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HEADlines TIMELY NEWS FROM THE DEPARTMENT OF NEUROSURGERY

Year in Review | Winter 2022

HEADlines TIMELY NEWS FROM THE DEPARTMENT OF NEUROSURGERY

Year in Review | Winter 2022

MESSAGE FROM THE CHAIR OF NEUROSURGERY: Happy New Year to all and welcome to 2022! The year 2021 was, to say the least, challenging. Despite the challenge, however, I am incredibly proud of how our staff and faculty rose to the occasion, continuing to offer exceptional patient care, even at the height of the pandemic. If COVID has taught us anything, it is perseverance. This 2022 winter edition is an overview of the many “bright spots” that did occur this past year. We invite you to celebrate the new year with us and read the many patient stories and exciting research advances that have taken place in each of our neurosurgical “programs of excellence”: Neuro-Oncology (brain tumor), Peripheral Nerve Treatment, Neuropsychology, Functional Neurosurgery, Skull-base Neurosurgery, Pediatric Neurosurgery, Neurotrauma, Stroke, Pediatric and Pituitary Disorders. In this “year in review”, we present an overview of our efforts in launching the campus wide Neuroscience Innovation Initiative (NII), along with our completed four months of the “TED for your HEAD” community events. As we enter the new year, we would like to extend our sincere appreciation to everyone who has contributed to our department’s ongoing success. We congratulate all of our neuroscience partners, both research and clinical, who are working with us to pull together the Neuroscience Innovation Initiative (NII), and we appreciate all our patients who have written wonderful notes, cards and letters to us over this past year. We wouldn’t be here without all of you, and we are grateful! Kevin O. Lillehei, MD Professor & Ogsbury-Kindt Chair Department of Neurosurgery

A YEAR IN REVIEW Our Ten Programs Of Excellence Shine!

BRAIN TUMOR & NEURO ONCOLOGY PROGRAM OF EXCELLENCE Neurosurgeons in our Neuro-Oncology Program Kevin O Lillehei, MD Chair, Neurosurgery Director, Neuro Oncology Program

D. Ryan Ormand, MD, PhD Associate Professor Director, Brain Tumor Program

A Samy Youssef, MD, PhD Professor and Vice Chair, Education, Director, Complex Cranial and Skull Base Surgery

Michael Graner, PhD Associate Professor Director, Neurosurgery Neural Tissue Bank

PATIENT HIGHLIGHT: In Memorium

Jessica Lewis

Although some brain tumors are treatable and patients go on to live relatively normal lives, some aren’t so fortunate. Those dealing with glioblastomas, the most serious and hard to treat malignant brain tumors, often have fewer options. Jessica Lewis was one such woman. Yet, in the face of her difficult diagnosis, she did much in the two years following her diagnosis. A mother of two and an active fitness trainer, she had a huge following of faithful clients, friends and supporters. They even held a “run” for her called “vibin4Jess” in the summer of 2019 to help raise funds for brain tumor research. People all over the metro Denver area posted signs, painted rocks, made Instagram posts, and followed along on Facebook. Jessica and her mother helped the department make a very impactful video about glioblastoma and our own brain tumor (neural) tissue bank. Jessica was truly beloved by so many and made a huge impact on her community and on the world. She died this past fall and left behind her husband, Steve, and her children, Silas (age 12) and Gus (age 9). The family graciously channeled memorial funds to our brain tumor research fund and, to date, close to $9,000 has been donated in Jessica’s memory. More About Brain Tumor Research in the Neurosurgery Department: An ongoing highlight for brain tumor research in the Department this past year has been the Neurosurgery Neural Tissue Bank (for which Jessica and her family & friends have contributed so greatly over the past couple of years). Despite the challenges of the COVID pandemic, we have maintained accruement to the Bank, obtaining surgical specimens and biofluids, and we have nearly 1,500 samples. This tissue has been instrumental in ongoing research, currently resulting in three publications this year alone, with one additional manuscript under review and several others in preparation. The samples have been used in biomarker studies, to develop viable tumor cell lines for experimental drug screening, and also used in exosome/extracellular vesicle research. Data from these studies have been presented at numerous national and international conferences in both oral and poster presentations. This tissue bank has been invaluable in work related to NIH grant funding, and in collaboration with national entities such as the GLASS (Glioma Longitudinal AnalySiS) Consortium.

CEREBROVASCULAR & STROKE NEUROSURGICAL PROGRAM OF EXCELLENCE Neurosurgeons in our Neuro-Oncology Program

Robert Breeze, MD Professor and Vice Chair, Department of Neurosurgery

Christopher Roark, MD Assistant Professor

David Case, MD Assistant Professor

Joshua Seinfeld, MD Associate Professor Director, Endovascular Neurosurgery

Zach Folzenlogen, MD Assistant Professor of Neurosurgery Director of Endovascular Neurosurgery, Highlands Ranch Hospital

The NeuroInterventional (NIR) service has seen exciting growth over the past year. While already covering UCH Anschutz and UCH Highlands Ranch Hospital, NIR has expanded coverage to Children’s Hospital Colorado on the Anschutz Medical Campus. Beginning in the spring of 2021, the NIR service began performing highly specialized Neuroendovascular procedures in the new biplane NeuroInterventional room at Children’s Hospital. NIR now performs all head/neck tumor embolizations, stroke treatments, aneurysm treatments, and vascular malformation treatments at Children’s Hospital, while partnering closely with all related subspecialties. In addition the NIR service has begun enrollment for 2 large pivotal clinical trials for the treatment of small wide neck ruptured aneurysms and chronic subdural hematomas.

FUNCTIONAL & RESTORATIVE/MOVEMENT DISORDERS NEUROSURGICAL PROGRAM OF EXCELLENCE Neurosurgeons in our Functional/Movement Disorders Program

Steven Ojemann, MD Associate Professor Director, Stereotactic and Functional Neurosurgery

Daniel Kramer, MD Assistant Professor Functional Neurosurgeon

Drew Kern, MD, MS Associate Professor Neurology, Complex Movement Disorders

Annual “Hands on” Functional Neurosurgical Conference A Success!

Open to international participants, this past fall, the Stereotactic and Functional Neurosurgery Hands-On Workshop provided ample time for hands-on training in the lab, and for questions and discussion with renowned faculty. To encourage faculty interaction, course participation was limited to 30 attendees. This two-and-a-half-day course held in November was conducted by internationally known neurosurgery faculty who addressed a variety of neuromodulation and ablative techniques, stereotactic planning and execution of stereotactic principles.

Dr. Bob Gross, one of the founding directors of the Stereotactic and Functional Hands on Course, presenting on Laser Ablation for Epilepsy

Prestigious Course Faculty included the Course Director, Dr. Steven Ojemann from CU. Featured speakers: Ellen Air, MD, Phd from the Hentry Ford Health System; Shabbar Danis, MD from Rutgers University; Paul S. Larson from the University of California; Bari Ausat, MD from UCLA Neurosurgery; John Rolston, MD, PhD from the University of Utah and Sameer Sheth, MD, PhD from Columbia University, John Thompson, PhD from CU; Drew Kern, MD from CU; Dan Kramer, MD from CU; Cameron McIntyre, PhD from Case Western; Joseph Neimat, MD from the University of Louisville; Paul Kock, MD from McGuire VAMC; Adrian Laxton from Wake Forest University; Jorge Martinez, MD, PhD from the University of Pittsburgh and Lora Kahn, MD from Ochsner Health.

NEUROPSYCHOLOGY PROGRAM OF EXCELLENCE

Neuropsychologists in the Department of Neurosurgery

Joie Molden, PhD Assistant Professor

Michael Greher, PhD Associate Professor

Brian Hoyt, PhD Associate Professor

Christopher Domen, PhD Assistant Professor

Thomas Wodushek, PhD Associate Professor

The Division of Neuropsychology’s newest faculty member, Joie Molden, completed her first full year as a faculty member and has contributed greatly to the care of patients at the Memory Disorders Clinic, while also taking an important role in the management and training of our technicians. On this latter note, Neuropsychology added a psychometrist lead position that has contributed to improved training workflows as well as greater efficiency and quality control in our psychometrist unit. After the initial COVID lockdowns demanded a number of alterations in the practice, we were able to reimagine our normal operations and how to best use our time and space. We subsequently have maintained a number of changes made during the COVID crisis and transitioned these into standard procedures, resulting in our ability to see more cases than ever before in the last 12 months. Members of our faculty have also continued their

involvement in service activities at the national, state, and university level. Neuropsychology’s growth goals for 2022 include the addition of a bilingual neuropsychologist to help build a Spanish language clinic, serving adult patients. This is a desperately needed service that currently is not only unavailable here at UCHealth, but almost nonexistent in all of Colorado.

NEUROTRAUMA & CRITICAL CARE PROGRAM OF EXCELLENCE Neurosurgeons Treating Adult Neuro Critical Care

Robert Neumann, MD Associate Professor Director, NeuroCritical Care

Peter Lennarson, MD Associate Professor

Kathryn Beauchamp, MD Assistant Professor

Luis Cava, MD Associate Professor

Jason Weedman, MD Assistant Professor

Daniel Craig, MD Assistant Professor

Alexander Mason, MD Visiting Associate Professor

David Case, MD Assistant Professor

Kerry Brega, MD Associate Professor

Jennifer Kang, MD Assistant Professor

Muhammed Riaz, MD Assistant Professor

Neuro ICU Wins Patient Experience Award! There are MANY neurosurgeons across all of our various facilities (University Hospital, the VA, Denver Health, etc.) that provide neuro critical care, including stroke care, traumatic brain injury, spinal cord injury and more. Those listed are only a few, and don’t include the many at Children’s Hospital who also treat serious traumatic brain and spinal cord injuries and other serious neuro trauma. The neuro critical care unit at University Hospital is the largest in the region, and a new tower is currently being build which will enlarge it by another 30%. We are quite proud of all of our neurosurgeons working in these areas, and are thrilled that the University Hospital at Anschutz received special recognition this past year.

The Neuro ICU was one of three units to have their name engraved on this 2 foot tall, 27 pound trophy, exemplifying ongoing high ratings for patient experience. “This is the Stanley Cup for patient experience,” explained Tim Wimbish, Director, Office of Patient Experience for UCHealth. The Department names were engraved and will be visible for years to come as a way of showing departments that take care of patients and each other in meaningful and lasting ways.

In addition, this past year marked and important clinical trial debut on the Neuro Intensive Care Unit. The Neuro-ICU is a participating site for the Lungpacer RESCUE 3 study using the AeroPace system. The AeroPace system is designed to help patients wean off a ventilator and breathe on their own. Artificial breathing support from a ventilator may weaken the diaphragm muscle more than 50% in less than one day making it difficult to regain independent breathing. Lungpacer’s AeroPace system is designed to stimulate the nerves that activate the diaphragm with repetitive exercises for 10-20 minutes twice per day to rebuild diaphragm strength and empower natural, independent breathing. Patients on prolonged invasive mechanical ventilation (IMV) are the most complicated and costly patients for a hospital and healthcare system. While

lifesaving, IMV is unfortunately known to cause diaphragm, lung, and brain injury. Every day a patient spends on ventilation increases healthcare costs, potential patient complications and has the potential to worsen clinical outcomes. Patients on ventilator support for more than 96 hours have 157% higher hospital costs vs. those with less than 96 hours of ventilator support and almost 4 times longer length of stay for respiratory inpatient admissions. Weaning patients quickly from IMV is, therefore, paramount for improving patient outcomes and essential for hospital fiscal health. Dr. Robert Neumann is the Principal Investigator for this clinical trial.

PEDIATRIC NEUROSURGERY TEAM OF EXCELLENCE Pediatric Neurosurgeons

Allyson Alexander, MD, PhD Assistant Professor

Brent O’Neill, MD Associate Professor

Michael Handler, MD The McMurry-Seebaum Chair in Pediatric Neurosurgery Associate Surgeon-in-Chief, Children’s Hospital Colorado

Charles Wilkinson, MD Associate Professor

Todd Hankinson, MD Division Head, Pediatric Neurosurgery Professor of Neurosurgery

Thomas Ridder, MD Senior Instructor, Neurosurgery Pediatric Neurosurgeon

Welcome Newest Team Members!

The service at Children’s Hospital has been quite busy this past year. In addition to helping to develop the onsite neuro-interventional program, they are also expanding the Pediatric Neurosurgery Program at the Children’s Hospital in Colorado Springs, with a plan to add a new faculty member in 2022. The Anschutz service now includes 6 Advanced Practice Practitioners (APPs), with increased service and OR responsibilities. Our most recent additions, Brooke Wiedman, Rachel Schwartz, Elana O’hara and Rebecca Palis are doing an amazing job working with Patti Batchelder and Chinonye Ihekweazu. The administrative team at Children’s also has 2 new members: Norma Vargas and Yoomee Wooten. Both are amazing and are helping Jenny Reed manage the service at Anschutz. Taylor Barrett has also joined the administrative team in Colorado Springs and is supporting the growing program there!

Brooke Wiedman

Rachel Schwartz

Elana O’hara

Rebecca Palis

Norma Vargas

Yoomee Wooten

Jenny Reed

Taylor Barrett

PERIPHERAL NERVE NEUROSURGICAL PROGRAM OF EXCELLENCE Neurosurgeons treating Peripheral Nerve Disorders:

Kevin Lillehei, MD Chair, Neurosurgery Department

Leah Domeshek, MD Assistant Professor, Plastic/Reconstructive Surgery (hand)

Angela Downes, MD Assistant Professor, Neurosurgery

Benjamin Marshall, DO Assistant Professor, Physical Medicine & Rehabilitation

A Patient Story: Innovation at Work!

Benjamin H is a 26 year old, healthy young man, living in Ft. Collins and working in a management capacity at a tire & auto store. Life was great until he dislocated his right arm during a motorcycle accident and ended up with a brachial plexus “stretch nerve injury” that left his right bicep and shoulder paralyzed. After seeing a neurologist, he was referred to Dr. Kevin Lillehei, Chair of the Department of Neurosurgery and well known for his work with innovative and aggressive treatments for peripheral nerve injuries. “Basically,” says Benjamin, “he rearranged my nerves to work around different muscles. My biceps muscle now works off nerves that previously went to my forearm. And a nerve that previously went to my tricep now goes to my deltoid. It’s really weird!” But, slowly, Ben is getting his feeling back in that arm. “I have to learn how to retrain my brain to make this all happen, and it may take awhile.” But Ben is cautiously optimistic that this innovative, creative approach may ultimately result in full function restored. “It’s pretty amazing. My neurologist told me Lillehei was the best. And he is.” As Dr. Lillehei explains it, “what we did was essentially the re-innervation of his biceps and deltoid muscle. It’s a surgical technique where nerves from one muscle are rerouted to another and it’s fairly state of the art. We are encouraged that Ben is already having some feeling and motion in his arm. This is a good first step.”

Ben H. Happy 26 year old patient

PITUITARY TUMOR NEUROSURGICAL PROGRAM OF EXCELLENCE The Pituitary Tumor Program is lead by Neurosurgery AND Endocrinology

Kevin Lillehei, MD Chair, Neurosurgery Department Director, Pituitary Tumor Program

Welcome to Christie Turin More, MD Department of Endocrinology

Margaret Wierman, MD Director Pituitary Program Chief of Endocrinology, Denver VAMC Professor, Internal Medicine

QUICK FACTS

One Tiny Gland Can Wreak Havok! • Over 10,000 pituitary tumors are diagnosed annually in the USA The University of Colorado Pituitary Tumor Program is one of the largest and most experienced multi-disciplinary pituitary programs in the country. The program, directed by Dr. Kevin O. Lillehei, Chair of the Department of Neurosurgery, has experience in the treatment of well over 2,500 surgical cases. In conjunction with Dr. Margaret Wierman, Director of the Pituitary Center, we have assembled a nationally recognized team to comprehensively evaluate pituitary tumors and their symptoms. The team includes specialists from neurosurgery, neuro-ophthalmology, neuro-pathology, neuroradiology, head and neck surgery, and radiation oncology. We would like to welcome our newest addition to the team, Dr. Christie Turin More, Endocrinology, who joined us from the University of Pennsylvania this past fall and has been a tremendous source of knowledge.

• Very few of these are cancerous • It is believed that 1 in 4 people are living with a pituitary tumor that has been undiagnosed • This tiny gland does many things—but is often called the “master gland” because it controls the functions of so many other endocrine systems. Through the secretion of it’s hormones, it is ultimately responsible for: - Our metabolism - Our growth (including bones, muscles and organs) - Our sexual maturation - Our reproduction - Our blood pressure - Our blood sugar (through glycogenolysis process by the liver) - Even the color of our skin (through the secretion of melanin)

SKULL BASE NEUROSURGICAL PROGRAM OF EXCELLENCE Skull Base Program Leadership

A. Samy Youssef, M.D., Ph.D. Director of Skull Base Surgery Professor of Neurosurgery & Otolaryngology University of Colorado School of Medicine

Samuel Gubbels, M.D. Co-Director of Skull Base Surgery Associate Professor of Otolaryngology University of Colorado School of Medicine

6th Annual Course For Microscopic And Endoscopic Approaches To The Skull Base Held In Colorado This Past Fall This national 3- day cadaveric dissection training course in Skull Base/Endoscopic Surgical Techniques was held in the CSI Laboratory, (Center for Surgical Innovation) at CU Anschutz Medical Campus. The course, led by our Department’s own Samy Youssef, offered state of the art teaching techniques and nuances involved with skull base procedures, including comprehensive 3-D anatomy and 3-D surgical video presentations. Participants and faculty attended from, literally, all over the world. Course Director: A. Samy Youssef, MD, PhD from CU. Course Co-Directors: Samuel Gubbels, MD and Vijay Ramakrishnan, MD, from CU School of Medicine. Course Faculty: Mustafa Baskaya, MD from U of Wisconsin; Stephen Cass, MD from CU School of Medicine; James Evans, MD from Thomas Jefferson University; Sebastien Froelich, MD from Laribiosiere University Hospital; Takanori Fukushima, MD from Duke University; Julie Goddard, MD from CU School of Medicine; Anne Getz, MD from CU School of Medicine; Daniel Kelly from John Wayne Institute; Todd Kingdom, MD from CU School of Medicine; Yoichi Nonaka, MD, PhD from Tokai University School of Medicine; John Song, MD from CU School of Medicine; Jeffrey Sorenson, MD from University of Tennessee; Gabe Zada, MD from USC; Titt Mathieson MD, PhD from University of Copenhagen; Torstein Meling, MD from University of Geneva. Kevin Lillehei, MD, Chair, Department of Neurosurgery, CU School of Medicine.

Dr. Samy Youssef Featured in: Neurosurgical Atlas Virtual OR Series!

Surgery of Petroclival Meningiomas In the Modern Time Link: https://www.neurosurgicalatlas.com/grand-rounds/ surgery-of-petroclival-meningiomas-in-the-moderntime?texttrack=en-US

NEUROSURGICAL SPINE PROGRAM OF EXCELLENCE Neurosurgical Spine Providers

Jens-Peter Witt, MD Director, Neurosurgery Spine Program

Peter Lennarson, MD Associate Professor

Michael Finn, MD Associate Professor

Daniel Craig, MD Assistant Professor

Donny “Mark” Melton, MD Assistant Professor Angela Downes, MD Assistant Professor

Brad Duhon, MD Assistant Professor

Kerry Brega, MD Associate Professor Zach Folzenlogen, MD Assistant Professor

SPINE PATIENT HIGHLIGHT: The spine program has continued to grow and expand with new programs and new procedures – and many happy patients. One such patient who is celebrating a new minimally invasive spine procedure is Tiffany. Dr. Peter Lennarson, a CU Neurosurgeon, was the first CU spine provider to try a new procedure called Intracept®. This minimally invasive procedure has been clinically proven to relieve chronic low back pain and, as of January, will have full insurance approval for patients who have been experiencing chronic back pain for years. This outpatient procedure targets a nerve located in the vertebrae, advances a probe into the area and uses radiofrequency energy (heat) to disable the nerve, rendering it unable to transmit pain signals. Clinical studies indicate that the long term effects last more than five years, and 80% of patients having gone through this procedure say they would do it again. Key findings also show statistically significant improvements in function, pain reduction and a decrease in the use of opioids and pain injections. “It’s amazing that we finally have something to offer these patients besides invasive spine surgery and pain injections,” says Dr. Lennarson. He is working in conjunction with Dr. Narayana Varhabhatla, Medical Director of the Interventional Pain Clinic at CU Anschutz. Currently they are the only two doctors authorized to do this particular procedure at CU.

Tiffany B. was the first patient to receive this treatment at the University of Colorado hospital in September of 2021. Tiffany is an active 38 year old who was in constant pain and had some degenerative disc issues in her back causing her feet to become numb and shooting pains in her legs. She had tried injections, physical therapy, and was having difficulty walking. “I just couldn’t take it anymore,” she says. “This is not how a 38 year old is supposed to live!” Tiffany states that she woke up from the procedure literally “pain free” for the first time in years and she “just wanted to hug her doctor!” As Tiffany explains it, the

procedure took about an hour, she went home the same day, and she had six weeks of very light, easy recovery. “But, the fact that I had immediate results – I just couldn’t believe the difference!” “I want everyone to know about this!” Tifanny is excited with her new lease on life. She is taking hip hop dance lessons for the first time in seven years! She is regularly walking her dog, and she is starting a yoga teacher training early this year. And, on top of that, a former burlesque dancer, she is performing again! “There is no down side to trying this!,” she says.

Neuroscience Innovation Initiative Launches

As many of you know, the Neurosurgery Department has been leading an effort to bring together, in a more cohesive way, all the neuroscience research and clinical care entities at the University of Colorado. We are establishing events and resources to help the entire CU Neuroscience community share research projects, communicate ideas, collaborate on grants and new programs and to increase the overall funding of large NIH grants which require multiple departments working together. Once all of this is accomplished, our ultimate vision is to have a flagship building on this campus that will house many of these clinicians and researchers together. Not everyone can fit in one place, but we would love to have a center that would anchor all of us. But, first we have lots of work to do and infrastructure to build, and that is what we are doing!! This entire effort has now officially been named The Neuroscience Innovation Initiative (NII) and it is growing quickly!

NII CHOOSES “ PROGRAM AREAS” Seven program areas have been chosen on which to focus the future efforts of the Neuroscience Innovation Initiative.

Neurodegenerative Disorders & the Aging Brain

Neural Engineering & Human-Device Interface

Neuro-Injury, Repair & Rehab

Brain Tumor & Neuro Oncology

Neuro Circuitry, Addiction & Psychiatric Disease

Neuro-immunology & Neuro-virology

Neuro Development, Neuro Genetics, Learning & Memory

SEPTEMBER Matt Vogl, MPH, Executive Director National Mental Health Innovation Center CU Anschutz Seasoned TEDx Speaker! Cutting Through the Hype of Tech for Your Brain! Richard Weir, PhD and Emily Gibson, PhD Bio Engineering, School of Medicine, CU Anschutz Optogenetics, Neural Interface & Robotic Limbs, Oh My!!

OCTOBER Abigail Person, PhD Associate Professor & Co-Director, Neuroscience Program. Department of Physiology & Biophysics, School of Medicine, CU Anschutz “To Understand The Brain—Start With The ‘Little Brain’” Peter Pressman, MD Behavioral Neurologist, Assistant Professor, Department of Neurology “Conversational Speech & Early Dementia Detection: Diagnostics, Ethics, Quality Control & More…”

NOVEMBER Cristin Welle, PhD Associate Professor & Vice Chancellor of Research, Department Neurosurgery Boost Your Brain! Can technology really help us get smarter?? Edward Macphee, MD Associate Professor, Department of Psychiatry UCH Psychiatric Clinical Director & Medical Director, UCH Outpatient Psychiatry Clinic And Amy Sholler Dreier, PhD Licensed Psychologist, Senior Instructor, Department of Psychiatry GRATITUDE: The Neuroscience & Clinica Benefits for our brains

DECEMBER Sarah Thompson, MM, MT-BC, CBIS Music Therapist-Board Certified Certified Brain Injury Specialist PhD Student—CU Clinical Sciences Music & Your Brain: What does science show?

WELCOME TO ALL OF OUR NEW DEPARTMENT HIRES: Kristal Biesecker is a part time research assistant, working on one of Dr. Case’s clinical trials. Isaac (“Zaac”) Colvett is a student research assistant in the Granholm/Ledreux lab. He is currently studying Biology with a minor in Chemistry and Medical Physics at the University of Denver, with plans to pursue research after graduating. Anah Gilmore is a Research Assistant in the Granholm/Ledreux lab where she manages the local portion of the Down Syndrome Brain Bank Consortium, as well as being the on-staff phlebotomist and coordinator for a collaboration project with DU that explores biomarkers in athletes with repeat concussions. Paul Glasheen, a medical student at CU Anschutz and a graduate student at CU Anschutz Public Policy, will be working with Dr. Judith Gault. Alyssa Moreno, a Bioengineering student at CU Anschutz, will be providing research assistance for Dr. Judith Gault. Khoa Nguyen, a medical student at CU Anschutz, will be working in research with Dr. Michael Graner. Miguel Parra, a Bioengineering graduate student at CU Anschutz, part of the NERD CO (Neural Engineering Research and Development of Colorado.), will be working with Dr. John Thompson and Dr. Daniel Kramer. Hannah Saternos, PhD, MS joined the Granholm/Ledreux Lab as a post doctoral fellow in June of 2021 where she is studying noradrenergic dysfunction in Down Syndrome. Marie Smith has joined Dr. Graner and Dr. Yu’s lab as a Professional Research Assistant (PRA)

NEW FUNDING ANNOUNCEMENTS New Funding Announcements

Faculty: Cristin Welle, PhD Sponsor: NIH (NINDS & NEI) Title: Development of 3D-FAST Optical Interface for Rapid Volumetric Neural Sensing and Modulation (R01) Total Amount: $2,665,761 ($420,433 NSUR) Project Period: 9/1/2021-6/30/2024 Todd Hanksinson, MD received $55,000 from the Morgan Adams Foundation for his work on the following projects: Project Title: Demonstrate the Impact of MMP-9 Knockdown in 3 Novel ACP Models Project Title: Multiplex Immunofluoresence spatial distribution in ACP Project Title: Preclinical testing of the small molecule inhibitors Navitoclax, and Binimetinib using ex vivo Adamantinomatous Craniopharyngioma Tissue Project Title: Development of a public webbased tool to refine interpretable AI tools in pediatric neuro-oncology Faculty: Luis Cava, MD Sponsor: Integra LifeSciences Corporation Title: A Prospective, Multicenter study to Evaluate the Performance and Safety of the CerebroFlo® EVD Total Amount: $171,438 Project Period: 12/1/2021-12/31/2024 Faculty: Luis Cava, MD Sponsor: Ottawa Hospital Research Institute Title: Aneurysmal SubArachnoid Hemorrhage - Red Blood Cell Transfusion And Outcome (SAHaRA): A Randomized Controlled Trial Total Amount: $41,100 Project Period: 12/15/202112/31/2024

Faculty: David Case Sponsor: Medtronic Title: EvaLuateEndoVascular treatment of Acutely ruptured shallow intradural aneurysms with the Pipeline™ Flex embolization device with Shield TEchnology (ELEVATE) Total Amount: $90,553 Project Period: 12/1/202112/31/2024 Faculty: Jens Peter Witt, MD Sponsor: NuVasive Title: Retrospective chart review of the safety and performance of NuVasive Fenestrated Screws with Bone Cement for the treatment of patients with advanced stage tumors in the thoracic and/or lumbar spine Total Amount: $23,836 Project Period: 9/1/202110/31/2021 Faculty: Corbett Wilkinson, MD Sponsor: Rocky Vista University Title: Correlation of histologic abnormality in sectioned nerve rootlets during selective dorsal rhizotomy (SDR) with degree of spasticity Total Amount: $5,000 Project Period: 8/26/2021-6/30/2022 Faculty: Robert Kowalski, MD, PhD Sponsor: NIH/NINDS (LRP) Title: “Ultra-early cellular, molecular and neuroinflammatory biomarkers in acute ischemic stroke.” Total Amount: $139,000 over two years; renewable Project Period: 7/1/2021-6/30/2023

CONGRATULATIONS Dr. Robert Kowalski, MD, PhD Dr. Kowalski has been offered the position of Assistant Managing Editor of the journal of Annals of Neurology. He is now splitting his time between Neurosurgery Research, and neurology under the director of Dr. Ken Tyler, Chair of Neurology, who is now the Editor of this journal.

Michael Graner, PhD Michael Graner has been named Associate Editor of a A New Journal Focused on Extracellular Vesicles and Circulating Nucleic Acids (EVCNA). This journal, launched in December of 2020 aims to provide an online platform for the sharing of research data, new methodology, reviews and commentaries in the areas of extracellular vesicles and circulating nucleic acids including DNA, RNA and miRNA and their therapeutic use. America biochemist and molecular biologist, Dr. York Peng Loh serves as the founding Editor-in-Chief.

PATENTS & INNOVATIONS PENDING! Xiaoli Yu, PhD U.S. Provisional Patent Application #1 TITLE: MULTIPLE SCLEROSIS SERUM IGG ANTIBODIES PRODUCE COMPLEMENTDEPENDENT APOPTOSIS AND NECROSIS IN NEURONAL CELLS AND BRAIN TISSUES Application No.: 63191306 Country: U.S. Filing Date: May 20, 2021 Applicant: The Regents of the University of Colorado, a body corporate Inventor(s): Xiaoli Yu (60%), Michael Graner (30%), Wenbo Zhou (10%) DORSEY & WHITNEY LLP CU Innovations Ref.: CU5655H

U.S. Provisional Patent Application #2 Title: METHODS, COMPOSITIONS AND APPLICATIONS FOR DIAGNOSING MULTIPLE SCLEROSIS (MS) Application No.: 63/249,741 Country: U.S. Filing Date: September 29, 2021 Applicant: The Regents of the University of Colorado, a body corporate Inventor(s): Xiaoli Yu (50%), Michael Graner (20%), Wenbo Zhou (10%), Timothy Vollmer (10%) & Enrique Alvarez (10%) Polsinelli Ref.: 106549-702782 CU5589H-PPA1 CU Innovations Ref.: CU5589H-PPA1 CU Innovations File No.: CU5709H Title: RAPID BLOOD TEST FOR DETECTION OF PATIENTS WITH GLIOBLASTOMA Filing Date: July 28, 2021 Inventor(s): Xiaoli Yu (50%), Michael Graner (20%), Wenbo Zhou (10%), Kevin Lillehei (10%), David Ormond (5%), Samy Youssef (5%).

PUBLICATIONS

Note: All authors bolded are within the CU Department of Neurosurgery, unless otherwise indicated. (August - November 2021)

Vranic JE, Harker P, Stapleton CJ, … Seinfeld, J, Roark, C, Case, D, et al. Determinants of intracranial aneurysm retreatment following embolization with a single flow-diverting stent. The Neuroradiology Journal. November 2021. doi:10.1177/19714009211049086 Martinez-Perez R, Kunigelis KE, Ward RC, Ung TH, Arnone GD, Cass SP, Gubbels SP, Youssef AS. Hydroxyapatite cement cranioplasty for reconstruction of translabyrinthine approach: aesthetic results, long-term satisfaction, quality of life, and complications. Acta Neurochir (Wien). 2021 Oct 13. doi: 10.1007/s00701-021-05024-6. Epub ahead of print. PMID: 34642820. Martinez-Perez R, Aref M, Ramakhrisnan V, Youssef AS. Combined biportal unilateral endoscopic endonasal and endoscopic anterior transmaxillary approach for resection of lesions involving the infratemporal fossa. Acta Neurochir (Wien). 2021 Dec;163(12):34393445. doi: 10.1007/s00701-021-04994-x. Epub 2021 Oct 11. PMID: 34633545. Murcia D, D’Souza S, Abozeid M, Thompson JA, Djoyum TD, Ormond DR. Investigation of Asleep versus Awake Motor Mapping in Resective Brain Surgery. World Neurosurg. 2021 Oct 4:S1878-8750(21)01472-8. doi: 10.1016/j.wneu.2021.09.119. Epub ahead of print. PMID: 34619401. Hirt, L., Grassia, F., Feuerstein, J., Thompson, J.A., Ojemann, S. and Kern, D.S., 2021. Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus in Writer’s Cramp: A Case Report. Tremor and Other Hyperkinetic Movements, 11(1), p.46. DOI: http://doi.org/10.5334/tohm.645 Ung TH, Serva S, Chatain GP, Witt JP, Finn M. Application of sodium fluorescein for spinal cord lesions: intraoperative localization for tissue biopsy and surgical resection. Neurosurg Rev. 2021 Oct 27. doi: 10.1007/s10143-021-01676-1. Epub ahead of print. PMID: 34708272. Ung TH, Kahn L, Hirt L, Chatain G, Humes E, David-Gerecht P, Drees C, Thompson JA, Ojemann S, Abosch A. Using a Robotic-Assisted Approach for Stereotactic Laser Ablation Corpus Callosotomy: A Technical Report. Stereotact Funct Neurosurg. 2021 Aug 17:1-6. doi: 10.1159/000518109. Epub ahead of print. PMID: 34515241.

PUBLICATIONS Yu X, Zizzo Z, Kennedy PG. An appraisal of antigen identification and IgG effector functions driving host immune responses in multiple sclerosis. Mult Scler Relat Disord. 2021 Oct 12;56:103328. doi: 10.1016/j.msard.2021.103328. Epub ahead of print. PMID: 34666240. Kunigelis KE, Kleinschmidt-DeMasters BK, Youssef AS, Lillehei KO, Ormond DR. Clinical Features of Pineal Parenchymal Tumors of Intermediate Differentiation (PPTID): A Single-Institution Series. World Neurosurg. 2021 Nov;155:e229-e235. doi: 10.1016/j. wneu.2021.08.056. Epub 2021 Aug 18. PMID: 34418607. Márquez-Ortiz RA, Contreras-Zárate MJ, Tesic V, Alvarez-Eraso KLF, Kwak G, Littrell Z, Costello JC, Sreekanth V, Ormond DR, Karam SD, Kabos P, Cittelly DM. IL13Rα2 Promotes Proliferation and Outgrowth of Breast Cancer Brain Metastases. Clin Cancer Res. 2021 Nov 15;27(22):6209-6221. doi: 10.1158/1078-0432.CCR-21-0361. Epub 2021 Sep 20. PMID: 34544797; PMCID: PMC8595859. Au TH, Willis C, Reblin M, Peters KB, Nghiemphu PL, Taylor JW, Colman H, Cohen AL, Ormond DR, Chakravarti A, Willmarth N, Menon J, Ma J, Bauer H, Watanabe AH, Ulrich CM, Singh P, Marshall A, Korytowsky B, Stenehjem D, Brixner D. Caregiver burden by treatment and clinical characteristics of patients with glioblastoma. Support Care Cancer. 2021 Sep 11. doi: 10.1007/s00520-021-06514-0. Epub ahead of print. Erratum in: Support Care Cancer. 2021 Nov 18;: PMID: 34510238. Winograd E, Germano I, Wen P, Olson JJ, Ormond DR. Congress of Neurological Surgeons systematic review and evidence-based guidelines update on the role of targeted therapies and immunotherapies in the management of progressive glioblastoma. J Neurooncol. 2021 Oct 25:1–57. doi: 10.1007/s11060-021-03876-7. Epub ahead of print. PMID: 34694567; PMCID: PMC8543777. Au TH, Willis C, Reblin M, Peters KB, Nghiemphu PL, Taylor JW, Colman H, Cohen AL, Ormond DR, Chakravarti A, Willmarth N, Menon J, Ma J, Bauer H, Watanabe AH, Ulrich CM, Singh P, Marshall A, Korytowsky B, Stenehjem D, Brixner D. Correction to: Caregiver burden by treatment and clinical characteristics of patients with glioblastoma. Support Care Cancer. 2021 Nov 18. doi: 10.1007/s00520-021-06691-y. Epub ahead of print. Erratum for: Support Care Cancer. 2021 Sep 11;: PMID: 34792647.

PUBLICATIONS Reynolds RA, Ahluwalia R, Krishnan V, Kelly KA, Lee J, Waldrop RP, Guidry B, Hengartner AC, McCroskey J, Arynchyna A, Staulcup S, Chen H, Hankinson TC, Rocque BG, Shannon CN, Naftel R. Risk factors for unchanged ventricles during pediatric shunt malfunction. J Neurosurg Pediatr. 2021 Sep 24:1-7. doi: 10.3171/2021.6.PEDS2125. Epub ahead of print. PMID: 34560626. Whitehead WE, Riva-Cambrin J, Wellons JC, Kulkarni AV, Limbrick DD, Wall VL, Rozzelle CJ, Hankinson TC, McDonald PJ, Krieger MD, Pollack IF, Tamber MS, Pindrik J, Hauptman JS, Naftel RP, Shannon CN, Chu J, Jackson EM, Browd SR, Simon TD, Holubkov R, Reeder RW, Jensen H, Koschnitzky JE, Gross P, Drake JM, Kestle JRW. Anterior versus posterior entry site for ventriculoperitoneal shunt insertion: a randomized controlled trial by the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr. 2021 Nov 19:1-11. doi: 10.3171/2021.9.PEDS21391. Epub ahead of print. PMID: 34798600. DeSisto J, Lucas JT Jr, Xu K, Donson A, Lin T, Sanford B, Wu G, Tran QT, Hedges D, Hsu CY, Armstrong GT, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Schüller U, Venkataraman S, Hoffman LM, Dorris K, Mulcahy Levy JM, Hankinson TC, Handler M, Liu AK, Foreman N, Vibhakar R, Jones K, Allen S, Zhang J, Baker SJ, Merchant TE, Orr BA, Green AL. Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma. Nat Commun. 2021 Sep 20;12(1):5531. doi: 10.1038/s41467-021-25709-x. PMID: 34545084; PMCID: PMC8452624. Grob ST, Nobre L, Campbell KR, Davies KD, Ryall S, Aisner DL, Hoffman L, Zahedi S, Morin A, Crespo M, Nellan A, Green AL, Foreman N, Vibhakar R, Hankinson TC, Handler MH, Hawkins C, Tabori U, Kleinschmidt-DeMasters BK, Mulcahy Levy JM. Clinical and molecular characterization of a multi-institutional cohort of pediatric spinal cord low-grade gliomas. Neurooncol Adv. 2020 Aug 24;2(1):vdaa103. doi: 10.1093/noajnl/vdaa103. PMID: 33063010; PMCID: PMC7542983. Labib MA, Zhao X, Houlihan LM, Abramov I, Catapano JS, Naeem K, Preul MC, Youssef AS, Lawton MT. Comparative analysis of the combined petrosal and the pretemporal transcavernous anterior petrosal approach to the petroclival region. J Neurosurg. 2021 Sep 10:1-12. doi: 10.3171/2020.12.JNS202740. Epub ahead of print. PMID: 34507299. Svokos K, Batista-Silverman L, Graber SJ, O’Neill BR, Handler MH. International survey on the management of lumbosacral cutaneous stigmata in infants with suspected occult spinal dysraphism. J Neurosurg Pediatr. 2021 Sep 3:1-8. doi: 10.3171/2021.5.PEDS2126. Epub ahead of print. PMID: 34479200.

PUBLICATIONS Lepard JR, Kim I, Arynchyna A, Lew SM, Bollo RJ, O’Neill BR, Perry MS, Donahue D, Smyth MD, Blount J. Early implementation of stereoelectroencephalography in children: a multiinstitutional case series. J Neurosurg Pediatr. 2021 Sep 3:1-8. doi: 10.3171/2021.5.PEDS20923. Epub ahead of print. PMID: 34479204. Talai A, Eschbach K, Stence NV, Palmer C, Bird W, Alexander A, O’Neill BR, Chapman KE, Joshi C. Comparison of subdural grid and stereoelectroencephalography in a cohort of pediatric patients. Epilepsy Res. 2021 Nov;177:106758. doi: 10.1016/j. eplepsyres.2021.106758. Epub 2021 Sep 10. PMID: 34530304. Nagahama Y, Zervos TM, Murata KK, Holman L, Karsonovich T, Parker JJ, Chen JS, Phillips HW, Fajardo M, Nariai H, Hussain SA, Porter BE, Grant GA, Ragheb J, Wang S, O’Neill BR, Alexander AL, Bollo RJ, Fallah A. Real-World Preliminary Experience With Responsive Neurostimulation in Pediatric Epilepsy: A Multicenter Retrospective Observational Study. Neurosurgery. 2021 Nov 18;89(6):997-1004. doi: 10.1093/neuros/nyab343. PMID: 34528103. Fallah A, Lewis E, Ibrahim GM, Kola O, Tseng CH, Harris WB, Chen JS, Lin KM, Cai LX, Liu QZ, Lin JL, Zhou WJ, Mathern GW, Smyth MD, O’Neill BR, Dudley RWR, Ragheb J, Bhatia S, Delev D, Ramantani G, Zentner J, Wang AC, Dorfer C, Feucht M, Czech T, Bollo RJ, Issabekov G, Zhu H, Connolly M, Steinbok P, Zhang JG, Zhang K, Hidalgo ET, Weiner HL, Wong-Kisiel L, Lapalme-Remis S, Tripathi M, Sarat Chandra P, Hader W, Wang FP, Yao Y, Champagne PO, Brunette-Clément T, Guo Q, Li SC, Budke M, Pérez-Jiménez MA, Raftopoulos C, Finet P, Michel P, Schaller K, Stienen MN, Baro V, Cantillano Malone C, Pociecha J, Chamorro N, Muro VL, von Lehe M, Vieker S, Oluigbo C, Gaillard WD, AlKhateeb M, Al Otaibi F, Krayenbühl N, Bolton J, Pearl PL, Weil AG. Comparison of the realworld effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study. Epilepsia. 2021 Nov;62(11):2707-2718. doi: 10.1111/epi.17021. Epub 2021 Sep 12. PMID: 34510448. Tekriwal A, Lintz MJ, Thompson JA, Felsen G. Disrupted basal ganglia output during movement preparation in hemiparkinsonian mice is consistent with behavioral deficits. J Neurophysiol. 2021 Oct 1;126(4):1248-1264. doi: 10.1152/jn.00001.2021. Epub 2021 Aug 18. PMID: 34406873; PMCID: PMC8560419.

PUBLICATIONS Winograd E, Kortz MW, Lillehei KO. Radiographic pituitary stalk disruption: A rare sequela of secondary empty sella syndrome. Surg Neurol Int. 2021 Aug 3;12:385. doi: 10.25259/SNI_530_2021. PMID: 34513152; PMCID: PMC8422539. Kortz MW, Kongs BM, McCray E, Grassia F, Hosokawa P, Bernstein JE, Moore SP, Yanovskaya M, Ojemann SG. How neuropsychiatric comorbidity, modulatory indication, demographics, and other factors impact deep brain stimulation inpatient outcomes in the United States: A population-based study of 27,956 patients. Clin Neurol Neurosurg. 2021 Sep;208:106842. doi: 10.1016/j.clineuro.2021.106842. Epub 2021 Jul 26. PMID: 34339900. Alvarez E, Nair KV, Hoyt BD, Seale RA, Sillau S, Miravalle A, Engebretson E, Schurr B, Corboy JR, Vollmer TL, Honce JM. Brain atrophy rates in patients with multiple sclerosis on long term natalizumab resembles healthy controls. Mult Scler Relat Disord. 2021 Oct;55:103170. doi: 10.1016/j.msard.2021.103170. Epub 2021 Jul 24. PMID: 34364034. Guglielmi G, Eschbach KL, Alexander AL. Smaller Knife, Fewer Seizures? Recent Advances in Minimally Invasive Techniques in Pediatric Epilepsy Surgery. Semin Pediatr Neurol. 2021 Oct;39:100913. doi: 10.1016/j.spen.2021.100913. Epub 2021 Aug 21. PMID: 34620456. Wang Z, Kennedy PG, Dupree C, Wang M, Lee C, Pointon T, Langford TD, Graner MW, Yu X. Antibodies from Multiple Sclerosis Brain Identified Epstein-Barr Virus Nuclear Antigen 1 & 2 Epitopes which Are Recognized by Oligoclonal Bands. J Neuroimmune Pharmacol. 2021 Sep;16(3):567-580. doi: 10.1007/s11481-020-09948-1. Epub 2020 Aug 18. PMID: 32808238; PMCID: PMC7431217. Bowles S, Williamson WR, Nettles D, Hickman J, Welle CG. Closed-loop automated reaching apparatus (CLARA) for interrogating complex motor behaviors. J Neural Eng. 2021 Aug 31;18(4). doi: 10.1088/1741-2552/ac1ed1. PMID: 34407518. Kowalski RG, Whyte J, Giacino JT. Traumatic Brain Injury Recovery Trajectories in Patients With Disorders of Consciousness-Reply. JAMA Neurol. 2021 Nov 1;78(11):1412-1413. doi: 10.1001/jamaneurol.2021.3430. PMID: 34605886

PUBLICATIONS Fringuello A, Tatman PD, Wroblewski T, Thompson JA, Yu X, Lillehei KO, Kowalski RG, Graner MW. Cytokine-Laden Extracellular Vesicles Predict Patient Prognosis after Cerebrovascular Accident. International Journal of Molecular Sciences. 2021; 22(15):7847. https://doi.org/10.3390/ijms22157847 Kowalski RG, Hammond FM, Weintraub AH, Nakase-Richardson R, Zafonte RD, Whyte J, Giacino JT. Recovery of Consciousness and Functional Outcome in Moderate and Severe Traumatic Brain Injury. JAMA Neurol. 2021 May 1;78(5):548-557. doi: 10.1001/jamaneurol.2021.0084. Perry MS, Shandley S, Perelman M, Singh RK, Wong-Kisiel L, Sullivan J, Gonzalez-Giraldo E, Romanowski EF, McNamara NA, Marashly A, Ostendorf AP, Alexander A, Eschbach K, Bolton J, Wolf S, McGoldrick P, DepositarioCabacar DF, Ciliberto MA, Gedela S, Sannagowdara K, Karia S, Shrey DW, Tatachar P, Nangia S, Grinspan Z, Reddy SB, Shital P, Coryell J. Surgical evaluation in children <3 years of age with drug-resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays. Epilepsia. 2021 Nov 15. doi: 10.1111/epi.17124. Epub ahead of print. PMID: 34778945. Winograd E, Kortz MW, Lillehei KO. Radiographic pituitary stalk disruption: A rare sequela of secondary empty sella syndrome. Surg Neurol Int. 2021 Aug 3;12:385. doi: 10.25259/SNI_530_2021. PMID: 34513152; PMCID: PMC8422539.

JOIN US! TED for your HEAD: Neurosciences Happy Hour When: Thursday, February 17th

BR ING A MA SK!

Time: 5:30 to 7:30 p.m. (TED talks begin promptly at 6 p.m.) Where: Plains Club Gallery (next to Cedar Creek & Lost Coffee) just north of CU Anschutz Campus 2100 N. Ursula St. (near Montview & Ursula) What: Networking, collaboration, and casual FUN!! Free beer and light snacks provided

How to get a Nobel Prize Lotta Granholm-Bentley, PhD, DDS

Professor & Researcher, Department of Neurosurgery Former Founding Executive Director, Knoebel Institute for Healthy Aging at University of Denver Current Part-time Faculty at Karolinska Institute in Sweden (home of the Nobel Prize)

Is loss of smell viral infection linked to Alzheimer’s? Diego Restrepo, PhD Professor of Cell and Developmental Biology

Maria Nagel, MD

Professor & Researcher , Neurology & Ophthalmology Neurology & Ophthalmology Departments

GET INVOLVED You can be involved in all the exciting programs and research innovations happening in the Department of Neurosurgery! Donations are currently needed for investigator initiated trials, new positions, and even some capital equipment! Recurring monthly donors are especially helpful – and you can give any amount! Follow these easy steps: Directions for online giving: 1. Go to: giving.cu.edu/fund/write-fund 2. Select the amount or write in an amount you would like to give. 3. If you would like to give this amount monthly, check the recurring box and indicate “monthly.” 4. If you are giving the gift in honor or in memory of someone, select ‘yes’. In the comment section, you can add the name of the person, or just mark “no.” 5. In the comment section, write the fund name and number. (See fund names and numbers on the right side of this page). 6. Select ‘Give Now’ button. 7. Follow prompts to fill in personal, payroll deduction or credit card information for processing. You will be able to print a receipt of your donation.

FUND NAMES & NUMBERS: General Neurosurgery Fund: #0223130 Neuro-oncology Research Funds: General Neurosurgery-Oncology # 221101 (includes brain tumor tissue bank) Meningioma Momma’s Research # 0223181 Brain Immunology Research # 222176 Functional Neurosurgery Research # 222277 Stroke, Aneurism & Neurovascular Funding: Foreman Family Research Fund # 0223133 Stem Cell & Gene Therapy Research # 0222912 Radiology & Imaging Research: Mannetti 3D Printer Fund # 0222672 Education and Scholarship Funds: Neurosurgery Resident Education # 221955 Foreman Family Lectureship Fund # 0223134 VanderArk Lectureship Fund # 0230389 Ogsbury/Kindt Neurosurgery Chair Endowment Fund # 0230133 Neurosurgery in Schizophrenia & Mental Illness Research Fund # 0222913 Checks of any amount can be sent with a note in the memo about the fund to be supported, and mailed to: University of Colorado Foundation Office of Advancement Attn: Marti Laule Mail Stop AO65 13001 E. 17th Place, WG112 Aurora, CO 80045

To talk more about your donation, contact Tami Lack Crawford | (303) 907-8977.