Methodology Newsletter Spring 2016

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METHODOLOGY The Research and Education Newsletter of Houston Methodist

SPRING 2016

Landmark preclinical nanoparticle study shows efficacy for triple negative breast cancer treatment by Gale Smith & Maitreyi Muralidhar

A team of investigators from the Houston Methodist Research Institute may have transformed the treatment of metastatic triple negative breast cancer by creating the first drug delivery system to successfully eliminate lung metastases in mice models. Results from this landmark study appeared in Nature Biotechnology. Mauro Ferrari, Ph.D., president and CEO of the Houston Methodist Research Institute and Haifa Shen, M.D., Ph.D., are co-senior authors on the paper.

In this study, 50 percent of the mice treated with the new drug delivery system had no trace of metastatic disease after eight months. That’s equivalent to about 24 years of long-term survival following metastatic disease for humans. >> CONT. PAGE THREE

We invented a method that actually makes the nanoparticles inside the cancer and releases the drug at the site of the cellular nucleus. We were able to do what standard chemotherapy drugs, vaccines, radiation, and other nanoparticles have all failed to do.

– Mauro Ferrari, Ph.D. President and CEO Houston Methodist Research Institute


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Methodology Newsletter Spring 2016 by Houston Methodist Professional Publications - Issuu