The Laboratory Report Summer 2013

The

Summer 2013

Laboratory Report A Publication of the Department of Pathology and Genomic Medicine

Dr. James Musser Heads American Society for Investigative Pathology

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r. James Musser, chair of the Department of Pathology and Genomic Medicine for The Methodist Hospital System, has received the gavel as the incoming and centennial president of the American Society for Investigative Pathology (ASIP), the 100year-old scientific society dedicated to advancing experimental pathology. He received the gavel at a ceremony at the Society’s annual meeting in Boston on April 22nd.

“This is both a great honor and a tremendous opportunity for service,” said Dr. Musser. “I look forward to continuing the Society’s important work advocating for the practice of investigative pathology, and fostering the professional career development of pathologists.” Dr. Musser

assumed his duties as president at the beginning of the academic year on July 1st.

ASIP is a society of biomedical scientists who investigate mechanisms of disease.

Investigative pathology is an integrative discipline that links the presentation of disease in the whole organism to its fundamental cellular and molecular mechanisms. The Society, founded in 1913, is celebrating its 100-year anniversary.

For more information about Dr. James Musser, visit methodisthealth.com/Musser.

For more information about ASIP, visit asip.org. 

Dr. Musser receiving the presidential gavel at the ASIP Annual Meeting on April 22nd.

Table of Contents

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Dr. Youli Zu Receives TechConnect Innovation Award Digital Pathology Update

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New Faculty Department Trainees to Present in Record Numbers at CAP’13 New Diagnostic Test Offerings

To register, visit cap.org.

Young Pathologists’ Section Retreat August 17-18, 2013 Hyatt Regency Hill Country For more information, visit texpath.org.

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In Focus: The Cytopathology Team

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Lab Star Award Winners

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Trainee Spotlight

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Summer Students Start on June 3rd

Methodist Laboratory Science Students Win Bowl Competition New Trainees Start on July 1st

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Dr. Youli Zu Receives TechConnect Innovation Award

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r. Youli Zu, medical director of Hematopathology for the Department, has received the TechConnect Innovation Award from the TechConnect World Innovation Summit in Washington, D.C. He received the award for a high-throughput, one-step assay to detect tumor cells in whole blood samples; an assay he has been developing with funding from the National Institutes of Health. The award was presented to Dr. Zu at the Summit on May 14, where Dr. Zu showcased the assay to attendees from industry, academia, and the federal government.

“I am very honored to receive this award,” said Dr. Zu, who is also the director of the Cancer Pathology Laboratory at The Methodist Hospital Research Institute. “This test very much represents an innovative approach to cancer diagnostics. It could have an immense impact on patient care.”

Light microscopy

Cell mixture

The TechConnect Innovation Awards selects the top, early-stage innovations from around the world through an industry review process that evaluates the top 20% of technologies submitted annually into the Summit. Rankings are based on the potential positive impact the submitted technology will have on a specific industry sector. The TechConnect World Innovation Showcase, as part of the Summit, is the world’s largest showcase and accelerator for industry-vetted emerging technologies ready for commercialization, with over 200 emerging technologies, federal laboratories, universities, and federal funding agencies represented.

For more information on Dr. Zu, visit methodisthealth.com/Zu. For more information on the TechConnect World Innovation Summit, visit techconnectworld.com. 

Youli Zu, M.D., Ph.D.

Detection of different tumor cells by polyclonal aptamer probes

X-tumor cells stained by aptamer-1

Y-tumor cells stained by aptamer-2

Overlap image

Z-tumor cells stained by aptamer-3

Light and fluorescent microscope images of aptamer-mediated cell detection in the one-step assay.

Digital Pathology Update The Department is pleased to report that phase III of the digital pathology validation was completed at the end of May, with all System hospitals validated and online. Select glass slides for all outside surgical pathology consults, including in-transfer patients, are now scanned using the latest in whole-slide imaging technology. The high-resolution digital images are used for consult, teaching, and archival purposes. Digital pathology is now also used for telepathology consults on intraoperative neuropathology specimens at Methodist Sugar Land Hospital.

Whole-slide imaging for primary pathologic diagnosis was approved in the European Union in March, and in Canada in April.

A similar approval from the FDA is expected later this year.

For more information on the Digital Pathology Laboratory at Methodist, contact Dr. Michael Thrall at mjthrall@tmhs.org. 

Dr. Thrall, in front, and Medical Technologist Fernando Zambrano scan slides in the Digital Pathology Laboratory.

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New Faculty Todd N. Eagar, Ph.D.

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r. Todd Eagar has joined the Department as the associate medical director of HLA. He returns to Methodist from the Department of Pathology and Immunology at The University of Texas Southwestern Medical Center in Dallas where he was an assistant professor. Dr. Eagar completed an HLA fellowship at Methodist and a post-doctoral research fellowship in immunology at the University of California at San Francisco. He received his Ph.D. in immunology and molecular pathogenesis from the Northwestern University Medical School in Chicago, Illinois in 2001.

Dr. Eagar’s research interests include identifying immune processes involved in the pathogenesis of multiple sclerosis and transplant rejection, with a focus on finding novel regulatory pathways involved in T cell activation that might be harnessed for therapeutic intervention.

For more information on Dr. Eagar, visit methodisthealth.com/Eagar. 

Todd N. Eager, Ph.D.

Susan L. Haley, M.D.

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r. Susan Haley has returned to Methodist after completing a cytopathology fellowship at The University of Texas MD Anderson Cancer Center. She completed a surgical pathology fellowship at Methodist in 2012. Dr. Haley received her M.D. degree from The University of Texas Health Science Center in Houston, and completed pathology residency at The University of Texas Medical Branch in Galveston.

Dr. Haley’s research focuses on quality assurance and process improvement in cytopathology.

For more information on Dr. Haley, visit methodisthealth.com/Haley. 

Susan L. Haley, M.D.

Bryce P. Portier, M.D., Ph.D.

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r. Bryce Portier has joined the Department as the medical director of Solid Tumor Molecular Diagnostics. He received his M.D. and Ph.D. degrees at The University of Texas Medical Branch in Galveston in 2008. Dr. Portier then completed pathology residency at the Cleveland Clinic and a fellowship in molecular genetic pathology at The University of Texas MD Anderson Cancer Center in Houston.

Dr. Portier’s research centers on the identification and validation of novel molecular biomarkers in breast and gastric carcinomas.

For more information on Dr. Portier, visit methodisthealth.com/Portier. 

Bryce P. Portier, M.D., Ph.D.

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Department Trainees to Present in Record Numbers at CAP’13

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he Department has set a new record for abstracts accepted for presentation at the annual meeting of the College of American Pathologists, CAP’13. Nineteen abstracts from Department residents and fellows were accepted for presentation at the meeting in Orlando, Florida. This surpassed the previous Department record from 2009 when 15 were accepted.

“These numbers represent a coordinated effort on behalf of the faculty and trainees to develop abstracts of particularly high quality that represent our programs well,” said Dr. Philip Cagle, medical director of Pulmonary Pathology for the Department and the editor-in-chief of Archives of Pathology and Laboratory

Medicine. “We need to thank Drs. Suzanne Powell, Mary Schwartz, and Youli Zu for leading this effort for the Department. They did a great job.”

The annual meeting of the College of American Pathologists is the only annual meeting designed specifically by and for board-certified pathologists.

Over 1,400 pathologists attend each year, including approximately 400 residents and fellows, who present abstracts of their academic work. CAP’13 will be held October 13-16 at the Gaylord Palms Orlando, in Orlando, Florida.

For more information on CAP’13, visit cap.org. 

New Diagnostic Test Offerings: Whole-Genome Sequencing of Microorganisms The Molecular Diagnostics Laboratory at The Methodist Hospital is now performing whole-genome sequencing of microorganisms as a clinical test. This unique service takes advantage of nextgeneration sequencing technology, automation, and a custom bioinformatics pipeline.

Compared to lower resolution molecular techniques, such as 16S rDNA sequencing or multi-locus sequence typing (MLST), which analyze a single gene or a few genes, whole-genome sequencing can unambiguously classify organisms and define clonal relationships. Wholegenome sequencing will be used in the clinical laboratory for: 1) species assignment of slow growing, difficult-tocultivate or difficult-to-identify organisms;

2) molecular typing of strains having important public health implications; 3) real-time investigation of nosocomial infections and possible infectious outbreaks; 4) understanding bacteria strain genotype – patient disease phenotype relationships; and 5) studying the molecular basis of severe, unusual, or interesting infections. The test is run once per week, with additional runs available on demand. It can be performed on bacteria, yeast, or fungi.

For more information , contact Dr. Randall Olsen at rjolsen@tmhs.org or Ms. Heather Hendrickson at hlhendrickson@tmhs.org. 

The flow cell of the Illumina Miseq, the instrument used for whole-genome sequencing of microorganisms.

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In Focus: The Cytopathology Team

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ytopathology is a branch of pathology that typically uses samples of cells or tissue fragments to study and diagnose disease processes at the cellular level. Samples may be directly smeared on glass slides, or concentrated with centrifugation to increase the number of cells examined. At Methodist, the newer, FDA-approved ThinPrep and SurePath technologies are used to enhance the cellular yield of samples by lysing blood and removing unwanted debris. The samples are then stained and evaluated using microscopic examination. An inpatient and outpatient fineneedle aspiration biopsy service is also available.

The Department of Pathology and Genomic Medicine has a team of 13 pathologists with subspecialty certification and expertise in cytopathology. This team provides vital clinical services for patients and invaluable support to the

Dina R. Mody, Ph.D. Medical Director, Cytopathology Dr. Mody graduated from the Seth G.S. Medical College at Bombay University in Bombay, India in 1979. She completed her pathology residency at the Baylor College of Medicine in Houston, Texas. Her special interests are in the areas of cervicovaginal cytology, especially glandular lesions, and skeletal cytopathology, and her research focuses on gynecologic cytology and quality improvement.

Dr. Mody has served as the elected

The cytopathology team: from left, Drs. Hidehiro Takei, Patricia Chevez-Barrios, Mojgan Amrikachi, Susan Haley, Blythe Gorman, Michael Thrall, Yimin Ge, Rose Anton, Mary Schwartz, Dina Mody, Donna Coffey, Ashok Balsaver, and Nour Sneige.

entire medical staff throughout The Methodist Hospital System, and at institutions served by Methodist Diagnostic Laboratories.

president of the American Society of Cytopathology (ASC), has been a member of the ASC Executive Board, and has received the President's Award, Excellence in Education Award, and Papanicolaou Award from that society as well. She has also been a recipient of the Lansky Award and Lifetime Achievement Award from the College of American Pathologists.

For more information on Dr. Mody, visit methodisthealth.com/Mody.

Dr. Mody (left) with Cytopathology Laboratory Manager Debora Smith.

For more information on the cytopathology service at Methodist, please contact Debora Smith at 713-441-1564. ď Ž

Rose C. Anton, M.D. Associate Medical Director, Cytopathology Dr. Anton received her M.D. degree in 1994 from the Medical University of South Carolina in Charleston. She then completed a pathology residency and fellowships in surgical pathology and cytopathology at the Baylor College of Medicine in Houston, Texas. Her research centers on process improvement and quality improvement in the cytopathology laboratory.

For more information on Dr. Anton, visit methodisthealth.com/Anton.

Dr. Anton (center) mentoring trainees, Dr. Rachel Donohue (left) and Dr. Lindsay Waters (right) in the Cytopathology Laboratory.

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Lab Star Award Winners

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he Lab Star Award recognizes the efforts of laboratory staff, including supervisors and managers, who go “above and beyond” their assigned responsibilities to ensure excellent patient care, and support the academic initiatives of the Department and The Methodist Hospital System.

The first two recipients received their awards on June 19th.

“We have an impressive laboratory workforce in this hospital system,” said Dr. James Musser, chair of the Department of Pathology and Genomic Medicine for the System. “Angela and Catherine are assets to our department, and I am pleased to see them recognized.”

The Lab Star Award is given quarterly to individuals nominated by peers, faculty, and management. Award decisions are made by a committee with system-wide representation.

Angela T. Sexton Autopsy Diener, Autopsy Laboratory Ms. Sexton received the award for coming in at 5am on a Saturday morning to prepare the laboratory and assist faculty with an autopsy at the request of a deceased patient’s family. It was important to the family and the physicians that the autopsy be conducted at that time so viable tissues could be removed for an ongoing genetic study that the patient was enrolled in and passionate about.

From left, AP Laboratory Manager Deborah Wallin, Angela Sexton, and Dr. Alberto Ayala.

Catherine H. Mingino, ACA Outpatient Phlebotomist, Sugar Land Laboratory Ms. Mingino received the award for developing an e-learning module for the American Society for Clinical Pathology (ASCP) that provides instruction on how to draw blood from patients with special needs and ensure a safe, painless, and pleasant experience for them. Not only is Catherine ensuring this at Methodist Sugar Land Hospital, but she is also sharing her expertise on a national scale through the ASCP certification program. 

From left, Sugar Land Laboratory Medical Director Dr. Seema Mullick, Catherine Mingino, and Laboratory Director Donna Hermis.

Methodist Laboratory Science Students Win Bowl Competition

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he team of four students currently enrolled in The Methodist Hospital Medical Laboratory Science (MLS) Program won first place at the Texas Association for Clinical Laboratory Science (TACLS) Student Bowl competition on March 28th as part of the TACLS Annual Meeting in Austin, Texas. A Methodist team has won the competition 13 times in the past 25 years.

“We have a great program here at Methodist, and our students demonstrate that every year when they win this state-wide competition,” said Tatia Feltman, program director for the Methodist MLS Program. “These are exceptional students that will enhance

MLS students, from left, Jessica Drewfs, Nancy Chan, Holli Duhon, and Linda Truong.

any laboratory they serve in after graduation.”

The Methodist MLS Program is a twelve-month professional course of study

that is fully accredited by the National Accrediting Agency for Clinical Laboratory Sciences.

Upon successful completion of the program, students will qualify for examination and certification by the Board of Certification of the American Society of Clinical Pathology. Many graduates of the program go on to work at Methodist in one of our many pathology laboratories. The Methodist MLS Program has been in existence since 1947.

For more information on the Methodist MLS Program, visit methodisthealth.com/mlsprogram 

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Trainee Spotlight: Jordan A. Roberts, M.D. PGY2 Resident

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r. Jordan Roberts, PGY2 pathology resident, has received the 2013 CAP Foundation Leadership Development Award from the College of American Pathologists (CAP). He will also be presenting two posters in October at the annual meeting of the College of American Pathologists, CAP’13. He recently published a review article with Dr. Jae Ro on intraductal carcinoma of the prostate, and won 3rd place in the Methodist GME Annual Creative Writing Competition for his essay entitled, “The Fisherman.”

Dr. Roberts received his bachelors degree in biological sciences from Louisiana State University in Baton Rouge in 2008, and his M.D. degree in 2012 from the Louisiana State University Health Sciences Center in New Orleans. He began the AP/CP pathology residency program at Methodist in July of 2012.

Jordan A. Roberts, M.D.

New Trainees Start on July 1st

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he Department welcomed 4 new residents and 10 new fellows on July 1st during a half-day trainee orientation session led by Dr. Suzanne Powell, vice-chair of education for the Department. The session followed a fourday orientation provided by the GME office of the Methodist Institute for Academic Medicine.

“We have a very large department with a substantial patient volume,” said Dr. Powell. “We not only provide services to all of our System hospitals, but to other hospitals and multi-specialty provider groups through Methodist Diagnostic Laboratories. It’s a lot, but we provide the trainees with close mentoring and other support resources so they can get the best possible training experience.”

The Department currently has 36 existing trainees, with 19 of them having completed their residency or fellowship program and graduated as of June 30th.

With the 14 new trainees, the Department will have a total of 33 residents and fellows for the 2013-2014 academic year.

PGY1 Residents David A. Cohen, M.D. University of Miami School of Medicine Miami, Florida

Neuropathology Matthew D. Cykowski, M.D. AP/CP Residency, University of Oklahoma Tulsa, Oklahoma

Brandon R. Driver, M.D. The University of Texas Medical Branch Galveston, Texas

Surgical Pathology Sapna M. Amin, M.D. AP/CP Residency Program, University of Kansas Medical Center Kansas City, Kansas

Nicola E. Dundas, M.D. The University of Texas Medical School Houston, Texas Katherine H. Lohmann, M.D. Tulane University School of Medicine New Orleans, Louisiana Incoming Fellows Clinical Chemistry Zheng Cao, Ph.D. University of Maryland College Park, Maryland Cytopathology Erin N. Consamus, M.D. AP/CP Residency, The Methodist Hospital Angela M. Wright, M.D. AP/CP Residency, The Methodist Hospital Selective Hematopathology Lauren C. King, M.D. AP/CP Residency, University of Tennessee Health Science Center Memphis, Tennessee

Roberto P. Domingo, M.D. Cytopathology Fellowship, Baylor College of Medicine Houston, Texas Niti Manglik, M.D. AP/CP Residency Program, The University of Texas Medical Branch Galveston, Texas Brian D. Stewart, M.D. AP/CP Residency Program, The University of Texas Medical School Houston, Texas Wendy A. Symons, D.O. AP/CP Residency Program, The University of Texas Medical School San Antonio, Texas For more information on Department training programs, visit methodisthealth.com/pathologytraining. 

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Summer Students Start on June 3rd

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leven summer students recently began their 10-week program in the laboratories of some of the Department’s faculty.

“We have numerous research programs in our department,” said Dr. Patricia Chévez-Barrios, founder and director of the Research Institute Summer Student Program, and the director of the Ocular Pathology Research Laboratory. “The Summer Student Program provides invaluable opportunities for aspiring scientists and physician scientists, and our faculty members are ideal mentors to develop their interests.”

First established in 2005, the Summer Student Program matches students with faculty mentors in Research Institute laboratories from June to August (10 weeks) and centers on a single research project. During this time, the students also attend required weekly didactic lectures given by the mentors and invited speakers. Students present their work at the end of the program at a daylong student retreat.

Center for Molecular and Translational Human Infectious Diseases Research Laboratory of Dr. Edward Graviss Samantha Rodriguez - Texas Tech

Dr. Chévez-Barrios (standing) and Senior Research Associate Rebecca Penland (reflection) mentor Magda Arredondo, summer student from Tecnologico de Monterrey.

Laboratory of Dr. James Musser Victor Issa - Tecnolόgico de Monterrey Susan Lee - Paul L. Foster School of Medicine Fernanda Faudoa - Tecnolόgico de Monterrey Katelyn Renke - Grove City College Kelsey Rice - Southwestern University Laboratory of Dr. Randall Olsen Ashley Ngo - Emory University

Ocular Pathology Research Laboratory Director, Dr. Patricia Chévez-Barrios Magda Arredondo - Tecnolόgico de Monterrey Cancer Pathology Laboratory Director, Dr. Youli Zu Kevin Liu - Columbia University For more information on the Research Institute Summer Student Program, visit methodisthealth.com/SummerStudentProgram. 

Anjali Raghuram - Rice University Laboratory of Dr. Adriana Rosato Brittany Shah - Case Western Reserve University

RECENT PUBLICATIONS Ahmed S, Truong L, Eknoyan G, Workeneh B. Evolving spectrum of HIV-associated nephropathy. Nephron Clin Pract. 2012;121(34):c131-5.

Boots-Sprenger SH, Sijben A, Rijntjes J, Tops BB, Idema AJ, Rivera AL, Bleeker FE, Gijtenbeek AM, Diefes K, Heathcock L, Aldape KD, Jeuken JW, Wesseling P. Significance of complete 1p/19q co-deletion, IDH1 mutation and MGMT promoter methylation in gliomas: use with caution. Mod Pathol. 2013 Feb 22. [Epub ahead of print] Cagle PT, Olsen RJ. The proposed new classification of pulmonary adenocarcinoma and the conservation of small tissue samples for testing. Arch Pathol Lab Med. 2013 Apr;137(4):453-4.

Cagle PT. The new American Cancer Society Lung Cancer Screening guidelines and the role of the pathologist. Arch Pathol Lab Med. 2013 Apr;137(4):451.

Chandler WL. Emergency assessment of hemostasis in the bleeding patient. Int J Lab Hematol. 2013 Jun;35(3):339-43.

Cho YM, Jung SJ, Cho N, Kim MJ, Kattan MW, Yu C, Ahn H, Ro JY; The Genitourinary Pathology Study Group of the Korean Society of Pathologists. Impact of international variation of prostate cancer on a predictive nomogram for biochemical recurrence in clinically localized prostate cancer. World J Urol. 2013 Jun 14. [Epub ahead of print] Continued page 9

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RECENT PUBLICATIONS continued Cornejo KM, Shi M, Akalin A, Uy K, Cagle PT, Fraire AE. Pulmonary papillary adenoma: a case report and review of the literature. J Bronchology Interv Pulmonol. 2013 Jan;20(1):52-7.

Crumley S, Ge Y, Zhou H, Shen SS, Ro JY. Interstitial cystitis: another IgG4-related inflammatory disease? Ann Diagn Pathol. 2013 May 31. [Epub ahead of print] Feske ML, Teeter LD, Musser JM, Graviss EA. Counting the homeless: a previously incalculable tuberculosis risk and its social determinants. Am J Public Health. 2013 May;103(5):839-48.

Gaber AO, Moore LW, Aloia TA, Suki WN, Jones SL, Graviss EA, Knight RJ, Bass BL. Cross-sectional and Case-Control Analyses of the Association of Kidney Function Staging With Adverse Postoperative Outcomes in General and Vascular Surgery. Ann Surg. 2013 Jul;258(1):169-77.

Hardin J, Gardner JM, Colomé MI, Chévez-Barrios P. Verrucous cyst with melanocytic and sebaceous differentiation: a case report and review of the literature. Arch Pathol Lab Med. 2013 Apr;137(4):576-9.

Hawkins SM, Loomans HA, Wan YW, Ghosh-Choudhury T, Coffey D, Xiao W, Liu Z, Sangi-Haghpeykar H, Anderson ML. Expression and Functional Pathway Analysis of Nuclear Receptor NR2F2 in Ovarian Cancer. J Clin Endocrinol Metab. 2013 May 20. [Epub ahead of print] Kassi M, Polsani V, Shen S, Chang SM. A Rare Case of Cardiac Hemangioma Causing Ventricular Fibrillation. J Am Coll Cardiol. 2013 Jun 3. [Epub ahead of print] Knight RJ, Devos JM, Patel SJ, Land G, Moore LW, Gaber L, Gaber AO. Outcomes of living donor renal transplants with a negative cross-match and pretransplant donor-specific antibody. Transplant Proc. 2013 May;45(4):1399-401.

Knight RJ, Gaber LW, Patel SJ, DeVos JM, Moore LW, Gaber AO. Screening for BK viremia reduces but does not eliminate the risk of BK nephropathy: a single-center retrospective analysis. Transplantation. 2013 Apr 15;95(7):949-54.

Li MM, Ewton A, Smith JL. Using Cytogenetic Rearrangements for Cancer Prognosis and Treatment (Pharmacogenetics). Curr Genet Med Rep. 2013, in press Liang A, Wang Y, Han G, Truong L, Cheng J. Chronic kidney disease accelerates endothelial barrier dysfunction in a mouse model of an arteriovenous fistula. Am J Physiol Renal Physiol. 2013 Jun;304(12):F1413-20.

Lindeman NI, Cagle PT, Beasley MB, Chitale DA, Dacic S, Giaccone G, Jenkins RB, Kwiatkowski DJ, Saldivar JS, Squire J, Thunnissen E, Ladanyi M. Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J Mol Diagn. 2013 Apr 4. [Epub ahead of print] Lindeman NI, Cagle PT, Beasley MB, Chitale DA, Dacic S, Giaccone G, Jenkins RB, Kwiatkowski DJ, Saldivar JS, Squire J, Thunnissen E, Ladanyi M. Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J Thorac Oncol. 2013 Apr 2. [Epub ahead of print] Lindeman NI, Cagle PT, Beasley MB, Chitale DA, Dacic S, Giaccone G, Jenkins RB, Kwiatkowski DJ, Saldivar JS, Squire J, Thunnissen E, Ladanyi M. Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. Arch Pathol Lab Med. 2013 Jun;137(6):828-860.

Makthal N, Rastegari S, Sanson M, Ma Z, Olsen RJ, Helmann JD, Musser JM, Kumaraswami M. Crystal structure of peroxide stress regulator (PerR) from Streptococcus pyogenes provides functional insights into the mechanism of oxidative stress sensing. J Biol Chem.

2013 May 3. [Epub ahead of print] McClure R, Balasubramanian D, Sun Y, Bobrovskyy M, Sumby P, Genco CA, Vanderpool CK, Tjaden B. Computational analysis of bacterial RNA-Seq data. Nucleic Acids Res. 2013 May 28. [Epub ahead of print] Continued page 10

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RECENT PUBLICATIONS continued Park S, Ro JY, Lee DH, Choi SY, Koo H. Immunoglobulin G4-associated inflammatory pseudotumor of urinary bladder: a case report.

Ann Diagn Pathol. 2013 Feb 20. [Epub ahead of print] Peresi E, Oliveira LR, da Silva WL, da Costa EA, Araujo JP Jr, Ayres JA, Fortes MR, Graviss EA, Pereira AC, Calvi SA. Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment. Tuberc Res Treat. 2013;2013:285094.

Plata KB, Riosa S, Singh CR, Rosato RR, Rosato AE. Targeting of PBP1 by β-lactams Determines recA/SOS Response Activation in Heterogeneous MRSA Clinical Strains. PLoS One. 2013 Apr 23;8(4):e61083.

Raparia K, Molina CP, Quiroga-Garza G, Weilbaecher D, Ayala AG, Ro JY. Inflammatory aortic aneurysm: possible manifestation of IgG4-related sclerosing disease. Int J Clin Exp Pathol. 2013;6(3):469-75.

Robboy SJ, Weintraub S, Horvath AE, Jensen BW, Alexander CB, Fody EP, Crawford JM, Clark JR, Cantor-Weinberg J, Joshi MG, Cohen MB, Prystowsky MB, Bean SM, Gupta S, Powell SZ, Speights VO Jr, Gross DJ, Black-Schaffer WS. Pathologist Workforce in the United States: I. Development of a Predictive Model to Examine Factors Influencing Supply. Arch Pathol Lab Med. 2013 Jun 5. [Epub ahead of print] Schindler BD, Seo SM, Jacinto PL, Kumaraswami M, Birukou I, Brennan RG, Kaatz GW. Functional Consequences of Substitution Mutations in MepR, a Repressor of the Staphylococcus aureus mepA Multidrug Efflux Pump Gene. J Bacteriol. 2013 Jun 7. [Epub ahead of print] Shu I, Wang P. A 70-year-Old Man with Blue Skin. Clin Chem. 2013, in press.

Shu I, Pina-Oviedo S, Quiroga-Garza G, Meng QH, Wang P. Influence of Vitamin D2 Percentage on Accuracy of 4 Commercial Total 25-Hydroxyvitamin D Assays. Clin Chem. 2013 Jun 12. [Epub ahead of print] Shu I, Wang P. Simultaneous serum nicotine, cotinine, and trans-3'-hydroxycotinine quantitation with minimal sample volume for tobacco exposure status of solid organ transplant patients. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jun 1;928:139-45.

Sneige N, Dawlett MA, Kologinczak TL, Guo M. Endosalpingiosis in peritoneal washings in women with benign gynecologic conditions: Thirty-Eight Cases Confirmed With Paired Box-8 Immunohistochemical Staining and Correlation With Surgical Biopsy Findings. Cancer Cytopathol. 2013 May 14. [Epub ahead of print] Takei H, Powell S, Rivera A. Concurrent occurrence of primary intracranial Epstein-Barr virus-associated leiomyosarcoma and Hodgkin lymphoma in a young adult. J Neurosurg. 2013 Apr 26. [Epub ahead of print] Thrall MJ, Galfione SK, Smith DA. The impact of LSIL-H terminology on patient follow-up patterns: A comparison with LSIL and ASC-H. Diagn Cytopathol. 2013 Apr 3. [Epub ahead of print] Tochigi N, Attanoos R, Chirieac LR, Allen TC, Cagle PT, Dacic S. p16 deletion in sarcomatoid tumors of the lung and pleura. Arch Pathol Lab Med. 2013 May;137(5):632-6.

Verhaegh SJ, Flores AR, van Belkum A, Musser JM, Hays JP. Differential virulence gene expression of group A Streptococcus serotype M3 in response to co-culture with Moraxella catarrhalis. PLoS One. 2013 Apr 23;8(4):e62549.

Wanat MA, Hart SR, Putney D, Liebl MG, Chandler W. Alternative monitoring of argatroban using plasma-diluted thrombin time.

Ann Pharmacother. 2013 Apr;47(4):e18.

Zhao N, You J, Zeng Z, Li C, Zu Y. An Ultra pH-Sensitive and Aptamer-Equipped Nanoscale Drug-Delivery System for Selective Killing of Tumor Cells. Small. 2013 Apr 23. [Epub ahead of print]. 

The Laboratory Report The Laboratory Report is a publication of The Methodist Hospital System Department of Pathology and Genomic Medicine.

Editor-in-Chief April A. Ewton, M.D.

Claudia P. Molina, M.D. Seema Mullick, M.D. Editorial Committee Thu Ngo, M.D. Hazel L. Awalt, M.D. Steven Shen, M.D., Ph.D. Christopher Leveque, M.D. Paul Sumby, Ph.D.

Ping Wang, Ph.D. Editorial Coordinator Philip Randall

The Methodist Hospital Clare Rose, M.B.A. Manuel Hinojosa, M.H.A.

Department Chair James M. Musser, M.D., Ph.D.