How chemical modifications on DNA keep genes off

Several diseases, including certain types of cancer and some neurodevelopmental conditions, have aberrant patterns of DNA methylation, a chemical modification that regulates gene expression in ways that keep genes in the ‘off’ position. Researchers in the group of Dirk Schübeler found that DNA methylation keeps genes silent mostly by inhibiting the binding of DNA by transcription factors — proteins that control how genes are expressed. The findings advance our understanding of how chemical modifications on DNA regulate gene expression.

Nature Genetics

Ho-Ho-Holiday Party

One of FMI’s longest-standing traditions is the end-of-year Holiday Party. In 2022, it took place in its full past glory, with FMIers, their partners and children getting together for a joyous celebration. The program included a year-end update by our director, a cake contest, a quiz, a clown show for kids and — in the second part of the evening — a cocktail bar and a DJ set that made the crowd dance until late.