Cisplatin Injection- All you need to know about What is Cisplatin: Cisplatin forms part of a group of drugs called cytostatics, which are recommended in the treatment of cancer. It can be used alone but more commonly it is used together with other cytostatics. Cisplatin has potential to destroy cells in your body that can cause certain types of cancer (tumour of testis, tumour of ovary, head and neck epithelial tumour, tumour of the bladder, lung cancer and for cervical cancer together with radiotherapy). Indications: The FDA approved cisplatin uses are as follows: • Cisplatin is indicated in order to treat advanced testicular cancer. • Cisplatin holds the approval in order to treat advanced ovarian cancer. • It is also used in order to treat advanced bladder cancer.
How does cisplatin work: Cisplatin mainly belongs to the platinum-based antineoplastic family of drugs. It specifically works in part by binding to DNA and then it inhibits replication. Dosage & Administration: The cisplatin injection should be administered by the slow intravenous infusion. It should be avoided in order to be given by rapid intravenous injection. • Metastatic Testicular Tumors: The usual cisplatin dose for treating testicular cancer together with the other approved chemotherapeutic agents is 20 mg/m2 should be given intravenously daily for the 5 days per cycle. • Metastatic Ovarian Tumors: For the treatment of metastatic ovarian tumors together with cyclophosphamide, the usual dose is cisplatin 75 to 100 mg/m2 intravenously per cycle once every 4 weeks. • The dose of cyclophosphamide when used together with cisplatin is 600 mg/m2 intravenously once every 4 weeks. • In combination therapy, the cisplatin and cyclophosphamide are given sequentially. • As a single agent, cisplatin should be given at a dose of 100 mg/m2 intravenously per cycle once every 4 weeks. • Advanced Bladder Cancer: Cisplatin is given as a single agent at a dose of 50 to 70 mg/m2 IV per cycle once every 3 to 4 weeks depending on the extent of prior exposure to the radiation therapy or prior chemotherapy. • For patients who are heavily pre-treated, the initial dose of cisplatin is 50 mg/m2, should be given per cycle repeated every 4 weeks.