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CONTROLID:4202891
TITLE:AnInnovativeInjectableandRetrievableDrugDeliverySystemforEndodonticTherapy
AUTHORS(FIRSTNAMEINITIALLASTNAME):A.Mahmoud ,A.sloutski ,Z.Katevatis ,A.Bordia ,M. Setia ,E.Krasnoff ,B.Ren ,S.Deng ,H.Luo ,R.Wang ,J.Liang ,M.Simon ,S.G.Walker ,J. Cymerman ,T.manders ,M.Rafailovich
AUTHORS/INSTITUTIONS:A.Mahmoud,A.sloutski,Z.Katevatis,H.Luo,R.Wang,M.Simon,S.G.Walker, M.Rafailovich,StonyBrookUniversity,StonyBrook,NewYork,UNITEDSTATES; J.Cymerman,PeriodonticsandEndodontics,StonyBrookDentalSchool,Patchogue,NewYork,UNITED STATES;
B.Ren,TheHarkerSchool,SanJose,California,UNITEDSTATES; E.Krasnoff,TheLoomisChaffeeSchool,Windsor,Connecticut,UNITEDSTATES; M.Setia,NewProvidenceHighSchool,NewProvidence,NewJersey,UNITEDSTATES; A.Bordia,ArchimedeanUpperConservatory,Miami,Florida,UNITEDSTATES; S.Deng,YKPaoSchool,Shanghai,CHINA; J.Liang,ExperimentalHighSchoolAttachedtoBeijingNormalUniversity,Beijing,CHINA; T.manders,PeriodonticsandEndodontics,StonyBrookDentalSchool,Patchogue,NewYork,UNITED STATES;
PREFERREDPRESENTATIONTYPE:NoPreference
CURRENTSCIENTIFICGROUPS&NETWORKS:DentalMaterials5:Biocompatibility,Bioengineeringand BiologicEffectsofMaterials
ABSTRACTBODY:
Objectives:Endodontictreatmentfailuresdueto Enterococcus faecalis andotherbacteriaremainsa significantchallenge.Calciumhydroxide,acommonlyusedintracanalmedicament,hasmanylimitations, includinglowflowability,difficultyinfullretrieval,andlimitedefficacyagainst E. faecalis Thisstudyaimsto assessamixtureofcalciumhydroxideandsalicylicacid(CASA),encapsulatedinthermo-reversibleF127-DMA hydrogel,asaninjectable,retrievableintracanalmedicamentwithantibacterialactivityagainstfibrinogen modified E. faecalis and Streptococcus mutans
Methods:CASAwaspreparedbymixingcalciumhydroxideandsalicylicacidina6:1ratio,respectively,and incorporatedintoF127-DMAatconcentrationsof5%,10%,and20%(w/w).ThemixturewasUV-crosslinked usinglithiumphenyl(2,4,6-trimethylbenzoyl)phosphonate(LAP).Chemicalpropertieswereanalyzedusing XRD,Ramanspectroscopy,FTIR,andXRF,whileinjectabilityandretrievabilitywereassessedusingaplastic rootcanalmodelandrheology In vitro antibacterialefficacyagainst E. faecalis and Streptococcus mutans biofilmswastestedusingbovineextractedteeth.Additionally,Cytotoxicityanddoublingtimeofdentalpulp stemcells(DPSCs)weremeasuredinresponsetoleakedCASAfromthehydrogel. In vivo modelusingbeagle dogswithinducedapicalperiodontitiswillassessbacterialreduction(CFU),periapicallesionchanges(3DCT scans)ofF127-DMA/CASA.
Results:EncapsulationofCASAinF127-DMAreducedtheviscositybythreeordersofmagnitudecompared tothepasteform,facilitatinginjectionandretrieval.Furthermore,XRD,Raman,andFTIRanalysesconfirmed theformationofcalciumsalicylateandsuccessfulintegrationofCASAintoF127-DMA.Nosignificant cytotoxicitywasobservedinDPSCs,anddoublingtimewasnotsignificantlydifferenttocontrol.F127-
DMA/CASAexhibitedcompleteeradicationof E. faecalis inplanktonicformandthebiofilmmodelshoweda three-logreductioninbacterialcountandnosignificantdifferencetotheendodonticgoldstandardofCa(OH)
Conclusions:F127-DMA/CASAexhibitssuperiorflowability,retrievability,optimalpH,biocompatibilityand antibacterialefficacywhichhighlightsitspotentialasasignificantimprovementovercalciumhydroxidefor endodontictherapy
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TABLEFOOTER:(NoTables)
IMAGECAPTION:
KEYWORDS:Antibacterial,Hydrogel,Enterococcusfaecalis,Calciumhydroxide.
SupportFundingAgency/GrantNumber:(none)
FinancialInterestDisclosure:NONE
AWARDS:AADOCRHattonCompetition|SCADA[Student Competition for Advancing Dental Research and its Application]
GroupAuthorAbstracts:(none)
SpecialSchedulingNeeds:(none)
StudentStatus:PhDStudent(afterprofessionaldegree)
StudentOtherDesignation:(none)
TrackSelection:BothClinicianandEducatorTracks
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