Really genetic plays behind baldness
ROLE OF GENES IN BALDNESS
M.B.B.S., M.S., M.Ch. (PLASTIC AND COSMETIC SURGERY)
DR ANAND KUMAR NAGWANI
Genetic Engineering  The Medical science in the form of Genetic
Engineering for baldness is still long way to go.  Medical scientists, genetic engineers are duing research, but everyone has agreed on the point that genes play an important role I your baldness.  Baldness in majority of cases is a genetic trait that is going to next generation.
Medical Genetic Engineering
Facts of Passing of Genes
 Above figure is giving us diagrammatic
representative how passing the genetic information from maternal grandfather and paternal grandfather to the bald person.  It is clear that male pattern baldness is most common result of genetics, so what we can expect with treatment is to delay and reduce
the symptom of baldness.
About 80% of baldness in male is due to heredity and 20% due to Stress, Diet,and other causes. CAUSES OF BALDNESS
Genetic Others
Genetics
SEX Chromos ome
Polygenic Nucleotide polymorphism – Mutation Autosomal Dominent
Autosomal Ressessive Baldness in ofspring
Early Age Baldness
Sparse hair –hypotrichosis –begning in infancy it may remain stable or progress to alopecia
Premature Baldness
 Study of male pattern baldness identified
more than 200 independent genetic signals that were linked to differences in the trait, AR gene among or them is very important and commonly related to male pattern baldness.  DHT is responsible for acting on end organ in
hair follicle.
FUTURE
 Focus on genetic engineering
for repair of gene is very big challenge but it will take long time hope for future.
Present Treatment for Baldneess Medical treatment for genetic related
baldness is Finasteride a 5-alpha-reductase inhibitor. Finasteride is antiandrogen which decrease DHT production by 70% in prostate and the scalp. It is FDA approve drug.