Karlee Silver - Grand challenges and integrated innovation

Grand Challenges and Integrated Innovation Karlee Silver, DPhil Director of Targeted Challenges October 2, 2013

Bold Ideas. Big Impact. A Better World.

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Focuses on global health

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Funded by Government of Canada

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Funds innovators from developing countries and Canada

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Encourages Integrated Innovation

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Catalyzes impact at scale and sustainability

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Focuses on results: Saving and improving lives

Joseph L. Rotman (pictured top left); Peter A. Singer and the Honourable James Flaherty (pictured bottom right) at the Launch of Grand Challenges Canada on May 3, 2010

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Grand Challenges Canada Programs

Saving Lives at Birth

Saving Brains

Stars in Global Health

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Global Mental Health

The Grand Challenges Approach To stimulate innovation with impact by identifying and tackling critical barriers between where we are and where we want to be.

The Benefits •

Stimulates innovation with impact = innovative solutions

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Accelerates innovation by creating communities of innovators

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Attracts talent to a defined challenge

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Captures public imagination

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Can lead to enterprise creation & jobs

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Can help link public and private organizations and finance

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Provides governance platform for different countries to solve together their common challenges

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Partners

Programs

In 2012-13: Grand Challenges India, Grand Challenges Brazil, Grand Challenges Israel CONFIDENTIAL

Integrated Innovation Grantees are encouraged to use an Integrated Innovation approach, which is the coordinated scientific/technological, social and business innovation to develop solutions to complex global health challenges. .

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Scientific/Technological Innovation • Has a scientific or technological base.

• Can come from the natural, health, social or behavioural sciences, or from engineering.

• Examples: • Efficient drug delivery system • Portable point-of-care diagnostic device • Mobile application to facilitate access to health care

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Social Innovation • Recognizes the broader social, structural and political determinants of health, and addresses one or more of these.

• Addresses local and/or cultural contexts that factor into implementation and scale.

• Examples:

• Intervention to address low social status of women • Engagement of religious leaders to spread health messages • Tool or process to alleviate financial barriers.

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Business Innovation •

Maximizes the value, relevance and unique quality of the solution to create demand.

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Addresses affordability and accessibility barriers to the solution.

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Recognizes that there is always someone who needs to be convinced that the solution is a worthwhile investment.

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Examples: • Affordable business model to get investor or government buy-in • Strategy for developing manufacturing and distribution partnerships • Incentivization within target community.

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Integrated Innovation: Our DNA Integrated Innovation is an approach that Grand Challenges Canada will encourage applicants to use from the outset and throughout their projects. Grand Challenges Canada will ensure: • Relevant criteria is included in each Request for Proposal • Peer Review Committees include scientific/technological, social and business innovation experts • Project milestones are incorporated into each grant to identify and address barriers to achieving scale • Enabled by program and platform teams

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Financial Ecosystem

100% subsidy

50% subsidy

0% subsidy

$100k grant

Up to $1M match

Social VC Fund Shared Value

Grant or loan

Government CONFIDENTIAL

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Transition-to-scale Example evaluation criteria: • • • • •

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Achieved proof of concept Integrated innovation approach to overcoming barriers to scale Key stakeholders have a role to play in the project activities Sufficient partnerships and alliances to scale the innovation Appropriate, feasible and technically sound metrics to track progress and evaluate outcomes Leadership capacity to create change

Full criteria listed in Request for Proposals launched 1 October 2013, available at www.grandchallenges.ca.

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Opponents to Champions (dRPC, Nigeria) •

Demand creation harnessing influential opinion leaders

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14 imams identified to reach the most people and make negative pronouncements about mnch

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Takes advantage of hierarchical structures and media amplification to scale; technology for continued dialogue with Egyptian scholars

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Odon Device (WHO, Argentina) •

Bold idea of a car mechanic

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Partnership with WHO to conduct safety trials in 30 women, another 100 women

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Partnership with Beckton Dickenson to establish high-scale, low-cost production

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Early Childhood Cognitive Stimulation and Successful Transition to Preschool (AKU, Pakistan) •

Use of community health workers to deliver cognitive stimulation

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Innovation for maximal effect on each child and ability to reach the most number of children

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Define how early childhood stimulation intervention changes attitudes and behaviours of family and community

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Early Treatment with Rectal Artusenate to Halt Severe Malaria Progression (Mahidol University, Thailand) •

Novel formulation that allows rapid administration of first-line malaria treatment in community

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Tested in Tanzania, Ghana, Bangladesh

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Defining long-term benefits of early treatment to influence policy change

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For more information, please contact: info@grandchallenges.ca T 416.673.6568 Grand Challenges Canada MaRS Centre, South Tower, 101 College Street, Suite 406 Toronto, Ontario, Canada M5G 1L7 grandchallenges.ca Connect with us on: Facebook, Twitter, YouTube and LinkedIn