abstract Sinistra.qxp_Stesura Seveso 16/05/19 13:57 Pagina 57 XXIV Congresso Nazionale UrOP - Abstracts in 16 women (48.5 %) at first f-up visit and in 3 women (9.1%) at second f-up visit; the persistence of all symptoms or the worsening of the condition was observed in 7 patients (21.2%) at first f-up visit and in none of the patients at second f-up. Regarding the mean score at the ACSS subscales, the analysis showed a significant reduction in all the sub-scales (typical, differential and quality of life) between first visit and both the first and the second f-up visit, and between the first and the second f-up. The reported mean score in typical symptoms at baseline was 11.5 (10.5 to 12.6), falling to 4.9 (4.0 to 5.9) at first f-up and to 2.7 (2.1 to 3.3) at the second one (p-values <0.0001). The mean score in differential symptoms was 3.1 (2.6 to 3.6) at baseline, falling to 0.6 (0.3 to 0.9) at first fup and to 0.3 (0.1 to 0.5) at the second one (p-values 0.009 to <0.0001). Lastly, the QoL mean score was 7.2 (6.7 to 7.7) at baseline, falling to 4.0 (3.3 to 4.6) at first f-up and to 1.7 (1.2 to 2.1) at the second (p-values <0.0001). The adherence to the prescribed therapy has been >98%, 6 patients required antibiotics. No adverse events were recorded. Conclusions. Our study suggest that the synergistic action of the different compounds of this new combination could help the bacterial washout, resulting in an effective management of acute cystitis in women without antibiotics in a wide majority of the cases. However, longer studies will ascertain the prophylactic potential of this combination and larger studies are needed to confirm the results. Lo studio ha avuto finanziamenti: No Conflitto d’interessi: No P_10 DETRUSOR UNDERACTIVITY: ARE DIFFERENT DIAGNOSTIC CRITERIA OFTEN RELIABLE IN CLINICAL PRACTICE? Rapisarda S1, Polara A2, Bada M1, Russo GI1, Lombardo R3, Cimino S1, Tubaro A3, Grosso G2. 1 University of Catania, Policlinico Gaspare Rodolico; 2 Ospedale Pederzoli, Peschiera del Garda; 3 Ospedale S.Andrea, Roma. Introduction and Objectives. Detrusor underactivity (DU) is a common clinical problem in patient being referred with lower urinary tract symptoms (LUTS). DU is defined as a contraction of reduced strenght and/or duration, resulting in prolonged bladder emptying and/or failure to achieve complete bladder emptying within a normal time span (ICS in 2003). However, the majority of published criteria concentrate on detrusor strenght with the combinations of maximal flow rate (Qmax) and maximal detrusor pressure at Qmax (Pdet/Qmax) resulting incomplete consequence with regarde to definition perspective. Finally, many other tools have been proposed with the aim of chacterizing DU, but specific recommendations have been made on this regarding. The aim of our study is to evaluate the diagnostic performance of different DU definitions in a large cohort of patients undergoing urodynamic study. Material and Methods. We prospectively collected data of patients receiving urodynamic examination from February 2010 to September 2018 according to EAU guidelines. Urodynamic exam has been performed on the basis of ICS recommendations. DU has been considered as the presence of a defined as detrusorial pressure (pDet)/Qmax < 30 cmH20 and it has been considered as the reference variable. We also calculated different variables including: bladder contractility index (BCI), watt factor (WF) and bladder voiding efficiency (BVE). The following cut-offs have been considered as suggestive for DU according to previious literature data: BCI < 100, BVE < 100, WF80 < 10. Results. In total, 792 patients have been included, 65.1% male and 34.9% female. The median age was 63.0 yrs (interquartile range: 47.0-71.0). 232 pts (29.29%) had a Pdet/Qmax < 30 cmH20, 590 (74.49%) had a BVE < 100, 370 (46.72%) had a BCI < 100 while 540 (68.2%) had a WF80 < 10. The agreements using the kappa Cohen’s coefficients between PdetQmax and the other parameters were as following: with BCI was 77.53% (p<0.01), with BVE was 36.87% (p=0.98) and with WF80 was 48.66% (p<0.01). At the univariate logistic regression analysis, BCI < 100 (odds ratio [OR]: 26.96; p<0.01), BVE < 100 (OR: 1.44; p=0.03) and WF80 < 10 (OR: 5.35; p<0.01) were associated with PdetQmax < 30 cmH20. We performed a bivariate logistic regression combining BCI < 100 with the other parameters and we showed that BCI (OR 0.94; p<0.01) and W80 (OR: 0.89; p=0.02) were both associated with DU. Finally, the decision curve analysis showed clinical benefit of BCI in predicting DU, with slightly increase in net benefit of BCI+WF80 over BCI. Conclusions. We found that BCI and WF80 exhibited agreement with PdetQmax for assessing DU and that combining both variables add clinical benefit in predicting DU. We suggest in improving definition of DU by investigating the clinical benefits of other variables for assessing DU. Lo studio ha avuto finanziamenti: No Conflitto d’interessi: No Archivio Italiano di Urologia e Andrologia 2019; 91, 1, Supplemento 1 57