Liposome Manufacturing using High Pressure Sanitary Pump and Liposome Extruders Introduction to Liposomes A liposome is a spherical-shaped vesicle composed of phospholipid bilayers. Phospholipid bilayers are critical components of cell membranes, with hydrophilic and hydrophobic properties. In an aqueous solution, the hydrophobic ends tend to bind to each other, and spontaneously form small spherical liposomes.
Gene Delivery Liposomes with phospholipid bilayers Genizer High-Pressure Sanitary Pump and Liposome Extruder The Genizer high-pressure pump combined with liposome extruder provides a scalable and sanitary solution for liposome and LNP production. Constructed from 316L stainless steel, the system ensures full compliance with pharmaceutical manufacturing standards.
Application: Research and Development for the liposomal drug delivery system, vaccine, gene delivery, and cosmetics How the System Works The high-pressure pump delivers controlled pressure to force lipid suspensions through the extruder membranes. The liposome extruder drives the mixture through track-etched filters of defined pore sizes, producing homogeneous liposomes with reproducible size distribution. Only a
few passes are needed to achieve the desired particle size and quality.
High Pressure Liposome Extrusion Systems Key Features and Advantages Key advantages include real-time pressure and temperature monitoring, user-friendly PLC touchscreen controls, and robust materials like titanium alloy, tungsten carbide, PTFE, and UHMWPE. This ensures both research-scale batches and production-scale volumes can be produced efficiently with consistent results. Applications in Pharmaceuticals and Cosmetics By combining high-pressure homogenization with membrane extrusion, Genizer’s system simplifies process optimization, enhances reproducibility, and delivers consistent liposome size and encapsulation efficiency. It is ideal for drug delivery, gene therapy, and cosmetic formulations, providing a reliable solution for modern liposome manufacturing. Contact us for more information about liposome extruders.