Bio-Tech Upcoming Advances in Bio-Tech Landscape Vol. 2022Issue0505 Leveraging Innovation to Provide the Best Safety First Five ways Businesses can safeguardusingthemselvesBio-Tech Dr. Vinodkumar Patil, Founder Best of 5Bio Technology Companies In India Dyna Biotech UrjaBioSystemPvt.Ltd EnsuringtheSustainable FutureofRenewableEnergy SPECIALPROFILE
THE VISTAS OF EVOLUTION Editor’s Note
hatdostone-washedjeansandin-houseWconceptiontestsallhaveonethingincommon withbread,cheese,andwine?Theyallare preciseexamplesofmanipulatinglivingorganismsto generatenewproductswithnewmethods.Thisisan innovationthatbiotechnologyhasenabledinthelastfew Sincedecades.thedawnofcivilization,humanshavebeenusing biotechnologytocreatenewproducts.Justlikethepeople ofEgyptwhoutilizedyeaststobakeleavenedcheese,the peopleofChinadevelopedandarrayedagitationtechniques inbrewingbeverages;moreover,theAztecsutilized Spirulinaalgaetobakecakes.
Theprimaryreasonwhybiotechnologyisspreadingits wings,isbeinglookedatasthescienceofthefutureandis oneoftheleadingindustriesinthedynamiceraof advancements—Geneticmanipulation—theanswerisquite simple. Biotechnologyisbecomingamajorengineformodern competitivenessinthetwenty-firstcentury.Emerging policymakersarelookingatitasakeytechnologytowards expandingthehorizonseventually.Biotechnologyis undoubtedlyaparadigmaticknowledge-basedeconomic activity,aknowledge-drivensectorconsistingofworking knowledgeincreatingvaluesanddecodinggenomics.
Thecompaniesinthistranscendingnichearenowamong themostinnovativeandcrucialmonetarydriversinthe contemporaryindustryeconomicalsector.Comprehending thesevitalfundamentals,InsightsSuccessembracesthe journeyofafewoftheprominentcompaniesinitslatest edition,'Bestof5Bio-TechnologyCompaniesInIndia,' thatareempoweringperpetualinnovationsandaugmenting themodernindustrythroughimpeccableservices.
Today—biotechnologyisbeingusedinvarioussectorslike agriculture,clinicalapplications,bioremediation,and forensics—itisbeingaprominentplayerwhereDNA sequencingisacustomarypractice.Alltheseinnovations includegeneticengineering,diagnostics,andassays, reflectingtheimportanceofsyntheticbiologyintheup-todatebiotechnologicaladvancements.
Fortheeminentcompaniesinthissector,thereisno arguingthatthebiotechindustryhasenteredanewerawith perpetualadvancements.Onthebrighterside,thebiotech marketisnowmoreinformedanddemandsproofof effectivenessintheformofimprovedoutcomesalongwith scientificdevelopments.
Abhishek Joshi Deputy Editor abhishek.joshi@insightssuccess.com
Flipthroughthepagesandexplorethehorizonsof advancements,Haveadelightfulread!
CoverStory Leveraging Innovation to Provide the Best Dyna Biotech
Articles 14 32 CONTENT 22 Bio-Tech Upcoming Advances in Bio-Tech Landscape Safety First Five ways Businesses can safeguardusingthemselvesBio-Tech 18 26 Leading a New Global Era of Biotechnology Nirav Biosolutions Private Limited URJA BIO SYSTEM PVT LTD Ensuring the Sustainable Future of Renewable Energy SpecialProfilesProfile
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NiravPvt.BiosolutionsLtd. MrGajananPatil, ManagingDirector UrjaBioSystemPvt.Ltd.specializesindesigningandexecuting turnkeyprojectsinsolidwastemanagementandconversionofsolid wasteintoenergy(intheformofelectricityandheat)andorganic fertilizerfromtheresidue.
Best of 5Bio Technology Companies In India
Featuring BriefCompanyName VinodkumarFounderPatil, DynaBiotechoffersexpertiseinAutomationSolutionswith manufacturingfacilitiesinfourcontinentsandisattheforefront ofmanufacturing,validation,installationandservicesforawide rangeofBiotechnologyandBiopharmaequipments.
DynaBiotech Amol ManagingShah,Director MJBiopharmisagrowingmulti-nationalconglomeratewitha presenceinPharmaceuticals,Biotechnological,Flavours, Fragrances,AgroChemicalsandSpecialityChemicalsIndustries. MJPvt.BiopharmLtd. MrsVaishaliCEOSharma, NiravBioSolutionsPvt.Ltd.isaLifeSciencecompanyandhas signedacollaborationwiththeInstituteofProfessional EducationandResearchtodevelopaprogrammeinpharmacyfor aspiringstudents.
UrjaBioSystem Pvt.Ltd.
“ Dyna Biotech’s omnipotent strategy supports advancement in all areas of development.” Leveraging Innovation to Provide the Best Dyna Biotech
C O V E R S T O R Y Dr. Vinodkumar Patil, Founder
Furthermore,biopharmaceuticalinnovationisa criticalcomponentofdevelopmentandeffective leadershipinexpandingindustrialoutput;such innovationisadriverofeconomicgrowthandassures thecountry’scompetitivenessintheglobalmarket.
Andacompanykeepingupwitheverytrendinthis industryisDynaBiotech.WithDr.Vinodkumar Patil,Founder,leadingthewayofDyna,itis reachingunchartedheightsofsuccess.
theboomingbio-equipmentmanufacturingmarket.
The Visionary Leader Dr.VinodkumarPatilisamultitaskerwithexperience inmicrobiologyaswellasengineering.Heisalso well-versedinbiotechnologyasaresultofhis diversifiedprofessionalexperience.Hewasreally enthusiasticaboutstartinghisownmanufacturing business.HewasmotivatedtocreateDynaBiotech afterworkingwithtop-tierbiotechandpharmaceutical companiesthroughouttheworldformorethantwo Dr.decades.Vinodkumar’sgoalwastopavetheroadforyoung aspirantsandprovidethemwithjobchances.He wantstotransformIndia'sbiotechnologysectorand giveitinternationalrespect.
The Great Beginnings Dr.VinodkumarPatilfoundedthecompanyinPunein April2013.Duringhis27yearsofengagementwith globalPharmagiantssuchasSartorius,B.Braun Biotech,LupinLtd,SerumInstitute,andShantha Biotechasamicrobiologist,Dr.Patilobtained significantinsightsintotheindustry’sneeds.
DynaBiotechhasestablisheditselfasasourceof high-qualitytechnologiesandpremiumequipmentata reasonableprice.Itiswideninghorizonsinthehealth careandveterinarysectorsbybuildingthebest productvariety,whichishavingasignificantandgood impactonAPIs,vaccines,pharmaceuticalproducts, drinks,food,anddairylandscapes,amongothers.
Best of 5 Bio Technology Companies In India
Dr.Patil’seducation,technicalskills,and entrepreneurialdriveformedthegroundworkfor DynaBiotech,adynamiccompany.Withbioreactors andfermenters,itbeganasamodestattempttojoin
Currently,therearenoteworthydevelopmentsinthe biopharmaceuticalfields.Whilenew biopharmaceuticalsanddrugdevelopmentmethods arefoundanddeveloped,theadvancementand developmentofbiotechnologyisthedrivingforce behindthisprogress.Biopharmaceuticalinnovation, ontheotherhand,comesupagainstmultiplehurdles fromvariousdirectionsinordertoinventandmarket newlyproducedbiodrugs. Thisdidnot,however,deterbiopharmaceutical companies,researchersinrelatedfields,and pharmacistsfromcontinuingtheirnobleworkand innovatingevenfurther,becausebiopharmaceuticsis oneofthemostimportantapproachestoshapingand improvinghealthcare,extendinghealthyproductive longevity,andreducingthespreadofseverediseases.
Providing the Best DynaBiotechhasbeenabletogetrequestsfrom overseasataconsistentpace,hasbuiltanewsetup, andhasdesignednewproductsforavarietyof industriesthroughouttheyears.Ithasdeveloped businessincountriessuchasTurkey,Germany, Taiwan,SouthKorea,Bangladesh,andothers,where theyprovideawiderangeoffermenter,bioreactor, andpressurevesselequipment.DynaBiotechhas establishedaninternationalsales,marketing,and serviceofficeinBangkok,Thailand,aswellasaPan IndiaserviceofficeinHyderabad,tosuitthedemands oftheworldwidemarketforbiotechequipment.
Everyday,biopharmaceuticalsaretransforming medicineandsavingthelivesofthousandsof people.Biopharmaceuticalsareamongthe mostimpressiveachievementsofmodernscience. Thesemedicationsareprogressivelybeingemployed inalmosteveryrealmofthemedicalsector,andthey haveshowntobeoneofthemostsuccessfulclinical therapymethodsforavarietyofillnesses,including cancerandmetabolicdisorders.
DynaBiotechisnowtheindustryleaderinthe production,installation,validation,automation,and supportofawiderangeofbiopharmaceuticaland biotechnologyequipment,withabroad,configurable productline.Withinnovation,customisation,and greatcustomerserviceithasusheredinaparadigm shiftinthebiopharmaceuticalandbiotechnology sectorsinIndiaandbeyond.
DynaBiotechusesaclient-specificmethodologyto monitoreverystageofdesign,manufacture, installation,commissioning,automation,integration, andvalidation.Thesespecificcustomerrequirements
DynaBiotech’singenuityand excellencehavewonawardsall aroundtheworld.Dr. VinodkumarPatilhas receivednumerous awardsoverthe aretakenintoaccountwhendevelopingprogressive customisedsolutions.Thefirmhasestablisheditselfas themarketleaderinthespecialityofhighlyspecialisedbioreactorproductionandautomated customisedfermenters. The Gems of Dyna Thefirmiscontinuallyattemptingtocreateand maintainaperfectbalancebetweenthefunctionality andcostofitsgoodswhilemaintaininghigh internationalqualitystandards.Theinfluenceofits managementpoliciesandpractises,aswellas excellentexecutionanddeftinnovationandresource management,hasbeenlaudedandrewardedwith great Dynasuccess.Biotechhasaskilledteamofover300 people,including150engineers,biotech, pharmaceutical,andmicrobiology specialists.Thisdedicatedgroup supportsanddirectsavarietyof operationsaimedatimproving productquality,effectiveness, efficiency,andestimate.It alsokeepsacloseeye
onshiftingmarkettrendsandpromptly respondstothem.
years,includingtheDoctorofPhilosophy(Science andBiotechnology),BusinessExcellenceAward, CompanyoftheYearAward2020,AdarshUdyojag Award,IndustryYoungAcademicEntrepreneur Award,CertificateofExcellencefromCEOMagazine, andsoon.
DynaBiotechiscertainthatsupplyingtheworldwide marketisthebestwaytogeneratemoreforeigncash forthecountry’sgrowth.Asaresult,theorganisation isdedicatedtothegrowthanddevelopmentofboth theinternationalandnationalcommunities.
Future Endeavours
DynaBiotechhasalargeanddevotedcustomerbase inGermany,theUnitedStates,Thailand,SouthKorea, Bangladesh,Taiwan,andTurkey.Thecompany’s long-termstrategyistogrowitsinternationalmarket network.Thefirmhasopenedinternationalsalesand serviceofficesinBangkok,ThailandandLondon,UK whichrunbyateamofhighly-skilledpeople,solely forthispurpose.
DynaBiotechhasrisentoprominenceinsocietyby creatingbothdirectandindirectjobpossibilities.It seesitselfasanimportantpartofsociety,hence corporatesocialresponsibilityiscrucial.Dyna Biotechhasbeeninvolvedinprogrammessuchas masstreeplantingondesolatelands,roadsides, railwaystations,andpubliccommonplacesoverthe pastfewyears.Itisalsolinkedtocharitableinitiatives fortheStatePoliceDepartmentandthe underprivileged.ThebiggestrewardforDynaBiotech istheopportunitytoservethecountry.
Mr Gajanan Rustumrao Pa l, Managing Director URJA BIO SYSTEM PVT LTD Ensuring the Sustainable Future of Renewable Energy “ By converting wet produceandwastebiodegradableintoBiogasBiogastopowerandBiogastoBio-CNG,UrjaBioSystemhelpingMotherEarthtoreducethegreenhousegasemissionandValue-addedManuretoimprovesoilfertility. “ “ “ 14 | May 2022 | www.insightssuccess.in
“ “ Urja Bio System has already reached in 18 states of India and in the countries like Zambia, Tanzania, Gambia and also going to expand in Bangladesh and Sri Lanka as well. “ “ Best of 5 Biotechnology Companies In India 15 | May 2022 | www.insightssuccess.in
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OvercomingtheTurbulentTimes AccordingtoMrShah,thegovernment ofIndiahadtakenaboldstepof declaringanationwidelockdownto arrestthespreadoftheCOVID-19 pandemic.Andhefurtheropinesthat thelockdown,whilstessentialto ensurethelargersafetyoftheIndian citizen,severelyrestrictedthemobility ofindividuals.
MovingForwardTogether Congruentwiththevisionofthe founderofthecompany,MJstarted withthechallengeofregisteringthe companywithvariousinstitutionsin India.Thepurposewastoprovide high-qualitydomesticinsulinatan economicalprice.Overaperiodof threeyears,thecompanyhasemerged asoneofthemainsupplierstoseveral institutionsaroundthecountry.
Wecannotlethealthgoout ofourfocus.A communityofhealthy individualsmakesahealthysociety. Andahealthysocietyisthe prerequisiteofahealthynation. Thenationwithamissiontobecomea ‘Vishwa-Guru’mustmakesurethat eachofitscitizensremainshealthyand leadsahealthfullifestyle.Thatisthe corevisionitmustneverlosefocusof. Thisvisionpromulgatesthephilosophy ofsupportinghumanlifeina responsibleway.Ahealthylifeleadsto ahappyandprosperouslifestyle.A truevisionaryobservesthatthefuture isnothingbutamanifestationofour constanteffortstoimproveitinthe presenttime.
MJGroupwasbornfromtheabovestatedphilosophyofonesuch visionary Founder – Mr Jashubhai Shah. Hepredictedthepositiveshiftin theeconomicpowerofdeveloping nationsandtheneedfornewage medicinesforlifestylediseases,such asdiabetes. InoursearchoftheBest BiotechnologycompaniesinIndia, fortunately,wemetwithMr.Amol Shah,ManagingDirectorofM.J. BiopharmPvtLtd.,apharmaand biotecharmofthethree-decades-old andgrowing conglomerate.multinational ATrustBuiltwithTime MrAmolShahisalsomanagingthe entireMJgroup,whichhasnurtured therichheritageandphilosophyofits founder,prioritizingpeople'swellbeingaboveeverythingelse. Herevealedthatthegroupstartedits biotechoperationsbycollaborating withEli-LillyofUSAandbecamethe firstintheindustrytomanufacture recombinanthumaninsulin formulationsinIndia. Hefurtherhighlightsthecompany’s continuedindependentjourneyin diabetescare.Healsopointsouttheir significantcontributionbysettingupa fullydedicatedbiotechfacilityto manufactureinsulindrugsubstances throughthebacterialfermentation route.
MrShahisveryproudofthe company’sachievementofbecominga preferredsupplierofInsulintothe prestigious‘PradhanMantriBharatiya JanaushadhiPariyojna’(PMBJP) scheme.Theschemeensuredthe availabilityofmedicinesatprices lowerthanMRPtothecommonIndian MJcitizens.continuestoprovideInsulinat preferredpricestothevarious institution.Itistofulfilthecompany’s vision,ofmakingIndiaself-reliantin meetingtherequirementofInsulin,for thediabeticpopulationofIndia.
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Best of Bio-Technology Companies
In India 19 | May 2022 | www.insightssuccess.in
However,hesays“Pharmaceutical manufacturing,logisticsandassociated supplychainwereexemptedfromthis lockdown.Biotechandpharma companieshavestronglyrallied,to ensuresmoothdeliveryoftheessential productsduringthelockdown.”Heis satisfiedthattheyhavedemonstrated theinnovativeandcreativesideofthe industry,bybeingtheearlieronesto developthecrucialvaccinetodeal withtheCOVID-19pandemic.
5
“ThebestmetaphorIfounddescribing AIinhealthcareinoneofthearticles, thatsaid,thatthequestionisnot‘if’ but‘when’AIwillrevolutionizethe healthcare,”heremarks. Heprovidesreal-lifeexamples,like companiessuchasModernaand BioNTechthathaverevolutionised vaccinedevelopmentbydeveloping mRNAtechnology.Andhehopesthat basedonthisextraordinaryimpact, improvementstothehealthcaresystem canhaveforsomanypeopleandits potentialtosavelivesandmoney.
BuildingaBetterFuture
MJpipeline.GrouphasahealthypoolofPhD’s nowheadingitsmanydepartments. Withnewproductsunderdevelopment, itisalsoworkingonthemodelofTech TransferLicensetobetheearlyones forofferingnewproducts.Itisfurther partneringwithcompaniesdeveloping softwaresolutionstoenhancethelife ofdiabeticpatients.
Finally,onthemarketingfront,Mr. Shahsaysthattheirfocusareais“To continuecollaborationwithstrong marketingpartnersacrossterritoriesfor ourentireproductrangeandinvestin noveldeliverysystems,tobeinline withthechangeshappeningaroundthe globe.”
Today,MJBiopharmisoneofthe largestmanufacturersofhumanInsulin forsuppliesinIndiaandMrShahis awarethatmillionsofpatientsare countingonthecompanytoprovide themwiththislifesavingproduct.“We hadmadeapromisetoourcustomers anddoctorsandnowitwasuptous,to ensurethatwedonotbreakthis promise.”MrShahsays
EmbracingTech-novation
Thelastyearhasbeenchallengingto theIndianeconomyduetotheongoing pandemicandMJgroupwasalso affectedinsomeways.However,ithas madealltheeffortstoensurethatit retainsitsstrongpositioninthemarket intheyearstocome.Andtocounter suchfuturechallenges,thecompany hasdevelopedend-to-endcapabilities rangingfrombiopharmaceutical processdevelopmenttodrugsubstance anddrugproductmanufacturingona largescaleandcontinuestoinvestin this Company’savenue.expansionprojectinPune istargetedforcompletionin2022, resultinginadditionalcapacitieswitha focustoenterregulatedmarketsand bringeconomiesofscale.Thestate-ofthe-artmanufacturingfacilitywillhave acapacityof25millionvialsandwill beEUGMPcompliant.
AsperMrShah,ArtificialIntelligence (AI),MachineLearning(ML),and DeepLearningaretakingthe healthcareindustrybystorm.He knowsthatsomehealthcareand technologyinnovatorsare collaboratingandtryingtochangethe currentrealitybyexperimentingwith theseconcepts. Heisalsohappythattheseconcepts areturningintorealityandpointingthe wayforthefuturegrowthofthe industry.Hebelievesthattheyarethe practicaltoolsthatcanhelpcompanies improvethestandardofcare,identify therisksearlierinmanycasesand improvetheoverallqualityoflife.
Thecompanyhasalsomadesignificant investmentsinR&Dandregulatory practices,tocreatearobustproduct
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Hefurthermentionsthathealthcarehas becomeakeyindustryforinvestment andeffortsforAIandmachine learning.Heinformsthatseveralstartupsandsmallerorganisationshave beguntheireffortstocreatetoolstoaid healthcare.
Tellingcompassionately.abouttheirstrictmeasures takenduringthepandemic,MrShah statesthattheytooknecessary precautionstoensureasafeand hygienicworkenvironment,including makingspecialtransportarrangements toensuresafedistancingintransitfor allouremployeesreportingtowork. Theyalsoarrangedforvaccinationof allemployeesofthecompanyto ensuretheirsafety,whilsttheywere dailyexposingthemselvestothe dangersofCOVID-19. Further,alongwiththeregular sanitisationprogram,adequatestocks werekeptofhandsanitisers,face masksandgloves,aswellasproper foodarrangementatthefactory premise,etc.toensurethewell-being ofMJgroup’semployees.
Unmatchedefficiency
Hestronglybelievesthatthecurrent pandemichasshownresilienceand capabilitiesofthepharmaceutical industryinIndia,toweatheranystorm, andtheindustryhascomeoutwith flyingcolours.
•Gene Manipulation Researchershaveidentifiedthatthespecifichuman endogenousretrovirusesorHERVs,whicharefound throughoutourgenome,areactivatedandseverelyimpair braindevelopment.Biotechnologydevelopmentshave helpedinabetterunderstandingoftheHERVprocess. Researchersproducedhumanendogenousretrovirusesin humanstemcellsandcreatedneuronsusingCRISPR technology.Theseviralcomponentshavetriggeredspecific geneslinkedtobraindevelopment,includingtraditional developmentfactors.
Identifyingthevariouscategoriesofdevelopments,the researchersarecontributingtoisinteresting.Someofthe promisingdevelopmentsareelaboratedasfollows
Thetechnologicaldevelopmentshavehelped numeroussectorsoftheindustryinachieving higherlevelsofpurpose,quality,speed,experience, safety,cost,andsatisfaction.Similarly,technological progressinthefieldofhealthcareandlifescienceshas reacheddifferentmilestonesinnumerousdimensions. Thedevelopmentshaveaidedinidentifying,analysing,and controllingnewerchallengesindiseasemanagementand eradication,improvinghealth,betterhandlingand managingnumerousailmentstowardsahealthylife. Theprogressmadeinbioscienceshasbeenfar-reachingand takenmedicalfunctioningfromahigherperspective.
Upcoming Advances in Bio-Tech Landscape
•COVID 19 Testing Recently,JeremyEdwards,directoroftheComputational GenomicsandTechnology(CGaT)LaboratoryatThe UniversityofNewMexico,andhisothercolleagues developedachipthatmakesgenomesequencingforviruses likeCOVID-19mucheasierandfaster. Eventually,theywereabletoidentify95percentofeach sample'sgenomewithanefficiencyofmorethan99.9%.
Edwards,whoisaprofessorintheUNMDepartmentof ChemistryandChemicalBiology,evenstatedthatthisnew chipwouldallowforfasterandmoreaccuratetracingof COVIDandotherviruses,includingnewvariants.
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•Gene Sequencing GenomeSequencingthatdeterminesthewholesetof geneticmaterialhasdevelopedphenomenally.The researcherssequenced3219patientswhere750genes revealedtohavedangerousmutations,with17newdisease geneswereuncovered.Patientswithhereditarymetabolic illnesses,uncommonepilepsies,andprimary immunologicaldeficiencieshavebenefitedfrom personalizedtreatmentinsomesituations.
CreatingaWorldofPossibilities
Allthedimensionsofinternalweakness,possibleexternal causes,andindividualvulnerabilityduetogeneresearch havereachedanimportantmilestoneinnumerousdisease prevention,recoverysequencescoupledwithmedication, andthecreationofsuitablegrowthenvironments.Itisan excellentsignoftheprogressofmedicalresearch,which cancontributetocreatingahealthy,stronger,andagile globalsociety.
Inaddition,theyalsodiscoveredthatthesystemcouldbe calibratedtocontrolthetimeanddegreeoftheshape alteration.Theresearchersimplantedbonemarrowstem cellsataveryhighdensityinthehydrogelwithout destroyingthemissignificantprogressinbioengineering.
•4DPrintingandTissueEngineering
-KedarBorgaonkar
Thehydrogelsmayalsomaintainveryhighcelldensities, allowingforadenseseedingofcells.
KarolinskaInstitutetandKarolinskaUniversityHospital, thistechniquehasalsoledtothediscoveryofother previouslyundiscovereddiseasegenes,openingnew avenuesforfurtherinvestigationofpathogenicpathways.
Manysyntheticbiologistshaveidentifiedanewapproachto increasethemanufacturingyieldsofprotein-based vaccinations,perhapsincreasingaccesstolife-saving medicines.Recently,asignificantcontributionwasmadeto thedevelopmentofCOVID-19vaccinesbyDrKatalin Karikó.Sheshowedthatalteringnucleosides,whicharethe buildingblocksofmessengerRNA(mRNA),makesitsafe foruseinvaccinesagainstpathogenicagents. Withherdiscoveriesonthestabilizingimpactofaltering nucleosides,scientistsconstructedmRNAvaccinesfor COVID-19,developedbyPfizerandModerna.Inclinical testing,thevaccinesshowed94percenteffectivenessin avoidingsymptomaticsicknessandareusedacrossthe UnitedStatestohelpstopthepandemic.
Thetechnologicaldevelopmentsinthenumerous biosciencessectorshaveaidedtheresearchersinreaching impressivebenchmarksinconformity,analysis,andcontrol overtheprogressinmedicalresearch.
•Vaccine Development
•Biosensors ToimproveandspeeduptheCOVID-19testing,KAUST scientistsmergedstate-of-the-artbioelectronicsequipment, materialsscienceengineering,andsyntheticbiologyprotein design.Thisnewbiosensortechnologycanbesuccessfulin deliveringverypreciseresults.Acombinationof electrochemicalbiosensorswithdesignedproteinstructures, thisdiagnosticallowsclinicianstodetectvirusbitsrapidly andprecisely,somethingthatwaspreviouslyonly achievablewithslowergeneticprocedures.
•SyntheticDNA ProfessorKurtGothelf'sgrouphasdevelopedadistinctway toproducethevolatilebuildingblocksinstantlybeforethey aretobeused,therebymakingDNAproductionmore efficient.TheDNAsequencesproducedneedanautomated methodforchemicalproduction.Theycreatedanoperative technologythatenablesthemanufacturingof phosphoramiditestobemechanizedandintegratedintothe DNAsynthesissystem,eliminatingtheneedformanual Nucleosidessynthesis.areflushedviaaresininthemethodof creatingphosphoramidites,whichcouldbefully incorporatedintoanautomatedprocessintheDNA synthesisequipment.Theresinguaranteesthatthe nucleosidesarequicklyphosphorylated,resultinginthe conversionofnucleosidestophosphoramidites,resultingin DNAsynthesis.
Hydrogel's4Dbioprintinghelpstoformnovel configurationsformorecomplex4Dconstructions.
Thecompletesystemmayoperateonunprocessedbloodat thepointofcare,eliminatingtheneedfortime-consuming samplecollection.Primarily,humansalivaandblood samplestreatedwithportionsofproteinfromthe coronavirusesthatcauseMERSandCOVID-19wereused tofine-tunethetest.
ResearcherEbenAlsbergformednew4Dmaterials structuredongelatin-likehydrogelsthatalternateshapein reactiontowaterandarecell-compatibleandrecyclable, makingthemidealchoicesforenhancedtissueengineering.
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We help our customers accelerate life sciences research, solve success,challenges,compleximproveandincreaselabproductivity. Mrs Vaishali Sharma, CEO 26 | May 2022 | www.insightssuccess.in
nthemodernera,biotechnologyhasbecomethe foundationofglobalhealthcare.Althoughpriortothe pandemic,theindustrywasmovingataconstantpacethrivingtokeepupwiththeexpectations.However,new diseasesandviruseswerebecomingregular,whileonlya handfulofpeoplewithscientificinsightsandinterestwere willingtoinvestintheR&Dofthehealthcareandlife Thatsciences.wasalsoinmostlyforeigncountriesandnotinIndia. Theseforeigncompanieswouldestablishtheirregional officeinthecountry.Still,theywouldstruggletoget preciseprofessionaltalentandstudentskeenontakingup medicalR&Dastheirfuturecareer.Allthishappenedwhen everybodyunderstoodthatR&Disthebackboneofthe entirelifescience,healthcare,andbiotechnologyindustry.
Nirav Biosolutions Private Limited
Thefoundersclearlyenvisionaddingvaluetoitsesteemed clientsinLifeScienceResearch.Strategicallyevery initiativewasdrivenwithaclearthoughttobridgegapsand provideasolutiontoresearchers.
TurnaroundandTurnover
Tobeginwith,NiravBiosolutionsworkedforcustomersin theperipheriesofPune.Still,soonitwasgivenan opportunitytoworkwithsomeelitecustomersinPunelike CSIR-NCL,ICMR-NIVandNCCSamongthecentral governmentinstitutesandLupinLimited,Gennova BiopharmaceuticalsandEmcureamongthePharmasectors.
Whileworkingattwogiantpharmaceuticalcompanies, initiallyas a Professional Service Officer at Pfizer andasa Regional Manager ofthewestzoneat Millipore, Pravin Sharma observedthisforalmosteightyearsbeforebeing readytoprovideasolutionforsureintheformofNirav BiosolutionsPvtLtd, a Life Science company incorporated in 2012.Soon,hiswife,MrsVaishali Sharma,joinedhimandthecompanyasaCEO APurposefulInnovation Vaishali shares,“IncorporatedinMarch2012,wehave completedtenyearsofservinglifescience. We help our customers accelerate life sciences research, solve complex challenges, improve success, and increase lab productivity. Through our premier, we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive services. We provide scientists and engineers with best-in-class lab materials, technologies and services ”
Initially,Niravstartedasabiotechtradingcompanywitha smallteamoftechnicallycompetentpeoplewhocould understandapplicationsinlifescienceandprovide appropriatesolutions. Vaishali adds,“Withinoneyearofinception,wefound ourselvesafavouriteamongBiotechProductManufacturers whobelievedinourtechnicalcapabilities.Wehavethe privilegeofworkingwithsomeofthebestbrandsinthe industrylikeThermoFisherScientific,Invitrogen,BD Bioscience,andPallLifesciencesintheearlyphaseofour business.”
Best of 5 Bio-Technology Companies
Althoughitgrewatadecentpaceintheinitialyears,itwas nottakingupbigprojectsbecauseofthefinancial limitationsoftheorganization.Thefirstbigprojectittook upwasin2016,whenitsetupafunctionalGenomicsLab atChitaleDairyfortheirBuffalobreadingprogram.
Leading a New Global Era of Biotechnology
In India 27 | May 2022 | www.insightssuccess.in
I
FightingFromtheFront Vaishaliremembers,“Our real metal was tested during the recent COVID-19 pandemic, where within complete lockdown and unavailability of any commercially approved testing kit.”
· Totrainmaster'sstudentswhowishtopursuea careerinR&DorQCinBiopharmaandPharma Drugdiscovery,wewantedtodosomethingforthe younggenerationbecausestudentsdon'thavethe practicalexperiencetheyneedtogetajob.
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ICMR-NIVwasattheepicentreoftestingCOVIDsamples flowingacrossthecountry.Thiswasthemost challenging/demanding/emotionaltimeofmylifewith smallkidsandoldin-lawsathome,andnoteammember wasavailable. Vaishali states,“Fortunately,we–MrPravin Sharma,myhusband(alsomybusinesspartner),andIhad toarrangetherequiredrawmaterialformanufacturing COVID-19 testing kits with no logistic support.”
· Toprovideacontractresearchlabwhichworkson Invitrostudiesatthecellularandmolecularlevel fornewdrugtargetsbytheBiopharma/Pharma companiesandInternationalCROs.
Theytravelledfromtheairporttotheairportof Bangalore,PuneMumbai,withthethoughtprocessof contributingtowardsthepandemic.Itwasthemost challengingtimeonthepeople,productavailability,and financialsides.Theyworked24×7tosupportNIV.They
TosupporttheresearchactivitiesofUniversities andAcademicinstitutestoworkintheApplied sideofBiology.
AStrategicLeapofInvention
By2017NiravBiosolutionswasreadytotakeasecondleap intermsofstartingupawetlabwiththenameInstituteof AppliedBiologyResearchandDevelopment(IABRD). Thislabhasthreeprimaryobjectives.
Vaishaliadds,"We started the lab with the purpose in mind of contributing toward better employability."
Thevalueoftheprojectwas25%ofNirav'sannual turnoverthen. Vaishaliputs,“This project was a turnaround in our thought process, and handling such big projects became a routine activity for us.”
Vaishali'sopiniononbiotechcompanies'needtoaligntheir offeringswithtechnologieslikeAIandML,especially whencateringtotheever-evolvinghealthcareneeds,is cautiouslyoptimistic.ShesaysthathavingAIandMLin theBiotechmanufacturingprocesscanbringinalotof automationandreduceerror,therebyimproving Itproductivity.isapersonalbeliefthatthesameshouldnotbeappliedin diagnosticsandtreatmentbecauseitcanneverreplace clinicalfindings.Also,AIandMLwillplayaverylimiting roleintheResearchandDevelopmentofnewtherapiesas biologicalsystemsarecomplexanddonotfunctionlikea However,machine.
hadtohandlefivetimestheirturnoverinoneyear,andthey clockedtheirfirst100Crplusturnoverthatyear.
ValueAddingTech-Knowledge
Mostoftheactivityinvolvedphysicalinvolvementin arrangingCOVIDtestingreagentsanddeliveringthemto ICMR-NIV;NiravBiosolutionshadtooperatewith logistics “However,support.teamswerekeptengagedinonlinetrainingand motivationaltalksfromourside.Wealsokeptthemupdated aboutwhatwashappeningatthegroundlevel,” reveals Vaishali.
However,Vaishalisaysproudly,“Ratherthantheturnover, what was more satisfying was that we could serve the nation when it was most needed.WearethankfultoICMRNIVandourprincipalclientThermoFisherScientificfor trustinginus.”
RecentlyNiravBiosolutionscelebratedits10thanniversary inanewofficespace.Vaishalifeels,"With a humble beginning from a 330 Sq. ft office to a 3000 sq. ft. it is a fulfilling journey."EvenforIABRD,thenewlabis designedtobeGLPcompliant;thissetupneedstoworkin thedrugdiscoverydomainofferingitsservicestoPharma andBiopharmacustomerslookingfordiscoveryservice partners.Also,itwillgivestudentstheexperienceof traininginaGLP-compliantlab.
Vaishalireveals,“Our Vision is to be a leading Solution Provider in the life science industry for the betterment of the Planet. As per our mission statement, we plan to take the brand globally.” WiththeGovernmentinitiativeofStart-upandMakein India,manyBiotechstartupsarecomingup.Andwithits strengthsbeingMarketingandSales,NiravBiosolutions wouldliketotakethesebrandstotheinternationalmarket.
Vaishalistates,“A lot of basic research has happened in our country over a few decades, and there are many aspiring scientists who are coming up with their innovations in healthcare with the support of the Government initiative under BIRAC.”Thisisdefinitelygoingtoboostthe industry. PuttingDownthePandemic
Abouttheirpandemicexperienceandovercomingit, Vaishali says,“During the pandemic, we had to be on the front foot as we were the only leading suppliers to ICMR, NIV, which was the epicentre of all the diagnostics during the first wave when no kits were available As a policy, we provide opportunities to freshers from rural parts. Post Lockdown announcement, our team had to be mobilized to their hometown as no PGs were working.”
AIandMLcanassistinbothhealthcareandR&D tocapturedata,reproduceitforfuturereference,and providesomeanalyticswhichcanguideCliniciansand Scientiststotakedecisions,butitcannotbecomeSOP.
RitualisticContinuousImprovement AccordingtoVaishali,fromthebusinessperspective, COVID-19hasmadetheworldrealisethepromisethat Biotechnologyholds,whetherdiagnosticsorvaccines Secondly, it has made the Biotech Industry and International Regulatory Authorities realise that they were really moving at a very sluggish pace. They have the capability of developing health care solutions at a much faster rate.
"Wehavealreadystartedbuildingcapabilitiesaroundthis andareassociatedwithmanystart-ups,"saysVaishali.
Discipline,IntegrityandPositivity
Thecomingyearswillbefortherapeuticantibodies, vaccines,POC(pointofcare)solutions,molecular diagnosticsandBiosimilar.
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ExpandingtheVisionofVishwaguru NiravBiosolutionsisworkinginruralareas,taking seminarsandprovidinghands-ontrainingonadvanced technologiestostudentsbecauseVaishaliandtheteam Niravbelievesinprovidingequalopportunitiestoall. ThebiotechnologyindustryinIndiaisgoingtogrowata supersonicspeed.Forthat,theworkforcewillbeneeded. “wewanttoincreasetheemployabilityofstudentsfromthe ruralareas. It is also our dream to engage, encourage and enable 25000 biologists by giving them an experience of advanced applied biological research by 2025, helping them reach their full potential,”saysVaishali. Finally,sheconcludes,“Our present and future purpose is to enrich and accelerate research in Applied Biology for the betterment of mankind through high-quality scientific tools, expertise and experience of developing innovative solutions.”
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Vaishali'svisionoffurtherstrengtheningNirav Biosolutions'strongholdin2022andbeyondismeticulous. Shesays,“By2027we, Intend to Develop bio clusters in rural India Reach PAN India 20% Revenue from Exports Contributing to drug discovery and clinical research area Establish a Service Organization to Serve the Customers Better Build and Start Facilities for Manufacturing.” So,theyear2022wouldbethefoundationyearforNirav's nextfiveyears'plans.Itisinfusingexperiencedteam membersanddoublingtheteamsize.Ithasalready increaseditsinfrastructureandbuiltupaGLP-compliant Vaishalilab.says,“We are working on setting up systems and processes like CRM and ERP on the cloud. We are collaborating with new principals and OEM manufacturers to reach out to at least three states by the end of the financial year 2022 For this, we are looking for an association with some business with whom we can establish synergy and work together.”
Asanestablishedindustryleader, Vaishali's advice to buddingentrepreneursandenthusiastsaspiringtoventure intothehealthcareservicesindustry is precise.Asperher experience,healthcareneedswillbeever-increasingwith thepopulation.Also,thepreventivehealthcheckis increasingwithgrowinghealthcareawarenessand insurancesupport.Lastly,post-pandemicBiotechnology willproliferateinareaslikeimmunisation,therapeutic antibodies,biosimilarandPOCdevices.So,allbudding entrepreneursshouldbefocusingonthisarea.
BuildingEnduringRelationships
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EncouragingIndividualInitiatives
TheothercentralareawhereBiotechnologycanserveisin thesustainabilityofresourcesontheplanetforthesurvival oflifeontheearth.So,Biofuel,Biofertilizers,and LivestockManagementareafewotherareastofocuson.“I recommend doing a personal and industry SWOT analysis before venturing into the industry,”suggestVaishali.
Thetastypickleinourkitchenispreservedeasilyfor monthstogetherwiththeuseoftablesaltandoil,whichact asnaturalpreservativesmakingthepicklelastformany Heremonths.aresomesimpleandfeasibletipsonusing biotechnologytosafeguardourbusinessesandfocusonthe mainwork.
Biotechnologyisanamazingsciencewhichhasbeenused forthousandsofyearsinitsapplicationsinagriculture,food preparation,foodpreservation,creatingofmedicines, beautification,decorationandmanymoreapplications.Itis basicallytheunderstandingofbasicbioelementsinvarious formsthat,whencombinedwithothersubstances,canform usefulcombinationsformultipleusages.
Aswetalkabouttheproblemofnumerouspestsininsects, rodents,birdsandevenanimals,avoidjumpingonchemical pesticideswithtoxicelements.Therearemultipleorganic elementsfromnaturewhichareeffectiverepellent properties.PlantslikeNeem,andEucalyptusoilhave medicinalpropertieswhichrepelinsects.Burningbay leavescankeepmosquitoesatbay.
Five Ways
OnionandGarlicsprayisaneffectivepesticidethatcanbe sprayedonvegetableplants,fruittreesandfloweringplants towardoffmealybugs,ants,andmoths.
Ratscanbedestructiveineveryformbydamaging importantdocuments,electricalwires,essentialwooden tools,andaccessories.SimpleuseofPeppermintoil,Garlic
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Businesses can safeguard themselves usingBio-Tech
•NaturalPesticides
33 | May 2022 | www.insightssuccess.in Safety First
PlantingBougainvilleafloweringplantsonthefarm's boundarycanprotecttheplantedfruitsandfloweringplants fromthethornsandbittertasteoftheleaves.
Organizationsshouldchoosetousenaturalandorganic consumablestobeusedintheirpremisesforvarious applicationsoffloorcleaners(saltandneem),soaps, handwash,roomfreshenersandstorageaccessories.The firstaidkitshouldhavenaturalhealingagentslikeAloe veragel,turmericpowder,cloveoil,coconutoiland Thymolseeds.
PeoplemanagementactivitiesshouldincludeYoga,Zumba, useofnaturalcommuteslikebicycles,staircases,etc.,to helpdevelopgoodhealthyhabitsforemployees.
•OrganicKitchens
Thestructureisplannedsmartlywiththecorrectprovision forventilation,lightmanagement,andheatcontrolduring thedaytime.Verticalgardeningwiththesystematicuseof creeperplantsandpottedbusheshashelpedconvertmodern businesshousesintosmartecosystems.Theroofing solutionstoohavenaturalelementstosupportlightand allowplentyofventilationthroughthetiltedglasswindows andfaçadestructures.
Theparkingareacanbetransformedintonaturalgreen parkingbysmartlyhorizontallyplantingbushesand creeperstocoverthedesignatedarea,creatingaremarkable shareforthevehicles.
Companiesshouldensurethatemployeesgetfresh,clean, nutritious,organicfoodforasafeandhealthylifestyle.
Manycountries,includingJapan,haveimplementedthe naturalmeansinvariousaspectsoftheirlives.Itistimewe shouldwakeupandmaketheseslightchangestocontribute towardsahealthyandsustainablefuture.Weowethis planettoourfuturegenerations,soletustakeresponsible stepstowardsbuildinganorganicworldofharmonywith mothernature.
•BuildingEnergyEfficientBuildings
GreenShieldforDynamicFuture
Companieshaveidentifiedtheimportanceofnaturalways offunctioningandareadoptingtodevelopnaturalenergy efficientpremises.UsesolarpanelsforPVpower generationandsolarpanelstoheatwaterincompany kitchens.
-KedarBorgaonkar
•HealthyPractices,Eco-friendlyInitiatives
Thecorporatecompanykitchenstoimplementanorganic approachtowardstheirfunctioning.Menustoincludefresh vegetables,salads,fruits,nuts,andbeans.Healthy beveragesincludegreenteas,Blackcoffee,and Mint/Clove/Lemongrassteas.Freshjuicesofdifferent fruits,lemon,ginger,andIndiangooseberry,tobeprovided.
•UseofOrganicConsumables
Theorganizationsshouldencouragetheactivitiesoftree plantations,organicfarming,planninginitiativesto conserveandbuildourorganicecosystem,simplecooking withoutfire,andmanymore.
Weareallapartofthisnature.However,welive.Still,the naturehasagoverningroleinourlifeandwork.Itwould besimpletounderstanditsimportanceandincludethe organicwayoflifeineverysphere.Astheworldbraces togethertofightclimatechange,wecantransformthe effortsthrougheffective,lasting,andsimpleorganicand naturalpractices.
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Thenaturaldisposalofdryandwetwastecreatesorganic fertilizerslikeCompostorearthwormfertilizers.
