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Pathophysiology: The Biologic Basis for Disease in Adults and Children Kathryn L McCance, Sue E. Huether 2019 8th ed 8th Edition Pathophysiology: The Biologic Basis For Disease In Adults And Children Kathryn L Mccance
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TableofContents
Coverimage
TitlePage
HealthPromotionBoxes
Copyright Reviewers
Contributors
Preface
OrganizationandContent
FeaturestoPromoteLearning
ArtProgram
Teaching/LearningPackage
Acknowledgments
IntroductiontoPathophysiology
PartOneBasicConceptsofPathophysiology
Unit1TheCell
1CellularBiology
ProkaryotesandEukaryotes
CellularFunctions
StructureandFunctionofCellularComponents
Cell-to-CellAdhesions
CellularCommunicationandSignalTransduction
CellularMetabolism
MembraneTransport:CellularIntakeandOutput
CellularReproduction:TheCellCycle
Tissues
DidYouUnderstand?
KeyTerms
References
2GenesandGeneticDiseases
DNA,RNA,andProteins:HeredityattheMolecularLevel
Chromosomes
ElementsofFormalGenetics
TransmissionofGeneticDiseases
LinkageAnalysisandGeneMapping
MultifactorialInheritance
DidYouUnderstand?
KeyTerms
References
3EpigeneticsandDisease
EpigeneticMechanisms
EpigeneticsandHumanDevelopment
GenomicImprinting
InheritanceofEpigeneticStates
EpigeneticsandCancer
FutureDirections
DidYouUnderstand?
KeyTerms
References
4AlteredCellularandTissueBiology
CellularAdaptation
CellularInjury
ManifestationsofCellularInjury:Accumulations
CellularDeath
AgingandAlteredCellularandTissueBiology
SomaticDeath
DidYouUnderstand?
KeyTerms
References
5FluidsandElectrolytes,AcidsandBases
DidYouUnderstand?
KeyTerms
References
PartTwoBodySystemsandDiseases
Unit4TheNeurologicalSystem
13StructureandFunctionoftheNeurologicalSystem
OverviewandOrganizationoftheNervousSystem
CellsoftheNervousSystem
TheNerveImpulse
TheCentralNervousSystem
ThePeripheralNervousSystem
TheAutonomicNervousSystem
GeriatricConsiderations
DidYouUnderstand?
KeyTerms
References
14Pain,Temperature,Sleep,andSensoryFunction
Pain
TemperatureRegulation
Sleep
TheSpecialSenses
SomatosensoryFunction
GeriatricConsiderations
GeriatricConsiderations
GeriatricConsiderations
DidYouUnderstand?
KeyTerms
References
15AlterationsinCognitiveSystems,CerebralHemodynamics,andMotorFunction
AlterationsinCognitiveSystems
AlterationsinCerebralHemodynamics
AlterationsinNeuromotorFunction
AlterationsinComplexMotorPerformance
ExtrapyramidalMotorSyndromes
Unit11TheDigestiveSystem
35StructureandFunctionoftheDigestiveSystem
TheGastro-IntestinalTract
AccessoryOrgansofDigestion
GeriatricConsiderations
DidYouUnderstand?
KeyTerms
References
36AlterationsofDigestiveFunction
DisordersoftheGastro-IntestinalTract DisordersoftheAccessoryOrgansofDigestion CanceroftheDigestiveSystem
DidYouUnderstand?
KeyTerms
References
37AlterationsofDigestiveFunctioninChildren
DisordersoftheGastro-IntestinalTract DisordersoftheLiver
Gastro-IntestinalMalignanciesinChildren
DidYouUnderstand?
KeyTerms
References
Unit12TheMusculo-skeletalandIntegumentarySystems
38StructureandFunctionoftheMusculo-skeletalSystem
StructureandFunctionofBones
StructureandFunctionofJoints
StructureandFunctionofSkeletalMuscles
AgingandtheMusculo-skeletalSystem
DidYouUnderstand?
KeyTerms
References
39AlterationsofMusculo-skeletalFunction
Musculo-skeletalInjuries
DisordersofBones
DisordersofJoints
DisordersofSkeletalMuscle
Musculo-skeletalTumours
DidYouUnderstand?
KeyTerms
References
40AlterationsofMusculo-skeletalFunctioninChildren
CongenitalDefects
BoneInfection
JuvenileIdiopathicArthritis
Osteochondroses
Scoliosis
MuscularDystrophy
Musculo-skeletalTumours
NonaccidentalTrauma
DidYouUnderstand?
KeyTerms
References
41Structure,Function,andDisordersoftheIntegument
StructureandFunctionoftheSkin
DisordersoftheSkin
DisordersoftheHair
DisordersoftheNail
GeriatricConsiderations
DidYouUnderstand?
KeyTerms
References
42AlterationsoftheIntegumentinChildren
AcneVulgaris
Dermatitis
InfectionsoftheSkin
InsectBitesandParasites
CutaneousHemangiomasandVascularMalformations
OtherSkinDisorders
DidYouUnderstand?
KeyTerms
References
Index
PrefixesandSuffixesUsedinMedicalTerminology
WordRootsCommonlyUsedinMedicalTerminology
Copyright
UNDERSTANDINGPATHOPHYSIOLOGY,FIRSTCANADIANEDITION
ISBN:978-1-77172-117-2
Copyright©2018ElsevierCanada,adivisionofReedElsevierCanada,Ltd.
ThisadaptationofUnderstandingPathophysiology,SixthEdition,bySueE.HuetherandKathrynL. McCanceispublishedbyarrangementwithElsevier,Inc.
ISBN:978-0-323-35409-7
Copyright©2017,ElsevierInc.Allrightsreserved. Previouseditionscopyrighted2012,2008,2004,2000,1996.
Nopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans,electronicor mechanical,includingphotocopying,recording,oranyinformationstorageandretrievalsystem,without permissioninwritingfromthepublisher.Reproducingpassagesfromthisbookwithoutsuchwritten permissionisaninfringementofcopyrightlaw.
Requestsforpermissiontomakecopiesofanypartoftheworkshouldbemailedto:CollegeLicensing Officer,access©,1YongeStreet,Suite1900,Toronto,ONM5E1E5.Fax:(416)868-1621.Allother inquiriesshouldbedirectedtothepublisher.
Everyreasonableefforthasbeenmadetoacquirepermissionforcopyrightedmaterialusedinthisedition andtoacknowledgeallsuchindebtednessaccurately.Anyerrorsandomissionscalledtothepublisher's attentionwillbecorrectedinfutureprintings
Notices
Knowledgeandbestpracticeinthisfieldareconstantlychanging.Asnewresearchandexperience broadenourunderstanding,changesinresearchmethods,professionalpractices,ormedicaltreatment maybecomenecessary
Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluatingand usinganyinformation,methods,compounds,orexperimentsdescribedherein Inusingsuchinformation ormethodstheyshouldbemindfuloftheirownsafetyandthesafetyofothers,includingpartiesfor whomtheyhaveaprofessionalresponsibility.
Withrespecttoanydrugorpharmaceuticalproductsidentified,readersareadvisedtocheckthemost currentinformationprovided(i)onproceduresfeaturedor(ii)bythemanufacturerofeachproducttobe administered,toverifytherecommendeddoseorformula,themethodanddurationofadministration, andcontraindications Itistheresponsibilityofpractitioners,relyingontheirownexperienceand knowledgeoftheirpatients,tomakediagnoses,todeterminedosagesandthebesttreatmentforeach individualpatient,andtotakeallappropriatesafetyprecautions.
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Reviewers
ColleenBattistaBScN,RN,MN
NursingFaculty
CollaborativeBScNProgram
St.LawrenceCollege/LaurentianUniversity
St.LawrenceCollege,CornwallCampus Cornwall,Ontario
BrendaDafoeEnnsBA,RN,MN
NursingInstructor
BaccalaureateNursingProgram
SchoolofHealthSciencesandCommunityServices RedRiverCollege Winnipeg,Manitoba
DaphneGillBA,PhD SessionalLecturer DepartmentofBiology UniversityofPrinceEdwardIsland Charlottetown,PrinceEdwardIsland
HeatherHelpardBN,MN,PhD AssistantProfessor SchoolofNursing DalhousieUniversity Halifax,NovaScotia
Anne-MarieKowatschBSc,MSc Instructor
BaccalaureateNursingProgram RedRiverCollege Winnipeg,Manitoba
TaraLysterBScN,RN,MN SessionalLecturer SchoolofNursing ThompsonRiversUniversity Kamloops,BritishColumbia
JoanMillsRN,MN,CCN(C) AssistantProfessor FacultyofNursing MacEwanUniversity Edmonton,Alberta
DeborahMorrisonRN,BScN,MN NursingChair Interim SchoolofHealth&CommunityServices
DurhamCollege Oshawa,Ontario
MahaOthmanMD,MSc,PhD
Professor
SchoolofBaccalaureateNursing St LawrenceCollege Kingston,Ontario
JenniferPerryRN(EC),NP-PHC,PhD Professor
SchoolofNursing St.LawrenceCollege Kingston,Ontario
KaraSealockBN,RN,MEd,CNCC(C)
NursingInstructor FacultyofNursing UniversityofCalgary Calgary,Alberta
ToddCameronGreyMD ChiefMedicalExaminer OfficeoftheMedicalExaminer StateofUtah SaltLakeCity,Utah
RobertE.JonesMD,FACP,FACE ProfessorofMedicine EndocrinologyDivision UniversityofUtahSchoolofMedicine SaltLakeCity,Utah
LynnB.JordePhD
H.A.andEdnaBenningPresidentialProfessorandChair DepartmentofHumanGenetics UniversityofUtahSchoolofMedicine SaltLakeCity,Utah
LynneM.KerrMD,PhD AssociateProfessor DepartmentofPediatrics,DivisionofPediatricNeurology UniversityofUtahMedicalCenter SaltLakeCity,Utah
NancyE.KlinePhD,RN,CPNP,FAAN † Director,NursingResearch,Medicine PatientServices/EmergencyDepartment BostonChildren'sHospital Boston,Massachusetts
LauriA.LinderPhD,APRN,CPON AssistantProfessor CollegeofNursing UniversityofUtah ClinicalNurseSpecialist CancerTransplantCenter PrimaryChildren'sHospital SaltLakeCity,Utah
SueAnnMcCannMSN,RN,DNC ProgrammaticNurseSpecialist Nursing ClinicalResearchCoordinator Dermatology UniversityofPittsburghMedicalCenter Pittsburgh,Pennsylvania
NancyL.McDanielMD AssociateProfessorofPediatrics UniversityofVirginia Charlottesville,Virginia
AfsoonMoktarPhD,EMBA,CT(ASCP) AssociateProfessor SchoolofPhysicianAssistantStudies
