Nutramedic &Cosmetics

References:

1 FMCG GURUS Custom Survey Geographical Immunoty Poland, Serbia, Slovenia 2022;

2 Sperber, A.D.; Bangdiwala, S.I.; Drossman, D.A.; Ghoshal, U.C.; Simren, M.; Tack, J.; Whitehead, W.E.; Dumitrascu, D.L.; Fang, X.; Fukudo, S.; et al. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study. Gastroenterology 2021, 160, 99­114.e3, doi:10.1053/j. gastro.2020.04.014.

3 Takiishi, T.; Fenero, C.I.M.; Câmara, N.O.S. Intestinal Barrier and Gut Microbiota: Shaping Our Immune Responses throughout Life. Tissue Barriers 2017, 5, doi:10.1080/21688370.2017.1373208.

4 Vighi, G.; Marcucci, F.; Sensi, L.; Di Cara, G.; Frati, F. Allergy and the Gastrointestinal System. Clin. Exp. Immunol. 2008, 153, 3–6, doi:10.1111/j.1365­2249.2008.03713.x.

5 Shi, N.; Li, N.; Duan, X.; Niu, H. Interaction between the Gut Microbiome and Mucosal Immune System. Mil. Med. Res. 2017, 4, 1–7, doi:10.1186/s40779­017­0122­9.

6 Madison, A.; Glaser­Kiecolt, J.K. Stress, Depression, Diet, and the Gut Microbiota: Human–Bacteria Interactions at the Core of Psychoneuroimmunology and Nutrition. Curr Opin Behav Sci 2019, 28, 105–110, doi:10.1016/j.cobeha.2019.01.011.

7 Camilleri, M. The Leaky Gut: Mechanisms, Measurement and Clinical Implications in Humans. 2019, 68, 1516–1526, doi:10.1136/ gutjnl­2019­318427.The.

8 Niewiem, M.; Grzybowska­Chlebowczyk, U. Intestinal Barrier Permeability in Allergic Diseases. Nutrients 2022, 14, doi:10.3390/ nu14091893.

9 Fasano, A. All Disease Begins in the (Leaky) Gut: Role of Zonulin­Mediated Gut Permeability in the Pathogenesis of Some Chronic Inflammatory Diseases. F1000Research 2020, 9, 1–13, doi:10.12688/f1000research.20510.1.

10 Taylor, H.B.; Gudi, R.; Brown, R.; Vasu, C. Dynamics of Structural and Functional Changes in Gut Microbiota during Treatment with a Microalgal β­Glucan, Paramylon and the Impact on Gut Inflammation. Nutrients 2020, 12, 1–17, doi:10.3390/nu12082193.

11 Kemin Technical Literature KHTL­017­159.

12 Kemin Technical Literature KHTL­017­150.

13 Kemin Technical Literature KHTL­017­149.

14 Evans, M.; Falcone, P.H.; Crowley, D.C.; Sulley, A.M.; Campbell, M.; Zakaria, N.; Lasrado, J.A.; Fritz, E.P.; Herrlinger, K.A. Effect of a Euglena Gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double­Blind, Placebo­Controlled Trial. Nutrients 2019, 11, 2926.

15 Kemin Source Document Data TD­20­6867

16 Kemin Source document TD­17­00322

17 Kemin Source Document SD­17­00243 (TL­17­00067

18 Kemin Source Document SD­19­21271

19 Kemin Source Document WP­18­00135

20 Kemin Source Document. KHTL­017­164

21 Commission Implementing Regulation (EU) 2020/1820 of 2

December 2020 authorising the placing on the market of dried Euglena gracilis as a novel food under Regulation (EU) 2015/2283 of the European Parliament and of the Council and amending Commission Implementing Regulation (EU) 2017/2470 https:// eur­lex.europa.eu/legal­content/EN/TXT/PDF/?uri=CELEX­

:32020R1820&from=EN

22 https://food.ec.europa.eu/system/files/2022-11/novel-food_sum_ ongoing-app_2019-1261.pdf

23 Nakashima, A.; Sasaki, K.; Sasaki, D.; Yasuda, K.; Suzuki, K.; Kondo, A. The Alga Euglena Gracilis Stimulates Faecalibacterium in the Gut and Contributes to Increased Defecation. Sci. Rep. 2021, 11, 1–8, doi:10.1038/s41598­020­80306­0.

24 Umei, M.; Akazawa, H.; Saga­Kamo, A.; Yagi, H.; Liu, Q.; Matsuoka, R.; Kadowaki, H.; Shindo, A.; Nakashima, A.; Yasuda, K.; et al. Oral Administration of Euglena Gracilis Z Alleviates Constipation and Cardiac Dysfunction in a Mouse Model of Isoproterenol­Induced Heart Failure. Circ. Reports 2022, 4, 83–91, doi:10.1253/circrep.cr­21­0094.

25 Bhattad, T.; Koradiya, A.; Prakash, G. Prebiotic Activity Of Paramylon Isolated From Heterotrophically Grown Euglena Gracilis. Heliyon 2021, 7, e07884, doi:10.1016/j.heliyon.2021.e07884.

26 Sakanoi, Y.; Shuang, E.; Yamamoto, K.; Ota, T.; Seki, K.; Imai, M.; Ota, R.; Asayama, Y.; Nakashima, A.; Suzuki, K.; et al. Simultaneous Intake of Euglena Gracilis and Vegetables Synergistically Exerts an Anti-Inflammatory Effect and Attenuates Visceral Fat Accumulation by Affecting Gut Microbiota in Mice. Nutrients 2018, 10, 1–15, doi:10.3390/nu10101417.

27 Ishibashi, K.; Nishioka, M.; Onaka, N.; Takahashi, M. Effects of Euglena Gracilis EOD­1 Ingestion on Salivary IgA Reactivity and Health­Related Quality of Life in Humans. Nutrients 2019, 11, 1144.

28 Nakashima, A.; Suzuki, K.; Asayama, Y.; Konno, M.; Saito, K.; Yamazaki, N.; Takimoto, H. Oral Administration of Euglena Gracilis Z and Its Carbohydrate Storage Substance Provides Survival Protection against Influenza Virus Infection in Mice. Biochem. Biophys. Res. Commun. 2017, 494, 379–383, doi:10.1016/j.bbrc.2017.09.167.

29 Salminen, S.; Collado, M.C.; Endo, A.; Hill, C.; Lebeer, S.; Quigley, E.M.M.; Sanders, M.E.; Shamir, R.; Swann, J.R.; Szajewska, H.; et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) Consensus Statement on the Definition and Scope of Postbiotics. Nat. Rev. Gastroenterol. Hepatol. 2021, 18, 649–667, doi:10.1038/s41575­021­00440­6.

Kemin Industries is a global ingredient manufacturer that strives to sustainably transform the quality of life every day for 80 percent of the world with its products and services. Kemin is the science inside countless products you interact with every day. Established in 1961, Kemin is a privately held, family­owned­and­operated company producing more than 500 specialty ingredients, spanning six continents, employing thousands of team members, and serving more than 120 countries. The company science, spirit of innovation, and servant leadership has driven it to make things better for people, animals, plants, and the planet. The Human Nutrition and Health division grows and extracts functional ingredients from natural sources around the world. These ingredients, clinically shown to support the vision, cognition, immune health and weight management platform, are used in a range of dietary nutrition products, including supplements and snack foods.

Kemin Human Nutrition and Health

Samanta Maci samanta.maci@kemin.com

Tel. +351 214 157 500 www.kemin.com