DailyZz™: Something to dream about

Daily Zz™ supplementation in healthy people who have occasional sleep problems supports healthy and quality sleep and improves performance the next day. It is a new, dual action of one botanical ingredient and an important point of differentiation that opens up space for innovation in the formulation of sleep products.

AUTHOR: Samanta Maci, Kemin Nutrition and Health

Background

Consumers are increasingly recognizing that poor sleeping patterns can have a greater impact on health beyond simply feeling fatigue or short temper after a single poor night’s sleep. Getting enough quality sleep can help protect cognitive and physical health, quality of life, and get the best out of your day1

Research from 2022 shows that 46% of global consumers state their sleeping habits have worsened either slightly or a lot in the last two years. 33% of

European consumers are dissatisfied with the quality of overall life as a result of sleeping habits and 30% do not feel refreshed after sleeping which impacts daytime function and overall health2

In fact, consumer needs translate to a sleep aids global market size of 4.8 billion USD with Eastern Europe reaching proximately 280 million USD and expected to surpass 300 million USD by 2024. Natural, chemical free and additive free are within the top buying characteristics that consumers look for in their supplements and Eastern Europe is no excep­ tion with over 70% of botanicals market share3. This creates the perfect momentum for natural and science-based ingredients to breakthrough in this platform.

Kemin Human Nutrition and Health blended science and nature together to create a powerful botanical blend rich in naturally occurring polyphenols providing much­needed sleep quality and the strength of next day performance – meet DailyZz™

Features

DailyZz™ is a proprietary blend of gentle water extraction of a certified sustainably grown spearmint (Menthaspicata L.) and green tea (Camellia sinensis) developed for use as a dietary ingredient in supplements and food and beverages applications. Rich in polyphenols, DailyZz™ is standardized to rosmarinic acid (RA) and epigallocatechin gallate (EGCG) combined and over 25% of total polyphenolic complex.

DailyZz meets the condition of use for Camellia sinensis related to the EU on­hold botanical claims ”Supports natural sleep / relaxing / promotes concentration” (ID 1222 ­ EFSA on hold botanical claims list)*.

Powered by science

Sleep and wakefulness are tightly controlled processes. Many distinct systems with their neurochemicals contribute to specific aspects of the sleep- wake cycle. Excitatory neurotransmitters such as acetylcholine (Ach), glutamate, and different monoamines promote wakefulness while gamma aminobutyric acid (GABA) together with neuropeptides, promote sleep4. Interestingly, Ach plays a dual role as a sleep and wake neurochemical5

On top of the well-known antioxidant and neuroprotective properties6,7, Mentha spicata and Camellia sinensis have been associated with sleep, relaxation and brain function possibly through the ability of RA, a major polyphenol amongst more than 50 other polyphenols from the spearmint plants, to modulate Ach and of RA and EGCG from the green tea to interact with GABA receptors8­15

In addition to the scientific rational for the potential beneficial role of the polyphenols present in the proprietary blend, supportive evidence from an innovative dual night and day activity was obtained in a randomized, double blind, placebo­controlled, parallel design, clinical trial conducted by leading sleep expert Dr. Michael Grandner in hundred and five healthy men and women with occasional mild sleep complaints16

The study showed that, when taken daily for 30 days before bedtime at 485mg dose, DailyZz™ supports healthy and quality sleep and improves next day (following day) performance parameters such as concentration, judgement, reaction time and executive function when compared to placebo (Figure 1). Remarkably, these are cognitive areas impacted by a bad night of sleep. Furthermore, benefits from DailyZz™ started to be observed as early as 7 days17

One ingredient – countless applications

FIGURE 1 Benefits of DailyZz™ supplementation in support of sleep quality and next day performance. Findings for DailyZz™ compared to placebo (p<0.05 for all). ISI­Insomnia Severity Index; BART­Baloon Analog Risk Task; PVT-Psychomotor Vigilance Test16

DailyZz is a versatile water­soluble tan­dry powder that can be included in different galenic dry formulations such as hard and softgels capsules, tablets, gummies, and water­based applications such as spray, sticks and drops to dissolve in water. The ingredient has a 3­years shelf life, is stable across a range of temperatures and pH values and in formulation with melatonin, vitamins and other botanical ingredients. The suggested dosage is 485 mg/day, 30 minutes before bedtime.

Final remarks

In Eastern Europe the use of botanical sleep aid ingredients is very well established. DailyZz™ supplementation in healthy men and women with occasional sleep complaints supports healthy and quality sleep and improves next day performance. This is a novel finding for a botanical ingredient and an important point of differentiation that unlocks innovation in sleep formulations.

* Consolidated list of Article 13 Health Claims ID1222; Condition of use: Not less than 10 mg of Camellia sinensis leaf extract 5:1 a day. The determination of the acceptability of a botanical health claim rests fully with the food business operator placing the finished food product on the market.

References:

1 U.S. Department of Health & Human Services Sleep Deprivation and Deficiency. https://www.nhlbi.nih.gov/health-topics/ sleep-deprivation-and-deficiency.

2 FMCG Gurus Sleep and Stress Management in 2022 ­ Global Report; 2022;

3 Euromonitor Sleep Aids Eastern Europe 2020 ­ 2025; 2022;

4 España, R.A.; Scammell, T.E. Sleep Neurobiology from a Clinical Perspective. Sleep 2011, 34, 845–858, doi:10.5665/SLEEP.1112.

5 Carley, D.W.; Farabi, S.S. Physiology of Sleep. Diabetes Spectr. 2016, 29, 5–9, doi:10.2337/diaspect.29.1.5.

6 Fonseca, B.A. Key Polyphenols in Neumentix Phenolic Complex K110­42 Can Act in Multiple Ways to Support Cognitive Performance. Kemin Document KHTL­01­134;

7 Cabrera, C.; Artcho, R.; Giménez, R. Beneficial Effects of Green Tea: A Literature Review. J. Am. Coll. Nutr. 2006, 25, 79–99, doi:10.1186/1749­8546­5­13.

8 Falé, P.L.V.; Madeira, P.J.A.; Florêncio, M.H.; Ascensão, L.; Serralheiro, M.L.M. Function of Plectranthus Barbatus Herbal Tea as Neuronal Acetylcholinesterase Inhibitor. Food Funct. 2011, 2, 130–136, doi:10.1039/c0fo00070a.

9 Awad, R.; Muhammad, A.; Durst, T.; Trudeau, V.L.; Arnason, T. Bioassay­Guided Fractionation of Lemon Balm (Melissa Officinalis L.) Using an In Vitro Measure of GABA Transaminase Activity. Phyther. Res. 2009, 23, 1075–1081, doi:10.1002/ptr.

10 Kwon, Y.O.; Hong, J.T.; Oh, K.W. Rosmarinic Acid Potentiates Pentobarbital­Induced Sleep Behaviors and Non­Rapid Eye Movement (NREM) Sleep through the Activation of GABAa­Ergic Systems. Biomol. Ther. 2017, 25, 105–111, doi:10.4062/biomolther.2016.035.

11 Adachi, N.; Tomonaga, S.; Tachibana, T.; Denbow, D.M.; Furuse, M. (­)­Epigallocatechin Gallate Attenuates Acute Stress Responses through GABAergic System in the Brain. Eur. J. Pharmacol. 2006, 531, 171–175, doi:10.1016/j.ejphar.2005.12.024.

12 Vignes, M.; Maurice, T.; Lanté, F.; Nedjar, M.; Thethi, K.; Guiramand, J.; Récasens, M. Anxiolytic Properties of Green Tea Polyphenol (­)­Epigallocatechin Gallate (EGCG). Brain Res. 2006, 1110, 102–115, doi:10.1016/j.brainres.2006.06.062.

13 Park, K.S.; Oh, J.H.; Yoo, H.S.; Lee, Y.M.; Lee, M.K.; Hong, J.T.; Oh, K.W. (-)-Epigallocatechin-3-O-Gallate (EGCG) Reverses Caffeine-Induced Anxiogenic-like Effects. Neurosci. Lett. 2010, 481, 131–134, doi:10.1016/j.neulet.2010.06.072.

14 Caro, D.C.; Rivera, D.E.; Ocampo, Y.; Franco, L.A.; Salas, R.D. Pharmacological Evaluation of Mentha Spicata L. and Plantago Major L., Medicinal Plants Used to Treat Anxiety and Insomnia in Colombian Caribbean Coast. Evidence­based Complement. Altern. Med. 2018, 2018, doi:10.1155/2018/5921514.

15 Campbell, E.L.; Chebib, M.; Johnston, G.A.R. The Dietary Flavonoids Apigenin and (­)­Epigallocatechin Gallate Enhance the Positive Modulation by Diazepam of the Activation by GABA of Recombinant GABA A Receptors. Biochem. Pharmacol. 2004, 68, 1631–1638, doi:10.1016/j.bcp.2004.07.022.

16 Tubbs, A.S.; Kennedy, K.E.R.; Alfonso­Miller, P.; Wills, C.C.A.; Grandner, M.A. A Randomized, Double­Blind, Placebo­Controlled Trial of a Polyphenol Botanical Blend on Sleep and Daytime Functioning. Int. J. Environ. Res. Public Health 2021, 18, 1–11, doi:10.3390/ijerph18063044.

17 Sadewasser Chris DailyZz Shown to Improve Sleep Quality Is Less than 2 Weeks. Tech. Lit. 2020.

AUTHOR: Samanta Maci, Kemin Human Nutrition and Health