PHARMANEWS PARO PRESENTS
Mechanism of action of Pharmacotherapies used against COVID-19 Find out about the new discoveries!
PHARMANEWS PARO #7
MECHANISM OF ACTION OF PHARMACOTHERAPIES USED AGAINST COVID-19 KEYWORDS: PHARMACOTHERAPY, COVID-19, ANTIVIRAL, PHARMACY, DRUGS
INTRODUCTION The
new
disease
pathologies virulent
COVID
such
as
pneumonia
respiratory declared
distress
the
pandemic
public
on
19
has
life-threatening
and
also
syndrome. health
March
caused
12,
severe
The
WHO
emergency 2020.
as
In
a
this
review we will observe the different drugs that
are
recommended
the
WHO
although against
to the
the
new discoveries.
authorized
different
have
COVID-19,
and
positive, so
we
must
by
countries, effective wait
for
PHARMANEWS PARO #7
DRUGS USED AGAINST COVID-19 Chloroquine: Its main action is to increase the endosomal pH and it also interferes with the
glycosylation
of
the
virus's
cellular
receptors, which is why it can be said to block viral infection. It should be noted that it also achieves
the
inhibition
of
cathepsins
that
causes the formation of autophagosome that damages the protein at the tip of the virus. It has also shown a potential inhibitor of MAP kinase, so it interferes with crosstalk SARS-
Figure 1: mechanisms of action of the different drugs against COVID-19.
CoV-2 molecules, in addition to altering the virion assembly and the proteolytic processes
Lopinavir-ritonavir: Its mechanism of action
of the M protein.
is to cut or divide the protein replicase into Hydroxychloroquine: This drug has the same
functional units by virus-encoded proteinases,
chemical structure as chloroquine, except that
which
hydroxychloroquine contains a hydroxy group.
inhibition combinations.
are
inhibited
by
these
protease
An advantage of hydroxychloroquine is that it has a broader and safer therapeutic index and
Convalescent
plasma:
There
are
positive
safety profile than chloroquine, in addition to
reports such as the case of some patients who
being more potent therapeutically speaking.
administered and obtained a decrease in the nasopharyngeal viral load, as well as there was
Remdesivir:
This
drug
inhibits
viral
a decrease in the disease severity score and
replication through premature termination of
oxygenation
viral RNA transcription. It can also inhibit the
transfusion.
improved
12
days
after
the
replication of SARS-CoV-2 in Vero-E6 cell. Drugs
that
act
against
proinflammatory
factors Interleukin 1: These can inhibit the action of interleukin 1, therefore leading to an inhibition of the cytokine storm, this storm is what
produces
reactions
that
many
produce
proinflammatory one
of
the
most
common reasons for death on COVID-19. One of the most popular drugs is Anakinra.
All credits of scientific information are for the authors of the scientific article creation! Scientific information reference: Salvi,
R.,
&
Patankar,
P.
(2020). Emerging
pharmacotherapies
for
Biomedicine & Pharmacotherapy, 110267. doi:10.1016/j.biopha.2020.110267
COVID-19.
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