References

Bryer, E. (2005). A Literature Review of the Effectiveness of Ginger in Alleviating Mild-to-Moderate Nausea and Vomiting of. Journal of Midwifery & Women›s health, 50(1), e1-e3.

Chiarella, G., Marciano, G., Viola, P., Palleria, C., Pisani, D., Rania, V., . . . Gallelli, L. (2021). Nutraceuticals for Peripheral Vestibular Pathology: Properties, Usefulness, Future Perspectives and Medico-Legal Aspects. Nutrients, 13(10), 3646. doi:10.3390/nu13103646

Ding, M., Leach, M., & Bradley, H. (2012). The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting: A systematic review. Women and Birth, 26, 26-30.

Ensiyeh, J., & Sakineh, M. (2009). Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: a randomised controlled trial. Midwifery, 25, 649-653.

Ernst, E., & Pittler, M. (2000). Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. British Journal of anaesthesia, 84(3), 367-371.

Lete, I., & Allue, J. (2016). The Effectiveness of Ginger in the Prevention of Nausea and Vomiting during Pregnancy and Chemotherapy. Integrative Medicine Insights, 11, 11-17. doi:10.4137/IMI.S36273

Matok, I., Clark, S. C., Umans, J., Hankins, G., Mattison, D., & Koren, G. (2014). Studying the antiemetic effect of vitamin B6 for morning sickness: Pyridoxine and pyridoxal are prodrugs. The Journal of Clinical Pharmacology, 54(12), 1429-1433. doi:10.1002/jcph.369 Nunes, C., Rodriques, C., Cardaso, C., Cytrynbaum, N., Kaufman, R., Rzetelna, H., . . . Geller, M. (2020). Clinical Evaluation of the Use of Ginger Extract in the Preventive Management of Motion Sickness. Current Therapeutic Research, 1-7.

Ozgoli, G., Goli, M., & Simbar, M. (2009). Effects of Ginger Capsules on Pregnancy, Nausea, and Vomiting. The Journal of Alternative and Complementary Medicine, 15(3). doi:10.1089/acm.2008.0406

Sahakian, V., Rouse, D., Sipes, S., Rose, N., & Niebyl, J. (1991). Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study. Obstetrics and Gynecology, 78(1), 33-36.

Smith, C., Crowther, C., Willson, K., Hotham, N., & McMillian, V. (2004). A Randomized Controlled Trial of Ginger to Treat Nausea and Vomiting in Pregnancy. Obstetrics & Gynecology, 103(4), 639-645. doi:10.1097/01. AOG.0000118307.19798.ec

Quality and Product Development

DB Pharmaceuticals is a registered, Grade A certified pharmacy under the South African Pharmacy Council (SAPC) – with registration number Y60310.

We are fully compliant with the current South African Health Products Regulatory Authority (SAHPRA) and the Medicines and Related Substances Control Amendment Act, No. 19 of 1976 requirements for Category D – Complementary Medicines.

DB Pharmaceuticals welcomes SAHPRA’s approach to regulate the manufacture and sale of Complementary Medicines and Health Supplements which we believe will result in a safer, more efficient experience for patients who seek quality natural health products.

All our products old and new have been developed by our two in-house responsible pharmacists who have 37 years of experience between them.

Once products and formulations have been researched and developed the formulation is sent to our team of specialist formulary pharmacists at the manufacturing site who review and test formulations against recent research to ensure safety, quality, and efficacy. The manufacturing facility is licensed with the South African Health Products Regulatory Authority (SAHPRA) which is only granted after a positive GMP inspection by the regulator.

The manufacturing plant is further accredited by the South African Pharmacy Council as a pharmacy owner, grading certificate Grade A, and recording of a pharmacy.

Certification of the manufacturing plant also includes a Department of Health Manufacturing Pharmacy certificate and a Certificate of Acceptability for Food Premises and is registered with the South African National Department of Health.

36 Sovereign Drive, Route 21 Corporate Park, Irene, Centurion Gauteng, South Africa 0062 info@preganause.co.za www.preganause.co.za Helpline: 012 111 8313

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