MSTP Annual Report - June 2021

JULY 2021

MEDICAL SCIENTIST TRAINING PROGRAM Icahn School of Medicine at Mount Sinai

PROGRAM DIRECTORS: Margaret H. Baron, MD, PhD Talia H. Swartz, MD, PhD ASSOCIATE DIRECTORS: Uraina Clark, PhD Praveen Raju, MD, PhD PROGRAM MANAGER: Bianca Taylor, MSEd

ABOUT ISMMS MSTP Mission

Vision

Our mission is to educate a diverse cadre of future physician-scientists in a rigorous, integrated dual degree program that prepares them to contribute to the improvement of human health through careers in a variety of clinical specialties and biomedical research environments.

To attract and train a diverse and talented group of students in an inclusive community, to help them reach their full potential as rigorous, visionary and resilient physician scientists and leaders in the biomedical revolution.

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STUDENT AND ALUMNI OUTCOMES

96% OUR STUDENTS ARE PROLIFIC Of graduates over the past 10 years, 96% have published with an average of 5.6 publications and 2 first-author publications

46% OUR STUDENTS ARE COLLABORATIVE Of graduates over the past 10 years, 46% have collaborated with another MSTP student during their training

96% OUR STUDENTS ARE TENACIOUS Of matriculants over the past 10 years, 96% have stayed in the program and have graduated or are currently in training in the program

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ALUMNI RESIDENCIES Residency choices Among 200 graduates who have completed their training since the establishment of our program, ISMMS MSTP alumni have pursued residencies in a range of specialties, most commonly Internal Medicine, Pediatrics, Pathology, Surgery, and Neurology.

Child Neurology 2%

Other 3%

Psychiatry 4.5%

Internal Medicine 30.2%

Ophthalmology 4.5% Anesthesiology 5.4% Neurology 7.4% Pediatrics 14.9%

Surgery 9.4% Pathology 10.9%

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Clinical Practice 17.4%

Institute 3.5% Industry 5% Consulting/Law/Finance 0.5%

Alumni Areas

Academia 70.1%

ISMMS MSTP ALUMNI ARE LEADERS Among alumni who completed training more than 10 years ago, 38% hold leadership positions in academic medicine, industry, and govenment.

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MATRICULATION TRENDS We strive to increase the diversity of the physician-scientist workforce.

Women

% matriculants

40 30

URM

20 10

20 15 -p re se nt

20 05 -2 01 4

19 95 -2 00 4

19 85 -1 99 4

19 75 -1 98 4

0

~12 students matriculate per year ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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FACTS ABOUT MATRICULANTS (2021 CLASS)

447 99 12 APPLICATIONS

INTERVIEWS

MATRICULANTS

3.78 (3.33-3.99) MEDIAN GPA

517 (510-522) MEAN MCAT

23 (21-26) MEAN AGE

4879 58547

AVERAGE NUMBER OF PREMATRICULATION RESEARCH HOURS COMBINED NUMBER OF PREMATRICULATION RESEARCH HOURS

58%

42%

women

URM

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OUR STUDENTS Come from diverse backgrounds Demonstrate commitment to patient-centered innovation Build and serve their community Are lifelong learners committed to developing skills as future physician-scientists

38%

23%

women

URM

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Time to degree: 7.8 years PAGE 10

CHARACTERISTICS WE VALUE

love of science

intellectual curiosity

patient advocacy

collaboration

empathy

commitment to community

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OUR CURRICULUM MD Years 1-2

Preclinical: Patient Care Preclinical: Scientific and Clinical Knowledge Preclinical: Learning, Scholarship, and Collaboration Preclinical: Professionalism and Advocacy

PhD years

AIET

CAB

DRS

GDS

IMM

MIC

NEU

PTD

MD Years 3-4 (Clinical)

Clinical: Patient Care Clinical: Scientific and Clinical Knowledge Clinical: Learning, Scholarship, and Collaboration Clinical: Professionalism and Advocacy ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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TRANSITIONAL SUPPORT MD-to-PhD MSTP student guide describing expectations Individualized meetings with students, mentors, MTA directors, and MSTP leadership Regular communication about expectations and guidance for coursework Individual development plan to track progress Solicitation of student feedback for continuous quality improvement

PhD-to-MD Individualized planning between students, mentors, and MSTP leadership to anticipate degree completion Peer mentoring for schedule planning 2-month Clinical Refresher Course for rebuilding clinical skills prior to re-entry Solicitation of student feedback for continuous quality improvement ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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TEACHING OPPORTUNITIES Medical School Opportunities Teaching Assistants for Structures (Anatomy, Histology, Human Embryology) Brain & Behavior Medical Microbiology Physiology

Graduate School Opportunities Teaching Assistants for BMS course for PhD students

MSTP-specific Opportunities Teaching Assistants Problem Solving in Biomedical Sciences Teaching Assistants for BMS for MD-PhDs

Pipeline programs and community Tutoring grades 7 through college by the Mount Sinai Center for Excellence in Youth Education (CEYE) MedStart Enrichment Program for middle school students (grades 6-8) Teaching in Medical Discovery of Careers (MEDDocs) Program for high school students College essay assistance in First Generation Scholars Program for high school seniors who will be the first generation in their families to attend college or who come from underserved communities.

Tutoring at the Adolescent Health Center at Mount Sinai Mount Sinai Mentoring in Neuroscience Discovery at Sinai (MiNDS): classroom activities for elementary school children; lessons on comparative brain anatomy for high schoolers Tutoring at City University of New York (7 year BS/MD Program for URM and economically/educationally disadvantaged students) MSAR MCAT Preparation for ISMMS Pipeline students

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OUR SCIENCE The Icahn School of Medicine at Mount Sinai (ISMMS) is home to dozens of top-funded research institutes, centers, and laboratories, collaborating across disciplines to make swift and meaningful advances in medicine.

Our Multidisciplinary Training Areas

AIET

CAB

DRS

GGS

IMM

MIC

NEU

PTD

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Student publications # publications

8 6 4 2 0

Total

Women

URiSM

non-URiSM

Publications First author publications

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PHYSICIAN SCIENTIST RESOURCES Curriculum Problem-solving in Biomedical Sciences Biomedical Sciences for MD/PhD students Medical Scientist Grand Rounds

Activities Meet the Physician Scientist EHHOP Physician Scientist Track WiMSTP, Table for 8

Alumni and Career Services Alumni Connect Series Office of Career Planning Slack / Facebook Alumni networking ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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PHYSICIAN SCIENTIST CAREER ADVISORS

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BUILDING COMMUNITY: MSTPhamilies

Sakura

Riverside

Fort Tryon

Sunset

Prospect

Battery

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ISMMS MSTP LIFE

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MANY THANKS TO OUR 20202021 STUDENT L EADERSHI P Student Council Representatives Jakleen Lee Jesse Mangold Lauren Stalbow Christian Stevens Learning Community Student Advisors Mark Bailey Prashanth Rajarajan Retreat Planning Committee Rachel Levantovsky, Chair Matthew Challman Steven Chen Joel Kim Sope Oguntuyo Matthew Park Christian Stevens Jessica Tan Cindy Tian William Zhao

Admissions and Recruitment Recruitment Chair Rachel Levantovsky Admissions Committee Members Michael Espino Temidayo Orederu Matthew Spindler Jessica Tan MSTP Newsletter Matthew Lin Joy Jiang Student Handbook Aum Patel Jessica Tan MSTP Survey Committee Fred Kwon Jakleen Lee Matthew Lin Don Nguyen Sope Oguntuyo Matthew Park Amara Plaza-Jennings Lauren Stalbow Christian Stevens

ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

WiMSTP Jennifer Diaz Joy Jiang Audrey Lee Alexandra Mills Grace Mosley Christie Nguyen Amara Plaza-Jennings Lauren Stalbow Jessica Tan Michelle Tran Sarah Weitzman EHHOP PhysicianScientist Track Amara Plaza-Jennings Meet the PhysicianScientist Jakleen Lee Chang Moon Carina Seah Table for 8 Rachel Levantovsky Don Nguyen

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2020- 2021 RECRUI TMENT AND ADMI SSI ONS I NI TI AT I VES Thanks to our Recruitment Volunteers Sam Allen Mark Bailey Winnie Chen Alice Chen-Liaw Phillip Cohen Brandon Dale Michael Espino Joy Jiang DeAnalisa Jones Jakleen Lee Rachel Levantovsky Matthew Lin Louise Malle

Adam Marks Alexandra Mills Chang Moon Arianna Neal Christie Nguyen Sope Oguntuyo Matthew Park Aum Patel Amara Plaza-Jennings Christian Porras Prashanth Rajarajan Felix Richter Carina Seah

Joan Shang Jeremy Sherman Camille Spencer-Salmon Matthew Spindler Lauren Stalbow Christian Stevens O'Jay Stewart Jessica Tan Alex Tepper Michelle Tran Camille Van Neste Chittampalli Yashaswini William Zhao

Local and National Events ABRCMS ISMMS ODI Open House SACNAS Partnership with SURP and PREP AAMC Career Fair NIH Career Fair

Longitudinal Engagement Campaign Student-applicant buddies Emphasis on the anti-racism agenda (welcome session, student panels, medical school overview) Inclusion of affinity group student networking opportunities, i.e. coffee chats for URM applicants and WiMSTP SinaiPlus – CMCA/Admissions collaboration for MD/MDPhD URM applicants to chat about life at ISMMS Focus on Trainee Wellness through Student Affairs, Learning Communities and Wellness Advisors, Office of Wellbeing, Student Trainee Mental Health ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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TEAM APPROACH TO RECRUITMENT AND ADMISSIONS

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TEAM APPROACH TO RECRUITMENT AND ADMISSIONS Students admissions committee members Student recruitment chairs Student volunteers

Students

CMCA/ ODIPipeline programs

Diversity Admissions Group Julio Arteaga Jackie Chudow Medical Carrie Ernst School Danielle Gal MSTP Kathleen Jackson admissions Jessica Maysonet Graduate Alyson Mehr leadership Ann-Gel Palermo School Valerie Parkas Michelle Sainte Talia Swartz Admissions committee members Bianca Taylor Selection committee members Faculty/mentor interviewers MTA directors Pipeline program partners

ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

Alyson Mehr Ann-Gel Palermo Hala Haronynicolas Jamilia Sly

Margaret Baron Uraina Clark Valerie Parkas Praveen Raju Talia Swartz Bianca Taylor

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UNDOING RACISM Admissions and Recruitment Partnerships with pipeline programs Mentoring and outreach Demonstration through action of clear commitment to holistic admissions and student support

Curriculum and special programming Racism and Bias Initiative to explicitly address and undo racism and bias in all areas of the school Graduate School Task Force to Address Racism and Bias ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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PRIORITIZING WELLNESS Office of Well-Being and Resilience Culture Robust advising (Wellness Advisors, Student Advisors, Faculty Advisors) IcahnBeWell Mental Health Resources expanded access, hours, and providers Personal health and resilience PEERS curriculum Mount Sinai Calm Life and wellness activities

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BUILDING A VIBRANT AND INCLUSIVE MSTP Student leads: PhD-phase concerns and transition Lauren Stalbow Will Zhao Recruitment and admissions Winnie Chen Brandon Dale Housing, benefits, and compensation Alexandra Mills Camille Van Neste MSTP-specific events and curriculum Amara Plaza-Jennings Jesse Mangold Activities, incentives and recognition Jessica Tan Sope Oguntuyo

Student input was solicited to drive new programmatic development new recruitment strategy to increase program visibility new communications plan to disseminate information to students and community increased outreach to improve recruitment and retention of students from underrepresented backgrounds

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COMMUNICATIONS STRATEGY MSTP MONTHLY UPDATES This newsletter is sent out to students and alumni each month to share high-level upcoming and past events in the MSTP and the institution of interest to physician-scientist training and showcasing the accomplishments of our students.

STUDENT NEWSLETTER This newsletter is published annually to share updates on student life. It is shared with students, faculty, alumni, and prospective students.

MSGR ANNOUNCEMENTS A monthly space for casual announcement of program updates, accomplishments, life events, and other celebrations.

MONTHLY STUDENT/MSTP LEADERSHIP MEETING An informal opportunity to drop in and share what's on your mind, hear about program updates, and ask questions or share feedback.

SLACK WORKSPACE: MSTPHAMILY Multiple channels to bring students and alumni together including MSTPhamilies, MTAs, year in program and phase.

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T3 2 I NSTI TUTI ONAL NATI ONAL RESEARCH S ERVI CE AWARD ( NRSA) T32 INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARD (NRSA) The Overarching Objective of the Institutional Research Training Grant (T32) Medical Scientist Training Program (MSTP) is to develop a diverse pool of highly trained physician-scientists.

THE ISMMS MSTP LEADERSHIP RECENTLY SUBMITTED A 5-YEAR FUNDING REQUEST UNDER THE DIRECTION OF DR. BARON The grant application showcases the following aspects of the program: The skills necessary to integrate research and clinical activities in support of a productive research career; The ability to utilize clinical experience and observations to identify important biomedical research questions and develop impactful research programs; A broad understanding across biomedical disciplines and the skills to independently acquire the knowledge needed to advance their chosen fields; The ability to think critically and independently and to identify important biomedical research questions and approaches that push forward the boundaries of their areas of study and that enable the translation of basic research findings into clinical practice; A strong foundation in scientific reasoning, rigorous research design, experimental methods, quantitative and computational approaches, and data analysis and interpretation; A commitment to approaching and conducting biomedical research and clinical practice responsibly, ethically and with integrity; Experience initiating, conducting, interpreting, and presenting rigorous and reproducible biomedical research with increasing self-direction; The ability to work effectively in teams with colleagues from a variety of cultural and scientific backgrounds, and to promote inclusive and supportive scientific research environments; The skills to teach and communicate scientific research methodologies and findings to a wide variety of audiences (e.g., discipline-specific, across disciplines, and the public); and The knowledge, professional skills, and experiences required to identify and transition into productive careers in the biomedical research workforce that utilize the dual-degree training.

https://grants.nih.gov/grants/guide/pa-files/par-19-036.html ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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R EC ENT M S T P

EVENTS

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Click to watch the video ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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Click to watch the video ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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Click to watch the video ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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CELEBRATIONS 2020 White Coat Ceremony

2021 MSTP Virtual Convocation

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WELCOME OUR INCOMING CLASS!

JERREL CATLETT

RACHEL GELTMAN

ELIZABETH KAHN

Dartmouth College CAB/GDS

Cornell University GDS/PTD

Brown University DRS/NEU

ERIKA NEMETH

KASOORELOPE OGUNTUYO

TRACY OKINE

SUNY Stony Brook GDS/CAB

Harvard University DRS/CAB

The Ohio State University NEU/IMM

EZEKIEL OLUMUYIDE

FREDERIKA RENTZEPERIS

CUNY Lehman College IMM/CAB

Dartmouth College GDS/CAB

Dartmouth College IMM/CAB

STEPHANIE SONG

BRIAN SOONG

KEVIN SPEHAR

Wellesley College GDS/MIC

Johns Hopkins University GDS/MIC

Wash U in St. Louis DRS/NEU

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SOPHIA SIU

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MSTP F30/F31 AWARDEES Varun Arvind Joshua Borgerding Matthew Chambers Daniel Charytonowicz Steven Chen David Gonzalez Rollie Hampton Nicholas Heitman Deepak Kaji Rachel Levantovsky

Michael Martini Grace Mosley Christie Nguyen Sope Oguntuyo Temidayo Orederu Prashanth Rajarajan Alexander Real Joan Shang Allen Zheng Royce Zhou

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DISSERTATION DEFENSES VARUN ARVIND The Role of Regulatory T-Cells in Tendon Regeneration Mentor: Dr. Alice Huang KEVIN BU Identifying Correlations Driven by Influential Observations in Large Datasets Mentor: Dr. Kevin Bu STEVEN CHEN Systemic and local innate immune dysfunction drives acute COVID-19 and post COVID-19 syndrome Mentor: Dr. Miriam Merad YOUNG JOON (FRED) KWON Methods for the Clinical Deployment of Machine Learning Algorithms Mentor: Dr. Anthony Costa RYAN NEFF Identifying and Modeling Multi-omic Interactions Across Molecular Subtypes of Alzheimer’s Disease Mentor: Dr. Bin Zhang KASOPEFOLUWA (SOPE) OGUNTUYO Functional characterization of and neutralization of Henipaviruses and SARS-CoV-2 entry Mentor: Dr. Benhur Lee JESSICA TAN Anti-neuraminidase antibodies as potential biopharmaceuticals for the prevention and treatment of influenza Mentor: Dr. Florian Krammer ALLEN ZHENG Influenza Virus Vaccines: Enhancing Immunogenicity of the Viral Neuraminidase Mentor: Dr. Peter Palese ROYCE ZHOU Cell-extrinsic super-enhancer reprogramming at PDZK1IP1 in colon cancer Mentor: Dr. Ramon Parsons ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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MSTP AWARD RECIPIENTS J EF FRE Y M O D E L L C L I N I C AL IMMUNOLOGY PRIZE

RANJAN UPADHYAY, MD, PHD, I SMMS MSTP ' 2021 P A T RIC I A L E V I N S O N A W A RD FOR THE ADVANCEMENT AND INCLUSION O F WOM E N I N M E D I C I N E , M D, PHD, DUAL DEGREE AC HIEVEMENT C ER EMO N Y

JENNI FER ELI ZABETH LONG DI AZ, MD, PHD, I SMMS MSTP ' 2021 T H E TE R R Y A N N K R U L W I C H DOCTORAL DISSERTATION AWARD, GRAD S C H OOL A C H I E V E M E N T A W ARDS

CONOR GRUBER, MD3, I SMMS MSTP ' 2022 EX C ELL E N C E I N C O M M U N I TY SERVICE, MOUNT SINAI STUDENT C O U NCI L S P R I N G A W A R D S

MI CHELLE TRAN, MP2 J A M ES C A R T E R , E X C E L L E NCE IN MENTORING, MOUNT SINAI STUDENT C O U NCI L S P R I N G A W A R D S

JAMES CARTER, MP3 E X C ELL E N C E I N L E A D E R S HIP, MOUNT SINAI STUDENT COUNCIL S P R ING A W A R D S

SAMUEL POWELL, MP4 T ER RY A N N K R U L W I C H P H YSICIAN SCIENTIST AWARD, MOUNT SINAI A L U MNI A S S O C I A T I O N

NOURA ABUL-HUSN, MD, PHD, I SMMS MSTP ' 2009 ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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NAME MARK BAILEY MATTHEW CHAMBERS

PROGRAM NAME GENERAL SURGERY PATHOLOGY

FIONA DESLAND

INTERNAL MEDICINE

JENNIFER DIAZ

INTERNAL MED/ RESEARCH

PRASHANTH RAJARAHJAN

FELIX RICHTER

RANJAN UPADHYAY

NEUROLOGY

PEDIATRICS/ RESEARCH INTERNAL MED/ RESEARCH

INSTITUTION UCLA MED CTR-CA UPMC MEDICAL EDUCATION-PA ISMMS MOUNT SINAI HOSPITAL-NY UCLA MED CTR-CA

BRIGHAM & WOMENS HOSP-MA ISMMS MOUNT SINAI HOSPITAL-NY ISMMS MOUNT SINAI HOSPITAL-NY

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OUR NEW ASSOCIATE DIRECTORS

Uraina Clark, PhD

Praveen Raju, MD, PhD

MSTP Associate Director for Student MSTP Associate Director for Program Affairs and Enrichment Development and Career Planning Dr. Clark will participate in advising and outreach to individual students during the PhD years, tracking student progress, and organizing sessions for skill building and peer networks.

Dr. Raju will participate in advising students about laboratory rotations, developing new MSTPspecific career development activities, and tracking student progress.

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MSTP PARTNERS

Eric Nestler, MD, PhD

Valerie Parkas, MD

Kara Bagot, MD

Dean for Academic and Scientific Affairs

Senior Associate Dean for Admissions Department of Medical Education

MD/PhD Student Faculty Advisor Department of Medical Education

Ann-Gel Palermo, DrPH

Leona Hess, PhD

Senior Associate Dean for Diversity, Equity, and Inclusion

Director of Strategy and Equity Education Programs

Matthew O'Connell, PhD

Nicole Dubois, PhD

Jenny Lin, MD, MPH

Course Co-Director BioMedical Sciences for MD/PhD Students

Course Co-Director BioMedical Sciences for MD/PhD Students

Course Co-Director MD/PhD Clinical Refresher Course

Marta FIlizola, PhD

David Muller, MD

Dean, Graduate School of Biomedical Sciences

Dean for Medical Education

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OUR LEADERSHIP TEAM Margaret H. Baron, MD, PhD Senior Associate Dean for MD PhD Education Co-Director, MD PhD Program Talia H. Swartz, MD, PhD Associate Dean for MD PhD Education Co-Director, MD PhD Program Uraina Clark, PhD MD PhD Program Associate Director for Student Affairs and Enrichment Praveen Raju, MD, PhD MD PhD Associate Director for Program Development and Career Planning Bianca Taylor, MSEd MD PhD Program Manager

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Updates to share? Questions or comments? We'd love to hear from you.

https://icahn.mssm.edu/ education/dual-specialty/md-phd

mstphamily.slack.com SinaiMSTP mountsinaimstp SinaiMSTP mdphdprogrammountsinai ISMMS MEDICAL SCIENTIST TRAINING PROGRAM

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