MIRACLE MOLECULES THAT REVERSE BIOLOGICAL AGE

By Rob Verkerk PhD, founder, executive and scientific director, ANH-Intl

How would you like to turn back your biological clock a few years – or even a decade or more? I don’t just mean so you might look better on the outside, as that can, after all, be just cosmetic.

Robert Verkerk PhD is an internationally acclaimed scientist with over 35 years-experience in sustainability, specifically in the fields of agriculture, food production and healthcare. He has Masters and Doctorate degrees from Imperial College London, where he continued his research for a further 7 years as a postdoctoral research fellow. In 2002 he founded the Alliance for Natural Health International (ANH-Intl), an independent non-profit organisation that promotes natural, sustainable, and bio-compatible approaches to healthcare—using the tools of ‘good science’ and ‘good law’.

spin-off that Aubrey de Grey may have been linked to?

dissemination in the world – Big Pharma itself.

Are they the ultimate anti-aging elixir?

I’m talking here about the genuine reversal of ageing that affects the inside of your body as well, from your brain to your big toes. Reducing the risk of degenerative diseases like Alzheimer’s, heart disease and cancer. Feeling like you’re bounding with energy as you might have been years or even decades ago. In fact, reversing ageing so comprehensively that you can confirm your clock- reversing feat via one of the most robust markers of ageing and disease risk – your telomere length. For those who aren’t familiar, telomeres are the caps made up of repetitive nucleotide sequences at the ends of chromosomes that play a key role in complete chromosome replication and their length is a strong predictor of potential life span.

Is this just science fiction, or is it something we’re still waiting to hear about from some Californian biotech

As it happens, neither is the case. It can be done, and it is being done by those in the know. Sadly, what many of us who’ve been studying this area for some time might regard as the most powerful approach to biological age reversal currently known on the planet, is barely known outside limited groups of anti-ageing specialists. The approach works directly against Big Pharma’s model that benefits from a world awash with lots of sick people who take its drugs on the recommendation of doctors who consider they have, courtesy of their education and licensing boards, few other options. Remarkably, the scientific achievements in the form of biological age reversal I’m talking about have happened without any support from the biggest economic powerhouse in research and media

So it was fascinating to be invited to speak at the Profound Health Summit at the Luton Hoo (UK) and meet with and learn more about the incredible progress that’s been made over the last 45-years by Prof Vladimir Khavinson and his team at the Institute of Bioregulation and Gerontology, St Peterburg, Russia. It was both an honor and a privilege to be asked to speak at the Summit on the same stage, in my case mapping the global regulatory threats and opportunities for different classes of health product, including peptide regulators..

Vladimir Khavinson and the key role of peptide bioregulators

Prof Khavinson’s credentials are impressive and include the publication of over 700 peer reviewed papers. His curriculum vitae can be found here

Nobel Prize.

(https://khavinson.info/ curriculum-vitae). At the heart of his approach is the recognition that some of the most powerful bioregulators within humans (and other animals) are very small molecules comprised of a small number of bonded amino acids, referred to as small or short peptides.

This remarkable and important finding emerged from research carried out over 50-years ago in the Soviet Union, when Vladimir Khavinson was only in his 20s, that was heavily funded by the Soviet government. One of the main goals of the research was to find ways of overcoming eye and ear injuries suffered by military personnel, and the starting point of the research was apparently some of the original work by Ivan Pavlov on regulatory peptides. Pavlov is of course better known for his work on dogs, digestion, and the conditioned response for which he was awarded a

While the bioregulatory role of small peptides has been known for over 100 years, there have been ongoing discoveries on their significance, including more recently the work of Aaron Ciechanover, Avram Hershko and Irwin Rose who were awarded the Nobel Prize in Chemistry in 2004 for their discovery that the polypeptide ubiquitin was critical to the cell cycle, with ubiquitin-marked cells being consigned to cellular ‘waste bins’ (proteasomes).

But it was Vladimir Khavinson’s work that exposed the even more critical role of small peptides, in protein biosynthesis and gene expression.

And a Nobel Prize, disappointingly, has yet to be awarded.

What Khavinson’s research team found was that these small peptides can bind between prised-open DNA strands that are freed from histones prior to transcription (Fig. 2), leading to the control of gene expression and protein biosynthesis.

Speakers

treatments with peptide bioregulators (as injectables, oral supplements and cosmeceuticals).

The work that has led to commercialization of peptide bioregulators started in earnest in the late 1970s with the investigation of responses in mice following administration of peptide preparations isolated from thymus and pineal glands, the thymus being the source of peptides first found to reverse age-related declines in immune responses during the mid-1970s.

humans and animals can not only halt the age-related deterioration of multiple functions, but it can also even reverse them with clear evidence that healthy lifespan can be increased accordingly.

Khavinson peptides enter clinical studies in the USA

The work of Prof Khavinson’s group over the last 45-years spans everything from theoretical work to cell culture studies, animal experiments, clinical trials, and the development of medical centres and clinics that specialize in providing

The work has culminated in showing that peptide bioregulators play a key role in preserving the normal, homeostatic function of younger, healthy humans and other animals, and that the decline of these functions with age is strongly linked to declining production of these small bioregulatory peptides within the body and this is, in turn, strongly linked to premature ageing and age- associated pathology.

In terms of the application of this knowledge, it has also been shown that administering specific peptide bioregulators to

As far as I am aware, there is not a single other top-level researcher and associated research group which has made major contributions to basic science, in this case discovering the fundamental role of small peptides in bioregulation and gene expression, that have gone on to develop a suite of products and protocols that both treat and prevent almost every common degenerative disease.

Not only that, the emerging evidence from many thousands of people already treated, some of which are currently participants in trials, is that treatment using these food supplements for healthy populations enables them to extend their lives significantly and maintain good health at the same time.

Prof Khavinson recognizes the extreme importance of getting this knowledge outside Russia. And it’s for this reason he has been collaborating with Dr Bill Lawrence, a lawyer, turned entrepreneur, turned longevity researcher and expert who has been administrator for two major clinical trials on peptides in the USA.

I was fortunate enough to meet Bill this weekend and those of us present were privy to some of the remarkable interim results, including how the peptides are reversing biological age, as measured by Dr Steve Horvath’s epigenetic clock. You can learn more about Dr Bill Lawrence’s collaboration with Prof Khavinson in these 2021 products, known as peptide bioregulators currently available, as injectable pharmaceuticals, food supplements and cosmeceuticals. Some are manufactured in Russia, others in Italy and Portugal.

For many people, the food supplement forms will be of greatest benefit – and interim results from the clinical trials that are underway, one of

• www.natniddam.com/podcast/bioregulator-peptidesincrease-health-span-lengthen-telomeres-turn-backthe-clock-with-dr-bill-lawrence-phd

• www.natniddam.com/podcast/episode-46-dr-billlawrence-reversing-aging-part-2-bioregulatorpeptides-effect-on-dna-methylation-clinical-trial interviews with nutritionist Nat Niddam:

Commercialisation

There are over 21 commercial which is some 5-years in, the other some 3-years in, all under the administration of Bill Lawrence, and they are showing that they have immense power not only in

Peptide extracts that have been found to contribute to functional correction to specific systems are listed below:

Peptide extract organ/tissue Site of primary

Brain extract

Thymus gland extract

Pineal gland extract

Thyroid gland extract

Vessels extract

Pancreas extract

Cartilage extract

Liver extract

Liver extract

Kidney extract

Testis extract

Ovary extract

Urinary bladder extract

Retinal extract

Spring 2024

5-star Luton Hoo Hotel, Golf & Spa Resort, Bedfordshire, England

Being organised for May 25/26, 2024

Maximising Heathspan

Utilising stem cells, peptides, hormones and nutrition for longevity medicine.

Meet world experts in the field of preventative and regenerative therapies, learn from them about how to optimize your health and assist in slowing, halting and reversing numerous degenerative issues.

Correction of brain and central nervous system functions

Correction of immune system functions

Correction of endocrine system functions

Correction of cardiovascular system functions

Correction of pancreatic function

Correction of function of joints and spine

Correction of liver and digestive system functions

Register your interest and see more at the website.

For more information visit profound-health-summit.com or email emma@profound-health-summit.com

We welcome individuals, health professionals and business owners www.profound-health-summit.com

Correction or urogenital system functions

Adrenal extract

Correction of visual functions

Correction of adrenal function and improvement in stress response

Information gathered from Peptide Bioregulator Report (2007), www.gerontology.ru/cytomaxs (http://www. gerontology.ru/cytomaxs) website, and UK Antiaging Peptides website (https://antiaging-peptides.com/ natures-marvels/) halting biological age, but also reversing it.

The full range of commercially-available natural peptide bioregulators (including synthetic versions for vegetarians and vegans) can be found at the Institute of Bioregulators and Gerontology website (https://www.gerontology.ru/ cytomaxs).

End Note

For my part, I was honored be invited by Phil Micans to the conference. It was an extraordinary privilege to share some meaningful time, as well as the speakers’ stage, with Profs Khavinson and Svetlana Trofimova, the latter being responsible for the clinical work at the medical centre in the St Petersburg institute.

Having heard Aubrey de Grey say more than once that science had yet to turn up any product that could successfully reverse ageing, I was pleased to find myself sitting within 2 meters of Aubrey during Prof Khavinson’s main lecture, watching him take detailed notes. Aubrey was the guest speaker at the gala dinner, and it was clear he recognised the importance of the findings of Prof Khavinson’s team, which clearly had not yet landed in the biotech-based world of anti-ageing research.