Open Session

OPEN SESSION, 12-15 October 2004 PROVISIONAL TIMETABLE

DAY/TIME PRESENTER/ FIRST AUTHOR Pg no. of abstract book ABBREVIATED TITLE

Tuesday 12th

8.30 Opening Ceremony

Representatives of the Government of Greece, and the EUFMD Executive Committee 8.50 Sumption The Open Session; purpose and procedures 9.00 De Clercq Progress report

Recent findings in molecular epidemiology of FMDV

9.10 Valarcher 1 Global FMD situation in 2003 and 2004 9.40 Vosloo 2 FMD in sub-Saharan Africa 10.10 Coffee 10.40 Christensen 3 Novel type O lineage detected 10.55 Knowles 4 Identification of a ninth foot-and-mouth disease virus type O topotype 11.10 Christensen 5 High-resolution molecular analysis of the 1982-3 FMD epidemic in Denmark 11.30 Nunez 6 Genetic and antigenic analysis of Italian 1993 FMDV isolates 11.45 Haydon 7 Outstanding but tractable questions regarding the micro-evolution of FMDV

Surveillance – for what purpose and how much is enough?

12.15 Serratosa EFSA – statement 12.30 Lunch 14.00 Uppal 8 FMD in small ruminants -cause for concern 14.10 Gilbert FMD in Turkey and Iran - trends and relationships 14.40 Perez 9 Epidemiological models for global surveillance of foot-and-mouth disease 15.00 Thurmond 11 Concepts and Considerations for Global FMD Surveillance 15.20 Coffee

Transmission -and its control

15.50 Alexanderson 12 Exposure intensity and FMD transmission 16.20 Esteves 13 Natural aerosol transmission of FMD in sheep 16.35 Gloster 14 Understanding airborne transmission of FMD 16.55 Orsel 15 Effect of vaccination on transmission 17.15 Eblé 16 Quantification of experimental transmission of FMDV O Taiwan in pigs 17.35 Cox 17 Emergency FMD vaccine: effect of antigen payload 17.55 Discussion 18.10 Close Depart for Tour of old Chania and dinner

Wednesday 13th

8.00 Wernery 18 FMD and camelids: international relevance of current research

Managing Diagnostic demand

8.20 Hammond 19 Laboratory surge capacity - Australian approach 8.40 Ferris 20 Prospects for improved lab diagnosis using real time RT-PCR 8.55 Reid 21 Use of automated RT-PCR to detect FMDV in milk 9.15 Discussion point 9.20 Brocchi 22 Validation of a SPCE, for antibodies to FMDV type Asia 1. 9.40 Grazioli 23 Mapping of neutralising sites on FMD virus type Asia 1 9.55 Johnson 24 Bayesian methods and predicting FMDV infection from serologic results 10.10 Coffee

Sero-diagnosis – improvements and standardisation

10.30 Paton 25 Phase XVIII serology exercise 11.00 Goris Nesya 26 Development of secondary standards for SPCE 11.20 Discussion

Regulatory issues affecting FMD vaccine selection and use

11.30 Mackay 27 Progress and regulatory requirements for FMD vaccines within the European Union

DAY/TIME PRESENTER/ FIRST AUTHOR

Pg no. of abstract book

12.00 TBC Issues and approaches - selection of vaccine seed viruses 12.20 Discussion 12.30 Lunch

Optimisation of conventional vaccines

14.00 Haas Prediction of protection by FMD vaccines on the basis of in-vitro results 14.20 Smitsaart (Biogenesis) 28 Addition of saponin to double oil emulsion FMD vaccines 14.40 Barteling/ Yadin 29 Guidelines for field monitoring of vaccines & vaccination 15.10 Coffee

Novel vaccines

15.40 Summerfield (IVI) 30 Novel immunological approaches for emergency FMD vaccines

16.00 Zhang 31 Immune responses in nasal associated lymphoid tissues 16.15 Rodriguez Progress on vectored vaccines expressing anti-virals for early protection 16.30 Lynn_UBI 32 Full protection in pigs against FMDV challenge following synthetic emergency FMDV vaccines

16.50 Barnett/ Yanmin Li 33 Enhancing immune responses to DNA vaccines against FMD

17.05 Borrego 34 DNA vaccines based on FMDV mini-genes in a mouse model 17.25 Close

19.00 Poster Session 21.00-* 10 mins each *Programme subcommittee may opt to bring some of these into main sessions-authors will be informed on 12th

Pathobiology and diagnostics

Durand 35 Identification of FMDV replication in epithelial cells Ahmed, Raza 36 Laser microdissection studies of FMDV in pigs Quan 37 Modelling early FMD virus dynamics in vivo Ryan 38 Pathogenesis of FMD in young lambs King 39 Towards engineered cell lines for diagnosis Ferris 40 Recombinant integrin αvβ6 as a capture reagent

Thursday 14th International issues including access to reference laboratory services

8.15 TBC Transport of Specimens 8.35 Schudel 41 Update from the OIE

Persistent and subclinical infections - diagnostic and surveillance issues

8.55 Sutmoller 42 Discussion Paper on the risks posed by FMD carriers among vaccinated cattle 9.15 Bashiruddin 43 Age and the likelihood of persistence in FMDV infected cattle 9.30 De Clercq 44 Comparative evaluation of NSP tests -Brescia workshop 9.50 Dyrting 45 Swine and NSP tests 10.05 Luyten 46 Need for control before release of FMD ELISA kits 10.25 Discussion 10.30 Coffee

Surveillance using DIVA tests

11.00 Sammin 47 Serological responses in relation to vaccination and natural infection 11.30 Yadin 48 Post-outbreak serosurveillance in Israel, 2004 12.00 Discussion 12.15 Georgiev 49 Use of NSP ELISA as a tool for FMDV serosurveillance in Bulgaria 12.30 Lunch

14.00 Bulut 50 Serosurveillance following FMD vaccination campaign in Turkish Thrace

DAY/TIME PRESENTER/ FIRST AUTHOR Pg no. of abstract book

Test development and standardisation

14.20 Jacobs_Cedi 51 The FMD-NS ELISA, to detect FMDV infected animals in a vaccinated population 14.35 El-Shehawy 52 3ABC ELISA for the diagnosis of FMD in Egyptian sheep. 14.40 Clavijo 54 New strategies for DIVA

15.00 Parida 56 In vitro production of Interferon-γ from whole blood of FMD vaccinated and infected cattle

15.15 Parida 2/Paton 57 Secretory IgA as an indicator of oropharyngeal FMDV replication 15.30 Coffee

Regulatory compliance

16.00 Paton/De Clercq 58 Discussion on Postvaccination surveillance requirements

16.30 End 16.3018.30 Report prep Reporting groups prepare conclusions and recommendations

Evening Gala dinner

Friday 15th

8.30 Hilton (Avis) Knowledge management in FMD prevention and control 9.00 Marshall 59 Policy and science of FMD control: the stakeholders contribution to decisionmaking

9.30 Feedback session Feedback groups present – and discussion

10.00 Break Hand-in reports to Secretariat 10.30 Excursion or free time 15.00 Circulation of report 17.00 Close of Session

ABSTRACTS PROPOSED / SELECTED FOR POSTER PRESENTATIONS

PRESENTER/ FIRST AUTHOR Page no. of abstract book ABBREVIATED TITLE

Avalos 60 FMDV RNA detection in pig samples by conventional and Real Time RT-PCR methods Avalos 61 Immunogenicity and protection conferred by synthetic peptides Doel, Claudia 62 Evaluation of real time RT-PCR for the detection of carrier animals Dukes 63 A novel but simple molecular method for the detection of FMDV Fowler 64 Toward the construction of an O1 Manisa chimeric vaccine

Grazioli

65 Production of monoclonal antibodies against the three FMDV SAT serotypes helpful as standardised reagents in diagnostic assays Horsington 66 Potential sequence variations between virual genomes from various FMDV infected tissues King 67 A ring test for the lab detection of FMDV by VI and RT-PCR

Sakamoto

68 Purification of RNA dependant RNA polymerase and its predicted three-dimensional structure van Borm 69 Analytical validation of One-Step real-time RT-PCR for FMDV RNA Kim 70 Production of a single-chain variable fragment antibody against FMDV

Persson

71 Development of an indirect ELISA for the detection of antibodies to the non-structural protein 3ABC of the Foot-and-Mouth Disease virus; the use of a polyclonal conjugate that allows a multi-species detection of antibodies Sangula 73 Complexity of Foot-and-Mouth disease outbreaks in Kenya Bergmann 74 Diagnostic tools for epidemiological surveillance in South America Staes 75 Rolling circle amplification for detection of FMDV

Date Subject Time Chair Rapporteur/Supporting members for reporting

Tuesday FMD trends/Mol epid 9.00 David Paton Vosloo, Christensen, Haydon,

Valarcher

Tuesday Global Surveillance 12.15 Preben Willeberg Thurmond, Gilbert, Bronsvoort

Tuesday Transmission and refined control 15.50 Aldo Dekker Orsel, Cox, Alexandersen Wedns Camel FMD 8.00 Keith Sumption Wedns Managing diagnostic demand 8.20 Bernd Haas Hammond, Johnson, Ferris Wedns Stndn of serodiagnosis 9.20 Kris De Clercq Paton, Brocchi Wedns Regulatory issues –FMD vaccines 11.30 Kris De Clercq MacKay Wedns Optimising conventional vaccines 14.00 Hagai Yadin Barteling, Smitsaart, Rweyemamu Wedns Novel vaccines 15.40 Jose SanchezViscaino Summerfield, Chang, Barnett Wedns Poster Session 19.00 Stephan Zientara Georgiev, Unal, Zientara Thurs Pathobiology/diagnosis 21.00 Donal Sammin Sammin, King, Kitching Thurs Intl issues/transport 8.15 Kris De Clercq De Clercq, Schudel Thurs Persistent infections 8.55 Aldo Dekker Sutmoller, Dyrting, Bashiruddin Thurs Surveillance using DIVA 11.00 Matthias Greiner Moutou, Sammin, Paton, Fuessel Thurs DIVA test development 14.20 Franco de Simone/ Emiliana Brocchi Parida, Jacobs, Kitching, Merza

Thurs Compliance with Post vaccination surveillance 16.00 Francois Moutou Moutou, Sammin, Paton, Füssel

Fri Various 8.30 Keith Sumption Report 15.00 Kris De Clercq Sumption