this volume is designed to provide, “…a number of ‘hands on’ approaches and ‘step-by-step’ protocols to help natural products researchers follow and implement these protocols in their own research” (page vii). As may be expected, this book comes under the area entitled, “Springer Protocols,” being part of the “Methods in Molecular Biology” series (No. 864), and is now in its third edition. This impression has been carefully revised and contains twenty chapters, some of which are new to this edition. Most other chapters have been expanded, restructured and modernized to enhance their appeal and helpfulness in applying available methodologies and techniques to those involved in the field of natural product extraction. After an opening commentary and an essay on initial bulk extraction, the following chapters discuss various extraction methods including, accelerated solvent extraction, microwave-assisted extraction, planar chromatography, low-pressure column chromatography, ionexchange methods, countercurrent chromatography, high performance liquid chromatography, preparative gas chromatography, and several hyphenated techniques. This section is followed by articles addressing plant secondary metabolites, marine products, microbial products, saponins

and phenolic compounds, with the tome culminating in discussions of scaling up natural product isolation, their follow-up and their role in modern drug discovery programmes. The 31 authors involved have produced some interesting and informative works. The layout is easy to read with many figures and references enhancing the volume. Good quality paper, firm binding and overall solid construction ensure that this book will remain functional for many years. This is strongly recommended for those involved in this area of natural product research, and that probably means most of us from time to time.

Reviewed by

Steve Mitchell Faculty of Medicine Imperial College London London SW7 2AZ, UK

Book ordering information: Humana Press Springer-Verlag GmbH Tiergartenstrasse 17 69121 Heidelberg Germany Web: http://www.springer.com Fax: +49 (0)6221-487-8366

UPCOMING MEETINGS 10th International ISSX Meeting

5th Asia Pacific ISSX Meeting

29th JSSX and 19th North American ISSX Meeting

20th North American ISSX Meeting

The Westin Harbour Castle Hotel Toronto, Ontario, Canada September 29–October 3, 2013 MOC Chair: Denis Grant

Tianjin, China May 9–12, 2014 MOC Chairs: Zhuohan Hu, John O. Miners

Hilton San Francisco San Francisco, California, USA October 19–23, 2014 MOC Chairs: Tetsuya Terasaki, Eric Johnson

Hilton Orlando Bonnet Creek Orlando, Florida, USA October 18–22, 2015 MOC Chairs: Hartmut Derendorf, Stephen Schmidt

International

Announcement Reminder

Toronto, Ontario, Canada • September 29 - October 3, 2013

Why You Should Attend the 10th International ISSX Meeting

Meeting Organizing Committee and International Scientific Advisory Board

This meeting will bring together individuals who are actively working on drug/ xenobiotic research in diverse fields including basic and clinical pharmacology and therapeutics, toxicology, oncology, endocrinology, physiology, biochemistry, medicinal chemistry, molecular and structural biology, and genetics. If you work in the fields of toxicology, pharmacy, or molecular biology or if you study xenobiotics, you can’t afford to miss the 10th International ISSX Meeting.

Denis Grant (Meeting Chair), University of Toronto, Toronto, ON, Canada

• L earn the latest information in this dynamic and specialized field through our Short Course program, a variety of timely scientific symposia, and topical keynote and plenary sessions. •E xpand your knowledge of drug metabolism and disposition by learning from our outstanding faculty assembled from leading experts in the field worldwide. •S cientific meetings organized by ISSX offer numerous outstanding scientific sessions and many opportunities for substantive conversations with scientists worldwide. Our exhibitors will be showcasing the products and services important to you in your research and development.

Jack Bend, University of Western Ontario, London, ON, Canada Chantal Guillemette, Laval University, Quebec, QC, Canada Malle Jurima-Romet, Celerion, Montreal, QC, Canada David K.H. Lee, NoAb Biodiscoveries, Mississauga, ON, Canada Tom Massey, Queen’s University, Kingston, ON, Canada Eddie Morgan, Emory University, Atlanta, GA, USA Sandy Pang, University of Toronto, Toronto, ON, Canada Allan Rettie (SAC Member), University of Washington, Seattle, WA, USA David Riddick, University of Toronto, Toronto, ON, Canada Nathalie Rioux, Boehringer Ingelheim (Canada), Ltd., Laval, QC, Canada Rachel Tyndale, University of Toronto, Toronto, ON, Canada Peter Wells, University of Toronto, Toronto, ON, Canada A complete listing of the International Scientific Advisory Board (ISAB) is available online at www.issx.org/ international2013/isab

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Issue 3, 2013

•E njoy informal social interactions with fellow researchers, and also enjoy exploring Toronto - Canada’s largest city, its financial center, and the capital of the province of Ontario. In Toronto you will find a vibrant, safe and walkable downtown core, excellent transit access to many cozy neighborhoods, stunning traditional and modern architecture, world-class museums and galleries, an abundance of nightlife, and more than 7,000 restaurants of every price range and ethnic flavor imaginable!

Stelvio Bandiera, University of British Columbia, Vancouver, BC, Canada

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Maximize Your Time in Toronto by Attending an ISSX Short Course! Visit www.issx.org/international2013/shortcourses for complete course details.

Scientific Program (Schedule is subject to change)

Sunday, September 29, 2013 Concurrent Morning Short Courses | 09:00 – 12:00 Short Course I: Metabolomic Profiling as a Tool for Identifying Novel Drug-Target Interactions | Harbour Ballroom C Chair: David Wishart, University of Alberta, Edmonton, AB, Canada Short Course II: Model Systems and Methods for Assessing Uptake and Efflux of Small Molecules | Harbour Ballroom AB Chair: Reina Bendayan, University of Toronto, Toronto, ON, Canada Concurrent Afternoon Short Courses | 13:30 – 16:30 Short Course III: Strategies and Techniques for Predicting Human Drug Metabolism and DrugDrug Interactions | Harbour Ballroom AB Chairs: Uwe Fuhr, Uniklinik Koln, Koln, Germany; Olavi Pelkonen, University of Oulu, Oulu, Finland Short Course IV: Application of Novel Mass Spectrometric Methods to Drug Metabolism and Pharmacokinetics Studies | Harbour Ballroom C Chair: Ragu Ramanathan, QPS, Newark, DE, USA Keynote Lecture | 18:45 – 19:30 Systems Pharmacology – Systems Biology Meets Drug Discovery & Development | Frontenac Doug Lauffenburger, Massachusetts Institute of Technology, Cambridge, MA, USA

Monday, September 30, 2013

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Plenary Session 1 | 09:00 – 10:30 Plenary Session 1: Drug-Metabolizing Enzymes as Potential Therapeutic Targets | Frontenac Chair: Paul Hollenberg, University of Michigan, Department of Pharmacy, Ann Arbor, MI, USA

2013 Frederick J. Di Carlo Distinguished Service Award Presentation to Robert P. Hanzlik, Ph.D. Parallel Sessions 1 and 2 | 13:30 – 15:30 Parallel Session 1: Nuclear Receptors as Regulators of Drug Metabolism and as Therapeutic Targets | Frontenac Co-Chairs: Ulrich Zanger, Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; Hongbing Wang, University of Maryland, School of Pharmacy, Department of Pharmaceutical Science, Baltimore, MD, USA Parallel Session 2: Pharmacogenomics and Personalized Medicine: Progress in Clinical Implementation | Harbour Ballroom Chair: Rachel Tyndale, University of Toronto, Toronto, ON, Canada Parallel Sessions 3 and 4 | 16:00 – 18:00 Parallel Session 3: Regulation of Drug Transporter Expression and Function | Frontenac Chair: Micheline Piquette-Miller, University of Toronto, Toronto, ON, Canada Parallel Session 4: Application of Structural Biology to the Prediction of Drug Response, Metabolism and Toxicity | Harbour Ballroom Chair: James Halpert, University of California, San Diego, CA, USA

Tuesday, October 1, 2013 Plenary Session 2 | 09:00 – 10:30 Plenary Session 2: Utility of Genetic and Epigenetic Technologies in Drug Development and Safety Assessment | Frontenac Chair: Ann Daly, Newcastle University, Institute of Cellular Medicine, Newcastle Upon Tyne, UK Parallel Sessions 5 and 6 | 11:00 – 13:00 Parallel Session 5: Metabolism, Pharmacokinetics and Interactions of Traditional Medicines and Natural Products | Frontenac Co-Chairs: Chuan Li, SIMM, Shanghai, China; Ge Lin, Chinese University Hong Kong, School of Biomedical Sciences, Hong Kong, China

2013 ISSX Awards Presentation | 11:00 – 12:00 Frontenac | ISSX Awards 2013 R.T. Williams Distinguished Scientific Achievement Award Presentation and Lecture Yuichi Sugiyama, Ph.D.

Register before September 27 to take advantage of the pre-meeting registration discount and to avoid long lines at the registration counter. Visit www.issx.org/international2013/registration today.

Parallel Session 6: Cell Type Specific Mechanisms of Adverse Drug Reactions | Harbour Ballroom Chair: Michael Aleo, Pfizer, Global Research and Development, Groton, CT, USA Free Afternoon in Toronto | 14:00 Wednesday, October 2, 2013 Plenary Session 3 | 09:00 – 10:30 Plenary Session 3: Identification and Use of Novel Biomarkers for Xenobiotic-Induced Toxicity | Frontenac Chair: Malle Jurima-Romet, Celerion, Drug Development, Hudson, QC, Canada Parallel Sessions 7 and 8 | 11:00 – 13:00 Parallel Session 7: Targeted Drug Delivery for Enhanced Therapy | Frontenac Chair: Christine Allen, University of Toronto, Toronto, ON, Canada Parallel Session 8: Use of PB-PK Modeling in Pharmaceutical Safety Assessment | Harbour Ballroom Chair: Aleksandra Galetin, University of Manchester, Manchester, UK Parallel Sessions 9 and 10 | 14:30 – 16:30 Parallel Session 9: Regulatory Perspectives in Drug-Drug Interactions and Metabolites in Safety Testing | Frontenac Chair: Greg Slatter, Amgen, Seattle, WA, USA Parallel Session 10: Toxicogenomic and Metabolomic Profiling: Current Status and Future Utility in Assessing Drug Efficacy and Safety | Harbour Ballroom Chair: Tim Zacharewski, Michigan State University, East Lansing, MI, USA ISSX Party at the Hockey Hall of Fame | 19:00 – 22:00 Enjoy a delicious buffet dinner, catch up with friends, and meet new acquaintances at the ISSX Party at the Hockey Hall of Fame! This is a ticketed event and a separate fee of $100 applies.

Plenary Session 4 | 09:00 – 10:30

Parallel Session 12: Development and Uses of HepatocyteDerived and Hepatocyte-Like Cells for Predicting Human Drug Metabolism | Harbour Ballroom Chair: Martine Daujat-Chavanieu, INSERM, Montpellier, France

OPENING KEYNOTE LECTURE:

Systems Pharmacology – Systems Biology Meets Drug Discovery & Development Douglas A. Lauffenburger is Ford Professor of Bioengineering and Head of the Department of Biological Engineering at MIT, and also holds appointments in the Department of Biology and the Department of Chemical Engineering. He is a member of the Koch Institute for Integrative Cancer Research, the Center for Biomedical Engineering, the Center for Environmental Health Sciences, and the Center for Gynepathology Research. Dr. Lauffenburger’s BS and PhD degrees are in chemical engineering from the University of Illinois and the University of Minnesota, in 1975 and 1979 respectively. His major research interests are in cell engineering: the fusion of engineering with molecular cell biology. Lauffenburger has coauthored a book entitled Receptors: Models for Binding, Trafficking & Signaling, published by Oxford University Press in 1993, and coedited another entitled Systems Biomedicine, published by Elsevier Press in 2010. More than 90 doctoral students and postdoctoral associates have completed their training under his supervision or co-supervision. Prof. Lauffenburger has served as a consultant or scientific advisory board member for Astra-Zeneca, Beyond Genomics, CellPro, Eli Lilly, Entelos, Genstruct, Insert Therapeutics, Johnson & Johnson, Merrimack Pharmaceuticals, Pfizer, Precision Therapeutics, SyStemix, the Burroughs-Wellcome Fund, and the Whitaker Foundation. He is a member of the National Academy of Engineering and of the American Academy of Arts & Sciences, and has served as President of the Biomedical Engineering Society, Chair of the College of Fellows of AIMBE and on the Advisory Council for the National Institute for General Medical Sciences at NIH.

Poster Awards Presentation | 10:30 – 10:45 2013 International Meeting Poster Awards Presentation | Frontenac

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Plenary Session 4: Genetically Modified Animal Models for Predicting Human Drug Disposition and Response | Frontenac Chair: Xinxin Ding, Wadsworth Center, NYSDOH, Albany, NY, USA

Parallel Session 11: Tissue Imaging and Distribution Studies in Drug Development | Frontenac Chair: Yasuyoshi Watanabe, RIKEN Center for Life Science Technologies, Kobe, Japan

Issue 3, 2013

Thursday, October 3, 2013

Parallel Sessions 11 and 12 | 11:00 – 13:00

2013 International ISSX Awards

individual differences in drug disposition and response.

The R.T. Williams Distinguished Scientific Achievement Award Sponsored by Charles Crespi and Family

Overall, Professor Sugiyama has produced a remarkable body of scientific work, with a profound impact on how we understand the pharmacokinetics, pharmacodynamics and use of drugs. Professor Sugiyama was ranked by ISI as the most highly cited scientist in Pharmacology and Toxicology over the period 1997-2007.

The 2013 R.T. Williams Distinguished Scientific Achievement Award is presented to an ISSX member or non-member from any region that has made substantial and seminal scientific contributions to the field over a sustained period. The focus of this award is the individual’s scientific accomplishments and it is intended to recognize the best in the field, internationally. The 2013 recipient is Yuichi Sugiyama, Ph.D., RIKEN Innovation Center, Research Cluster for Innovation, Japan.

/ISSX Newsletter / Issue 3, 2013

Professor Sugiyama is a world leader in drug transporters and physiologically-based pharmacokinetics. His work is firmly based on quantitative principles whereby drugs are absorbed, reach their target tissue (to produce their pharmacological effect), are metabolized, and eventually excreted. A central goal of his research is to establish reliable predictions of drug action in vivo, thereby optimizing drug therapy. By integrating physiological, molecular, and genetic studies with pharmacokinetics, Professor Sugiyama has created a new research area—Molecular Pharmacokinetics. A physiologically-based molecular pharmacokinetic model takes into consideration all relevant processes in the body. Professor Sugiyama dissects these processes by creatively interweaving a range of approaches that include mathematical modeling, pathophysiology, enzyme kinetics, genetics, and the molecular biology of receptors, enzymes and transporters. His work has succeeded to a degree unmatched by any other laboratory. Of particular note is Professor Sugiyama’s leadership in the field of drug transporters — he has published many seminal papers in this area. Detailed in vitro studies with transporters now allow prediction of transporter-mediated drug-drug interaction in vivo, while genetic variations in transporter genes are being identified in his laboratory that can account for inter-

Professor Sugiyama has been actively involved in professional organizations for decades. Notably, he served as a Councilor of ISSX from 1998 – 2003 and was elected President-Elect in 2004. He then served as president of ISSX from 20062007 while concurrently serving as the President of JSSX. He was Chair of the Pharmaceutical Sciences World Conference in Kyoto in 2004, and has served as co-chair of a multitude of highly regarded international symposia over the years. To recognize and celebrate Professor Sugiyama’s substantial and sustained scientific contributions to the field of xenobiotic disposition spanning almost four decades, he is awarded the 2013 R.T. Williams Distinguished Scientific Achievement Award. Award Presentation and Lecture: Monday, September 30 | 11:00 – 12:00 | FRONTENAC The Frederick J. Di Carlo Distinguished Service Award The 2013 Frederick J. Di Carlo Distinguished Service Award is presented to an ISSX member from any region with an illustrious record of important service to the Society and its goals. The 2013 recipient is Robert P. Hanzlik, Ph.D. Professor Hanzlik has a history of service to ISSX and its goals. A charter member of the Society, Professor Hanzlik helped establish what has become the premier association for academic and industrial researchers in this area. In the early years he worked diligently to advance ISSX by serving in leadership and service roles including Councilor (1984-1987) and

ISSX CAREER CENTER Do you know about the ISSX Career Center? Searching for experts in the field of drug metabolism, pharmacokinetics, pharmacodynamics, and other related areas? The ISSX Career Center job board is your premier resource to find skilled applicants. • Create Your Company Profile free of charge and explain the organization and work environment in detail. •W hen your positions are advertised on the ISSX Career Center, an e-mail advertising the position is sent automatically to job seekers who have requested notifications about opportunities matching their search criteria. •B rowse Resumes for free and pay only for the resumes that you select. Post your jobs online today! When you use the ISSX Career Center, you ensure that your open positions are advertised in the right place. Visit www.issx.org/careercenter.

as the first chairman of the Scientific Affairs Committee (1986-1987). He was active in organizing meetings, serving as the program co-chairman for the very first ISSX North American Symposium (1985) and organizing and presenting a short course titled “Reactive Metabolite Chemistry for Toxicologists” at the 2nd North American ISSX Meeting in Florida, organized by Fred Di Carlo and Richard Welch (1987). During the early 1990’s as ISSX grew, Professor Hanzlik’s steady hand and attention to detail significantly contributed to both the ISSX Bylaws Committee (1991) and the Publications Committee (1991-1995). Professor Hanzlik has also organized several successful symposia and short courses for ISSX (6th North American ISSX Meeting in North Carolina in 1994) and Program Committee member for the 4th International ISSX Meeting in Seattle (1995). Professor Hanzlik then accepted the highest levels of ISSX leadership and responsibility as ISSX president-elect (1994 and 1995), president (1996-1997) and past president (1998 -1999), providing a well-organized and strong leadership vision. In addition to his record of outstanding support and leadership to ISSX, Professor Hanzlik brings honor to ISSX as a distinguished scientist with an international reputation and as a leading trainer of more than 50 graduate students and post-doctoral fellows who now occupy positions in the pharmaceutical industry, non-profit organizations, and academia. He has published in excess of 150 scientific papers and has served as a member of editorial and advisory boards for several prestigious scientific journals. For his involvement, leadership, expertise, contributions, and commitment, ISSX is proud to honor Professor Robert P. Hanzlik with the 2013 Frederick J. Di Carlo Distinguished Service Award.

10th International ISSX Meeting Exhibitors The 10th International Meeting will feature an exhibition showcasing the products and services that researchers need to advance their work. The exhibition begins with the welcome reception on Sunday evening and continues throughout the meeting. Meet with representatives from top suppliers and maximize the value of your attendance! The following companies will exhibit at the 10th International ISSX Meeting. To add your company to the list of exhibitors, visit www.issx.org/international2013/exhibits. AB SCIEX

MicroConstants

Agilux Labs

MPI Research

AIM Research Company

Nexcelom Bioscience

Alliance Pharma, Inc.

Optibrium

Alturas Analytics

Optivia Biotechnology

Bioreclamation IVT

PhoenixBio USA Corporation

Bruker Daltonics

Promega Corporation

Busan, South Korea, 11th International ISSX Meeting

Puracyp, Ltd Qualyst Transporter Solutions, LLC

Charles River CNBE INRS

Quintiles

Corning Life Sciences

Award Presentation: Monday, September 30 | 11:00 – 12:00 | FRONTENAC

Covance, Inc.

Special Event: ISSX Party at the Hockey Hall of Fame

Cyprotex

Quotient Bioresearch SafeSciMET

Cypex

SAGE Labs Sigma Life Science

Eicom USA

Simulations Plus, Inc.

Frontage Labs

SOLVO BIOTECHNOLOGY

Hepregen Corporation

Taconic

HepatoChem Huntingdon Life Sciences Hurel Corporation International Institute for the Advancement of Medicine (IIAM) InterVivo Solutions

Tandem Labs Thermo Scientific (part of Thermo Fisher Scientific) Triangle Research Labs University of Washington, Drug Interaction Database Program

Lablogic Systems Limited

XenoBiotic Laboratories, Inc.

Lhasa Limited

XenoTech, LLC

Life Technologies Exhibitor listing as of August 27, 2013.

Be sure to select this registration option and plan to attend. Continued on next page

/ISSX Newsletter / 7

Waters Corporation

In Vitro ADMET Laboratories, LLC

Issue 3, 2013

Join your fellow attendees at a museum and entertainment destination like no other. Enjoy a delicious buffet dinner, catch up with friends, and meet new acquaintances at the ISSX Party at the Hockey Hall of Fame! Located in an architecturally ornate former bank building in downtown Toronto, the Hockey Hall of Fame is only three blocks from the Westin Harbour Castle Hotel. This spectacular museum is a highly unique venue that presents Canada’s national sport through the world’s largest collection of hockey artifacts and the fun of interactive games. Attendees can take shots at real-time goalies, stop the shots of Gretzky and Messier, call the play-by-play of some of hockey’s greatest goals, get up close and personal with the Stanley Cup in the museum’s vault, and explore the largest collection of hockey memorabilia in the world. A separate fee of $100 applies for this event ticket.

QPS Hepatic Biosciences

Hotel, Travel, and Visa Hotel rooms have been reserved at the Westin Harbour Castle Hotel at a special rate of $215 CAD for ISSX attendees. Book a room online by Monday, September 9, 2013 to obtain the special attendee rate. Located 28 km from Pearson International Airport (YYZ), the hotel is easily accessible by airport shuttle, public transportation, taxi, and rental car.

Depending on the agreements between Canada and your country, a visa may be required. Please check with your local embassy/consulate or travel agent to obtain information regarding visa requirements. If you require a letter of invitation in order to obtain a visa please contact ISSX at information@issx.org. Visit www.issx.org/international2013/ accommodations for more information.

Industry-Sponsored Symposia Industry-Sponsored Symposia (ISS) are commercially-supported educational and promotional activities held in conjunction with the 10th International ISSX Meeting. Although not an official part of the 10th International ISSX Meeting, these programs have been reviewed and these presentations permitted by MDO and ISSX. If you are attending the 10th International ISSX Meeting, make plans to participate in the morning Industry-Sponsored Symposia offered: Scheduled Industry-Sponsored Symposia Presentations Monday, September 30 | 07:45 - 08:45 | Concurrent Symposia

Promega Corporation | Pier 4/5

Thermo Scientific | Harbour Ballroom

USING MULTI-PARAMETRIC OPTICAL ASSAYS WITH SPECIALIZED CELL-TYPES TO ENHANCE THE BIOLOGICAL RELEVANCE OF EARLY ADMET SCREENING

APPLICATIONS OF HRAM AND NEW TOOLS FOR METABOLITE IDENTIFICATION

Presented by: James Cali, Promega Corporation

Presented by: Tim Stratton, Thermo Fisher Scientific and Jeff Gilbert, DOW Agro Sciences

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Tuesday, October 1 | 07:45 - 08:45 | Concurrent Symposia

Bruker Daltonics | Harbour Ballroom

Corning Incorporated | Pier 4/5

MALDI IMAGING MASS SPECTROMETRY: BRIDGING BIOLOGY AND CHEMISTRY TO ADVANCE DRUG DEVELOPMENT

USING CELL-BASED AND RECOMBINANT MODELS IN DRUG TRANSPORT

Presented by: M. Reid Groseclose and Stephen Castellino, GlaxoSmithKline

Presented by: Na Li, Ph.D. and Inese Smukste, Ph.D., Corning Incorporated

Wednesday, October 2 | 07:45 - 08:45 | Concurrent Symposia

Hepregen Corporation | Harbour Ballroom

Bioreclamation IVT | Pier 4/5

HEPATOPACâ„˘ MICROPATTERNED CO-CULTURE SYSTEM - AN IMPROVED IN VITRO MODEL FOR METABOLITE IDENTIFICATION AND COMPOUND STABILITY

PREDICTIONS OF IN VIVO HETEROTROPIC ACTIVATION OF CYTOCHROME P450 ENZYMATIC ACTIVITY FROM IN VITRO SYSTEMS

Presented by: Edward LeCluyse, Hamner Institutes for Health Sciences

Presented by: Anna L. Bloblaum, Bioreclamation IVT

ISSX Supporters and 10th International ISSX Meeting Sponsors ISSX Supporters

CellTox™ Green More Biology, Less Work

10th International Meeting Sponsors

CellTox™ Green enables real-time mechanistic toxicity monitoring with a simple Add & Read protocol. Multiplexing with CellTiter-Glo® allows investigators to monitor temporal changes of membrane-modulated cytotoxicity in parallel with the key cell viability biomarker, ATP.

To see how easy better biology can be, request a free sample at: www.promega.com/ISSX13

ISSX Invites Members to Organize Scientific Meetings

Please direct inquiries to the ISSX Executive Director, Steven Kemp, at skemp@issx.org.

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Visit www.issx.org for more information including the document “Guidelines for the Organization of ISSX Meetings,” for sample meeting proposals, and for the meeting proposal submission form.

Issue 3, 2013

ISSX meetings provide invaluable opportunities for learning, networking, and exploring new ideas. Organizing an ISSX scientific meeting is a significant responsibility but also a tremendously valuable experience. Those who organized ISSX scientific meetings earn the gratitude of their contemporaries and add a highly impressive credit to their curriculum vitae.

ISSX Welcomes New 2013 Members! Olumide Ajani, University of Ibadan, Nigeria

Aurelie Krol, INSERM, France

Adekunbi Aluko, University of Ibadan, Nigeria

Yoshiki Kusunoki, Japan

Sara Amberntsson, Global DMPK, Sweden

Diana Lambert, Xenotech, LLC, United States

Guohua An, University of Florida, United States

Seok-Yong Lee, Sungkyunkwan University, Korea

Sandra Appiah, Middlesex University, United Kingdom

Mey Lee, Amgen, United States

Lars Blumenstein, Novartis Pharma, Switzerland

Minwoo Lee, Green Cross Corp., Korea

Jayaprakasam Bolleddula, Theravance, Inc., United States

Remi Magnan, Solvo Biotechnology, Hungary

Joris Braspenning, Medicyte GmbH, Germany

Edward Meek, United States

Tom Chan, Boehringer Ingelheim Pharmaceuticals, United States

Larry Morgan, University of Guelph, Canada

Chun-Lin Chen, Medicilon, Japan

Clayton Otwell, XenoTech, United States

Young-Won Chin, Dongguk University, Korea

Soo Heui Paik, Boryung Pharm., Korea

Young Hee Choi, Dongguk University, Korea

Jihye Park, Korea

Mukund Chorghade, Empiriko Corporation, United States

Juhee Park, Curachem, Inc., Korea

Laurent Chouchana, Université Paris Descartes, Sorbonne Paris Cité, France

Yan Qin, Pronova Biopharma, Norway

Edwin Chow, University of Toronto, Canada Jae Yong Chung, Seoul National University Bundang Hospital, Korea

Andrew Rowland, Flinders University, School of Medicine, Clinical Pharmacology, Australia

Ines De Lannoy, InterVivo Solutions, Inc., Canada

Svetlana Sapelnikova, KMT Hepatech Inc., Canada

Isabelle De Waziers, INSERM, France

Kari Schlicht, Agilent Technologies, United States

Bo Feng, Pfizer Inc., United States

Taurence Senn, University of Washington, United States

Pierre-Jean Ferron, Anses, France

Karine Sevin, GALDERMA R&D, France

Keizo Fukushima, Kobe Gakuin University, Japan

Miki Shimada, Tohoku University Hospital, Japan

Gerhard Gross, Janssen, Belgium

Sook Jung Shin, Curachem, Inc., Korea

Xiaowen Guan, United States

Dawn Stricker, Optivia Biotechnology, United States

Young Hwan Ha, Curachem, Inc., Korea

Huadong Sun, Bristol-Myers Squibb, United States

Hyekyung Han, Korea

Vibeke Hougaard Sunesen, LEO Pharma A/S, Denmark

Jessica Hartman, University of Arkansas for Medical Sciences, United States

Jana Swenke, Kaye/Bassman, United States

Robin Haw, OICR, Canada Charles Hendricks, Organovo, United States Alain Heron, Imabiotech, France Kevin Hogeveen, Anses, France

/ISSX Newsletter / Issue 3, 2013

Zhanying Hong, School of Pharmacy, Second Military Medical University, China

Debora Roaquin, Astrazeneca Pharmaceuticals, United States

Steven Hu, Zoetis, United States Marycarmen Hurtado, Cinvestav-IPN, Mexico Sabariah Ismail, Universiti Sains Malaysia, Malaysia Sylvie Kandel, Xenotech LLC, United States Seokuee Kim, Seoul National University College of Medicine, Korea Mirim Kim, Korea Min-Jung Kim, Korea Sangsoo Kim, University of Guelph, Canada Yun Sik Kim, Curachem, Inc., Korea

Apana Takwi, St. Jude Children’s Research Hospital, United States Ravi Talluri, Glenmark Pharmaceuticals, India Fuxing Tang, Forest Labs, Inc., United States Kazuhiro Tetsuka, Astellas Research Institute of America, United States Walid Touati, INSERM, France Thuy Tran, Amgen, Inc., United States

Ilya Tsyrlov, XENOTOX, Inc., United States Ayse Ufuk, University of Manchester, United Kingdom Gillian Wallace, Life Technologies, United Kingdom Peter Ward, Janssen, United States Peter Webborn, AstraZeneca, United Kingdom Ian Westley, The Queen Elizabeth Hospital, Australia Zhihong Yang, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, China Zhiyuan Yin, Western University, Canada

Gordon Kirby, University of Guelph, Canada

Jingjing Yu, University of Washington, Dept. of Pharmaceutics, United States

Tarra Knotts, United States

Liming Zhang, Takeda Pharmaceutical Company Ltd., United States

Risako Kon, Japan

Culturing and maintaining transporter cell lines can be expensive and time-consuming. In addition, it can take a week—or more—to prepare cells for assaying. New Corning® TransportoCells™ Cryopreserved Transporter Cells can be thawed, plated and assayed in just two days with high uptake ratios. Visit Corning booth 203 at ISSX to learn about our complete ADME offering, including Transwell® Permeable Supports, Corning cellgro® media, and Gentest SM Contract Research Services. www.corning.com/lifesciences

NOMINATE A COLLEAGUE FOR THE 5TH ASIA PACIFIC ISSX MEETING AWARDS Nominations are now being accepted for the following awards to be presented at the 5th Asia Pacific ISSX Meeting May 9-12, 2014. The two awards to be presented at this meeting are:

Visit www.issx.org/awards/nominations to learn more and submit a nomination.

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Asia Pacific New Investigator Award - Presented to an ISSX member who has made significant contributions to the field during their early career years (normally within 5 -10 years from the time of receiving his/her highest earned degree). The purpose of this award is to encourage and recognize developing scientists who are active in the field within the Asia Pacific region. The award will consist of a plaque or medal, an honorarium, and travel support to the 5th Asia Pacific ISSX Meeting in Tianjin, China.

Issue 3, 2013

Asia Pacific Scientific Achievement Award - Presented to an ISSX member who has made major scientific contributions to the field in the Asia Pacific region. The purpose of this award is to recognize meritorious contributions by senior or mid-career scientists that have had a major impact on research in the field. The award will consist of a plaque or medal, an honorarium, and travel support to the 5th Asia Pacific Meeting in Tianjin, China where a lecture will be presented by the awardee.

Submit an abstract for the 5th Asia Pacific ISSX Meeting in Tianjin, China May 9-12, 2014. Visit www.issx.org/5asiapacific/abstracts to submit an abstract. Abstract submissions for the general poster presentations and Poster Awards Competition are due by Friday, January 31, 2014.

ISSX 2013 Membership Renew with ISSX for the 2013 Membership term to receive steep registration discounts for the 10th International ISSX Meeting! www.issx.org/Membership.

/ISSX Newsletter / Issue 3, 2013

Enabling Tissue Molecular Imaging with Mass Spectrometry n n n n n

Protein and Peptide Distribution Biomarker Studies Tissue Structure Analysis and Differentiation Lipid and Membrame Analysis Small Molecule Drug and Metabolite Distribution

Innovation with Integrity

MASS SPECTROMETRY

Join ISSX on Wednesday, October 2 for a Party at the Hockey Hall of Fame!

Add this event to your meeting schedule! Log in to update your registration at: www.issx.org/international2013/registration

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A separate registration fee of $100 applies. Tickets may still be available.

Attendees can either meet in the hotel lobby at 18:45 or meet at the Hockey Hall of Fame located a short walk from the hotel at 30 Yonge Street.

Issue 3, 2013

Are you attending the 10th International ISSX Meeting? Join fellow attendees for a delicious dinner in a unique venue that presents Canada’s national sport through the world’s largest collection of hockey artifacts and the fun of interactive games. Attendees can take shots at real-time goalies, stop the shots of Gretzky and Messier, call the play-by-play of some of hockey’s greatest goals, get up close and personal with the Stanley Cup in the museum’s vault, and explore the largest collection of hockey memorabilia in the world. This is the premier social event at this meeting and no better place for attendees to catch up with old friends and make new acquaintances.

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INDUSTRY-SUPPORTED SYMPOSIUM: Use of HepatoPac™ - An Improved In Vitro Model for Metabolite Identification and Compound Stability. Edward LeCluyse, Hamner Institutes VISIT US AT BOOTH #211

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ISSX Member Spotlight

UPCOMING MEETINGS

What do you think the future of xenobiotic research will look like?

10th International ISSX Meeting The Westin Harbour Castle Hotel Toronto, Ontario, Canada September 29 – October 3, 2013

What excites you about your research? What advice can you offer to students and young investigators?

5th Asia Pacific ISSX Meeting Tianjin, China May 9 – 12, 2014

Answer these questions and you could be featured in our next newsletter.

29th JSSX and 19th North American ISSX Meeting

Complete the form online: www.issx.org/Membership/Spotlight

Hilton San Francisco San Francisco, California, USA October 19 – 23, 2014

20th North American ISSX Meeting Hilton Orlando Bonnet Creek Orlando, Florida, USA October 18 – 22, 2015

11th International ISSX Meeting

Busan Exhibition and Convention Center Busan, Korea June 12 - 16, 2016

Hepatocytes and Subcellular Fractions • Hepatocytes, Microsomes and S9 Fractions • Human and Animal • Custom Products

/ISSX Newsletter / Issue 3 2013

Biological Matrices • Blood, Plasma, Serum, CSF, Urine, Tissues, etc. • Normal Human and Animal • Disease State Samples • Custom Processing

Stop by booth no. 401 to check out the new product offerings from BioreclamationIVT (formerly Celsis In Vitro Technologies). Pick-up our latest microsome data sheet and get a free giveaway.

The complete resource for all biologicals BioreclamationIVT.com

ISSX Newsletter is published quarterly in the spring, summer, autumn, and winter. For information concerning advertising in this publication, including rates and specifications, please visit www.issx.org or contact information@issx.org. Advertise with ISSX in the quarterly ISSX Newsletter. Rates and additional advertising opportunities are available at www.issx.org/advertising.

Change of Address

If your mailing address, telephone, fax number, or e-mail has changed or will change, please let us know as soon as possible. You may update your contact information at any time using the online membership directory, which you can access in the Member Only section of the Web site. If you have forgotten your username and/or password, please contact information@issx.org.

Deadline for the submission* of material to the ISSX Office: ISSUE

MATERIALS DEADLINE

RELEASE DATE

Issue 4, 2013

October 11, 2013

November 2013

Subject to change

Editor Dr. Allen Cato, III Cato Research, LTD 6480 Weathers Place, Suite 104 San Diego, California 92121 USA Telephone: +1-858-452-7271 Fax: +1-858-452-7784 E-mail: jcato@cato.com

Advertise with ISSX The quarterly ISSX Newsletter is an online publication featuring Society updates, scientific articles of interest, book reviews, summaries of ISSX meeting proceedings, and more. This publication is designed to update the ISSX membership on the activities and events of the organization and to provide an information forum. The ISSX Newsletter reaches every ISSX.org site visitor as well as the ISSX membership. Visit www.issx.org/advertising2013 today!

Issue 3, 2013

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