Non-invasive Spinal Stimulation Enables Paralyzed People to Stand Unassisted

Dimitry Sayenko MD, PhD, assistant professor of neurosurgery, and his colleagues in the Neuromodulation & Recovery Lab are developing ways to promote mobility in people who have sustained a spinal cord injury.

Regaining the ability to control a full weight-bearing standing posture without assistance from weight-supporting devices or other people is a key goal for someone who is paralyzed. Not only does this ability provide a greater level of physical independence and mobility, maintaining balance when standing is the foundation for regaining the ability to walk, including stepping with assistance from robotic devices being developed at Houston Methodist and other places. In a well-controlled clinical study published in the Journal of Neurotrauma, people with spinal cord injuries who could not stand unassisted received noninvasive transcutaneous electrical spinal cord stimulation via electrodes placed on the spinal column three days per week for a month. Following this treatment, all the participants could maintain an upright standing position either independently or with

minimal external assistance applied to the knees or hips, using their hands for upper-body balance as needed. The quality of their balance control improved with continued training. When the participants shifted their weight while standing, high levels of leg muscle activity emerged that depended on the amount Dimitry Sayenko MD, PhD of muscle loading. These findings suggest that the noninvasive stimulation therapy can modulate the spinal circuitry into a physiological state that enables sensory inputs during weight-bearing to serve as a primary source of neural control to maintain externally unassisted upright posture and balance. Sayenko recently began collaborating with Niche Biomedical to initiate a sponsored clinical trial evaluating the effects of spinal stimulation on upper limb function in individuals with spinal cord injuries. Niche Biomedical is a multidisciplinary bioelectronics medical device company focused on developing neuromodulatory technologies to address chronic conditions that have previously defied conventional medical treatment.

Our clinical research program focuses on central nervous system plasticity throughout the course of motor learning and regaining lost sensorimotor function. We are especially interested in exploring the strategies for regaining functionality during self-assisted standing and stepping, as well as for improving control of motor and autonomic functions. ”

– Dimitry Sayenko MD, PhD

Assistant Professor, Neurosurgery

Houston Methodist