New Treatments

Finerenone blocks angiotensin II-induced aldosterone from binding to MR. This results in upregulation of NO, which inhibits angiotensin II The drug holds a similar mechanism of action as spironolactone, but may be safer due to having less affinity to other steroid hormone receptors.

Gorilla Head thinks salicylic acid may work as a direct AMPK activator.

Herber t repor ts that caffeine has only been shown to work in vitro.

DukeNuke thinks topical cetirizine seems like a low risk for good chance of ROI as a product or compounded treatment for HairDAO to sell.

Melatonin topically makes sense as lipophilic molecule, says Herber t. If it becomes metabolized in skin as opposed to liver, the natural compound may have a very different effect.

Zoon and Pevjo analyze antioxidant Tocotrienol, which upregulates Wnt co-activator B-catenin.

Herber t lists a series of natural WNT upregulators in this general WNT background. On the list are: alpinetin, baicalin, morroniside, Aconitie Ciliare Tuber extract, Centipeda minima extract, linoleic acid, and Prunus mira seed oil.

Herber t investigated the protective effects of epigallocatechin gallate (EGCG) from green tea on human dermal papilla cells (DPCs) when treated with dihydrotestosterone (DHT).

Metabobbly seeing good progress with his treatment. What is his stack? It’s patent pending, he claims.

ROS scavenger Allium Hookeri activates B-catenin and NRF2 in a new paper drop.

NDimension and Synthetic Pug tell us we may be able to suppress TGFb1 with NAC, a ROS scavenger that is widely available.