Icahn Mount Sinai MSTP 2023 Annual Report

2023

Medical Scientist Training Program

Annual Report

Table Of Content About Our Program Meet Our Team Vision And Mission Admissions Our Students Our Match Our Programs Our Alumni Dissertations and Publications Contact Us

About the Medical Scientist Training Program (MSTP) Since 1977, the MSTP at Mount Sinai has been supported by a T32 training grant from the NIH. The training of our students starts the summer before their first year of medical school, with a laboratory rotation of their choice. At the end of the summer, they officially begin our MD-PhD curriculum with a dual degree curriculum that takes place during the pre-clinical phase of medical school. Students then transition to their graduate school years, and our students will choose to conduct their thesis research. Finally, after defending their thesis, they will return to medical school for clinical training, completing both degrees.

Letter from the Director I am delighted to share the accomplishments and highlights of the Medical Scientist Training Program (MSTP) at the Icahn School of Medicine at Mount Sinai. Our program continues to prepare exceptional individuals to become physician-scientists, bridging the gap between research and clinical practice.

Our students have achieved outstanding academic accomplishments throughout the year and demonstrated a strong commitment to scientific inquiry. They represent diverse research interests and contribute to a collaborative and inclusive community.

Located in the vibrant city of New York, our program offers unique opportunities for trainees to live and learn in a dynamic ecosystem.

They benefit from cultural richness, collaborative partnerships, and access to abundant resources.

We appreciate your support in shaping the success of our program and advancing biomedical research.

Please explore our comprehensive annual report for more information on our trainees' achievements and future initiatives.

Thank you for your collaboration, and we look forward to the exciting endeavors ahead.

-Talia

TALIA H. SWARTZ, MD, PHD ISMMS MSTP '2008 SENIOR ASSOCIATE DEAN FOR MD-PHD EDUCATION DIRECTOR, MEDICAL SCIENTIST TRAINING PROGRAM

Meet Our Team TALIA H. SWARTZ, MD, PHD

SENIOR ASSOCIATE DEAN FOR MD-PHD EDUCATION DIRECTOR, MEDICAL SCIENTIST TRAINING PROGRAM Dr. Talia H. Swartz serves as the Director of the MD-PhD Program at Mount Sinai, overseeing and providing guidance to students pursuing the combined medical and research training pathway.

URAINA CLARK, PHD

ASSOCIATE DIRECTOR FOR STUDENT AFFAIRS AND ENRICHMENT Dr. Clark is the Associate Director for Student Affairs and Enrichment, supporting students in the MD-PhD Program at Mount Sinai by providing resources, mentorship, and opportunities for personal and professional development.

PRAVEEN RAJU, MD, PHD

ASSOCIATE DIRECTOR FOR CAREER DEVELOPMENT AND PROGRAMMING Dr. Raju is the Associate Director for Career Development and Programming, offering guidance and resources to MD-PhD students at Mount Sinai to foster their career development and help them navigate the diverse opportunities available in academia, industry, and beyond.

BIANCA TAYLOR, MSED ADMINISTRATIVE DIRECTOR

Ms. Taylor serves as the Administrative Director, providing essential administrative support and operational oversight to ensure the smooth functioning of the MD-PhD Program at Mount Sinai.

Vision And Mission Vision To train a diverse group of students within a warm and inclusive community, fostering rigorous, compassionate, and innovative physician-scientists and leaders in the revolution of biomedicine.

Mission Our mission is to educate a diverse cadre of future physician-scientists in a rigorous, integrated dual degree program that prepares them to contribute to the improvement of human health through careers in a variety of clinical specialties and biomedical research environments.

Admissions 40 Women

30

%

20

URiSM

10

0

1975-1983

1984-1993

1994-2003

2004-2013

2014-2023

Over the past years, our institution has strongly emphasized increasing the diversity of the physician-scientist workforce. We firmly believe that a diverse workforce brings unique perspectives, experiences, and ideas essential for driving innovation, addressing health disparities, and providing equitable healthcare. We are pleased to report that our efforts have yielded positive results, with a noticeable increase in the number of matriculants who self-identify as women and individuals from underrepresented groups in science and medicine (URiSM). This work continues to be a priority.

APPLICANTS INTERVIEWED MATRICULANTS

589

87 11

NUMBER OF PRE3301 AVERAGE MATRICULATION RESEARCH HOURS PATHWAY PROGRAMS: FLEXMED FLEXGRAD MD-TO-MSTP

45% WOMEN

36%

23

11

UNDERREPRESENTED IN SCIENCE AND MEDICINE

AVERAGE AGE (RANGE 21-26)

UNDERGRADUATE INSTITUTIONS

Our Students

Our students are passionate about science and medicine, embodying a drive to excel in their studies and research. They actively seek collaboration, fostering a dynamic learning environment where diverse perspectives come together. Over 50% of recent graduates have collaborated on publications with fellow MSTP students, reflecting our program's commitment to collaboration and the professional growth of our students. Together, they strive to make meaningful contributions to scientific and medical research.

94 students 47% identifying as women 30% identifying as underrepresented in science and medicine 8 multidisciplinary training areas 8 years average time to degree 26 students with F30/F31 awards, 48% success rate 96% of students publish by the time they graduate with an average of 5.6 publications and 2 first-author publications more than 50% of recent graduates collaborated on a publication with another MSTP student

Our incoming class

We are thrilled to introduce the exceptional incoming class of the Medical Scientist Training Program (MSTP) at the Icahn School of Medicine at Mount Sinai. Comprising a diverse group of highly accomplished individuals, this year's cohort brings a wealth of experiences, talents, and passions that will undoubtedly enrich our program.

Bukola Ajanaku (GGS) Michael Beauzile (NEU) Manan Krishnamurthy (CAB) Juhana Habib (IMM) Alexander Chung (NEU) Young Jun Song (NEU) Naomi Freilich (GGS) Braxton Schuldt (NEU) Emily Leventhal (AIET) Chinonso Nwakama (NEU) Kennedy Salamat (AIET)

Our Match

96% of graduates pursue residency after graduation

Most common specialties

Internal Medicine 30% Pediatrics 13% Pathology 11% Neurology 8% Psychiatry 5%

Areas of research after graduation include: translational (50%), basic (45%), clinical (41%)

MSTP Match 1977-2023

Most common institutions

Columbia Presbyterian University Med Ctr Brigham and Women's Hospital Hospital of the University of Pennsylvania NYP Weill-Cornell Medical Center University of California San Francisco Yale New Haven Hospital

78% of graduates pursue academia, industry, federal agency, or federal institutes after training

283 graduates in 45 years

44% stay in NY 22% stay at Mount Sinai 15% West

6% Midwest

68% Northeast

10% South

Top states outside of NY

CA 12% MA 11% PA 7% MD 4% CT 4%

Our Alumni Industry 9.2%

Other 1%

Clinical Practice 19.3%

Academia 67.6%

Our alumni, who completed their training over a decade ago, have excelled in their respective fields, with an impressive 38% holding leadership positions in academic medicine, industry, and government. In the realm of academic medicine, our alumni have assumed influential roles as department chairs, division heads, and research institute directors. Their expertise and vision have driven innovation, collaboration, and advancements in medical education, research, and patient care.

Furthermore, our alumni have made significant contributions to industry leadership. As executives, directors, and managers in pharmaceutical, biotechnology, and medical device companies, they have utilized their research expertise to guide strategic initiatives, drive product development, and shape industry standards. Their ability to bridge the gap between research and commercialization ensures the translation of groundbreaking discoveries into tangible benefits for patients.

In the government sector, our alumni have taken on leadership positions in regulatory agencies, policy-making bodies, and public health organizations. They actively contribute to shaping public health policies, advancing scientific agendas, and improving healthcare systems. Through their influential roles, they address critical health challenges, promote evidence-based practices, and advocate for equitable access to healthcare.

The exceptional success of our alumni, with 38% holding leadership positions in academic medicine, industry, and government, highlights the effectiveness of our training programs and the caliber of individuals we nurture. We take great pride in their accomplishments and remain committed to cultivating the next generation of leaders who will continue to make transformative contributions to medicine, research, and healthcare.

Our Alumni

Our Programs The Icahn School of Medicine at Mount Sinai (ISMMS) is home to dozens of top-funded research institutes, centers, and laboratories, collaborating across disciplines to make swift and meaningful advances in medicine.

AIET

CAB

DRS

DMT

GGS

IMM

MIC

NEU

MSTP-specific programs: Physician-Scientist Career Advisors Meet the Physician-Scientist JEDI (Justice Equity Diversity and Inclusion) Table for 8 MSTPhamilies Medical Scientist Grand Rounds MSTP Survival Skills / Leadership Course Annual Retreat MSTP Virtual Convocation

DRS

Recent Dissertations Alice Chen-Liaw, PhD (IMM, Mentor: Jeremiah Faith, PhD) Gut microbiota bacterial strain richness is species-specific and limits therapeutic engraftment Donald Doanman, PhD (MIC, Mentor: Benjamin K. Chen, MD, PhD) Single Cell Analysis of Acute and Latent HIV Infection using Novel Reporter Systems Michael Espino Horesh, PhD (IMM, Mentor: Dusan Bogunovic, PhD) Gain-of-Function Variants in JAK1 cause Autoimmunity, Atopy, Colitis, and/or Dermatitis (JAACD Syndrome) Iain Forrest, PhD (GGS, Mentor: Ron Do, PhD) Integration of large-scale genetic and clinical data in population-based biobanks for precision medicine David Gonzalez, PhD (DRS, Mentor: Nicole Dubois, PhD) Transient Notch Activation Converts Pluripotent Stem Cell Derived Cardiomyocytes towards a Purkinje Fiber-like Fate DeAnalisa Jones, PhD (PTD, Mentor: Eric Sobie, PhD) Modeling the ultrastructural features of ventricular cardiomyocytes: Implications for Ca2+ signaling in heart failure Kaustubh Kulkarni, PhD (NEU, Mentors: Daniela Schiller, PhD and Xiaosi Gu, PhD) A computational psychiatry approach towards momentary craving Rachel Levantovsky, PhD (IMM, Mentor: Judy Cho, MD) Advances in understanding IBD pathogenesis across populations via multimodal data integration Randal Serafini, PhD (NEU, Mentor: Venetia Zachariou, PhD) Studies on Epigenetic and Transcriptional Regulation of Peripheral Nerve Injury in Mesocorticolimbic Circuitry Camille Spencer-Salmon, PhD (NEU, Mentor: Kanaka Rajan, PhD) Dynamical foundations of task-related computation Lauren Stalbow, PhD (GGS, Mentor: Ruth Loos, PhD) A genotype-first approach to diabetes Christian Stevens, PhD (MIC, Mentor: Benhur Lee, MD) Viruses are the Best Cell Biologists: Viral Engineering to Deliver Gene Editing Tools and Interrogate SARS-CoV-2 Entry

Select Publications Bu K et al. "Identifying correlations driven by influential observations in large datasets."

Brief Bioinform. 2022 Jan 17;23(1):bbab482. PMID: 34864851; PMCID: PMC8769929.

Chen ST et al. "A shift in lung macrophage composition is associated with COVID-19 severity and recovery." Sci Transl Med. 2022 Sep 14;14(662):eabn5168. PMID: 36103512; PMCID: PMC10117220.

Forrest IS et al. "Genome-first recall of healthy individuals by polygenic risk score reveals differences in coronary artery calcium." Am Heart J. 2022 Aug;250:29-33. PMID: 35526571.

Frere JJ et al. "SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery." Sci Transl Med. 2022 Sep 28;14(664):eabq3059. PMID: 35857629; PMCID: PMC9210449.

Gonzalez DM et al. "Dissecting mechanisms of chamber-specific cardiac differentiation and its perturbation following retinoic acid exposure." Development. 2022 Jul 1;149(13):dev200557. PMID: 35686629; PMCID: PMC9340554.

Malle L et al. "Autoimmunity in Down's syndrome via cytokines, CD4 T cells and CD11c+ B cells." Nature. 2023 Mar;615(7951):305-314. PMID: 36813963; PMCID: PMC9945839.

Malle L et al. "Excessive negative regulation of type I interferon disrupts viral control in individuals with Down syndrome." Immunity. 2022 Nov 8;55(11):2074-2084.e5. PMID: 36243008; PMCID: PMC9649881.

Plaza-Jennings AL et al. "HIV integration in the human brain is linked to microglial activation and 3D genome remodeling." Mol Cell. 2022 Dec 15;82(24):4647-4663.e8.

PMID: 36525955; PMCID: PMC9831062.

Serafini RA et al. "SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model." Sci Signal. 2023 May 9;16(784):eade4984. PMID: 37159520.

Spindler MP et al. "Human gut microbiota stimulate defined innate immune responses that vary from phylum to strain." Cell Host Microbe. 2022 Oct 12;30(10):1481-1498.e5.

PMID: 36099923; PMCID: PMC9588646.

Stalbow LA et al. "The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations." Diabetologia.

2023 Jan;66(1):116-126. PMID: 36216889; PMCID: PMC9729131.

Zhou RW et al. "A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma." Nat Commun. 2022 Oct 17;13(1):6041. PMID: 36253360; PMCID: PMC9576746.

Honors and Awards DeAnalisa Jones, PhD MSTP Service Award Icahn School of Medicine at Mount Sinai Achievement Award Ceremony Fred Kwon, MD, PhD, ISMMS MSTP '2023 Burton Drayer Prize in Radiology and Biomedical Imaging Icahn School of Medicine at Mount Sinai Achievement Award Ceremony Steven Chen, MD, PhD, ISMMS MSTP '2023 Jeffrey Modell Clinical Immunology Prize Icahn School of Medicine at Mount Sinai Achievement Award Ceremony DeAnalisa Jones, PhD Excellence in Mentoring Award Icahn School of Medicine at Mount Sinai Student Council Chittampali Yashaswini Excellence in Mentoring Award Icahn School of Medicine at Mount Sinai Student Council Daniel Weiss, MD, PhD, ISMMS MSTP ‘1988 Terry Ann Krulwich Award Mount Sinai Alumni Awards David A. Braun, MD, PhD, ISMMS MSTP ‘2013 Young Physician-Scientist Award American Society for Clinical Investigation Andrew Chow, MD, PhD, ISMMS MSTP ‘2014 Young Physician-Scientist Award American Society for Clinical Investigation Benjamin Goldman-Israelow, MD, PhD, ISMMS MSTP ‘2016 Young Physician-Scientist Award American Society for Clinical Investigation Yonit Lavin, MD, PhD ISMMS MSTP '2018 Young Investigator Award Conquer Cancer, American Society of Clinical Oncology

Contact Us www.mssm.edu/education/mdphd

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