Digestive Diseases Center 2020 Report - UChicago Medicine

The Digestive Diseases Center at the University of Chicago Medicine is a collaborative, multidisciplinary network of physicians, researchers and allied health professionals who share a legacy of innovation and a common purpose: to improve the lives of patients who suffer from digestive diseases.

Within the Digestive Diseases Center, a database of material pertaining to more than 5,000 patients, is the vital infrastructure for clinical trials of conventional and novel medical therapies intended to diagnose and treat a wide range of digestive diseases. In hepatology, we are currently conducting research in the areas of liver transplantation, viral hepatitis and other inflammatory liver disorders. Our research in nutrition is studying

Atsushi Sakuraba, MD, PhD

the impact of lactose intolerance in minority health outcomes, as well as

Director, Clinical Trials

obesity and celiac disease.

Other studies are examining the optimization of colorectal cancer screening for average and high-risk patients, the effects of genetic counseling, and the possibilities of chemoprevention. We are currently leading more than 200 research studies on human subjects with digestive diseases. This includes more than 20 IBD-related clinical trials, such as an NIH-supported human microbiome study that seeks to understand the role of intestinal

Kristi Kearney, RN Clinical Trials Manager

microbes in the development of IBD. Whether working independently or as part of multicenter research teams, we are asking—and answering—the questions that will lead to more effective treatments, better practice and better patient outcomes for healthcare professionals across the country and around the world.

Daniel Catenacci, MD, PhD Medical Director, Gastrointestinal Oncology

Researchers Atsuhi Sakuraba, MD, PhD Director, Clinical Trials

Daniel V.T. Catenacci, MD Director, Gastrointestinal Oncology

Assistant Professor of Medicine

Assistant Director, Translational Research, Comprehensive Cancer Center

Kristi Kearney, RN Clinical Trials Manager for Gastroenterology, Hepatology, Inflammatory Bowel Disease, Nutrition and Translational Research

Associate Professor of Medicine

Research Nurse

Clinical Trials in Digestive Diseases Novel therapies for Crohn’s disease and ulcerative colitis

Disparities in digestive diseases delivery of care Phase 3 clinical trials for Hepatitis C

Medical therapies for celiac disease Interventional trials related to advanced endoscopy The utility of chromoendoscopy in ulcerative colitis surveillance

Assessment of robotic and minimally invasive surgical outcomes Anastomotic leak prevention Innovative treatment trials in esophageal, hepatic, pancreatic, gastric and colorectal cancer

The role of the microbiome in IBD pathogenesis

Clinical Trials in Gastrointestinal Oncology Novel personalized and precision medicine therapies for gastrointestinal oncology including colorectal, gastric, esophageal, pancreatic, liver, bile duct/gallbladder, small bowel, neuroendocrine and anal cancers

Investigational phase III, II, and I studies for various perioperative and advanced settings and evaluating novel targeted therapies, immunotherapies and vaccines, and chemotherapeutic strategies to improve the outcomes of our patients

Contact To learn more about our clinical trials, call: 1 (773) 702-5382

For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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Through our groundbreaking research and patient care, we remain proudly at the forefront of digestive disease care.�

David T. Rubin, MD

VISION

Contents

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12

16

18

20

22

Center for Colon and Rectal Diseases

Center for Esophageal Diseases

Center for Endoscopic Research and Therapeutics (CERT)

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28

30

Center for Liver Diseases

Pancreatic Disease Center

General Gastroenterology

32

34

38

Gastrointestinal Cancer Risk and Prevention Clinic

Basic and Translational Research

Center for Gastrointestinal Oncology

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44

46

Inflammatory Bowel Disease Center

Center for the Surgical Treatment of Obesity

Celiac Disease Center

Center for Endoscopic Treatment of Obesity

Center for Small Bowel Disease and Nutrition

Clinical Research

We are steadfast believers in using interdisciplinary wisdom to improve the lives of our patients.

Our legacy is one of relentless patient advocacy. We are steadfast believers in close collaboration across multiple disciplines to improve the lives of our patients. We are the Digestive Diseases Center at the University of Chicago Medicine.

Our emphasis on patient-centric, collaborative medicine began when the visionary, driven and compassionate Joseph B. Kirsner, MD, joined the University of Chicago Medicine in 1935. He truly embodied the University of Chicago credo: We exist to change the world.

An Audacious Idea Throughout his storied 74-year career, Joseph B. Kirsner, MD, advanced a patient-centric model of care that encouraged prolific medical discovery and pushed clinical boundaries to change patient outcomes. Supported by the innovation of Nobel Laureates and other luminaries within the area of digestive diseases at the University of Chicago Medicine, Kirsner and his colleagues changed the face of digestive medicine.

Kirsner’s combination of audacity, clarity of purpose and humility, as well as his fundamental belief in the power of interdisciplinary, patient-focused care, has continued to bring like-minded professionals to the University of Chicago Medicine.

These bedrock principles remain the driving force behind the Digestive Diseases Center. We continue to set the standard for digestive disease care and are a preferred care destination for people from throughout the country and around the world.

The Next Generation of Care Kirsner’s colleague, friend and mentee, David T. Rubin, MD, was determined to keep the University of Chicago Medicine at the forefront of the field when he formed the Digestive Diseases Center in 2014. A visionary in his own right, Rubin organized the Center to be co-directed by a physician, and a surgeon—making it truly collaborative and innovative.

This team structure, led by Rubin and surgeon Neil H. Hyman, MD, has resulted in some of our most groundbreaking research and surgical successes to date. Supported by one of the most advanced research and clinical teams in the world, the Digestive Diseases Center has eliminated the ever-present silos that can diminish innovation. The Center is staffed with passionate caregivers and scientists who actively collaborate to deliver patient-centered medicine throughout the entire lifecycle—not just until the patient has received a diagnosis or treatment.

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Care Beyond Treatment Our exceptional care has made the Digestive Diseases Center one of the best in the country for gastroenterology and gastrointestinal surgery. However, it is our emphasis on improving the patient experience that has made us a go-to referral choice by doctors and a destination for patients worldwide.

Through bar-raising practitioner accessibility and practices that look at the whole patient, we strive to decrease the burden on patients and their families by: • Helping to arrange travel and appointments for patients living outside the Chicago area who have come to the University of Chicago Medicine for care • Building online networks, forums and information sessions to extend support to patients unable to travel to one of our locations • Decreasing appointment wait times for new patients to less than two weeks • Offering patients access to leading-edge minimally invasive surgeries and techniques, including our distinguished robotic surgery program Our goal is simple: Improve the lives of our patients. To ensure that goal is met, our involvement doesn’t end once we’ve delivered a diagnosis. Once a patient has joined the Digestive Diseases Center network, they are in our care throughout treatment, surgery, recovery and ongoing symptom management.

Moreover, patients who come to the Digestive Diseases Center get access to world-class physicians who work with patients, their providers and their families to develop treatments that incorporate some of the best technology, research and intellect in the world.

With discovery and innovation so deeply engrained in the work of our institution, we continuously push boundaries to remain at the forefront of advances in digestive disease care.

David T. Rubin, MD, (left) and Neil H. Hyman, MD For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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History First full-time academic section in gastroenterology founded

by Walter L. Palmer, MD, PhD

First hospital to use a gastroscope to view organs of the digestive system

1934

1927

1935

1938

Joseph B. Kirsner, MD, joined the staff at the University of Chicago Medicine

Developed first animal models of inflammatory bowel disease and discovered that patients with active colitis lost high levels of protein

1940’s

William E. Adams, MD, and Dallas B. Phemister, MD, performed the first curative esophagogastrostomy for cancer with intrathoracic anastomosis in the U.S.

Developed surgeries to avoid the need for an ileostomy when removing the colon

1960s

1955 Lester R. Dragstedt, MD, played an instrumental role in the first successful separation of Siamese twins by dividing their liver

1962 Kirsner co-founded the Gastro-Intestinal Research Foundation, for which he was a tireless fundraiser for medical research

Discovered the first Crohn’s disease gene (NOD2)

1990 Launched the NIH-funded Digestive Diseases Research Core Center

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2001

2004 Identified roles of intestinal heat shock protein (Hsp70) in immunomodulation of intestinal lymphoid cells and host defense against invasive pathogens

2014 David T. Rubin, MD, formalized the University of Chicago Medicine’s Digestive Diseases Center The University of Chicago Medicine pioneered a new IBD treatment combining cyclosporin and similar drugs with vedolizumab to help patients with severe IBD avoid surgery

Developed vagotomy, still in use today, for treatment of ulcers

1943

1947

1944 Discovered the relationship between a shortage of dietary protein and decreased immune function and surgical infection

1985

1989

1988

First segmental liver transplant in the U.S

First split-liver transplant in the U.S.

Developed the “rat depletion model,” used to determine the minimum daily requirements for the essential amino acids, calories and potassium

First successful living donor transplant in the world

Performed the nation’s first back-to-back heart-liver-kidney transplants in two patients

Identified reovirus as a potential initiator of celiac disease

2015 Identified the genetic and microbiome drivers of pouchitis

For referrals and consultations: 1 (844) UC GI DOC

2017

2018 John C. Alverdy, MD, received the American Surgical Association’s Flance-Karl Award for identifying the invasive bacteria that lead to surgical anastomotic leakage and failure

For more information visit: UChicagoMedicine.org/GI

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Destination UChicago Medicine: Personalized Support for Traveling Patients Each year thousands of patients from around the world travel to Chicago to meet with and receive care from the medical teams at the Digestive Diseases Center.

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Our team is committed to making access to care seamless for those who travel to us. Our mission is to help reduce the anxiety that traveling for care can cause

”

through our empathic outreach.

Caroline Costello, Director, Destination UChicago Medicine

Understanding that traveling away from home can

during their visit to Chicago. The team assists with

be overwhelming, the University of Chicago Medicine

appointment scheduling, including the first visit and

established Destination UChicago Medicine, a patient follow-up needs, retrieval of medical records from concierge service for patients coming from outside

various providers, travel recommendations, hotel

the Chicagoland area to receive care at the University

information, reservations and local areas of interest,

of Chicago Medicine. The goal is to take care of all

as well as in-person help for any patient services

the planning and scheduling related to a patient’s

located on the medical campus.

stay in Chicago, and to ease the burden and worry of

“Our team is committed to making access to care

receiving care away from home.

seamless for those who travel to us,” said Destination

As one of the top medical centers in the field,

UChicago Medicine Director Caroline Costello. “Our

the Digestive Diseases Center sees patients from

mission is to help reduce the anxiety that traveling

all corners of the world. This draw makes the

for care can cause through our empathic outreach.”

Destination UChicago Medicine program incredibly

To access care or refer a patient to the program,

important for our patients and is a vital component

call 773-702-0525 or email DestinationUChicago@

of our patient-centric approach.

uchospitals.edu.

The dedicated Destination UChicago Medicine team supports patients before their arrival and

Kimberly Muhammad, Patient Navigation Coordinator, (left), Judy Gilbert, MHA, Program Manager and Natalie Jackson, Patient Experience Liaison For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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INFLAMMATORY BOWEL DISEASE CENTER

Russell D. Cohen, MD

The Inflammatory Bowel Disease Center is committed to providing the highest caliber of care to patients who suffer from Crohn’s disease, ulcerative colitis and other related conditions. From providing state-of-the-art medical therapies and nutritional counseling to using minimally invasive approaches for complex surgeries to decrease pain, scarring and recovery times, outstanding patient care is at the center of everything we do.

In order to best serve our patients, we conduct ongoing medical research to advance our understanding of these conditions. We also deliver unique and highly relevant educational programs for patients and professionals. As one of only a limited number of research centers in the country testing new

Russell D. Cohen, MD Director, Inflammatory Bowel Disease Center

David T. Rubin, MD Chief, Section of Gastroenterology, Hepatology, and Nutrition Co-Director, Digestive Diseases Center

IBD treatments, we can offer a variety of clinical trial therapies—the most advanced treatments available—at the earliest possible time in patients’ care. Every patient benefits from the expertise of our world-renowned clinicians and researchers, whose multidisciplinary, collaborative approach extends from patient care to advancing the science of medicine.

Neil H. Hyman, MD

Physicians

Co-Director, Digestive Diseases Center

Adult Gastroenterology

Surgery

Russell D. Cohen, MD Director, Inflammatory Bowel Disease Center

Neil H. Hyman, MD Co-Director, Digestive Diseases Center

Professor of Medicine

Chief, Colon and Rectal Surgery

Sushila Dalal, MD Director, Program for Fertility, Pregnancy and Sexual Function in Inflammatory Bowel Disease

Professor of Surgery

Assistant Professor of Medicine Ira Hanan, MD Professor of Medicine Edwin K. McDonald IV, MD Associate Director, Adult Clinical Nutrition Assistant Professor of Medicine Joel Pekow, MD Assistant Professor of Medicine David T. Rubin, MD Co-Director, Digestive Diseases Center Chief, Section of Gastroenterology, Hepatology, and Nutrition Joseph B. Kirsner Professor of Medicine Atsushi Sakuraba, MD, PhD Assistant Professor of Medicine

Pediatric Gastroenterology Ranjana Gokhale, MD Associate Director, Inflammatory Bowel Disease Center

Roger D. Hurst, MD Associate Director, Inflammatory Bowel Disease Surgery Professor of Surgery

Chief, Colon and Rectal Surgery

Eugene B. Chang, MD Associate Director, Inflammatory Bowel Disease Center

Benjamin Shogan, MD Assistant Professor of Surgery Konstantin Umanskiy, MD Associate Professor of Surgery

Research Eugene B. Chang, MD Director, Digestive Diseases Research Core Center Director, Host-Microbe Core Associate Chief, Research

Ranjana Gokhale, MD Associate Director, Inflammatory Bowel Disease Center

Associate Director, Inflammatory Bowel Disease Center Martin Boyer Professor of Medicine Christopher Weber, MD, PhD Professor of Pathology A. Murat Eren, PhD Assistant Professor of Medicine

Roger Hurst, MD Associate Director, Inflammatory Bowel Disease Center

Associate Professor of Pediatrics Ritu Verma, MBChB Medical Director, Celiac Disease Center Section Chief of Pediatric Gastroenterology, Hepatology, and Nutrition Professor of Pediatrics For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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Physicians

(continued)

Bana Jabri, MD, PhD Co-Director, Digestive Diseases Research Core Center Director, Integrated Translational Research Core

Specialty Pharmacy Shivani Patel, PharmD Associate Director, Inflammatory Bowel Disease Center

Vice Chair, Research, Department of Medicine Shivani Patel, PharmD

Director, Research for Celiac Disease Center

Associate Director, Inflammatory Bowel Disease Center

Professor of Medicine and Pathology and Pediatrics

Advanced Practice Nurses Gastroenterology Care

Surgical Care

Emily A. Dobrez, APN Jennifer Labas, APN Ashley Perkovic, APN Alexandra Masching, APN

Noelle Kakuk, APN Michele Rubin, APN Associate Director, Inflammatory Bowel Disease Center

Michele Rubin, APN

Ostomy Clinic

Associate Director, Inflammatory Bowel Disease Center

Janice Colwell, APN Michele Kaplon-Jones, APN Paulina Petrishka, APN

Nutritionists Courtney Schuchmann, MS, RD, LDN Elizabeth Wall, MS, RD, LDN

Lori Welstead, MS, RD, LDN

Services Secondary or tertiary care for the most complex and difficult IBD cases Advanced mucosal imaging techniques for surveillance and detection of cancer and precancerous changes in the bowel mucosa (chromoendoscopy)

Upper GI endoscopy, colonoscopy Ileoscopy Pouchoscopy Wireless capsule endoscopy (“pill camera”) Ostomy care

CT/MRI enterography

Surgical services

Dedicated small bowel radiography

Bowel resections (traditional, minimally invasive, robotic)

Endoscopic retrograde cholangiopancreatography (ERCP) Interventional endoscopy Enteroscopy, traditional and deep (balloon-assisted) Flexible sigmoidoscopy and colonoscopy Positron emission technology (PET) scans Radionucleotide scanning

Strictureplasties “J” pouch formations Ileostomy, colostomy Specialized surgeries

Contact To learn more about the Inflammatory Bowel Disease Center, please visit: uchicagomedicine.org/ibd For referrals and consultations, please call: 1 (844) UC GI DOC (824–4362) An IBD patient support group meets regularly. For more information, please visit: uchicagomedicine.org/ibd-events

Number of patients seen in last 12 months More than

10

6,000

New Guidelines Help Ulcerative Colitis Patients Experience Sustained Remission At the Digestive Diseases Center, we are constantly working toward a better patient experience. For patients with ulcerative colitis (UC), which affects roughly one million Americans, this means relieving symptoms, preventing harmful secondary effects that may be brought on by treatment and helping patients into remission.

Since the previous guidelines were introduced in 2010, we’ve had tremendous advances in the management of UC, and we’ve moved from being reactive to being much more proactive to achieve sustained, stable remission and minimize complications. We looked to develop new guidelines that sufficiently reflect

”

today’s understanding and, in turn, provide better care for our patients.

David T. Rubin, MD, founder and co-director of the Digestive Diseases Center

New guidelines for diagnosing and managing UC

They aim to help doctors better prevent and care

—developed by David T. Rubin, founder and co-

for patients with UC by shifting from managing

director of the Digestive Diseases Center, as well as

flare-ups to better monitoring and preventing them

chief of gastroenterology, hepatology and nutrition,

in the first place.

in collaboration with a team of experts – aim to do

In practice, these guidelines encourage a sustained

just that.

period of remission from inflammation and

The guidelines, published in the March 2019 issue of

ulcers and decrease the possibility of surgery or

The American Journal of Gastroenterology, represent

hospitalization and cancer risk—resulting in a better

a significant step forward in the treatment of UC and

quality of life. These new guidelines also rely less on

are now the official practice recommendations of the

traditionally used steroids.

American College of Gastroenterology.

For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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Ritu Verma, MBChB Medical Director, Celiac Disease Center

Stefano Guandalini, MD Founder, Celiac Disease Center

CELIAC DISEASE CENTER

Bana Jabri, MD, PhD Research Director, Celiac Disease Center

Ritu Verma, MBChB Hilary Jericho, MD, MSCI Director of Pediatric Clinical Research

The University of Chicago Medicine’s Celiac Disease Center is an internationally recognized center of excellence providing comprehensive patient and professional education, expert diagnosis and treatment for both children and adults, groundbreaking bench and clinical research, and active leadership in advocacy efforts.

Our mission is to cure celiac disease. As we focus on research toward a cure, we also strive to raise awareness and diagnosis rates through education and advocacy.

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Physicians Stefano Guandalini, MD Founder, Celiac Disease Center

Sonia S. Kupfer, MD Director of Clinical Genetic Research, Celiac Disease Center

Professor Emeritus of Pediatrics

Director, Gastrointestinal Cancer Risk and Prevention Clinic

Ritu Verma, MBChB Medical Director, Celiac Disease Center

Co-Director, Comprehensive Cancer Risk and Prevention Clinic

Section Chief of Pediatric Gastroenterology, Hepatology, and Nutrition Professor of Pediatrics Bana Jabri, MD, PhD Co-director, Digestive Diseases Research Core Center

Associate Professor of Medicine, Section of Gastroenterology and Center for Clinical Cancer Genetics

Director, Integrated Translational Research Core

Carol Semrad, MD Director, Small Bowel Disease and Nutrition Program

Vice Chair, Research, Department of Medicine

Director of Adult Clinical Research, Celiac Disease Center

Research Director, Celiac Disease Center

Professor of Medicine

Professor of Medicine, Pathology and Pediatrics

Vijaya Rao, MD Assistant Professor of Medicine

Hilary Jericho, MD, MSCI Director of Pediatric Clinical Research, Celiac Disease Center

Sonia S. Kupfer, MD Director of Clinical Genetic Research, Celiac Disease Center

Carol Semrad, MD Director of Adult Clinical Research, Celiac Disease Center

Assistant Professor of Pediatrics

Dieticians Lori Welstead, MS, RD, LDN Courtney Schuchmann, MS, RD, LDN

Macy Mears, MS, RDN, LDN Vicki Gainsberg, RD, LDN

Services Expert diagnostic practices and evidence-based, patient-focused and family-oriented care of adult and pediatric celiac disease patients

Lori Welstead, MS, RD, LDN

Activities Patient education and resources, including an online Answer Bank and Essentials of Celiac Disease and the Gluten-Free Diet guide

Contact To learn more about the Celiac Disease Center or explore our physician and patient resources, please visit: cureceliacdisease.org To refer patients to one of our celiac specialists, please call: 1 (773) 702–6140 for adults; 1 (773) 702-6169 for children

Number of patients treated in last 12 months Approximately

1,200

For referrals and consultations: 1 (844) UC GI DOC

children and adults

For more information visit: UChicagoMedicine.org/GI

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Understanding Celiac Disease The University of Chicago Celiac Disease Center research team, led

by Dr. Bana Jabri, continues to make great strides in determining what triggers the abnormal reaction to gluten in celiac disease and is working toward finding a cure for the disease.

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Care Beyond Treatment

A 2017 study published in Science focused on

Recent research from Dr. Jabri and other researchers

reovirus as a trigger for celiac disease (and other

and physicians at the University of Chicago published in Cell found that the chronic inflammation in the

autoimmune disorders) and proved that intestinal viruses can induce the immune system to overreact to

small intestine caused when someone with celiac

gluten and trigger the development of celiac disease.

disease eats gluten can lead to permanent damage

Using two different reovirus strains, the researchers

to the intestine. The research found that chronic

showed how genetic differences between viruses

inflammation in celiac disease displaces the tissue-

can change how they interact with the immune

resident lymphocytes normally found in the healthy

system. The research has now put the experts at the

intestine and replaces them with new immune cells

Digestive Diseases Center in the position to precisely

that show sensitivity to gluten.

define the viral factors responsible for the induction

The study showed that chronic inflammation in

of the autoimmune response.

patients with celiac disease permanently scars the

The new research raises the possibility that vaccines

community of immune cells in the small intestine,

targeting viruses infecting the intestine could one

which may have a lasting impact on how the gut

day be used to protect children at risk for celiac and

responds in the future.

other autoimmune disorders.

The Possibility of a Vaccine Other recent research led by Dr. Jabri looks at the connection between celiac disease and reovirus, a common, but otherwise harmless virus.

Bana Jabri, MD, PhD

For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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CENTER FOR SMALL BOWEL DISEASE AND NUTRITION 16

Carol Semrad, MD

The Small Bowel Disease and Nutrition Program includes comprehensive management of small bowel bleeding, short bowel syndrome/intestinal failure, celiac disease and obesity. We were one of the first in the United States to perform double balloon enteroscopy for the treatment of small bowel bleeding and use expert radiologists in small bowel imaging and minimally invasive small bowel surgery.

We are uniquely staffed by a multidisciplinary nutrition support team to diagnose and manage short bowel syndrome/intestinal failure, diarrhea/malabsorption syndromes, and patients with feeding difficulties. The team, established in 1980, provides expert administration of parenteral and enteral nutrition in the inpatient and outpatient setting.

Our obesity management program is unique in its focus on nutrition education by a certified physician-chef. In addition to the education and treatments provided to our patients, we also are actively researching novel therapies in the treatment of celiac disease, short bowel syndrome and other intestinal disorders.

Physicians Gastroenterology

Surgery

Carol Semrad, MD Director, Small Bowel Disease and Nutrition Program

John C. Alverdy, MD, FACS Executive Vice Chair, Department of Surgery Sara and Harold Lincoln Thompson Professor of Surgery

Director of Adult Clinical Research, Celiac Disease Center

Mustafa Hussain, MD Medical Director, Bariatric Surgery

Professor of Medicine Hilary Jericho, MD Assistant Professor of Pediatrics

Assistant Professor of Surgery Vivek Prachand, MD, FACS Chair, Surgical Quality Improvement and Patient Safety

Edwin K. McDonald IV, MD Associate Director, Adult Clinical Nutrition Assistant Professor of Medicine

Carol Semrad, MD Director, Small Bowel Disease and Nutrition Program

Professor of Surgery

Dejan Micic, MD Assistant Professor of Medicine

Yalini Vigneswaran, MD Assistant Professor of Surgery

Nutrition Support Team Jean Herlitz, RN Physician Resource Nurse

Elizabeth Wall, MS, RD, CNSC, LDN

Edwin K. McDonald IV, MD

Annie Widlicka, MS, RD, CNSC, LDN

Associate Director, Adult Clinical Nutrition

Scott Lozano, PharmD, BCNSP Clinical Pharmacist

Services Video capsule endoscopy Double balloon enteroscopy Laparoscopic resection of small bowel lesions

Contact

Dejan Micic, MD

For referrals and consultations, call: 1 (844) UC GI DOC (824–4362)

Elizabeth Wall, MS, RD, CNSC, LDN

Dejan Micic, MD, (left), Edwin K. McDonald IV, MD

For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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CENTER FOR COLON AND RECTAL DISEASES 18

Neil H. Hyman, MD, (left), with resident Kristina Guyton, MD

The University of Chicago Medicine has a rich tradition of national leadership and innovation in the surgical management of complex colorectal disease, especially IBD and sphincter-saving approaches to rectal cancer. Our team, as part of the Digestive Diseases Center, continues to build on this legacy in the treatment of a wide range of challenging colon, rectal and anal diseases, including pelvic floor disorders and perianal disease.

We are recognized experts in the surgical treatment of these diseases and, when appropriate, use some of today’s most advanced, leading-edge surgical techniques. In fact, more than half of colorectal surgeries we perform are done using minimally invasive techniques.

Our collaborative team approach—including physician assistants, medical assistants, nurses and nurse practitioners, as well as highly experienced enterostomal and wound care nurses— has a profound effect on patient outcomes. Our combined expertise ensures that each patient receives the care he or she needs to thrive after surgery.

Physicians Neil H. Hyman, MD Co-Director, Digestive Diseases Center Chief, Colon and Rectal Surgery Professor of Surgery

Benjamin Shogan, MD Assistant Professor of Surgery Konstantin Umanskiy, MD Associate Professor of Surgery

Roger Hurst, MD Professor of Surgery Neil H. Hyman, MD

Advanced Practice Nurses Noelle Kakuk, APN Nurse Practitioner

Meredith Stidham, APN, MSN, RN

Co-Director, Digestive Diseases Center Chief, Colon and Rectal Surgery

Michele Rubin, APN, CNS, CGRN IBD Nurse Specialist

Wound Ostomy and Skin Care Nurses Janice C. Colwell, RN, MS, CWOCN, FAAN Stoma Nurse

Paulina Petrishka, APN Stoma Nurse

Michele Kaplon-Jones, MSN, RN, ANP-BC, CWOCN Stoma Nurse

Roger Hurst, MD

Conditions and Services Intraoperative radiation therapy (IORT)

Oncology

Pelvic floor disorders

Colon cancer

Sacral nerve stimulation

Rectal cancer

Endoanal ultrasound

Anal cancer

Anorectal manometry, electromyography, and pudendal nerve testing

Second opinion services Management of hereditary colorectal cancer

Dynamic and MRI defecography and transit studies Prolapse repair Treatment of constipation Fecal incontinence

Polyposis Laparoscopic colon cancer surgery Robotic rectal cancer surgery Transanal endoscopic microsurgery (TEMS)

Colon and rectal disease

Diagnostic and surveillance colonoscopy

Complicated diverticular disease

Endorectal ultrasound and pelvic MRI

Presacral tumor excision Treatment of colonic volvulus Endometriosis Lower GI carcinoid

Perianal disease

Konstantin Umanskiy, MD

Inflammatory bowel disease Crohn’s disease

Benjamin Shogan, MD

Ulcerative colitis Perianal fistulizing disease

Hemorrhoids

Laparoscopic surgery for inflammatory bowel disease

Anal fissure

Reoperative disease

Management of abscess and fistula

J-pouch procedure

Rectovaginal fistula treatment

Advance enterostomal nursing care

Sexually transmitted diseases

State-of-the-art diagnostic imaging

Janice C. Colwell, RN, MS, CWOCN, FAAN

Pruritis ani Pilonidal disease Paget’s disease of the anus

Contact To learn more about the Center for Colon and Rectal Diseases, please visit: uchicagomedicine.org/colon-rectal-surgery

Michele Rubin, APN, CNS, CGRN

To schedule an admission, make a referral or request a consultation, please call UCM Physician Connect at: 1 (800) 824–2282

For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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CENTER FOR ESOPHAGEAL DISEASES 20

Mitchell C. Posner, MD

The Center for Esophageal Diseases is one of the few centers in the U.S. dedicated solely to the diagnosis and treatment of esophageal disease.

We bring together nationally and internationally recognized clinicians and researchers in a variety of related disciplines to provide patients with advanced options, resources and a level of experience and innovation available at only a handful of leading medical centers in the world. Our approach is both personalized and multidisciplinary, and our outcomes are considered a model for outstanding patient care.

Physicians Irving Waxman, MD Director, Center for Endoscopic Research and Therapeutics

Surgery John C. Alverdy, MD, FACS Executive Vice Chair, Department of Surgery

Sara and Harold Lincoln Thompson Professor of Medicine and Surgery

Sara and Harold Lincoln Thompson Professor of Surgery

Pediatric Gastroenterology

Mark K. Ferguson, MD Professor of Surgery

Tiffany J. Patton, MD Assistant Professor of Pediatrics

Mustafa Hussain, MD Medical Director, Bariatric Surgery

Pulmonology

Robert T. Kavitt, MD, MPH Director, Center for Esophageal Diseases

Edward Garrity, MD Professor of Medicine

Assistant Professor of Surgery Mitchell C. Posner, MD Chief, Surgical Oncology

D. Kyle Hogarth, MD Director, Bronchoscopy and Minimally Invasive Diagnostics

Chief, General Surgery Medical Director, Clinical Cancer Programs Physician-in-Chief, Comprehensive Cancer Center

Co-Director, Upper Aerodigestive Cancer Risk Clinic Medical Director, Pulmonary Rehabilitation Program Professor of Medicine

Thomas D. Jones Professor of Surgery Vivek N. Prachand, MD, FACS Chief Quality Officer, Department of Surgery

Ear, Nose & Throat Elisabeth Blair, MD Professor of Surgery

Director of Minimally Invasive Surgery Professor of Surgery

John C. Alverdy, MD, FACS Executive Vice Chair, Department of Surgery

Louis de Guzman Portugal, MD Professor of Surgery

Yalini Vigneswaran, MD, MS Assistant Professor of Surgery

Medical Oncology

Adult Gastroenterology

Daniel Catenacci, MD Medical Director, Gastrointestinal Oncology

Robert T. Kavitt, MD, MPH Director, Center for Esophageal Diseases

Assistant Director, Translational Research

Associate Professor of Medicine

Associate Professor of Medicine

Christopher Chapman, MD Director, Bariatric and Metabolic Endoscopy Assistant Professor of Medicine Uzma Siddiqui, MD Director, Center for Endoscopic Research and Therapeutics Professor of Medicine

Pathology

Mitchell C. Posner, MD, FACS

John Hart, MD Professor of Pathology

Chief, General Surgery

Chief, Surgical Oncology

Namrata Setia, MD Assistant Professor of Pathology

Nurses Megan Henry, RN, BSN

Leslie Mote, LPN

Services

Uzma Siddiqui, MD

Endoscopy Evaluation and treatment of eosinophilic esophagitis

ENT evaluation of vocal cord problems related to GERD

Associate Director, Center for Endoscopic Research and Therapeutics

Evaluation of respiratory disorders such as cough or asthma of unknown origin, IPF

Endoscopic dilatation Endoscopic ultrasound

Minimally invasive myotomy for achalasia

Radiofrequency ablation

POEM (Per-Oral Endoscopic Myotomy)

Endoscopic mucosal resection

Minimally invasive antireflux surgery

High-resolution esophageal manometry

Minimally invasive treatment of paraesophageal hernia

Catheter-based pH/impedance testing

Multimodal therapy for esophageal cancer

Wireless pH testing Radiology

Minimally invasive resection for esophageal cancer

Irving Waxman, MD

Cryotherapy

Director, Center for Endoscopic Research and Therapeutics

Contact To learn more about the Center for Esophageal Diseases, please visit: uchicagomedicine.org/esophageal-diseases To make a referral or request a consultation, please call: 1 (844) UC GI DOC (824–4362)

For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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CENTER FOR ENDOSCOPIC RESEARCH AND THERAPEUTICS (CERT) 22

Uzma Siddiqui, MD

CERT offers patients, and their referring physicians, the benefits of endoscopic expertise, as well as a comprehensive approach to patient care. Our resources—from leading-edge technology to physicians, advanced practice nurses and scheduling staff—are exclusively dedicated to serving CERT patients.

Our state-of-the-art endoscopy suite, located in the Center for Care and Discovery, offers the most advanced complement of technologies in the region. We use these technologies to diagnose and/or treat a wide variety of complex gastrointestinal disorders, including esophageal and pancreatic cancers, large colon polyps, pancreatic and bile duct stones, pancreatitis and Barrett’s esophagus.

Physicians Irving Waxman, MD Director of The Center for Endoscopic Research and Therapeutics (CERT) Sara and Harold Lincoln Thompson Professor of Medicine, Surgery and The University of Chicago Comprehensive Cancer Center Uzma Siddiqui, MD Associate Director, Center for Endoscopic Research and Therapeutics (CERT) Director, Advanced Endoscopy Training and Endoscopic Ultrasound Professor of Medicine

Christopher Chapman, MD Director, Bariatric and Metabolic Endoscopy Assistant Professor of Medicine

Services Endoscopic ultrasound (EUS)

Complex polypectomy

Fine-needle aspiration (FNA)

Radiofrequency ablation (RFA) of Barrett’s esophagus, radiation proctitis, and gastric antral vascular ectasia (GAVE)

Celiac plexus nerve block Endoscopic retrograde cholangiopancreatography (ERCP)

Confocal laser endomicroscopy (CLE) Pancreatic pseudocyst drainage and necrosectomy

Cholangioscopy Ablation of cholangiocarcinoma with photodynamic therapy (PDT) and radiofrequency ablation (RFA)

Irving Waxman, MD Director, Center for Endoscopic Research and Therapeutics

Endoscopic suturing Palliative stenting of GI tract and pancreaticobiliary malignancies

Lithotripsy of large biliary and pancreatic duct stones

Extracorporeal shock wave lithotripsy

Ampullectomy

(ESWL) for pancreatic stones

Endoscopic mucosal resection (EMR)

Per-oral endoscopic myotomy (POEM)

Endoscopic submucosal dissection (ESD) Uzma Siddiqui, MD

Contact To learn more about the Center for Endoscopic Research and Therapeutics, please visit:

Associate Director, Center for Endoscopic Research and Therapeutics

uchicagomedicine.org/cert To schedule an admission, make a referral or request a consultation, please call UCM Physician Connect at: 1 (800) 824–2282 or contact the center directly at: 1 (773) 702–1459

Christopher Chapman, MD Director, Bariatric and Metabolic Endoscopy

Christopher Chapman, MD, (left), Irving Waxman, MD, and Uzma Siddiqui, MD

Number of patients seen in last 12 months More than

2,000

For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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Michael Charlton, MD Director, Center for Liver Diseases Co-Director, Transplant Institute Professor of Medicine

Michael Charlton, MD

Andrew Aronsohn, MD

CENTER FOR LIVER DISEASES

Program Director, GI Fellowships

Ruba K. Azzam, MD Medical Director, Pediatric Liver Transplant Program

For more than 20 years, the Center for Liver Diseases has helped set the standard of care for the management of many liver diseases, including chronic hepatitis C, which has now reached the pinnacle of its therapy. We also have helped shape the therapeutic journey toward a cure for chronic hepatitis B. Today, we are helping to find an effective treatment for nonalcoholic fatty liver disease, and we are studying various biologic markers for the diagnosis and potential treatment targets of liver cancer.

Sonali Paul, MD Director, Metabolic and Fatty Liver Clinic

Our experienced team of hepatologists, mid-level providers and specialty nurses work with patients very closely to deliver personalized medicine that addresses each patient’s needs.

Our liver transplant program is renowned nationally and worldwide. It is the oldest in the Midwest, and fourth oldest in the nation. Our program has the lowest waitlist mortality

Anjana Pillai, MD Medical Director, Liver Tumor Clinic

in Illinois—that is, patients on our waitlist have the lowest chance of dying before they receive a liver transplant. We also have excellent graft and patient survival rates that are either at or above expectations for our patient population.

Physicians Hepatology K. Gautham Reddy, MD

Michael Charlton, MD Director, Center for Liver Diseases Co-Director, Transplant Institute Professor of Medicine Andrew Aronsohn, MD Program Director, GI Fellowships Associate Professor of Medicine

Ruba K. Azzam, MD Medical Director, Pediatric Liver Transplant Program Associate Professor of Pediatrics Sonali Paul, MD Assistant Professor of Medicine Anjana Pillai, MD Medical Director, Liver Tumor Clinic Program Director, Transplant Hepatology Fellowship Associate Professor of Medicine

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K. Gautham Reddy, MD Associate Professor of Medicine

J. Michael Millis, MD Vice Chair, Global Surgery

Helen S. Te, MD Medical Director, Adult Liver Transplant Program Professor of Medicine

Professor of Surgery Diego DiSabato, MD Director, Living Donor Liver Transplant Program Assistant Professor of Surgery

Surgery

Medical Oncology

John Fung, MD, PhD Co-Director, Transplant Institute

Chih-Yi “Andy” Liao, MD Assistant Professor of Medicine

Chief, Transplant Surgery

Helen S. Te, MD Medical Director, Adult Liver Transplant Program

Anu Neerukonda, MD Assistant Professor of Medicine

Professor of Surgery Talia Baker, MD Surgical Director, Liver Transplantation Associate Professor of Surgery

Advanced Practice Nurses Melanie Samardzija, APN, PhD Hepatology Nurse Practitioner

Elizabeth Reyna, MSN, AGNP-C Hepatology Nurse Practitioner

John Fung, MD, PhD Co-Director, Transplant Institute Chief, Transplant Surgery

Services Multidisciplinary evaluation and management of hepatitis, fatty liver disease, cirrhosis, liver cancer, benign liver masses, hepatic vascular disorders and other liver diseases Liver fibrosis assessments Hepatobiliary surgery Laparoscopic liver surgery Liver transplantation and multi-organ transplantation

Clinical trials for novel therapies of liver diseases and the complications of cirrhosis, hepatocellular carcinoma, and for novel immunosuppressive agents Innovative management strategies for challenging patient cases, including liver resection for large hepatic malignancies, liver transplantation for cholangiocarcinoma and more advanced hepatocellular carcinoma, liver transplantation for obese patients

Talia Baker, MD Surgical Director, Liver Transplantation

Contact We treat patients at several locations in Chicago, its suburbs and Northwest Indiana. For location details and more information about the Center for Liver Diseases, please visit: uchicagomedicine.org/liver-diseases For referrals for liver transplantation, please call UCM Liver Transplant Intake Center at: 1 (773) 702–4500 For liver cancer referrals, as well as any other referrals and consultations, please call UCM Physician Connect at: 1 (800) 824–2282

J. Michael Millis, MD Vice Chair, Global Surgery Professor of Surgery

Diego DiSabato, MD Director, Living Donor Liver Transplant Program

Melanie Samardzija, APN, PhD

Sonali Paul, MD, (left), K. Gautham Reddy, MD, and Michael Charlton, MD

Elizabeth Reyna, MSN, AGNP-C For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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Breakthroughs in Transplant Surgery – The Legacy Continues The University of Chicago Medicine has a legacy of being at the forefront of medical breakthroughs in transplant surgery. We are known for a number of firsts: The first segmental liver transplant in the U.S. (1985), the first split-liver transplant in the U.S. (1988) and the first successful living donor transplant in the world (1989).

At the Digestive Diseases Center, we are continuing

Both patients, Sarah McPharlin, 29, and Daru Smith,

and expanding upon this legacy. Our revolutionary

29, were in critical need of heart, liver and kidney

multi-organ transplant surgeries, spearheaded by

transplants. When the team was notified about

John Fung, MD, PhD, chief of the section of

donor matches for both patients, they immediately

transplant surgery, inaugural director of the

got to work.

Transplant Institute and world-renowned leader in

Daru and Sarah’s surgeries took 17 and 20 hours

the field of organ transplantation, have placed the

to complete, respectively. With time being such

Digestive Diseases Center at the top of national

a significant factor, the complex triple surgeries

rankings for such procedures.

highlighted the importance of coordination

Back-to-Back Triple-Organ Transplants

and collaboration throughout the process. By

In 2018, the Digestive Diseases Center hepatology team, including Fung, Talia Baker, MD, Yolanda Becker, MD, and Michael Charlton, MD, participated in performing the world’s first back-to-back heartliver-kidney transplants in two patients.

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synchronizing efforts, the 22-person transplant team was able to minimize blood loss and trauma, giving both patients maximum chance for a positive outcome and a quicker recovery.

Autologous Transplant

not at risk for rejection, meaning patients are able to

Also in 2018, Fung performed a rare and highly

return to their lives faster and with fewer concerns

technical autologous transplant for a patient with a

about post-operative outcomes.

cancerous tumor found in part of the liver that made

An autologous transplant can be performed on

typical resection difficult and risky.

several types of organs, but only a handful of these

This innovative treatment for such a problematic tumor

surgeries take place nationwide each year, in part

involved removing the liver from the body and cutting the cancer out while the organ was on a table in the

due to the skill and experience required from the surgeon and surgical team. Fung has performed five

operating room. After an almost 13-hour surgery,

liver autologous transplants in his career.

Fung transplanted the patient’s own healthy organ.

Fung’s dedication to innovation has been recognized

Unlike traditional transplants from an organ donor,

by the American College of Surgeons, which invited

patients who receive an autologous transplant are

him to give the prestigious Ravdin lecture at the 2018 Clinical Congress.

John Fung, MD, PhD

For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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PANCREATIC DISEASE CENTER

Sajan Nagpal, MD

Diseases of the pancreas require comprehensive care from a multidisciplinary and integrated team of experts. Our pancreatic disease team includes recognized leaders in specialties from gastroenterology to interventional radiology and pain management, and extends to include nutritionists, nurses and genetic counselors.

Together, we offer unparalleled expertise in diagnosing and treating all types of pancreatic conditions, including severe acute and chronic pancreatitis, complications from pancreatitis, pancreatic pseudocyst and walled-off necrosis, treatment of large pancreatic duct stones using extracorporeal shock wave lithotripsy (ESWL); pancreatic cystic lesions; genetic conditions that affect the pancreas including CFTR, PRSS1, CTRC and SPINK; and autoimmune pancreatitis, among others. In conjunction with the Center for Endoscopic Research and Therapeutics, we are leaders in the use of minimally invasive, per-oral techniques for complex conditions that might otherwise require major surgery. We are also leaders in early detection in patients who are at high risk of developing pancreatic cancer.

Our physician-scientists are involved in several multicenter research trials examining novel genetic links to pancreatitis and pancreatic cancer, new medications that improve outcomes after total pancreatectomy and islet autocell transplantation, and treatment outcomes after transmural treatment of walled-off necrosis, a complication from severe pancreatitis.

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Physicians Gastroenterology & Interventional Gastrointestinal Endoscopy

Pathology John Hart, MD Professor of Pathology

Sajan Nagpal, MD Director, Pancreas Clinic Assistant Professor of Medicine

Radiation Oncology Stanley Liauw, MD Associate Professor of Radiation and Cellular Oncology

Sonia S. Kupfer, MD Director, Gastrointestinal Cancer Risk and Prevention Clinic

Ralph R. Weichselbaum, MD Chair, Department of Radiation and Cellular Oncology Daniel K. Ludwig Distinguished Service Professor of Radiation and Cellular Oncology

Co-Director, Comprehensive Cancer Risk and Prevention Clinic Associate Professor of Medicine, Section of Gastroenterology and Center for Clinical Cancer Genetics

Sajan Nagpal, MBBS Director, Pancreas Clinic

Radiology Abraham H. Dachman, MD Professor of Radiology

Uzma Siddiqui, MD Associate Director, Center for Endoscopic Research and Therapeutics

Brian Funaki, MD Chief, Vascular and Interventional Radiology Professor of Radiology

Professor of Medicine Irving Waxman, MD Director, Center for Endoscopic Research and Therapeutics Sara and Harold Lincoln Thompson Professor of Medicine and Surgery

Jeffrey A. Leef, MD Associate Professor of Radiology

Medical Oncology

Surgery

Daniel Catenacci, MD, PhD Medical Director, Gastrointestinal Oncology

Aytekin Oto, MD Chief, Abdominal Imaging Professor of Radiology and Surgery

Daniel Catenacci, MD, PhD Director, Gastrointestinal Oncology Assistant Director, Translational Research, Comprehensive Cancer Center Associate Professor of Medicine

John C. Alverdy, MD, FACS Executive Vice Chair, Department of Surgery Sara and Harold Lincoln Thompson Professor of Surgery Mustafa Hussain, MD Medical Director, Bariatric Surgery Assistant Professor of Surgery

Hedy Kindler, MD Professor of Medicine

Hedy Kindler, MD

Jeffrey B. Matthews, MD Chair, Department of Surgery Dallas B. Phemister Professor of Surgery

Blase Polite, MD Assistant Professor of Medicine Chih-Yi “Andy” Liao, MD Assistant Professor of Medicine Anu Neerukonda, MD Assistant Professor of Medicine

Pain Management Magdalena Anitescu, MD, PhD Associate Professor of Anesthesia & Critical Care David Dickerson, MD Assistant Professor of Anesthesia & Critical Care

Mitchell C. Posner, MD Chief, Surgical Oncology Chief, General Surgery Medical Director, Clinical Cancer Programs Physician-in-Chief, Comprehensive Cancer Center Thomas D. Jones Professor of Surgery

Blase Polite, MD

Vivek N. Prachand, MD, FACS Chair, Surgical Quality Improvement and Patient Safety Professor of Surgery Kevin Roggin, MD Professor of Surgery

Pancreas Transplant Surgery Piotr Witkowski, MD, PhD Director, Pancreatic and Islet Transplant Program Assistant Professor of Surgery

Jeffrey B. Matthews, MD

Dieticians

Chair, Department of Surgery

Lori Welstead, MS, RD, LDN

Courtney Schuchmann, MS, RD, LDN

Services Minimally invasive pancreatic procedures and surgeries

Total pancreatectomy with islet autocell transplantation (autologous islet cell transplantation)

Extracorporeal shock wave lithotripsy for patients with chronic calcific pancreatitis

Pylorus-preserving pancreatic resection (Whipple procedure) for benign and malignant disease

Minimally invasive pancreatic surgeries such as laparoscopic and video-assisted retroperitoneal debridement (VARD)

Vascular reconstruction for major cancer operations Duodenum-sparing pancreatic operations for chronic pancreatitis

Contact To learn more about the pancreatic diseases group, please visit: uchicagomedicine.org/pancreatitis To make a referral or request a consultation, please call: 1 (877) DOM–2730 For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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K. Gautham Reddy, MD

K. Gautham Reddy, MD

GENERAL GASTROENTEROLOGY

Ira Hanan, MD

Edwin K. McDonald IV, MD

The Center for General Gastroenterology provides comprehensive and innovative endoscopic and medical treatment for a variety of digestive disorders.

Our physicians have experience and expertise in managing conditions such as heartburn and gastroesophageal reflux disease, acid-peptic disorders, colorectal cancer screening, occult and overt gastrointestinal bleeding, gastrointestinal infections and functional bowel diseases.

Our general gastroenterologists are involved in robust

Dejan Micic, MD

clinical research programs including optimizing outcomes of patients hospitalized with upper and lower gastrointestinal bleeding, and improving quality of colorectal cancer screening.

Physicians K. Gautham Reddy, MD Associate Section Chief for Clinical Operations Neil Sengupta, MD

Dejan Micic, MD Assistant Professor of Medicine

Associate Professor of Medicine

Neil Sengupta, MD Assistant Professor of Medicine

Ira Hanan, MD Professor of Medicine

Vijaya Rao, MD Assistant Professor of Medicine

Edwin K. McDonald IV, MD Associate Director, Adult Clinical Nutrition

Ruben Khan, MD Clinical Associate of Medicine

Assistant Professor of Medicine

Services Vijaya Rao, MD

Screening and surveillance for Barrett’s esophagus Gastroesophageal reflux disease Peptic ulcer disease and Helicobacter pylori infection Gastrointestinal bleeding Diverticular disease Colonic diverticular disease

Ruben Khan, MD

Infectious colitis or infectious enteritis Iron deficiency anemia Colorectal cancer screening Chronic constipation Disorders of malabsorption Irritable bowel syndrome Functional bowel disease Celiac disease

Contact To learn more about the section of General Gastroenterology, please visit:

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UChicagoMedicine.org/gi

Changing the Way Colorectal Cancer is Diagnosed and Treated Colorectal cancer (CRC) is the third most common cancer in the United States. Through our Center for Gastrointestinal Oncology, colorectal cancer patients have access to a multidisciplinary team of experts focused on the causes and treatment of colon cancer.

In addition to the University of Chicago Medicine’s

Translational Lab Research

outstanding care for colorectal cancer patients, our

In addition to clinical research surrounding CRC, the

team is at the forefront of research into this difficult and common form of cancer.

Digestive Diseases Center is also at the forefront of translational lab research to test the colon’s response

Clinical Research on Lynch Syndrome

to different protective and risk factors.

Among U.S. populations, African Americans have the

Researchers at the University of Chicago Medicine

highest CRC incidence and mortality. In order to better

have grown organoids from biopsy samples. These

understand why that is and what can be done to

organoids are then introduced to various factors that

intervene, the University of Chicago Medicine

affect the colon.

conducted a clinical study looking at the mutation

By studying how individuals respond to genetic

spectrum and risk of CRC in African American families

and environmental factors, our team can better

with Lynch Syndrome, an inherited cancer syndrome

understand how CRC develops and gain insight into

that increases a patient’s risk for CRC and other cancers.

prevention possibilities for patients—including those

The research, spearheaded by Sonia S. Kupfer, MD,

with genetic and racial risk factors

director of the Gastrointestinal Cancer Risk and

Making Colonoscopies a Thing of the Past

Prevention Clinic, found that the cumulative risk for CRC in individuals with Lynch Syndrome is similar, despite race and ethnicity, however minority patients, including African Americans, were significantly less likely to be referred for genetic evaluation.

This has created a discrepancy in diagnosis and understanding of family history, which could be

Beyond research into the causes and ways to prevent CRC, the experts at the Digestive Diseases Center are also in the process of developing a groundbreaking new technique for colon cancer screening.

Currently, patients over the age of 50 are screened for CRC through an uncomfortable, invasive and expensive

linked to the higher rate of CRC.

procedure: the colonoscopy.

As a result of this research, the University of

Experimental research conducted by Marc Bissonnette,

Chicago Medicine initiated an important discussion about how to increase identification of Lynch

MD, and invented by Chuan He, PhD found that 5hmC-based biomarkers of circulating cancer-free DNA

Syndrome and achieve universal screening among

were highly predictive of colorectal and gastric cancers.

all CRC patients.

This circulating DNA is extracted through a simple blood test, creating an equally effective, minimally invasive and more economical screening that could increase compliance rates among patients in the future.

For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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GASTROINTESTINAL CANCER RISK AND PREVENTION CLINIC

Sonia S. Kupfer, MD

The Gastrointestinal Cancer Risk and Prevention Clinic offers personalized and precision medicine for patients who are at increased risk for gastrointestinal malignancies.

As gastroenterologists, genetic counselors, oncologists and surgeons,

Sonia S. Kupfer, MD Director, Gastrointestinal Cancer Risk and Prevention Clinic

we work together in a multidisciplinary collaborative team to provide leading-edge cancer risk assessments, genetic testing, management of hereditary syndromes, and cancer prevention strategies, such as control of inflammation in colitis.

Physicians Sonia S. Kupfer, MD Director, Gastrointestinal Cancer Risk and Prevention Clinic

David T. Rubin, MD Co-Director, Digestive Diseases Center Chief, Section of Gastroenterology, Hepatology, and Nutrition

Co-Director, Comprehensive Cancer Risk and Prevention Clinic

Neil H. Hyman, MD Co-Director, Digestive Diseases Center Chief, Colon and Rectal Surgery

Joseph B. Kirsner Professor of Medicine

Associate Professor of Medicine, Section of Gastroenterology and Center for Clinical Cancer Genetics

Carol Semrad, MD Director, Small Bowel Disease and Nutrition Program Director of Adult Clinical Research, Celiac Disease Center

Neil H. Hyman, MD Co-Director, Digestive Diseases Center

Professor of Medicine Uzma Siddiqui, MD Associate Director, Center for Endoscopic Research and Therapeutics

Chief, Colon and Rectal Surgery Professor of Surgery Blase Polite, MD Associate Professor of Medicine

Blase Polite, MD

Professor of Medicine

Kevin Roggin, MD, FACS Professor of Surgery

Affiliated Faculty Olofunmilayo Olopade, MD Director, Center for Clinical Cancer Genetics

David T. Rubin, MD

General Cancer Risk Program Director, HONC

Co-Director, Digestive Diseases Center

Walter L. Palmer Distinguished Service Professor of Medicine and Human Genetics

Chief, Section of Gastroenterology, Hepatology, and Nutrition

Services GI cancer risk assessment and genetic testing

Pancreatic cancer screening for high-risk patients

Cancer prevention counseling

Gastrointestinal surgical procedures

Colorectal cancer screening and surveillance

Colitis prevention

Hereditary gastric cancer risk assessment and management

Contact

Uzma Siddiqui, MD

To make an appointment, call: 1 (773) 702-6140

Associate Director, Center for Endoscopic Research and Therapeutics

To learn more about the Gastrointestinal Cancer Risk and Prevention clinic, please visit: UChicagoMedicine.org/GI-cancer-risk

Number of patients seen in last 12 months More than

250

For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

33

BASIC AND TRANSLATIONAL RESEARCH

Eugene B. Chang, MD (left) and A. Murat Eren, PhD

At the heart of the Digestive Diseases Center lies basic and translational research, the latter defined as the application of basic knowledge to clinical practice. In this regard, our program is uniquely and intimately connected with the clinicians and clinical research programs at the University of Chicago Medicine.

Within the Digestive Diseases Research Core Center (DDRCC), we focus on providing the best possible patient care by building a better understanding of gastrointestinal diseases in order to improve diagnosis, treatment and outcomes. Our research programs are supported by investigator-initiated grants of nearly $10 million per year from the NIH, Crohn’s & Colitis Foundation of America, Gastro-Intestinal Research Foundation of Chicago, Broad Medication Research Program, and other sources of extramural and philanthropic funds.

The DDRCC promotes collaborative, multidisciplinary development of research and technology, and is one of only 17 such centers in the U.S. Our support of GI research has led to the discovery of the first IBD gene (NOD2), new understanding of the causes and management of celiac disease, insights into the role of gut microbes in complex immune disorders, and elucidation of the genetic and dietary mechanisms causing colon cancer.

34

We are internationally renowned for our work on the gut microbiome, mucosal immunology, host-microbe interactions and cancer. Strong interactions and collaborations with Argonne National Laboratory and the Marine Biological Laboratory at Woods Hole (both affiliate research institutions of the University of Chicago) complement and extend our reach, as does our participation in SHARE, a consortium of seven research institutions whose pooled patient databases and other resources permit studies that otherwise could not be conducted by a single institution.

Eugene B. Chang, MD Director, Digestive Diseases Research Core Center

Physicians Eugene B. Chang, MD Director, Digestive Diseases Research Core Center

Neil H. Hyman, MD Co-Director, Digestive Diseases Center

Director, Host-Microbe Core

Chief, Colon and Rectal Surgery

Associate Chief, Research

Professor of Surgery

Director, Microbiome Medicine Program

Bana Jabri, MD, PhD Co-director, Digestive Diseases Research Core Center

Martin Boyer Professor of Medicine John C. Alverdy, MD, FACS Associate Director, Digestive Diseases Research Core Center

Director, Integrated Translational Research Core Vice Chair, Research, Department of Medicine

Executive Vice Chair, Department of Surgery

Director, Research for Celiac Disease Center

Sara and Harold Lincoln Thompson Professor of Surgery

Sara and Harold Lincoln Thompson Professor of Medicine and Pathology and Pediatrics

Dionysios Antonopoulos, PhD Joint appointment with Argonne National Laboratory Institute for Genomics and Systems Biology

Sonia S. Kupfer, MD Co-Director, Comprehensive Cancer Risk and Prevention Clinic

Assistant Professor of Medicine Daniel. V.T. Catenacci, MD Director, Gastrointestinal Oncology Assistant Director, Translational Research, Comprehensive Cancer Center Associate Professor of Medicine B. Marc Bissonnette, MD Assistant Director, Translational Research Associate Professor of Medicine Alexander Chervonsky, MD, PhD Chair, Committee on Immunology, Department of Pathology Professor of Pathology Yan Chun Li, MD Associate Professor of Medicine Erika Claud, MD Professor of Pediatrics Sushila Dalal, MD Director, Program for Fertility, Pregnancy and Sexual Function in Inflammatory Bowel Disease Assistant Professor of Medicine A. Murat Eren, PhD Assistant Professor of Medicine

Bana Jabri, MD, PhD Co-director, Digestive Diseases Research Core Center

Associate Professor of Medicine, Section of Gastroenterology and Center for Clinical Cancer Genetics Co-Director Physician-Scientist Development Program

John C. Alverdy, MD, FACS Associate Director, Digestive Diseases Research Core Center

Vanessa Leone, PhD Instructor Folker Meyer, PhD Computational Biologist, Argonne National Laboratory Professor of Medicine Cathy Nagler, MD Bunning Food Allergy Professor of Pathology and Medicine Joel Pekow, MD Assistant Professor of Medicine

B. Marc Bissonnette, MD Assistant Director, Translational Research

Mitchell L. Sogin, PhD Marine Biological Laboratory Senior Scientist Christopher Weber, MD, PHD Assistant Professor of Pathology Vivek N. Prachand, MD, FACS Chief Quality Officer, Department of Surgery Professor of Surgery Yalini Vigneswaran, MD Assistant Professor of Surgery

A. Murat Eren, PhD

Research Associates George Gulotta Database Manager

Kristi Kearney, RN Clinical Project Director, SHARE Research Program and Genesys Translational Research Core

Contact To learn more about the University of Chicago Digestive Diseases Research Core Center,

Kristi Kearney, RN

please visit: uchicagoddrcc.org For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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Microbiome Breakthroughs at the Digestive Diseases Center Our research and clinical teams are spearheading breakthrough work in the burgeoning field of the microbiome—the unique collection of microbes that live in each person’s gut. Our pioneering team, in collaboration with The Microbiome Center and Microbiome Medicine Program, is exploring the role the microbiome plays in patient illness, healing and recovery. Discoveries around the many ways the microbiome is associated with various health and disease states have the potential to have a sweeping impact across all areas of medicine.

36

We are approaching a new era of discovery that will lead to microbiome-based interventions and diagnostics that will become the future tools of precision medicine—and ultimately lead to improved clinical outcomes and the prevention

”

and cure of many diseases.

Eugene B. Chang, MD, Director, Digestive Diseases Research Core Center

Microbiome to Medicine

best to treat—and prevent—them. Understanding

The Microbiome Medicine Program (MMP), co-directed the microbiome’s role in surgical infections has the

by Eugene B. Chang, MD, and Marisa Alegre, MD, PhD, potential to revolutionize patient care, changing furthers the study of the microbiome in the context

the way clinical teams operate on patients, as

of human health. The program is examining changes

well as the ways they diagnose patients, prepare

metabolic systems, and in the development of acute

In recognition of the significance of this research,

and chronic diseases.

Alverdy received the 2018 American Surgical

in the collective human microbiome and the vital role them for surgery, and feed and rehabilitate them that gut microbiota play in shaping our immune and postoperatively.

For example, Chang’s work has highlighted the effects Association’s Flance-Karl Award, one of the world’s that high-fat, Western diets have on the gut microbiome. most prestigious recognitions of scientific achievement.

In 2018, he published a study showing how such foods He also was invited to share his insights on microbiome can encourage the growth of gut microbes that aid in medicine by delivering the I.S. Ravdin Lecture in the the digestion and absorption of fats. This in turn can

Basic and Surgical Sciences at the American College

lead to obesity and increased risk for heart disease.

of Surgeons Clinical Congress in 2017.

Chang’s lab has also focused on the impact of the

Leveraging International Partnerships

microbiome on the development of inflammatory

Because of our unparalleled expertise in microbiome

bowel disease (IBD). In 2017, his lab published a study related research, the University of Chicago Medicine showing links between the use of antibiotics late in

was recently selected in a very competitive

pregnancy and increased risk for IBD in offspring. He international grant process to partner with the Hong is also currently collaborating with David T. Rubin, MD, Kong government and with the Chinese University and Mitchell Sogin, PhD, a microbiologist from the

of Hong Kong on a multiyear collaboration to study

UChicago-affiliated Marine Biological Laboratory, on

100,000 moms and their newborns to evaluate

a project to understand how the microbiome affects

the effect of microbiomes on the development of

certain forms of ulcerative colitis.

digestive diseases.

Leveraging the Microbiome to Reduce Surgical Infections

Additionally, research led by Cathryn R. Nagler, PhD,

John Alverdy, MD, and Benjamin Shogan, MD, have led groundbreaking research around the influence of intestinal microbes on pre- and post-operative treatments. Together, Alverdy and Shogan identified the invasive bacteria that leads to surgical anastomotic leakage and failure—potentially deadly complications of

in partnership with researchers at the University of Naples Federico II in Italy, are exploring the origins of food allergies. The research has found significant differences in the gut microbiomes of healthy infants and those with cow’s milk allergy and demonstrated the critical role of the gut microbiota in the development of food allergy.

colorectal surgery. They found that virulent microbes This research could be used to identify specific bacterial can be the root cause of these complications, thereby species that protect against allergic responses to offering new insight into the mechanisms by which patients develop infections after surgery and how For referrals and consultations: 1 (844) UC GI DOC

food, helping to develop treatments for the millions of people worldwide with food allergies.

For more information visit: UChicagoMedicine.org/GI

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CENTER FOR GASTROINTESTINAL ONCOLOGY

Danial Catenacci, MD, PhD, (lef), and Kristine Bautista, RN

The Center for Gastrointestinal Oncology brings together experts from two of our nationally recognized programs: cancer and gastroenterology. Both programs are consistently ranked among the top in the nation and include physicians who are internationally recognized for their expertise. Our approach to diagnosis and treatment is multidisciplinary and consensus-based, so that patients —including those with rare or complex diseases—benefit from collaborative problem solving among specialists in medical, surgical, and radiation oncology, general surgery and gastroenterology.

Whenever possible, we offer minimally invasive, including robotic, procedures for GI tumor biopsy and resection. Our team includes internationally renowned GI specialists and physicians who are pioneers in the use and development of endoscopy—including the use of probe-based confocal laser endomicroscopy (pCLE).

Our patients receive access to revolutionary clinical trials, offering the next generation of treatment to those with gastrointestinal cancer. Through innovative surgical and radiation techniques, investigational and established medicines, and novel molecular targeted therapies, our physicians offer patients the highest chances of success against a wide variety of cancers.

Our center also ranks at the top nationally in multi-organ transplant procedures. In terms of both volume and experience, we have performed the greatest number of combined liver, heart and kidney transplants, and are fourth in combined liver and heart transplants in the country.

Leadership Medical Oncology

Interventional Gastroenterology

Daniel V.T. Catenacci, MD Associate Professor of Medicine

Irving Waxman, MD Director, Center for Endoscopic Research and Therapeutics

Program Director, Interdisciplinary Gastrointestinal Oncology Assistant Director Translational Research

Surgical Oncology Mitchell C. Posner, MD, FACS Chief, Surgical Oncology Chief, General Surgery Medical Director, Clinical Cancer Programs Physician-in-Chief, Comprehensive Cancer Center Thomas D. Jones Professor of Surgery

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Sara and Harold Lincoln Thompson Professor of Medicine and Surgery

Radiation Oncology Stanley Liauw, MD Associate Professor of Radiation and Cellular Oncology

Principal Physicians Kevin Roggin, MD, FACS Professor of Surgery

Colon and Rectal Surgery Neil H. Hyman, MD Co-Director, Digestive Diseases Center Chief, Colon and Rectal Surgery

Kiran Turaga, MD, MPH Associate Professor of Surgery

Professor of Surgery

Gastroenterology

Roger D. Hurst, MD Professor of Surgery

Karen E. Kim, MD Professor of Medicine

Benjamin Shogan, MD Assistant Professor of Surgery

Interventional Gastroenterology

Daniel Catenacci, MD, PhD

Konstantin Umanskiy, MD, FACS Associate Professor of Surgery

Uzma Siddiqui, MD

Director, Gastrointestinal Oncology

Associate Director, Center for Endoscopic Research and Therapeutics

Assistant Director, Translational Research, Comprehensive Cancer Center

Medical Oncology

Professor of Medicine

Hedy Kindler, MD Professor of Medicine

Christopher Chapman, MD Assistant Professor of Medicine

Blase Polite, MD Associate Professor of Medicine

Complex Foregut/Bariatrics John C. Alverdy, MD, FACS Sara and Harold Lincoln Thompson

Anu Neerukonda, MD Clinical Associate of Medicine

Professor of Surgery

Chih-Yi ‘Andy’ Liao Assistant Professor of Medicine

Mustafa Hussain, MD Medical Director, Bariatric Surgery

Mitchell C. Posner, MD, FACS

Surgical Oncology

Associate Professor

Chief, Surgical Oncology

Jeffrey B. Matthews, MD, FACS Chair, Department of Surgery

Vivek N. Prachand, MD, FACS Chief Quality Officer, Department of Surgery

Chief, General Surgery

Dallas B. Phemister Professor of Surgery

Professor of Surgery

Oliver Eng, MD Assistant Professor of Surgery

Yalini Vigneswaran, MD Assistant Professor of Surgery

Medical Director, Clinical Cancer Programs Physician-in-Chief, Comprehensive Cancer Center

Xavier M. Keutgen, MD, FACS Assistant Professor of Surgery

Advanced Practice Nurses/Physician Assistants Medical Oncology

Colon and Rectal Surgery

Bariatric Surgery

Christine Racette, APN Kenisha Allen, APN

Noelle Kakuk, APN Michele Rubin, APN Meredith Stidham, APN

Angela Willis, APN

Surgical Oncology Emily Fenton, PA Barbara Gordon, MSN, APN Alaine Kamm, RN, APN

Ostomy

Irving Waxman, MD Director, Center for Endoscopic Research and Therapeutics

Jan Colwell, APN Michele Kaplon-Jones, APN

Services Minimally invasive esophagectomy, gastrectomy, pancreatectomy, hepatic resection, and colorectal resection Diagnostic and therapeutic endoscopy for pancreatic, hepatobiliary, and esophageal cancers

Segmental colectomy Total abdominal colectomy Total proctocolectomy Stoma creation

Laser confocal microscopy, using advanced technology that allows physicians to view live images of internal human tissues at the cellular level so they can identify and remove cancerous tissue sooner

Dedicated wound and ostomy care

Gene therapy for upper GI cancers

Beger procedure

Combined chemoradiation therapies

Frey procedure

Intensity-modulated radiation therapy (IMRT), which targets tumors better than conventional radiation

Bern modification

Staging laparoscopy Transanal endoscopic microsurgery Duodenum-sparing pancreatic head resection

Spleen-preserving pancreatic tail resection

Organ preservation for patients with rectal cancer Small bowel resection

Stanley Liauw, MD

Endoscopic placement of pancreatic stents Pancreatic duodenectomy (Whipple procedure) Robotic surgery

Contact To learn more about the Center for Gastrointestinal Oncology, please visit: UChicagoMedicine.org/GI-cancer For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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Leading-Edge Approach to Gastrointestinal Cancer Gives Patients New Hope At the University of Chicago Medicine Center for Gastrointestinal Oncology, we understand that cancer is an incredibly difficult diagnosis for a patient and their family. This is why we place such an emphasis on being at the forefront of cancer treatments and surgeries. Our team is highly experienced in diagnosing specific gastrointestinal cancer, which helps us tailor treatment for each individual patient.

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Neuroendocrine Tumors

Hyperthermic Intraperitoneal Neuroendocrine tumors (NETs) form in neuroendocrine Chemotherapy (HIPEC) cells, which are found throughout the body, particularly Hyperthermic (or Heated) Intraperitoneal in the small bowel, pancreas, stomach, adrenal glands, Chemotherapy (HIPEC) is a surgical procedure that lungs, and thyroid. NETs are some of the most complicated tumors to treat because they do not cause symptoms early on and are consequently found at a more advanced stage.

gives new hope to patients with abdominal cancers.

Only available at select centers, this state-of-theart procedure is performed immediately after a viable tumor is removed by circulating a 108-degree

In these later stages, NETs require more specialized

chemotherapy bath inside the peritoneal cavity

and advanced therapy. Our multidisciplinary and

to directly target residual cancerous cells in the

dedicated team, led by Xavier M. Keutgen, MD, has

abdomen. Our premier HIPEC team, led by Kiran

made the University of Chicago Medicine

Turaga, MD, MPH, includes nationally known HIPEC

neuroendocrine tumor program a destination center

surgeons, medical and radiation oncologists,

for patients. We offer leading diagnosis and therapy

radiologists, pathologists, nurses and cancer scientists.

options for patients, including:

Patients who undergo HIPEC at the University

• Advanced techniques for surgical removal of NETs,

of Chicago Medicine, one of a few institutions to

including minimally invasive and robotic procedures.

offer this treatment to adult and pediatric patients,

• Leading-edge technologies like precision-enhancing

benefit from fewer side effects than traditional

navigation-controlled ablation of liver tumors and

chemotherapy. HIPEC provides a deeper penetration

Peptide Receptor Radionuclide Therapy (PRRT), a

of the medicine which allows doctors to treat

systemic, targeted approach that delivers radiation to incurable cancers more like a chronic disease and can often lead to a long-term cure for abdominal cancers.

NET cells without damaging other organs.

• The only medical cyclotron in the region for creating and using novel PET radiotracers for detecting NETs. • The only Von Hippel-Lindau Alliance-certified clinical care center in the state treating patients with NETs linked to hereditary conditions.

Kiran Turaga, MD, MPH For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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CENTER FOR THE SURGICAL TREATMENT OF OBESITY 42

Mustafa Hussain, MD

Obesity is a multifaceted disease with many causes and treatments. Our program provides individualized, patient-centric, compassionate and multidisciplinary care to patients with severe obesity to achieve the best health outcomes possible.

We make our recommendations based on the individual circumstances of our patients, so that they may be successful in attaining their desired or needed health goals. Our physicians work side-by-side with our dietitians and psychologists in the clinic—both preand post-operatively—and are committed to lifelong follow up with our patients.

We are the only center in the region that individualizes recommendations and performs all four surgical options for the treatment of obesity. Our expertise in the treatment of super obesity (BMI >50) has garnered numerous invitations to present and demonstrate our approach and outcomes at local, regional, national and international conferences.

We are the regionally recognized referral center for complications and other suboptimal outcomes following procedures performed at other institutions, and we routinely serve as educational hosts for visiting surgeons, dietitians and program managers as they initiate the incorporation of more advanced procedures and techniques into their practices.

Physicians John C. Alverdy, MD, FACS Executive Vice Chair, Department of Surgery Sara and Harold Lincoln Thompson

Edwin K. McDonald IV, MD Associate Director, Adult Clinical Nutrition

Professor of Surgery

Vivek N. Prachand, MD, FACS Chief Quality Officer, Department of Surgery

Mustafa Hussain, MD Medical Director, Bariatric Surgery Associate Professor

Assistant Professor of Medicine

Professor of Surgery Yalini Vigneswaran, MD Assistant Professor of Surgery

John C. Alverdy, MD, FACS Executive Vice Chair, Department of Surgery

Advanced Practice Nurses/Physician Assistants Caridad Macrae Bariatric Program Intake Coordinator

Alisha Wilson, BSN, RN Nurse Clinician

Augustine Owens Bariatric Program Intake Coordinator

Krystal Agnew, RN Nurse Clinician

Angela Willis, APN Bariatric Program Manager Mustafa Hussain, MD

Dietitians

Medical Director, Bariatric Surgery

Jackie Ferretti, RD Jessica Schultz, RD

Psychologists Jennifer Wildes, PhD

Services Laparoscopic vertical sleeve gastrectomy

Edwin K. McDonald IV, MD

Laparoscopic Roux-en-Y gastric bypass

Associate Director, Adult Clinical Nutrition

Laparoscopic duodenal switch Laparoscopic adjustable gastric banding Revision of previous bariatric surgery Comprehensive management of complications of bariatric surgery

Vivek N. Prachand, MD, FACS Chief Quality Officer, Department of Surgery

John C. Alverdy, MD, FACS For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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Christopher Chapman, MD

CENTER FOR ENDOSCOPIC TREATMENT OF OBESITY

At the Center for Endoscopic Treatment of Obesity, we partner with patients who are struggling with weight and provide them with a nonsurgical option that uses endoscopic therapies as a powerful tool to facilitate or enhance weight loss. Though it is not a cure for obesity, when used properly, endoscopy can provide an effective way to achieve sustained weight loss, with patients averaging between 8 percent to nearly 20 percent of their total body weight.

Christopher Chapman, MD Director, Bariatric and Metabolic Endoscopy

As the only program in Chicago currently offering endoscopic sleeve gastroplasty, we provide patients with the latest treatments for nonsurgical weight loss. In addition to performing a wide variety of procedures to best

Edwin K. McDonald IV, MD Associate Director, Adult Clinical Nutrition

meet our patients’ needs, we also offer patients access to clinical trials, enabling them to benefit from novel treatment solutions not yet widely available on the market.

Physicians Christopher Chapman, MD Director, Bariatric and Metabolic Endoscopy

Silvana Pannain, MD Director, Chicago Weight Program

Silvana Pannain, MD

Assistant Professor of Medicine

Assistant Professor of Medicine

Director, Chicago Weight Program

Edwin K. McDonald IV, MD Associate Director, Adult Clinical Nutrition Assistant Professor of Medicine

Advanced Practice Nurses/Physician Assistants Sarah Kosinski, DNP, FNP-BC Bariatric and Metabolic Endoscopy Nurse Practitioner

Rania Salah, CMA Intake Coordinator

Dietitians Lori Welstead, MS, RDN

Courtney Schuchmann, MS, RD, LDN

Psychologists Jennifer Wildes, PhD

Hana Zickgraf, PhD

Shannon O’Connor, PhD, MS, MA

Christine Daemicke, LCSW

Services Intragastric balloon Endoscopic sleeve gastroplasty Aspiration therapy with AspireAssist Secondary therapies for weight gain after bariatric surgery

Contact To learn more about the Center for Endoscopic Treatment of Obesity, please visit: UChicagoMedicine.org/nonsurgical-weight-loss To schedule an admission, make a referral or request a consultation, please call UCM Physician Connect at: 1 (800) 824-2282 For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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CLINICAL RESEARCH

Kristi Kearney, RN

At the Digestive Diseases Center, clinicians, patients and researchers participate in, and benefit from, a rigorous, research-based approach to patient care. Year after year, we conduct or participate in more clinical trials than any other hospital in Illinois, offering patients, and the physicians who refer them, access to the most promising treatments and new standards of care.

New ideas and new information shape our daily practice of medicine. They deepen our understanding of health and disease and amplify our ability to develop better treatments for all medical conditions, from the simplest to the most complex.

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The Digestive Diseases Center at the University of Chicago Medicine is a collaborative, multidisciplinary network of physicians, researchers and allied health professionals who share a legacy of innovation and a common purpose: to improve the lives of patients who suffer from digestive diseases.

Within the Digestive Diseases Center, a database of material pertaining to more than 5,000 patients, is the vital infrastructure for clinical trials of conventional and novel medical therapies intended to diagnose and treat a wide range of digestive diseases. In hepatology, we are currently conducting research in the areas of liver transplantation, viral hepatitis and other inflammatory liver disorders. Our research in nutrition is studying

Atsushi Sakuraba, MD, PhD

the impact of lactose intolerance in minority health outcomes, as well as

Director, Clinical Trials

obesity and celiac disease.

Other studies are examining the optimization of colorectal cancer screening for average and high-risk patients, the effects of genetic counseling, and the possibilities of chemoprevention. We are currently leading more than 200 research studies on human subjects with digestive diseases. This includes more than 20 IBD-related clinical trials, such as an NIH-supported human microbiome study that seeks to understand the role of intestinal

Kristi Kearney, RN Clinical Trials Manager

microbes in the development of IBD. Whether working independently or as part of multicenter research teams, we are asking—and answering—the questions that will lead to more effective treatments, better practice and better patient outcomes for healthcare professionals across the country and around the world.

Daniel Catenacci, MD, PhD Medical Director, Gastrointestinal Oncology

Researchers Atsuhi Sakuraba, MD, PhD Director, Clinical Trials

Daniel V.T. Catenacci, MD Director, Gastrointestinal Oncology

Assistant Professor of Medicine

Assistant Director, Translational Research, Comprehensive Cancer Center

Kristi Kearney, RN Clinical Trials Manager for Gastroenterology, Hepatology, Inflammatory Bowel Disease, Nutrition and Translational Research

Associate Professor of Medicine

Research Nurse

Clinical Trials in Digestive Diseases Novel therapies for Crohn’s disease and ulcerative colitis

Disparities in digestive diseases delivery of care Phase 3 clinical trials for Hepatitis C

Medical therapies for celiac disease Interventional trials related to advanced endoscopy The utility of chromoendoscopy in ulcerative colitis surveillance

Assessment of robotic and minimally invasive surgical outcomes Anastomotic leak prevention Innovative treatment trials in esophageal, hepatic, pancreatic, gastric and colorectal cancer

The role of the microbiome in IBD pathogenesis

Clinical Trials in Gastrointestinal Oncology Novel personalized and precision medicine therapies for gastrointestinal oncology including colorectal, gastric, esophageal, pancreatic, liver, bile duct/gallbladder, small bowel, neuroendocrine and anal cancers

Investigational phase III, II, and I studies for various perioperative and advanced settings and evaluating novel targeted therapies, immunotherapies and vaccines, and chemotherapeutic strategies to improve the outcomes of our patients

Contact To learn more about our clinical trials, call: 1 (773) 702-5382

For referrals and consultations: 1 (844) UC GI DOC

For more information visit: UChicagoMedicine.org/GI

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Digestive Diseases Center

L EG ACY

The primary research and treatment facilities of the Digestive Diseases Center at the University of Chicago Medicine are in Chicago’s Hyde Park neighborhood, six miles south of the downtown business district.

We also see patients in several other locations in Chicago, its suburbs and Northwest Indiana. Please visit UChicagoMedicine.org/GI-locations for specific location information.

It is our policy to see doctor-referred patients as soon as possible, within seven days for cancer diagnoses, and within 14 days for all other digestive diseases.

Contact us GI Physician Connect 1 (844) UC GI DOC 1 (844) 824-4362 Referrals and consultations UCM Transfer Connect 1 (855) 834-4782 Urgent patient transfers

Joseph B. Kirsner, MD