Hcs week 21

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Established in 1929

Health City Sun

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www.healthcitysun.com

New Mexico’s Legal & Financial Weekly

May 26, 2017

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Fighting Fungal Lung Infections with Innovative Inhaled Technology

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Vol. 7.88 No. 21

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ungal infections in the lungs are a serious, underreported medical issue.

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Most people don’t realize that the air we breathe is laden with the spores of many different types of fungi and molds. For the large majority, this isn’t a problem. The spores either get trapped in our airway mucus and expelled, or are tackled and neutralized by our immune systems. But in many people, especially those with compromised immune systems or lungs, such as those who have cystic fibrosis (CF), the spores germinate into fungi that cause both serious infections and allergic reactions.

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The ideal alternative would be to deliver the drug directly to the lungs of patients by inhalation. However, due to dosing limitations, standard inhalation technologies aren’t able to do this.

Usually caused by the spore-forming mold, Aspergillus fumigatus, the problem is particularly acute in CF patients, with half of that patient population requiring treatment for fungal infections in their lungs and, in the case of severe asthma, affecting millions of patients. “This infection can cause an allergic reaction, known as allergic bronchopulmonary aspergillosis or ABPA, that impairs lung function,” explains Dr. Richard Moss, former chief of the Pediatric Pulmonary and Allergy Divisions at Stanford University. Fighting these fungal lung infections has been difficult. There are oral anti-fungal drugs, such as one called itraconazole. The problem is getting enough of the drug through the bloodstream to the lungs, where it’s needed. Getting sufficient lung concentrations requires giving high oral doses that can cause severe side effects, including liver toxicity.

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But now there’s an innovative new technology from a Massachusetts-based company, Pulmatrix (NASDAQ:PULM), which uses small, dense particles that easily fly into the lungs. The company has incorporated itraconazole to the particles, enabling it to be efficiently delivered. Preclinical studies have already shown that Pulmatrix’s experimental anti-fungal inhaled drug can achieve high drug concentrations in the lungs, with very low amounts in the bloodstream. “This inhaled drug technology has great potential to treat serious fungal infections and the allergies those infections cause without the dangerous side effects and drug-drug interactions of using oral drugs,” says Moss. -(NewsUSA)

Tips For A 100 Percent Hassle-Free Move oving can be a hassle, stressful and emotional.

If you’re considering a move, know you’re not alone. According to the U.S. Census Bureau, 40 million Americans moved in 2016. That’s a lot of moving. “Every year, people take on the frustrating experience of moving,” said Adam Doron, CEO of Unpakt, an online platform designed to eliminate stress from the moving experience. “What many don’t realize is that moving doesn’t have to be difficult. There are resources available to ensure an easy, hassle-free move.” According to Doron, the main challenge when moving is guaranteeing the final price of a move, as moving prices can increase on move day with no notice. Another challenge? Verifying that a mover is licensed and insured. He suggests using a reliable online service to compare guaranteed, transparent prices from prescreened moving companies, as well as cus-

tomer reviews. That allows people to manage and control their move from start to finish. It’s also beneficial to have a third party handling payments and issues. “Working with an online platform like Unpakt means you can avoid the hassle of entrusting an unknown mover with getting your belongings to your new home,” said Doron. “Unpakt enables consumers to compare verified, reputable movers and enjoy a stress-free move. “For your next move, get online. Visit Unpakt and instantly compare guaranteed prices from prescreened moving companies. It’s easy to book your move online, just like you would a hotel or flight. We want to become the ‘go to’ online comparison site for everyone’s move.” For moving tips or to book a move, visit www.Unpakt.com or download the Unpakt app on iTunes or Google Play Store. Enter promo code UnpaktNews to save 5 percent on your next move. -(NAPSI)


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