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mechanisms associated with genetic instability in various experimental conditions. UN

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to assist researchers in identifying the underlying

Core Director: Randa El-Zein, MBChB, PhD Office: 713.441.6062 rel-zein2@houstonmethodist.org

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CENTROSOME AMPLIFICATIONS

Genomic Instability Assessment Core

Centrosome

Merge

CENTROSOME DISENGAGEMENT Pericentrin

ASSESSMENT OF DNA DAMAGE

Merge

Houston Methodist and the Texas Medical Center

10+

Abnormal

Our Genomic Instability Assessment Core provides

5+

-H2AX

Normal

Control

community with access to advanced chromosomal imaging and analysis. The core is staffed by

CHROMOSOME SEGREGATION DEFECTS Metaphase Misalignment

experienced professionals who provide assistance with experimental design, specimen preparation

DNA

Merge

analysis of biological samples. We will help troubleshoot and optimize experiments to ensure

Normal

and microscopy imaging techniques for data

The Core provides services for the assessment of mitotic spindle apparatus dynamics.

Misaligned

the highest quality data is acquired.

MITOTIC SPINDLE ORIENTATION 5.37

Normal

5.37

Assessment includes: • M  itotic spindle orientation and spindle angle measurement Telophase Bridging

7.76

DNA

Abnormal

7.76

• Centrosome disengagement

Normal a (direct)

c (rotated)

1 cosφ

=

• A  ssessment of spindle assembly and chromosome separation pathways • A  ssessment of consequences of mitotic alterations on DNA damage

a c

Bridge

Z-stacks

Merge

• Centrosome amplifications

• Chromosome segregation defects

SPINDLE ANGLE MEASUREMENT (13µm-thick sections)

Our Specialized Services

• Telomere length assessment using: - RT-PCR - Q-FISH

Houston Methodist - Genomic Instability Assessment Core Brochure  
Houston Methodist - Genomic Instability Assessment Core Brochure