ADVANCESIN OphthalmologyandOptometry
DavidA.Crandall
Optometry
OpticalCoherenceTechnologyinGlaucomaDiagnosis JosephSowka,JessicaSteen,andGregCaldwell
Introduction1
Opticalcoherencetomographyretinalnervefiberlayeranalysisin glaucomadiagnosis2
Opticalcoherencetomographymacularanalysisinglaucomadiagnosis4
Opticalcoherencetomographyangiographyinglaucomadiagnosis7
Clinicscarepoints10 Disclosure10
AnUpdateonNeurodegenerativeDiseaseforEyeCare Providers
KellyA.Malloy,ErinM.Draper,AshleyKayMaglione, TinaZeng,andElizabethMarunde
Introduction:neurodegenerativediseaseandtheeye13
Neurodegenerativediseasedefinition13
Variedpathophysiologyofneurodegenerativediseases14
Prevalentvisualandocularassociationsofneurodegenerativedisease14
Roleofeyecareprovidersinneurodegenerativedisease16
Visualandocularassociationsofneurodegenerativedisease16
Eyelidfunctioninneurodegenerativedisease16
Anteriorsegmentfindingsinneurodegenerativedisease20
Posteriorsegmentfindingsinneurodegenerativedisease21
Afferentvisualfunctioninneurodegenerativedisease22
Efferentvisualfunctioninneurodegenerativedisease24
Hallucinationsinneurodegenerativedisease25
Visualandocularsideeffectsofneurodegenerativediseasetreatments27
Adversesequela28
Associatedimprovementinneurodegenerativediseasemanifestations28
Futureavenues:neurodegenerativedisease,theeye,andthevisualsystem28
Expectedincreaseinprevalenceofneurodegenerativedisease28
Optimalbiomarkersinvolveeyesandvision31
Summary:neurodegenerativedisease,theeye,andthevisualsystem31
Eyecareprovidersasscreenersofneurodegenerativedisease31
Earlyidentificationandneurologyreferraliskey31
Eyecareprovidershelpimprovequalityoflifeofpatientswith neurodegenerativedisease32
Expectedsurgeofresearchintoneurodegenerativedisease34
Clinicscarepoints34
Disclosure34
NeuroanatomicalStructuresinExtraocularMusclesand TheirPotentialImplicationintheManagementof Strabismus
JanRichardBruenech
Introduction39
Structureandfunctionofhumanextraocularmuscles40
Sensoryreceptorsinhumanextraocularmuscles41
Musclespindles41
Tendonreceptors41
Theroleofproprioceptioninoculomotorcontrol43
Theneuralpathwayforproprioception43
Theneuralsubstrateforthecontrolofeyemovements44
Binocularvisionanomalies45
Currentconceptsinthediagnosisandmanagementofstrabismus46
Nonsurgicalmanagementofstrabismus46
Opticalcorrections46
Neuromuscularstimulationthroughexercise47
Surgicalmanagementofstrabismus48
Summaryanddiscussion49
Summary51
Disclosure51
Clinicscarepoints51
Pediatric
PrenatalDiagnosisofRetinoblastoma
KelseyChen,LuisF.Goncalves,and AparnaRamasubramanian
Introduction55 Incidence56 Riskfactors56
CurrentManagementofPediatricGlaucoma
SushmitaKaushik,DeepikaDhingra,andSurinderS.Pandav
SystemicImmunomodulatoryTherapyinPediatric Uveitis
IlariaMaccora,EthanS.Sen,andAthimalaipetV.Ramanan
IremKoc¸,HayyamKiratli,andBhavnaChawla
Classificationofseeding104
Impactofintravitrealinjectionsonpatientmanagement105
Usesofintravitrealchemotherapyotherthanforvitreousseeds107
Dosage107
Pharmacokineticsofintravitrealmelphalan112
Useofintravitrealtopotecan113
Pharmacokineticsofintravitrealtopotecan113
Stabilityofmelphalanandtopotecan114
Futureavenues115
Summary115
Clinicscarepoints116
OphthalmicPathology&OcularOncology
ApplicationsofPlaqueBrachytherapyinPosterior SegmentTumors:AClinicalReview
PuneetJain,PaulT.Finger,andBhavnaChawla
Introduction119
Historicalperspective120
Choroidalhemangioma121 Managementofchoroidalhemangioma122
Managementofdiffusechoroidalhemangioma122
Retinalcapillaryhemangioma124
Vasoproliferativeretinaltumors125
Retinoblastoma126
Choroidalmelanoma127
Limitationsofplaquebrachytherapy129
Futureavenues129
Methodsfordosede-escalation129
Clinicscarepoints130
IntraocularTumors—AdvancesinOphthalmicPathology
SnehaGiridhar,DipankarDas,andJyotirmayBiswas
Retinoblastoma133
Pathology134
MolecularPathology138 Uvealmelanoma138
Pathology140 Genetics141
Primaryvitreoretinallymphoma142
Cytologyandimmunohistochemistry142 Molecularfeatures144
Summary145
Clinicscarepoints145
Acknowledgments145 Disclosure146
AdenoidCysticCarcinomaoftheLacrimalGland
NurKhatib,IoanaCatalinaIonescu,DanielBriscoe,and PeeroozSaeed
Introduction147
Significance(in-depthanalysis)148 Signsandsymptoms148 Staging148 Histopathology148 Imaging150 Treatmentapproach150 Futureavenues155 Summary155 Clinicscarepoints156
Cataract&RefractiveSurgery
Micro-InvasiveGlaucomaSurgery
DavidA.CrandallandCandiceYousif
Introduction159
Significanceandcurrentrelevance160
IStenttrabecularmicro-bypassstent162
Hydrusmicrostent163
Goniotomy-assistedtrabeculotomy165 Trab360trabeculotomy166 Trabectome167 Kahookdualblade167 Abinternocanaloplasty168 Visco360andOMNI169 XENgelstent169 Preserflo170 Summary170 Clinicscarepoints171 Disclosure172 VitreoretinalDisease
Backgroundandintroduction175 Overviewofartificialintelligence176 Evaluatingdeeplearningalgorithms178 Diabeticretinopathy179 Age-relatedmaculardegeneration181 Future182 Summary183 Clinicscarepoints184 Disclosure184
RetinaintheAgeofCOVID-19
SamuelGelnick,MaribAkanda,andRonniLieberman
Background187
Introduction188
Generalcleaningandhygiene188
Personalprotectiveequipment188
Pandemicrestrictions189
Careinanactivepandemic189
Schedulingvisits189
Precautionsforprocedures192
Intravitrealinjections192
Precautionsforlaserprocedures193
Schedulingfollow-upvisits193
PatientswithpositivescreeningortestingforCOVID-19194
Careafterimmediatepandemicrestrictionsarelifted195
Continuedscreeningandschedulingprecautions195
Dayofappointmentprecautions195
Performingelectivesurgery196
Operatingroomprecautions197
Summary197
Clinicscarepoints198 Disclosure198
DiagnosticandTreatmentUpdateonSickleCell Retinopathy
CesarAlfaro,EthanK.Sobol,andRobinGinsburg
Introduction201
Classificationsystem205 Diagnosis206
Opticalcoherencetomography207
Opticalcoherencetomographyangiography207
Ultra-widefluoresceinangiography209 Management210
Anti-vascularendothelialgrowthfactor211
Glaucoma
GlaucomaSurgery:WhichSurgerytoPickforYour Patient?
RabeaKassemandPaulHarasymowycz
Introduction218
Significance218
Subconjunctivalsurgery219
Whennottooptforsubconjunctivalsurgery?219 Nonpenetratingglaucomasurgery219
Trabeculectomy222
XENGelImplant(AllerganInc,Irvine,CA,USA)222
PreserfloMicroshunt(SantenPharmaceuticalCoLtd,Osaka, Japan)223
Tubeshunts223
Cyclodestructiveprocedures224
Schlemmcanal–basedprocedures225 Selectivelasertrabeculoplasty225
Schlemmcanal-basedmicroinvasiveglaucomasurgery226
Suprachoroidal231
CyPass(Alcon,FortWorth,TX,USA)231
Specialconsiderations231
Patientswithveryadvanceddisease231
Patientswithveryhighintraocularpressure232
Patientswithangle-closureglaucoma232 Primaryangleclosure233 Primaryangle-closureglaucoma233
Patientswithneovascularglaucoma234 Reoperationafterfailedglaucomasurgery234 Currentrelevanceandfutureavenues236 Summary239 Clinicscarepoints241 Disclosure241
OcularBloodFlowasItRelatestoRaceandDiseaseon Glaucoma
BrentSiesky,AlonHarris,AliceC.VerticchioVercellin, GiovannaGuidoboni,andJamesC.Tsai Introduction245 Significance246
Racialdisparitiesinglaucoma248 Mechanismsbehindracialdisparitiesinglaucoma248 Summary258
Clinicalcarepoints259 Funding259 Financialdisclosures259
Neuro-ophthalmology
GlaucomaasaNeurodegenerativeDisease:AClinician Perspective
NoelC.Y.ChanandJaneW.Chan Introduction263
Isglaucomaaneurodegenerativedisease?264
Sickeyecomeswithasickbrain264
Commonclinicalcharacteristicsbetweenglaucomaand neurodegenerativedisease266
Overlappingpathophysiologybetweenglaucomaandother neurodegenerativedisease267
Neuroinflammation267
Oxidativestressandmitochondrialdysfunction267
Dysregulationofcalciumdependentprocess268
Alterationsofautophagymachinery268
Misfoldingofproteins268
Activationofglia269
Glaucomaandcerebrospinalfluid269 Lookingintothefuture269
Neuro-OphthalmologicManifestationsofNovel Coronavirus
DevinBetschandPaulR.Freund Introduction275
CorneaandExternalDiseases
AdvancesinEndothelialKeratoplastySurgery
ArielChen,DanielChoi,andMichaelE.SulewskiJr. Introduction289
Significance290
Lamellarkeratoplasty290
Descemetstrippingendothelialkeratoplasty293
Descemet’smembraneendothelialkeratoplasty295
Descemetorhexiswithoutendothelialkeratoplasty298 Relevanceandfutureavenues298
UpdateintheManagementofKeratoconus
EnnyOyeniranandZujajaTauqeer
Introduction307
Cornealcross-linking310
Spectaclesandcontactlenses313 Scleralcontactlenses315
Intrastromalcornealringsegments317
Penetratingkeratoplasty319
Deepanteriorlamellarkeratoplasty320 Summary320 Clinicscarepoints321 Disclosure321
UpdateonRefractiveSurgery
TianyuLiu,BrianM.Shafer,andVanceThompson
Introduction325
Significanceandin-depthanalysisofthetopic326
Cornealrefractivesurgery326
Intraocularrefractivesurgery328
Treatmentofpresbyopia330
Currentrelevanceandfutureavenuestoinvestigatethetopic332 Managementofhigher-orderaberrations:wavefront-optimized, wavefront-guided,andtopography-guidedlaserablation332 Advancesinrefractivelenticulesurgery333 Accommodativeintraocularlens334 Summary336
Oculoplastics
XanthelasmaPalpebrarum:AnOculoplasticViewpointof OptimalTreatment
LironPe’erandArieY.Nemet
RefractiveErrorChangesAssociatedwithEyelidWeight Placement
CatN.BurkatandSusanLuo
Introduction358
Significance359
Efficacyofuppereyelidweightplacement359 Causesoflagophthalmos360 Operativetechnique360 Complicationsofuppereyelidloading360 Refractiveerrorchanges360 Relevanceandfutureavenues367 Transitiontoplatinum368 Costofplatinumversusgold368 Futureavenues369
Summary369 Clinicscarepoints370 Acknowledgments371 Disclosure371
RefractiveChangeafterUpperEyelidSurgery
ChintanA.Pathak,NenitaMaganti,andCatN.Burkat
Introduction373 Preoperativechanges375 Postoperativechanges376 Clinicalrelevance377 Clinicscarepoints377 Acknowledgments378
CanalicularStenosisSecondarytoChemotherapeutic Agents
NenitaMaganti,ChintanA.Pathak,andCatN.Burkat
Introduction379
Chemotherapeuticagentsknowntocausecanalicularstenosis380 5-Fluorouracil380 Mitomycin-C381 Docetaxel381
Significanceofepiphorasecondarytocanalicularabnormality382 Managementofcanalicularstenosis382 Summary386 Clinicscarepoints386 Acknowledgments387
Uveitis
OpticalCoherenceTomographyAngiographyinWhiteDot Syndromes
KarlN.Becker,AngelineC.Rivkin,andPoojaV.Bhat
Introduction391
Overview392
Cross-sectionalandenfacevisualizationsoftheposteriorcirculation393
Birdshotchorioretinopathy394
Multipleevanescentwhitedotsyndrome395
Punctateinnerchoroiditis396
Serpiginouschoroiditis397
Acuteposteriormultifocalplacoidpigmentepitheliopathy398
Acutezonaloccultouterretinopathy399
Multifocalchoroiditis400
Relevanceandfutureavenues400
Summary401
Clinicscarepoints401
ADVANCESIN OphthalmologyandOptometry
Editor-in-Chief
MYRONYANOFF,MD,ChairEmeritus,DepartmentofOphthalmology,DrexelUniversity,AdjunctProfessor,DepartmentofOphthalmology,UniversityofPennsylvania,Philadelphia,Pennsylvania
SectionEditors
BHAVNACHAWLA,MD –OphthalmicPathology&OcularOncology
RPCenterforOphthalmicSciences,AllIndiaInstituteof MedicalSciences,NewDelhi,India
DAVIDA.CRANDALL,MD –Cataract&RefractiveSurgery
GlaucomaFellowshipDirector,HenryFordHealthSystem,Detroit,Michigan UniversityofUtah,SaltLakeCity,WayneStateUniversity,SaltLakeCity,Utah
PAULB.FREEMAN,OD,FAAO,FCOVD –Optometry
Diplomate,LowVision,Pittsburgh,Pennsylvania,ClinicalProfessor,Rosenberg SchoolofOptometry,UniversityoftheIncarnate,Word,SanAntonio,Texas
MORRISE.HARTSTEIN,MD,FACS –Oculoplastics
Director,OphthalmicPlasticandReconstructiveSurgery,Ophthalmology,Shamir MedicalCenter,Zerifin,Israel;TelAvivUniversity,SacklerSchoolofMedicine, TelAviv,Israel
RUSTUMKARANJIA,MD,PhD,FRCSC,DABO –Neuro-ophthalmology
DepartmentofOphthalmology,DavidGeffenSchoolofMedicineat UCLA,LosAngeles,California;DohenyEyeInstitute,LosAngeles, California,DohenyEyeInstitute,LosAngeles,California,DepartmentofOphthalmology,UniversityofOttawa,Ottawa,Ontario,Canada,OttawaHospital ResearchInstitute,TheOttawaHospital,Ottawa,Ontario,Canada
RONNIM.LIEBERMAN,MD –VitreoretinalDisease
AssistantProfessorofOphthalmology,IcahnSchoolofMedicineatMt.Sinai, QueensHospitalCenter,Jamaica,NewYork
ANN-MARIELOBO,MD –Uveitis
Co-Director,UveitisService,AssistantProfessor,Departmentof OphthalmologyandVisualSciences,IllinoisEyeandEarInfirmary, UniversityofIllinoisatChicago,Chicago,Ilinois
STEPHENORLIN,MD –CorneaandExternalDiseases
AssociateProfessor,ScheieEyeInstitute,UniversityofPennsylvania,Perelman SchoolofMedicine,Philadelphia,Pennsylvania
JOSEPHM.ORTIZ,MD,FRCOphth –Glaucoma
ConsultantinOphthalmology,SacredHeartHospital,Allentown, Pennsylvania;ConsultantinOphthalmology,AbingtonMemorialHospital, Abington,Pennsylvania;FormerlyAssistantProfessorofOphthalmology, HahnemannUniversityHospital,DrexelUniversitySchoolofMedicine, Philadelphia,Pennsylvania
LEONARDJ.PRESS,OD,FAAO,FCOVD –Optometry
PressConsulting,P.C.,Lakewood,NewJersey;AdjunctProfessor,Southern CollegeofOptometry,Memphis,Tennessee
APARNARAMASUBRAMANIAN,MD –PediatricOphthalmology
DirectorofRetinoblasmaandOcularOncology,PhoenixChildren’sHospital, Phoenix,Arizona
Director,ContinuityPublishing:DoloresMeloni
Editor:LaurenBoyle
DevelopmentalEditor:JessicaCanaberal
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