Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Nicardia Retard Tablets(Generic Nifedipine Sustained Release Tablets) are used to prevent certain types of chest pain (angina) and for the treatment of hypertension ( high blood pressure).It can also be used to treat disorder called Raynaud's phenomenon, and premature labor. This medication may allow you to exercise more and decrease the frequency of angina attacks. Nifedipine belongs to a group of medications known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily. This medication should be taken regularly to be effective. Nicardia Retard must not be used to treat attacks of chest pain after they have occured.

Chemical Structure

The structure of Nifedipine is given below:

Uses of Nicardia Retard Tablets

Nicardia Retard (Generic Nifedipine Sustained Release Tablets) is used alone or in combination with other drugs to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is also used for certain types of chest pain (angina). It may help increase your ability to exercise and decrease the frequency of chest pain attacks. It should not be used to treat chest pain when it occurs. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor.

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Nicardia Retard Tablets Dosage

The recommended dosage of Nicardia Retard tablets (Generic Nifedipine Sustained Release tablets) is orally once a day, on an empty stomach. Nicardia Retard is a sustained release dosage form and the tablets must be swallowed whole, not bitten or divided. Normally, titration should proceed over a 7 to 14 day period starting with 30 mg once daily. Upward titration must be based on therapeutic efficacy and safety and will have to be suited to the needs of the patient under treatment. The usual maintenance dose is 30 mg to 60 mg once daily. Titration to doses more than 90 mg daily is not recommended.

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Excessive Hypotension: Normally in most patients the hypotensive effect of Nifedipine is modest and well tolerated, occasional patients have had excessive and poorly tolerated hypotension. Increased Angina and/or Myocardial Infarction: Rarely, patients, particularly those who have severe obstructive coronary artery disease, have developed welldocumented increased frequency, duration and/or severity of angina or acute myocardial infarction upon starting therapy with Nifedipine tablets or at the time of dosage Beta-Blockerincrease.Withdrawal: When stopping a beta-blocker it is important to taper its dose, if possible, rather than stopping abruptly before starting treatment with Nifedipine. Patients recently withdrawn from beta blockers may develop a withdrawal syndrome with increased angina, which is most probably related to increased sensitivity to catecholamines.

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Congestive Heart Failure: Rarely, patients have developed heart failure after starting ConcomitantNifedipine.administration with strong P450 inducers, such as Rifampin, are contraindicated. Nifedipine should not be used in cases of cardiogenic shock. Since Nifedipine decreases peripheral vascular resistance, careful monitoring of blood pressure during the initial administration and titration of Nicardia Retard is recommended. Mild to moderate peripheral edema occurs in a dose-dependent manner with ClearanceNifedipine.of Nifedipine is decreased and systemic exposure increased in patients with cirrhosis. It is unknown how systemic exposure may be altered in patients with moderate or severe liver impairment. Careful monitoring and dose reduction may be necessary in such patients.

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Overdose

A number of persons have developed toxicity due to acute overdosage with Nifedipine, either accidentally or intentionally, and via either oral or parenteral administration. The adverse effects include heart rhythm disturbances, metabolic acidosis, hypoxia, cardiogenic shock with pulmonary edema, lethargy, bradycardia, marked hypotension (drop in blood pressure) and loss of consciousness. Usually, Nifedipine overdose leading to pronounced hypotension calls for active cardiovascular support including monitoring of cardiovascular and respiratory function, elevation of extremities, judicious use of calcium infusion, pressor agents (medication that tends to raise reduced blood pressure) as well as fluids.

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Overdose

After oral ingestion, thorough gastric lavage is recommended, in case necessary in combination with irrigation of the small intestine. In cases involving overdosage of a slow-release product like Nicardia Retard, removal should be as complete as possible, including from the small intestine, to prevent the subsequent absorption of the active substance.

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