CAN ORGANIC ACID METABOLITES BE USED AS POTENTIAL BIOMARKERS
Metabolism is a chemical reaction or process of breaking down organic compounds in a cell to provide energy for vital functions. It takes place with the help of a catalyst. During this process, some intermediate products are formed. Those are called metabolites. Metabolites are of two types. They are primary metabolites and secondary metabolites. 1. Primary metabolites : They are metabolites that are essential for metabolism. Amino acids, alcohols, vitamins, organic acids are some of the Primary metabolites that are involved in proper cell function and growth. 2. Secondary metabolites: These are not involved in the primary metabolic processes. They help make dyes, fragrances, pigments, and additives. They have industrial applications in the agriculture and pharmaceutical fields.
Organic acid metabolites are small molecules that are an intermediate product of breaking down organic compounds. Depending on the combination from which it gets separated, it can contain information about certain disorders. Thus, these organic acid metabolites can be used as biomarkers. A study was conducted by collecting metabolites from the urine samples of patients with metabolic
syndrome(Mets).
A
high-performance
liquid
chromatography-mass
spectrometry analysis was done on those biomarkers. The results gave insights into the metabolites’ functions and their properties. In another study, urinary amines and organic acid metabolites were collected for studying childhood aggression. They were able to identify the association between the metabolites and neurotransmitter ratios. Ultra performance liquid chromatography-tandem mass spectrometry and gas chromatography were used to study the metabolites. Organic acid metabolites play a considerable role in advancing studies on the human body and other organisms. They help find the correlation of several compounds and the path they are associated with the human body. www.iroatech.com
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