Gabbe’s obstetrics essentials: normal & problem pregnancies 1st edition mark b landon et al. - Exper

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Gabbe’s Obstetrics Essentials

Normal and Problem Pregnancies

Mark B. Landon, MD

Richard L. Meiling Professor and Chair, Department of Obstetrics and Gynecology, Ohio State University College of Medicine, Columbus, Ohio

Henry L. Galan, MD

Professor, Department of Obstetrics and Gynecology, University of Colorado School of Medicine

Co-Director, Colorado Fetal Health Center, Aurora, Colorado

Eric R.M. Jauniaux, MD,PhD, FRCOG

Professor of Obstetrics and Fetal Medicine, EGA Institute for Women’s Health, Faculty of Population Health Sciences, University College London, London, United Kingdom

Deborah A. Driscoll, MD

Luigi Mastroianni Professor and Chair, Department of Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania

Vincenzo Berghella, MD, FACOG

Professor, Department of Obstetrics and Gynecology, Director, Division of Maternal-Fetal Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania

William A. Grobman, MD, MBA

Arthur Hale Curtis Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois

Steven G. Gabbe, MD

Emeritus Chief Executive Officer, Ohio State University Wexner Medical Center, Professor of Obstetrics and Gynecology, Ohio State University College of Medicine, Columbus, Ohio

Jennifer R. Niebyl, MD

Professor, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, Iowa

Joe Leigh Simpson, MD

Senior Vice President for Research and Global Programs, March of Dimes Foundation, White Plains, New York

Professor of Obstetrics and Gynecology, Professor of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida

International University, Miami, Florida

Table of Contents

Cover image

Title page

Copyright

Contributors

PART I. Physiology

Chapter 1. Placental Anatomy and Physiology

Placental Anatomy

Placental Histology

Placental Physiology

Chapter 2. Fetal Development and Physiology

Umbilical Blood Flow

Amniotic Fluid Volume

Fetal Growth and Metabolism

Fetal Cardiovascular System

Fetal Kidney

Fetal Gastrointestinal System

Fetal Adrenal and Thyroid Glands

Fetal Central Nervous System

Chapter 3. Maternal Physiology

Overview

Cardiovascular System

Hematologic Changes

Respiratory System

Urinary System

Body Water Metabolism

Alimentary Tract

Endocrine Changes

Pancreas and Fuel Metabolism

Skeleton

Skin

Central Nervous System

Lower Reproductive Tract

Microbiome

Chapter 4. Maternal-Fetal Immunology

Introduction

Immune System Overview: Innate and Adaptive Immunity

Innate Immunity: First Line of Host Defense

Adaptive Immunity

Regulatory T Cells

Fetal Immune System

Maternal Tolerance of the Fetus

Solid Organ Transplantation in Pregnancy

Amelioration of Rheumatoid Arthritis in Pregnancy

Chapter 5. Developmental Origins of Adult Health and Disease

Introduction

Epigenetics and Programming

Fetal Nutrition and Growth

Energy-Balance Programming

Maternal Stress and Anxiety

Glucocorticoids and Prematurity

Immune Function

Other Programming

PART II. Prenatal Care

Chapter 6. Preconception and Prenatal Care

Definition and Goals of Prenatal Care

Components of Preconception Care and Well-Woman Visits

Preconception Health Counseling

Screening for Chronic Disease, Optimizing Care, and Managing Medication Exposure

Prenatal Care

Components of the Postpartum Visit

Chapter 7. Nutrition During Pregnancy

Overview

Integrating Nutrition Into the Obstetric History

Maternal Weight Gain Recommendations

Maternal Weight Gain Recommendations for Special Populations

Maternal Nutrient Needs: Current Recommendations

Vitamin and Mineral Supplementation Guidelines

Nutrition-Related Problems During Pregnancy

Special Nutritional Considerations During Pregnancy

Chapter 8. Drugs and Environmental Agents in Pregnancy and Lactation: Teratology and Epidemiology

Overview

Basic Principles of Teratology

Medical Drug Use

Drugs of Abuse

Drugs in Breast Milk

Occupational and Environmental Hazards

Chapter 9. Obstetric Ultrasound: Imaging, Dating, Growth, and Anomaly

Biophysics of Ultrasound

Optimizing the Ultrasound Image

Special Ultrasound Modalities

Scanning Technique

First-Trimester Ultrasound

Second- and Third-Trimester Ultrasound

Components of the Examination

Ultrasound for Determining Gestational Age

Safety of Ultrasound

Ultrasound Diagnosis of Malformations

“Entertainment” Ultrasound Examinations

Chapter 10. Genetic Screening and Prenatal Genetic Diagnosis

Genetic History

Genetic Counseling

Chromosome Abnormalities

Single-Gene or Mendelian Disorders

Multifactorial and Polygenic Disorders

Procedures for Prenatal Genetic Diagnosis

Preimplantation Genetic Diagnosis

Chapter 11. Antepartum Fetal Evaluation

Defining the Problem of Perinatal Mortality

Potential Utility of Antepartum Fetal Testing

What Do These Tests Tell Us About the Fetus?

Biophysical Techniques of Fetal Evaluation

Clinical Application of Tests of Fetal Well-Being

PART III. Intrapartum Care

Chapter 12. Normal Labor and Delivery

Labor: Definition and Physiology

Mechanics of Labor

Cardinal Movements in Labor

Normal Progress of Labor

Spontaneous Vaginal Delivery

Delivery of the Placenta and Fetal Membranes

Episiotomy and Perineal Injury and Repair

Ultrasound in Labor and Delivery

Chapter 13. Abnormal Labor and Induction of Labor

Diagnosis

Induction of Labor

Techniques for Cervical Ripening and Labor Induction

Chapter 14. Operative Vaginal Delivery

Operative Vaginal Delivery

Operative Vaginal Delivery Instruments

Risks of Operative Vaginal Delivery

Chapter 15. Intrapartum Fetal Evaluation

Direct Fetal Heart Rate and Uterine Activity Monitoring

Indirect Fetal Heart Rate and Uterine Activity Monitoring

Physiologic Basis for Electronic Fetal Heart Rate Monitoring

Summary of Placental Causes of Interrupted Oxygenation

Fetal Response to Interrupted Oxygen Transfer

Pattern Recognition and Interpretation

2008 National Institute of Child Health and Human Development

Consensus Report

Benefits of Electronic Fetal Monitoring

Limitations of Electronic Fetal Monitoring

Chapter 16. Obstetric Anesthesia

Personnel

Pain Pathways

Effects of Pain and Stress

Analgesia for Labor

Anesthesia for Instrumented Vaginal Delivery or Perineal Repair

Anesthesia for Cesarean Delivery

Chapter 17. Malpresentations

Overview

Clinical Circumstances Associated With Malpresentation

Abnormal Axial Lie

Management of a Singleton Gestation

Face Presentation

Brow Presentation

Compound Presentation

Breech Presentation

Term Breech Trial

Shoulder Dystocia

Chapter 18. Antepartum and Postpartum Hemorrhage

Pregnancy-Related Hemodynamic Changes

Physiologic Adaptation to Hemorrhage

Classification of Hemorrhage

Antepartum Hemorrhage

Chapter 19. Cesarean Delivery

Incidence

Indications for Cesarean Delivery

Technique of Cesarean Delivery

Complications of Cesarean Delivery

Tubal Sterilization

Chapter 20. Vaginal Birth After Cesarean Delivery

Trends

Risks Associated With a Trial of Labor After Cesarean

Chapter 21. Placenta Accreta

Overview

Pathogenesis

Epidemiology

Management

PART IV. Postpartum Care

Chapter 22. The Neonate

Cardiopulmonary Transition

Abnormalities of Cardiopulmonary Transition

Birth Injuries

Neonatal Thermal Regulation

Clinical Applications

Infant Feeding

Neonatal Hematology

Perinatal Infection

Respiratory Distress

Nursery Care

Outcome of Neonatal Intensive Care and Threshold of Viability

Late Preterm Infant

Chapter 23. Postpartum Care and Long-Term Health Considerations

Physiologic Changes

Management of the Puerperium

Health Maintenance

Pregnancy Prevention

Postpartum Psychological Reactions

Chapter 24. Lactation and Breastfeeding

Breast Anatomy and Development

Physiology of Lactation

Breast Milk: The Gold Standard

Role of the Obstetrician and Gynecologist

Focused Issues in the Successful Management of Breastfeeding

Anatomic Abnormalities of the Breast

Labor and Delivery Management

Maternal Nutrition During Lactation

Breast and Nipple Pain

Mastitis and Breast Abscess

Milk Transfer and Infant Growth

Jaundice in the Newborn

Galactogogues: Drugs to Improve Milk Production

Maternal Disease

Breast Masses During Lactation

Back-to-Work Issues

Contraception

PART V. Complicated Pregnancy

Chapter 25. Surgery During Pregnancy

Maternal Physiology

Diagnostic Imaging

Nonobstetric Surgery and Pregnancy Outcome

Fetal Monitoring

Laparoscopy in Pregnancy

Adnexal Masses in Pregnancy

Obesity, Bariatric Surgery, and Pregnancy

Chapter 26. Trauma and Related Surgery in Pregnancy

Incidence of Trauma in Pregnancy

Anatomic and Physiologic Changes of Pregnancy

Blunt Trauma

Specific Injuries

Management Considerations

Diagnostic Imaging

Exploratory Surgery for Traumatic Injuries During Pregnancy

Chapter 27. Early Pregnancy Loss and Stillbirth

Introduction

Frequency and Timing of Pregnancy Loss

Placental Anatomic Characteristics of Successful and Unsuccessful Pregnancies

Numerical Chromosomal Abnormalities: Most Frequent Cause of Early Pregnancy Loss

Chromosomal Rearrangements

Mosaics

Nonchromosomal Causes of Early Pregnancy Loss

Thrombophilias

Exogenous Agents

Management of Recurrent Early Pregnancy Loss

Late Pregnancy Loss (Stillbirth)

Obstetric Outcome After Early Pregnancy Complications

Chapter 28. Cervical Insufficiency

Overview

Short Cervix

Risk Factors for Cervical Insufficiency

Tests for Cervical Insufficiency

Clinical Diagnosis of Cervical Insufficiency

Sonographic Diagnosis of Cervical Insufficiency

Diagnosis of Cervical Insufficiency on Physical Examination

Treatment

Chapter 29. Preterm Labor and Birth

Overview

Definitions

Frequency of Preterm and Low-Birthweight Delivery

Clinical Care for Women in Preterm Labor

Diagnosis of Preterm Labor

Treatment for Women in Preterm Labor

Conduct of Labor and Delivery for the Preterm Infant

Prevention of Preterm Birth

Chapter 30. Premature Rupture of the Membranes

Overview

Fetal Membrane Anatomy and Physiology

Etiology of Premature Rupture of the Membranes

Clinical Course After Premature Rupture of the Membranes

Risks of Premature Rupture of the Membranes

Management of Premature Rupture of the Membranes

Chapter 31. Preeclampsia and Hypertensive Disorders

Definitions

Preeclampsia

Eclampsia

Chrionic Hypertension

Chapter 32. Multiple Gestations

Zygosity and Chorionicity

Diagnosis of Multiple Gestations

Maternal and Fetal Risks of Multiple Gestation

Perinatal Morbidity and Mortality

Issues and Complications Unique to Multiple Gestations

Selective Intrauterine Growth Restriction in Monochorionic Twin Pregnancies

Twin Anemia-Polycythemia Sequence

Antepartum Management of Multifetal Pregnancy

Timing of Delivery in Multiple Gestations

Mode of Delivery in Multiple Gestations

Intrapartum Management of Twin Vaginal Delivery

Chapter 33. Intrauterine Growth Restriction

Perinatal Mortality

Regulation of Fetal Growth

Definition and Patterns of Fetal Growth Restriction

Etiologies of Intrauterine Growth Restriction

Maternal and Fetal Manifestations of Intrauterine Growth Restriction

Diagnostic Tools in Fetal Growth Restriction

Screening and Prevention of Fetal Growth Restriction

Management in Clinical Practice

Assessment of Fetal Well-Being

Timing of Delivery

Delivery

Chapter 34. Red Cell Alloimmunization

Nomenclature

Historic Perspectives

Incidence

Pathophysiology

Rhesus Alloimmunization and Fetal/Neonatal Hemolytic Disease of the Newborn

Prevention of RhD Hemolytic Disease in the Fetus and Newborn

Clinical Management

Intrauterine Transfusion

Hemolytic Disease of the Fetus and Newborn Due to Non-RhD Antibodies

Chapter 35. Amniotic Fluid Disorders

Overview

Amniotic Fluid Volume

Amniotic Fluid Formation

Amniotic Fluid Removal

Oligohydramnios

Polyhydramnios

PART VI. Pregnancy and Coexisting Disease

Chapter 36. Prolonged and Postterm Pregnancy

Definition

Incidence

Etiology

Diagnosis

Perinatal Morbidity and Mortality

Maternal Complications

Management

Long-Term Neonatal Outcomes

Multiple Gestation

Chapter 37. Heart Disease in Pregnancy

Maternal Hemodynamics

Diagnosis and Evaluation of Heart Disease

General Care

Congenital Heart Disease

Summary

Cardiomyopathy

Myocardial Infarction

Marfan Syndrome

Pulmonary Hypertension

Other Conditions

Critical Care: Hemodynamic Monitoring and Management

Chapter 38. Respiratory Disease in Pregnancy

Pneumonia in Pregnancy

Bacteriology

Bacterial Pneumonia

Viral Pneumonia

Tuberculosis in Pregnancy

Asthma in Pregnancy

Restrictive Lung Disease

Chapter 39. Renal Disease in Pregnancy

Altered Renal Physiology in Pregnancy

Asymptomatic Bacteriuria

Pyelonephritis

Acute Renal Disease in Pregnancy

Chronic Renal Disease in Pregnancy

Chapter 40. Diabetes Mellitus Complicating Pregnancy

Perinatal Morbidity and Mortality

Maternal Classification and Risk Assessment

Early Screening for Overt Diabetes and Detection of Gestational Diabetes Mellitus

Treatment of the Patient With Type 1 or Type 2 Diabetes Mellitus

Antepartum Fetal Evaluation

Timing and Mode of Delivery

Glucoregulation During Labor and Delivery

Management of Gestational Diabetes

Postpartum Follow-up in Gestational Diabetes Mellitus

Prepregnancy Counseling in Preexisting Diabetes Mellitus

Contraception

Chapter 41. Obesity in Pregnancy

Prevalence of Obesity in Women of Reproductive Age

Pregnancy Complications in Obese Women

Postpartum Considerations

Neonate/Child

Other Considerations

Chapter 42. Thyroid and Parathyroid Diseases in Pregnancy

Parathyroid Disorders

Thyroid Diseases

Chapter 43. Pituitary and Adrenal Disorders in Pregnancy

Anterior Pituitary

Posterior Pituitary

Adrenals

Chapter 44. Hematologic Complications of Pregnancy

Pregnancy-Associated Thrombocytopenia

Evaluation of Thrombocytopenia During Pregnancy and the Puerperium

Therapy of Thrombocytopenia During Pregnancy

Management of Thrombotic Thrombocytopenic Purpura and HemolyticUremic Syndrome

Fetal/Neonatal Alloimmune Thrombocytopenia

Iron Deficiency Anemia

Megaloblastic Anemia

Hemoglobinopathies

von Willebrand Disease

Chapter 45. Thromboembolic Disorders in Pregnancy

Epidemiology and Incidence

Genetics

Pathophysiology of Thrombosis in Pregnancy

Chapter 46. Collagen Vascular Diseases in Pregnancy

Systemic Lupus Erythematosus

Antiphospholipid Syndrome

Rheumatoid Arthritis

Systemic Sclerosis

Sjögren Syndrome

Chapter 47. Hepatic Disorders During Pregnancy

Overview

Differential Diagnosis of Hepatobiliary Symptoms and Conditions During Pregnancy

Abdominal Imaging During Pregnancy

Pancreatobiliary Disease

Common Liver Diseases Incidental to Pregnancy

Chapter 48. Gastrointestinal Disorders During Pregnancy

Differential Diagnosis and Evaluation of Gastrointestinal Symptoms During Pregnancy

Diagnostic Testing During Pregnancy

Chapter 49. Neurologic Disorders in Pregnancy

Epilepsy and Seizures

Multiple Sclerosis

Stroke

Carpal Tunnel Syndrome

Chapter 50. Malignant Diseases and Pregnancy

Introduction

Cancer Therapy During Pregnancy

Radiation Therapy

Surgery and Anesthesia

Pregnancy Following Cancer Treatment

Cancer During Pregnancy

Postoperative Adjuvant Therapy

Central Nervous System Tumors

Neonatal Outcomes

Fetal-Placental Metastasis

Fertility Preservation

Gestational Trophoblastic Disease and Pregnancy-Related Issues

Chapter 51. Skin Disease and Pregnancy

Physiologic Skin Changes Induced by Pregnancy

Preexisting Skin Diseases and Tumors Affected by Pregnancy

Cutaneous Manifestations of Autoimmune Disorders

Pruritus in Pregnancy

Specific Dermatoses of Pregnancy

Chapter 52. Maternal and Perinatal Infection: Chlamydia, Gonorrhea, and Syphilis in Pregnancy

Chlamydia

Gonorrhea

Syphilis

Congenital Syphilis

Chapter 53. Maternal and Perinatal Infection in Pregnancy: Viral

Viral Infections

Human Immunodeficiency Virus

Influenza

Parvovirus

Measles

Cytomegalovirus Infection

Herpesvirus

Varicella

Hepatitis

Human Papillomavirus

Ebola

Chapter 54. Maternal and Perinatal Infection in Pregnancy: Bacterial

Group B Streptococcal Infection

Urinary Tract Infections

Upper Genital Tract Infections

Chapter 55. Mental Health and Behavioral Disorders in Pregnancy

Mood Disorders

Anxiety Disorders

Eating Disorders

Schizophrenia

Substance-Related Disorders

PART VII. Legal and Ethical Issues in Perinatology

Chapter 56. Patient Safety and Quality Measurement in Obstetric Care

Patient Safety

Approaches to Improve Obstetric Safety

Measurement of Obstetric Quality of Care

Chapter 57. Ethical and Legal Issues in Perinatology

Reproductive Liberty

Abortion Politics and “Obamacare”

Human Embryonic Stem Cell Research Funding

Genetic Counseling, Screening, and Prenatal Diagnosis

Forced Cesarean Delivery

Chapter 58. Improving Global Maternal Health: Challenges and Opportunities

Maternal and Reproductive Health

Sexual and Reproductive Health

Major Obstetric Complications: Prevention and Management in Resource-Poor Countries

Practical Advice on Volunteering to Work Overseas

Appendix

Appendix A. Normal Values in Pregnancy and Ultrasound Measurements

Appendix B. Anatomy of the Pelvis

Appendix C. Glossary of Key Abbreviations

Index

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