Role of Genes in Baldness

Really genetic plays behind baldness

ROLE OF GENES IN BALDNESS

M.B.B.S., M.S., M.Ch. (PLASTIC AND COSMETIC SURGERY)

DR ANAND KUMAR NAGWANI

Genetic Engineering  The Medical science in the form of Genetic

Engineering for baldness is still long way to go.  Medical scientists, genetic engineers are duing research, but everyone has agreed on the point that genes play an important role I your baldness.  Baldness in majority of cases is a genetic trait that is going to next generation.

Medical Genetic Engineering

Facts of Passing of Genes

 Above figure is giving us diagrammatic

representative how passing the genetic information from maternal grandfather and paternal grandfather to the bald person.  It is clear that male pattern baldness is most common result of genetics, so what we can expect with treatment is to delay and reduce

the symptom of baldness.

About 80% of baldness in male is due to heredity and 20% due to Stress, Diet,and other causes.

CAUSES OF BALDNESS

Genetic Others

Genetics

SEX Chromos ome

Polygenic Nucleotide polymorphism – Mutation Autosomal Dominent

Autosomal Ressessive Baldness in ofspring

Early Age Baldness

Sparse hair –hypotrichosis –begning in infancy it may remain stable or progress to alopecia

Premature Baldness

 Study of male pattern baldness identified

more than 200 independent genetic signals that were linked to differences in the trait, AR gene among or them is very important and commonly related to male pattern baldness.  DHT is responsible for acting on end organ in

hair follicle.

FUTURE

 Focus on genetic engineering

for repair of gene is very big challenge but it will take long time hope for future.

Present Treatment for Baldneess  Medical treatment for genetic related

baldness is Finasteride a 5-alpha-reductase inhibitor.  Finasteride is antiandrogen which decrease DHT production by 70% in prostate and the scalp.  It is FDA approve drug.