The Laboratory Report Fall 2011

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Fall 2011

Laboratory Report A Publication of the Department of Pathology and Genomic Medicine

New Name for Department

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he Department of Pathology and Laboratory Medicine has been renamed the Department of Pathology and Genomic Medicine to reflect the changing discipline of pathology and Methodist’s continuing commitment to lead medicine.

“The discipline of pathology is changing very rapidly and is expanding into new areas at an unusually brisk pace,” said Dr. James Musser, chair of the Department of Pathology and Genomic Medicine for The Methodist Hospital System. “One key growth area is the application of genome-scale analyses to highly diverse diagnostic and therapeutic problems such as cancer, infectious

agents, inherited diseases, and diseases of unknown etiology, to list just a few.”

The Department name change reflects the tectonic shift now underway in pathology, and one that will continue unabated well into the future. The Department plans to expand its genomic medicine capacity by adding infrastructure and faculty in this exciting area as it continues to adapt to the changing

diagnostic and therapeutic landscape and better serve its patients and medical colleagues. These plans and their progress will be highlighted in a future issue of this newsletter.

For more information on the Department of Pathology and Genomic Medicine, visit methodisthealth.com/ pathologyandgenomicmedicine. 

Dr. Philip Cagle is One of America’s Top Doctors

Philip T. Cagle, M.D.

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r. Philip Cagle, medical director of Pulmonary Pathology for the Department, was selected in July by U.S. News and World Report and Castle Connolly Medical, Ltd. as being among the top 1% in the nation in his

specialty. Castle Connolly bases its Top Doctors selections on nominations submitted by other doctors and reviewed by its physician-led research team.

“I am humbled to receive this prestigious designation,” said Dr. Cagle. “It is an honor to be among such a distinguished group of doctors, many of whom are also here at Methodist.”

In addition to being Editor-in-Chief of Archives of Pathology and Laboratory Medicine, Dr. Cagle is on the editorial board of CAP Today and Human Pathology, and is the only pathologist serving on the editorial board of the Journal of the American Medical Association. Dr. Cagle's research interests focus on biomarkers of prognosis and potential targets of molecular therapy in lung cancer and diffuse malignant mesothelioma, pathogenesis of pulmonary adenocarcinoma, and the pathology of lung transplantation.

To access the U.S. News Top Doctors directory, please visit health.usnews.com/topdoctors . For more information about Dr. Cagle, please visit methodisthealth.com/Cagle. 

Table of Contents

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First Clinical Genome Sequenced at Methodist Second Opinion Consultations Improve Outcomes

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Dr. Powell Receives Resident Advocate Award from CAP New Diagnostic Test Offerings New Faculty Join Department Mass Spectrometry Takes Flight New Instruments and Laboratory Renovations at San Jac West Houston Laboratory Sees Major Volume Increases Trainee Spotlight Department Adds New Clinical Chemistry Fellowship

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First Resident Begins Resident Research Program Dr. Peterson Receives Trainee Award

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Department Acquires New Transmission Electron Microscope OAD Conducts Writing Seminar

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First Clinical Genome Sequenced at Methodist

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or the first time, pathologists at The Methodist Hospital sequenced the genome of a clinical bacterium obtained from a patient with a lifethreatening infectious disease.

“The genome data permitted us to rapidly identify this strain, rule out the likelihood of bioterrorism, and help coordinate an appropriate clinical and public health response. Next-generation genome sequencing is playing an increasingly important role in all areas of pathology, including infectious disease events such as these,” said Dr. James Musser, chair of the Department of Pathology and Genomic Medicine for The Methodist Hospital System and director of the Center for Molecular and Translational Human Infectious Diseases Research at The Methodist Hospital Research Institute.

“Having the full-genome data allows us to determine if the organism has been genetically altered for malicious purposes – and that is vital information. So many

members of our department contributed to the success of this investigation, including Drs. Angela Wright, Stephen Beres, Erin Consamus, Randy Olsen, Roberto Barrios, Kathryn Stockbauer, Wesley Long, Rose Anton, and Mukul Divatia. Special thanks to Dr. Phil Cagle, who rapidly handled the manuscript for Archives and assured its timely publication. This was truly a team effort. I couldn’t be prouder of the individuals who Anthracotic pigment with numerous rod-shaped organisms seen in the patient’s bronchoalveolar fluid stain with an overlay of contributed so much to this efthe genetic dendrogram showing the estimated genetic relationfort.” ship of the pathogen from the patient with other Bacillus group The case report and descripstrains. tion of the coordinated response For access to the early online release of to this event were published online in the article, visit archivesofpathology.org/.

August in the Archives of Pathology and For more information on Dr. Musser, visit Laboratory Medicine. The print version of methodisthealth.com/Musser.  the article will appear in the November issue of the journal.

Second Opinion Consultations Improve Outcomes and Save Lives

Dr. Ayala in his office at The Methodist Hospital.

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n healthcare, obtaining the opinion of physician colleagues is a necessary and routine practice, especially when confronted with a rare condition or a potentially misleading disease presentation.

Situations like these require a level of pathology diagnostic expertise that is not commonly found in every hospital, referral pathology service, or even some academic medical centers. In many cases, a

second opinion can change disease management decisions significantly, whether it be to treat a disease that wasn’t originally diagnosed or to spare a patient a challenging treatment protocol (such as chemotherapy) for a disease that the patient does not actually have.

“To treat a patient effectively, you must start with the correct diagnosis,” said Dr. Alberto Ayala, deputychief of pathology for the Department.

“We have many pathologists on our faculty that have a rare level of diagnostic expertise that you simply don’t find in many other departments. That is why so many patients and doctors from other hospitals come to us.”

The faculty in the Department of Pathology and Genomic Medicine at Methodist include two Lifetime Achievement

Award recipients from the College of American Pathologists, and recipients of the prestigious Koss Medal from the International Society of Urologic Pathology and the Director’s Award from the National Institutes of Health. The faculty expertise is paired with outstanding facilities and instrumentation, including state-of-the-science molecular genetic diagnostic technology.

For more information on the second opinion consultation service, visit methodisthealth.com/secondopinion. For more information about Dr. Ayala, visit methodisthealth.com/Ayala. 

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Dr. Suzanne Powell Receives Resident Advocate Award from CAP

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r. Suzanne Powell, chief current chair of the Residency of neuropathology, viceProgram Directors of Pathology chair of education, and (PRODS) Council and the Residirector of the AP/CP residency dency Review Committee for Paprogram in the Department, rethology of the ACGME, where she ceived the Resident Advocate also serves on the Executive Award from the College of AmeriCouncil of Review Committee can Pathologists (CAP) during an Chairs as the Representative of event on September 10th at the Hospital-Based Specialties of the CAP Annual Meeting in GrapeACGME. She is a member of vine, Texas. The award is preother national committees includsented to a member of the College ing the CAP Neuropathology Rewho has demonstrated outsource Committee, the Histology Dr. Powell receives her Resident Advocate Award at the CAP’11 meetstanding contributions to and supCommittee of the American Sociing in Grapevine, Texas from (L-R) CAP President-Elect, Dr. Gene port of pathology residents and ety of Clinical Pathologists, and is Herbek, CAP President, Dr. Stanley Robboy, and (far right) Dr. fellows. the vice-chair of the CAP GraduStephen Bauer.

“I am grateful to my peers at the ate Medical Education Committee. will all benefit from. These residents and College of American Pathologists For more information on the fellows are the future of pathology.” and, specifically, the Residents Forum, College of American Pathologists, visit Dr. Powell is especially involved in the for this prestigious award,” said Dr. cap.org. For more information on Dr. mentoring of pathology trainees. In addiPowell. “Representing the needs of the Powell, visit methodisthealth.com/Powell.  tion to her leadership roles in the resinext generation of pathologists is an imdency programs at Methodist, she is the portant responsibility and something we

New Diagnostic Test Offerings: Cancer Antigen 19-9 The Cancer Antigen 19-9 (CA 19-9) is an electrochemiluminescent immunoassay that is used to monitor pancreatic, hepatobiliary, gastric, hepatocellular, and colorectal cancers. It tests for the presence of the cancer antigen 19-9 protein that is shed into the circulation by specific tumor cells. The test is not intended to be used to determine the presence or absence of cancer, only to monitor it after its presence has been confirmed by other methods.

The test, which was previously performed at a reference laboratory, was brought in-house in August. Providing the test in-house will allow Methodist physicians faster access to laboratory results so patient care decisions can be made in a more timely manner. Because the relationship between the new inhouse test and original send-out test results are not linear, both tests will be orderable in MethOD until November 3rd to allow physicians to re-establish baseline levels for their patients.

H&E stain of colorectal cancer cells (provided by Dr. Kelly Khan, cytopathology fellow).

For more information on the CA19-9 assay and the transition to the in-house test, please contact Dr. Ping Wang at pwang@tmhs.org.  Mycoplasma pneumoniae molecular assay The Molecular Diagnostics Laboratory at The Methodist Hospital System has implemented a new real-time PCR assay to detect Mycoplasma pneumoniae. M. pneumoniae is the causative agent of “atypical pneumonia,” also known as “walking

pneumonia,” due to its characteristically mild but prolonged disease course.

Studies suggest that M. pneumoniae may cause up to 50% of adult and pediatric cases of pneumonia. Real-time PCR is a highly sensitive method to detect the presence of DNA in clinical specimens.

M. pneumoniae is the first in a series of new molecular microbiology tests planned for our laboratory. This test, which was previously performed at a reference laboratory, was introduced inhouse on September 1st. Performing the test at Methodist will be more cost efficient and improve patient care by significantly decreasing turnaround times.

For more information on this assay or other tests offered by the Molecular Diagnostics Laboratory, contact Dr. Randall Olsen at 713-441-6802 (rjolsen@tmhs.org) or Brant Hilson at 713441-5725 (bhilson@tmhs.org). 

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New Faculty Join Department

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he Department of Pathology and Genomic Medicine continues to grow. Four new physicians have joined our faculty in recent months: Blythe K. Gorman, M.D. Staff Pathologist This is Dr. Gorman’s first faculty appointment. She joins us after completing surgical pathology and cytopathology fellowships here at Methodist. Dr. Gorman received her medical degree from the Louisiana State University School of Medicine in New Orleans in 2005, and completed her residency in anatomic and clinical pathology at The University of Texas Medical Branch (UTMB) in Galveston, TX. She earned numerous honors and awards during her education and training, including the UTMB Department of Pathology Teaching Award in 2007 and a first place medal for her podium presentation at the Texas Society of Pathologists John R. Rainey, MD Trainee Seminar in 2011.

For more information about Dr. Gorman, visit methodisthealth.com/Gorman. 

Blythe K. Gorman, M.D.

Yingchao Piao, M.D., Ph.D. Staff Pathologist Dr. Piao joins the Department from a private pathology practice group in Dallas, Texas. She received her M.D. degree from the Yanbian Medical School in Yanji, China and her Ph.D. in molecular biology from the University of Paris VII in Paris, France. Dr. Piao completed a pathology residency at The State University of New York at Buffalo, a hematopathology fellowship at New YorkPresbyterian Hospital of Columbia University's College of Physicians and Surgeons and Cornell University's Weill Medical College, and a cytopathology fellowship at The University of Texas M.D. Anderson Cancer Center. She will primarily provide anatomic and clinical pathology services at Methodist Willowbrook Hospital and Methodist West Houston Hospital.

For more information about Dr. Piao, visit methodisthealth.com/Piao.  Yingchao Piao, M.D., Ph.D.

Nour Sneige, M.D. Staff Pathologist Dr. Sneige joins the Department from The University of Texas M.D. Anderson Cancer Center where she is a professor in the Department of Pathology, Section of Pathology/Laboratory Medicine. Dr. Sneige received her M.D. degree from the Damascus University School of Medicine in Syria. She then completed a residency in anatomic and clinical pathology at the Wilmington Medical Center in Wilmington, Delaware and at Barnes Hospital and Washington University School of Medicine in St. Louis, MO followed by a surgical pathology fellowship at M.D. Anderson. She was recently honored with the Harlan J. Spjut Award, bestowed by the Houston Society of Clinical Pathology, and has received many other awards in her career.

For more information about Dr. Sneige, visit methodisthealth.com/Sneige.  Nour Sneige, M.D.

Arthur W. Zieske, M.D. Co-Director, Hematopathology Dr. Zieske joins the Department from the Louisiana State University Health Sciences Center in New Orleans where he was an associate professor in the Department of Pathology, the director of Hematopathology, and the medical director of flow cytometry and the cytogenetics and FISH laboratories.

Dr. Zieske received his M.D. degree in 1993 from the Louisiana State University Health Sciences Center (LSU-HSC) in New Orleans, LA. He remained there for his residency in anatomic and clinical pathology, and then completed a fellowship in hematopathology at the Yale University School of Medicine in New Haven, CT. For more information about Dr. Zieske, visit methodisthealth.com/Zieske.  Arthur W. Zieske, M.D.

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Mass Spectrometry Takes Flight

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he Microbiology Labomorphology, Gram stain interratory of The Methodpretation, and biochemical ist Hospital is nearing tests. Although these convencompletion of clinical validational methods are accurate, tion studies of the BioTyper they can be costly and time MALDI-TOF (matrix-assisted consuming. laser desorption/ionization“The BioTyper is able to go time of flight) mass spectromedirectly from culture to species ter made by Bruker Daltonics. identification in one step,” said Methodist is one of only a halfDr. Bryan Janssen, fourth-year dozen institutions in the pathology resident.

United States, and the first in “The BioTyper pairs greater Texas, to implement this new sensitivity with faster species technology. identification,” said Dr. Daniel “The BioTyper will make Wimmer, second-year patholDrs. Wimmer (left) and Janssen conduct validation studies on the new MALDITOF mass spectrometer. critical laboratory results ogy resident. “This is critical available to physicians in minfor enhanced patient care and The BioTyper MALDI-TOF MS identiutes rather than days. This is a tremenwill be an incredibly useful tool for The fies bacteria, yeast, and fungi by creating dous improvement in patient care,” said Methodist Hospital System.” a unique spectral fingerprint based on Dr. Randall Olsen, associate medical diFor more information on the BioTyper the molecular mass and charge of intact rector of the Microbiology Laboratory.

MALDI-TOF MS or to see the new inproteins from the unknown microorgan“Implementation of mass spectrometrystrument, please contact Patricia Cernoch ism. The characteristic pattern of each based diagnostics represents the cutting at 713-441-0333.  isolate is then electronically compared to edge in clinical microbiology, and The an extensive database to identify it. CurMethodist Hospital is leading patient rent methods of pathogen identification care by bringing this instrument online rely on a combination of colony now.”

New Instruments and Laboratory Renovations at San Jacinto

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he Pathology Laboratory at San Jacinto Methodist Hospital has been renovated and acquired two new coagulation instruments for hematology.

“The communities of East Houston continue to grow and so must our hospital and department,” said Dr. Joyce Maldonado, medical director of Laboratory Services at San Jacinto Methodist Hospital. “This renovation and the new instrumentation allow us to expand our infrastructure and continue providing the high level of service that our patients and medical staff have come to expect.”

Dr. Joyce Maldonado with Histology Coordinator, Donna Landrum, in the new laboratory space.

The renovation of the 6,182 sf facility included a 785 sf expansion that added new office and working space for laboratory staff and pathologists, as well as additional storage space.

Two new Sysmex CA-1500 fully automated coagulation analyzers were acquired in June and enable the laboratory to analyze larger volumes of samples in a more efficient manner.

For more information on San Jacinto Methodist Hospital, visit sanjacintomethodist.com . 

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West Houston Laboratory Sees Major Volume Increases

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rowth has been the hot Services at Methodist West Houston topic at the Methodist West Hospital.

Houston Hospital LaboraOverall growth continues with tory this summer. Recent campus anatomical pathology billable tests openings of the J.C. Walter Transincreasing by 45% and clinical laboplant Center Clinic and the Methodratory billable tests having nearly a ist Weight Management Center have 70% increase since the beginning of led to a 500% increase from April to the second quarter of 2011. Noted August in the number of outpatients sources of this growth are the addiserved in the Laboratory Patient tion of the Cardiovascular Service Service Center located in the Medical Line with CABs and other CV Office Building. procedures each week as well as Dr. Ngo and Medical Technologist, Juvy Binag, run patient “As expected, with our new hospiexpansion of the Family Birthing specimens through one of the automated chemistry analyzers in tal growing and continuing to bring Center with additional OB/Gyn practhe West Houston laboratory. new service lines on, we have seen tices on campus. tremendous increases in units of For more information on Methodist service in the laboratory,” said Dr. Thu West Houston Hospital, visit methodistNgo, medical director of Laboratory westhouston.com. 

Trainee Spotlight: Angela Wright, M.D. PGY3 Resident

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r. Angela Wright, a PGY3 resident, has published her first peer-reviewed manuscript as first author. The paper, entitled “Rapidly progressive, fatal, inhalation anthrax-like infection in a human”, was recently published online and will appear in the November print issue of Archives of Pathology and Laboratory Medicine. It is a case report that includes use of the first clinical genome at Methodist. Dr. Wright has also published a book chapter on lymphangioleiomyomatosis with Dr. Philip Cagle, medical director of Pulmonary Pathology for the Department. That chapter will be published in 2013 by Springer as part of The Encyclopedia of Pathology.

Dr. Wright received her bachelor’s degree in biology from the University of North Texas in Denton and her medical degree from The University of Texas Medical Branch in Galveston. She entered the AP/CP residency program at Methodist as a PGY1 resident in 2009.

Angela Wright, M.D.

Department Adds New Clinical Chemistry Fellowship

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he Department recently and translational research. It is imadded a clinical chemistry portant to have training and experifellowship program under ence in these areas to assist our pathe direction of Dr. Ping Wang. The tients and support our clinical colprogram’s first fellow, Irene Shu, leagues.”

Ph.D., began training on September Dr. Shu joins the program from the 1st.

University of Washington where she “Our program is designed for recently completed her doctoral postgraduate trainees who are interstudies in chemistry. The fellowship ested in pursuing a career in clinical is a two-year commitment and offers chemistry at a major academic medielective rotations in select laboratory cal center,” said Dr. Ping Wang, areas of interest, such as molecular Dr. Wang trains Dr. Shu in the Diagnostic Immunology Laboramedical director of Clinical Chemisdiagnostics, clinical microbiology, tory. try for the hospital. “Our program is and flow cytometry. particularly strong because it inFor more information about traincludes special emphasis on laboratory ing programs offered by the Department, management and self-initiated clinical visit methodisthealth.com/pathologytraining. 

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First Resident Begins Resident Research Program

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he Resident Research Prohere that allow us to train the next gram officially launched in generation of outstanding, NIH2008 and its first resident, funded practicing pathologists.”

Wesley Long, M.D., Ph.D., began Program trainees are guided by a research training on July 1st. Under primary research mentor, an interthe mentorship of Dr. James Musser, disciplinary mentoring committee, Dr. Long will spend the next two and a career development committee years developing an independent to create an individualized program research focus and the skills to sucof study. Dr. Long is studying the cessfully pursue it. molecular pathogenomics of infec“Wesley is an ideal candidate for tions caused by Staphylococcus aureus, this program. He has outstanding which are responsible for life-Dr. Long performs experiments in the laboratory with strains of research training with Dr. David threatening diseases such as pneuStaphylococcus aureus.

Walker at UTMB, a strong commitmonia, meningitis, and sepsis. Dr. ment to patient care, and sustained Long’s study focuses specifically on “This program is a superb opportunity interest in scholarly inquiry,” said Dr. drug-resistant strains of this bacterium. for Dr. Long and others like him who Musser, chair of the Department of PaFor more information about training want to pursue clinical, translational, or thology and Genomic Medicine and diprograms offered by the Department, basic research as part of their career. We rector of the Resident Research Program. visit methodisthealth.com/pathologytraining.  have tremendous faculty and facilities

Dr. Amanda Peterson Receives Department Trainee Award molecular testing for colorectal cancer throughout The Methodist Hospital System. Multiple national committees now recommend this testing for all newly diagnosed patients.

Testing for Lynch Syndrome (hereditary nonpolyposis colorectal carcinoma) is important for treating a patient’s primary or metastatic cancer and screening Dr. Peterson with Dr. Randall Olsen in the Molecular Diagtheir at-risk relatives. Even before nostics Laboratory. her fellowship began, Dr. Peterson conducted an extensive literar. Amanda Peterson is the newture review on the subject and began est recipient of the Department meeting with vendors. After identifying of Pathology and Genomic the MSI and BRAF test methodologies Medicine Trainee Leadership and Innovathat best integrated into our laboratory, tion Award. She received the award for she assembled the validation panels and her efforts to introduce and standardize

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In Our Next Issue…

Dr. Philip Cagle and the Department of Pathology and Genomic Medicine will host a major symposium at Methodist in 2012 - The Spring Symposium of the Houston Society of Clinical Pathologists and the Department’s Seminar on Advances in Lung Cancer will combine for a 2-day event (April 28th and 29th) in The Methodist Hospital Research Institute auditorium. Look for a complete article on the event in the winter issue of The Laboratory Report!

completed the validation studies with an optimized protocol. Both MSI and BRAF testing will be implemented in the Molecular Diagnostics Laboratory in October of 2011.

In the few months since becoming the molecular genetic pathology fellow, Dr. Peterson has also given multiple presentations to laboratory staff and pathology trainee peers.

Dr. Peterson received her M.D. degree from The University of Texas Health Science Center at Houston in 2006 and completed her AP/CP residency there as well.

Dr. Peterson then completed a surgical pathology fellowship at Methodist before pursuing a molecular genetic pathology fellowship. 

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Department Acquires New Transmission Electron Microscope

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he Department has obtained a JEM-1400 transmission electron microscope (TEM) from JEOL, Ltd. The TEM will be used for both clinical care and research purposes. For clinical applications, the TEM will mostly be used to image tissue from needle core and wedge kidney biopsies.

“Electron microscopy is a valuable diagnostic tool for pathologists,” said Dr. Luan Truong, medical director of Renal Pathology for the Department. “This instrument will be very helpful, especially for certain tissue specimens that are

not readily amenable to simple histologic analysis, such as kidney specimens.”

Other diagnostic applications include imaging of muscle, nerve, and heart biopsies. For research, electron microscopy continues to be an important technology for investigating new disease processes and newly-recognized biologic phenomenon.

For information on how to access the JEM-1400 at Methodist and for usage charges, contact Gwen Lusk at glusk@tmhs.org. 

The JEM-1400 transmission electron microscope.

Office of Academic Development Conducts Writing Seminar

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he Office of Academic Development (OAD) held its first writing seminar for trainees on July 5th. The one-hour seminar, presented by Dr. Kathryn Stockbauer, introduced Department residents and fellows to scientific writing and, specifically, how to structure and present research data in a scientific manuscript. The presentation also covered manuscript submission and the peer review process.

Dr. Stockbauer takes questions from trainees.

“Knowing how to present your research data is a necessary skill in the manager of OAD. “It is best to deacademic medicine, whether it be at a velop these skills early in training. Prepodium or in a poster, manuscript, or senting this seminar to residents and felgrant application,” said Dr. Stockbauer, lows during their postgraduate medical

training is ideal.”

The OAD in the Department of Pathology and Genomic Medicine provides assistance to faculty and trainees to increase their scholarly activity. OAD staff provides grant, manuscript, and poster editing services, assists in identifying new funding opportunities, and presents seminars and training in areas such as grantsmanship and scientific writing.

A seminar on Public Health Service (PHS) grant writing and peer review is planned for October.

For more information on the OAD, visit methodisthealth.com/OAD . 

RECENT PUBLICATIONS Cagle PT, Dacic S, Allen TC. Genomic pathology: challenges for implementation. Arch Pathol Lab Med. 2011 Aug;135(8):967-8.

Drachenberg CB, Torrealba JR, Nankivell BJ, Rangel EB, Bajema IM, Kim DU, Arend L, Bracamonte ER, Bromberg JS, Bruijn JA, Cantarovich D, Chapman JR, Farris AB, Gaber L, Goldberg JC, Haririan A, Honsová E, Iskandar SS, Klassen DK, Kraus E, Lower F, Odorico J, Olson JL, Mittalhenkle A, Munivenkatappa R, Paraskevas S, Papadimitriou JC, Randhawa P, Reinholt FP, Renaudin K, Revelo P, Ruiz P, Samaniego MD, Shapiro R, Stratta RJ, Sutherland DE, Troxell ML, Voska L, Seshan SV, Racusen LC, Bartlett ST. Guidelines for the Diagnosis of Antibody-Mediated Rejection in Pancreas Allografts-Updated Banff Grading Schema. Am J Transplant.

2011 Sep;11(9):1792-1802.

Gatalica Z, Lilleberg SL, Monzon FA, Koul MS, Bridge JA, Knezetic J, Legendre B, Sharma P, McCue PA. Renal medullary carcinomas: histopathologic phenotype associated with diverse genotypes. Hum Pathol. 2011 Jul 4. [Epub ahead of print] Ge Y, Mody DR, Smith D, Anton R. P16INK4a and ProEx C immunostains facilitate differential diagnosis of hyperchromatic crowded groups in liquid based Pap test with menstrual contamination. Acta Cytologica. 2011, In Press.

Continued page 9

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RECENT PUBLICATIONS continued Hagenkord JM, Gatalica Z, Jonasch E, Monzon FA. Clinical genomics of renal epithelial tumors. Cancer Genet. 2011 Jun;204(6):285-97.

Hanby DF, Gremillion G, Zieske AW, Loehn B, Whitworth R, Wolf T, Kakade AC, Walvekar RR. Harmonic scalpel versus flexible CO2 laser for tongue resection: A histopathological analysis of thermal damage in human cadavers. World J Surg Oncol. 2011 Aug 1;9:83.

Homma S, Troxclair DA, Zieske AW, Malcom GT, Strong JP; for the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Histological changes and risk factor associations in type 2 atherosclerotic lesions (fatty streaks) in young adults. Atherosclerosis. 2011 Jul 21. [Epub ahead of print] Kim HJ, Yoo YS, Park K, Kwon JE, Kim JY, Monzon FA. Genomic Aberrations in Salivary Duct Carcinoma Arising in Warthin Tumor of Parotid Gland: DNA Microarray and HER2 Fluorescence In Situ Hybridization. Arch Pathol Lab Med. 2011 Sep;135(9):1088-91.

Kumaraswami M, Avanigadda L, Rai R, Park HW, Howe MM. Genetic analysis of phage Mu Mor amino acids involved in DNA minor groove binding and conformational changes. J Biol Chem. 2011 Aug 22. [Epub ahead of print] Masud F, Larson-Pollock K, Leveque C, Vykoukal D. Establishing a Culture of Blood Management Through Education: A Quality Initiative Study of Postoperative Blood Use in CABG Patients at Methodist DeBakey Heart & Vascular Center. Am J Med Qual. 2011 Sep-Oct;26(5):349-56.

Monzon FA, Alvarez K, Peterson L, Truong L, Amato RJ, Hernandez-McClain J, Tannir N, Parwani AV, Jonasch E. Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis. Mod Pathol. 2011 Jul 1. [Epub ahead of print] Mukherjee A, Peterson JE, Sandberg G, Takei H, Adesina A, Goodman JC, Powell S. Central nervous system pathology in fatal swine -origin influenza A H1N1 virus infection in patients with and without neurological symptoms: an autopsy study of 15 cases. Acta Neuropathol. 2011 Sep;122(3):371-3.

Panagis L, Zhao X, Ge Y, Ren L, Mittag TW, Danias J. Retinal gene expression changes related to IOP exposure and axonal loss in DBA/2J mice. Invest Ophthalmol Vis Sci. 2011 Sep 9. [Epub ahead of print] Raghunathan A, Barber SM, Takei H, Moisi MD, Mukherjee AL, Rivera AL, Powell SZ, Trask TW. Primary intracranial sarcomatoid carcinoma arising from a recurrent/residual epidermoid cyst of the cerebellopontine angle: a case report. Am J Surg Pathol. 2011 Aug;35(8):1238-43.

Ryu SY, Hong GU, Kim DY, Ro JY. Enolase 1 and calreticulin regulate the differentiation and function of mouse mast cells. Cell Signal.

2011 Jul 23. [Epub ahead of print] Si Q, Dancer J, Stanton ML, Tamboli P, Ro JY, Czerniak BA, Shen SS, Guo CC. Small cell carcinoma of the kidney: a clinicopathologic study of 14 cases. Hum Pathol. 2011 Jul 4. [Epub ahead of print] Wright AM, Beres SB, Consamus EN, Long SW, Flores AR, Barrios R, Richter GS, Oh SY, Garufi G, Maier H, Drews AL, Stockbauer KE, Cernoch P, Schneewind O, Olsen RJ, Musser JM. Rapidly Progressive, Fatal, Inhalation Anthraxlike Infection in a Human: Case Report, Pathogen Genome Sequencing, Pathology, and Coordinated Response. Arch Pathol Lab Med. 2011 Aug 9. [Epub ahead of print] Yang Y, Li F, Gao L, Wang Z, Thrall MJ, Shen SS, Wong KK, Wong ST. Differential diagnosis of breast cancer using quantitative, label-free and molecular vibrational imaging. Biomed Opt Express. 2011 Aug 1;2(8):2160-74. ď Žď€

The Laboratory Report The Laboratory Report is a publication of The Methodist Hospital System Department of Pathology and Genomic Medicine.

Editor-in-Chief April A. Ewton, M.D.

Claudia P. Molina, M.D. Seema Mullick, M.D. Editorial Committee Thu Ngo, M.D. Hazel L. Awalt, M.D. Steven Shen, M.D., Ph.D. Christopher Leveque, M.D. Paul Sumby, Ph.D.

Ping Wang, Ph.D. Editorial Coordinator Philip Randall

The Methodist Hospital Clare Rose, M.B.A. Manuel Hinojosa, M.H.A.

Department Chair James M. Musser, M.D., Ph.D.