Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Nicardia Retard Tablets(Generic Nifedipine Sustained Release Tablets) are used to prevent certain types of chest pain (angina) and for the treatment of hypertension ( high blood pressure).It can also be used to treat disorder called Raynaud's phenomenon, and premature labor.

This medication may allow you to exercise more and decrease the frequency of angina attacks. Nifedipine belongs to a group of medications known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily. This medication should be taken regularly to be effective. Nicardia Retard must not be used to treat attacks of chest pain after they have occured. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Active Ingredient The active ingredient present in Nicardia Retard tablets is Nifedipine. Each tablet of Nicardia contains 10 mg, 20 mg or 30 mg of Nifedipine.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Chemical Structure The structure of Nifedipine is given below:

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Nicardia Retard, manufactured by J B Chemicals and Pharmaceuticals Limited, India is available as tablets of 10 mg, 20 mg and 30 mg.

(Website: https://jbpharma.com/)

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Nifedipine Tablets – Brand Names

Nifedipine tablets are available under various drug trade names that include Adalat, Adalat Retard, Procardia, Nicardia, Nicardia Retard, Nifedine, Nifelat, Calbloc, Calcigard and Depin.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Uses of Nicardia Retard Tablets Nicardia Retard (Generic Nifedipine Sustained Release Tablets) is used alone or in combination with other drugs to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

This medication is also used for certain types of chest pain (angina).

It may help increase your ability to exercise and decrease the frequency of chest pain attacks. It should not be used to treat chest pain when it occurs. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Uses of Nicardia Retard Tablets Chronic Stable Angina: Nicardia Retard (Nifedipine extendedrelease tablets) is indicated in the management of chronic stable angina (effort-associated angina) without evidence of vasospasm in patients who remain symptomatic despite adequate doses of beta blockers and/or nitrates, or who cannot tolerate these agents.

Hypertension: Nicardia Retard is indicated in the management of mild to moderate essential hypertension. Nicardia Retard should normally be used in those patients in whom treatment with diuretics or beta blocker has been ineffective, or has been associated with unacceptable adverse effects.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Nicardia Retard Tablets Dosage The recommended dosage of Nicardia Retard tablets (Generic Nifedipine Sustained Release tablets) is orally once a day, on an empty stomach.

Nicardia Retard is a sustained release dosage form and the tablets must be swallowed whole, not bitten or divided. Normally, titration should proceed over a 7 to 14 day period starting with 30 mg once daily.

Upward titration must be based on therapeutic efficacy and safety and will have to be suited to the needs of the patient under treatment.

The usual maintenance dose is 30 mg to 60 mg once daily. Titration to doses more than 90 mg daily is not recommended.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Contraindications Nicardia Retard tablets are contraindicated in persons with a hypersensitivity (allergy) to Nifedipine or any of the other ingredients of this medicine.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Storage Instructions

Nicardia Retard Tablets(Generic Nifedipine Sustained Release Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F).

Keep this as well as all other medicines away from children and pets.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Warnings

Excessive Hypotension: Normally in most patients the hypotensive effect of Nifedipine is modest and well tolerated, occasional patients have had excessive and poorly tolerated hypotension.

Increased Angina and/or Myocardial Infarction: Rarely, patients, particularly those who have severe obstructive coronary artery disease, have developed welldocumented increased frequency, duration and/or severity of angina or acute myocardial infarction upon starting therapy with Nifedipine tablets or at the time of dosage increase.

Beta-Blocker Withdrawal: When stopping a beta-blocker it is important to taper its dose, if possible, rather than stopping abruptly before starting treatment with Nifedipine. Patients recently withdrawn from beta blockers may develop a withdrawal syndrome with increased angina, which is most probably related to increased sensitivity to catecholamines.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Warnings

Congestive Heart Failure: Rarely, patients have developed heart failure after starting Nifedipine.

Concomitant administration with strong P450 inducers, such as Rifampin, are contraindicated. Nifedipine should not be used in cases of cardiogenic shock.

Since Nifedipine decreases peripheral vascular resistance, careful monitoring of blood pressure during the initial administration and titration of Nicardia Retard is recommended.

Mild to moderate peripheral edema occurs in a dose-dependent manner with Nifedipine.

Clearance of Nifedipine is decreased and systemic exposure increased in patients with cirrhosis. It is unknown how systemic exposure may be altered in patients with moderate or severe liver impairment. Careful monitoring and dose reduction may be necessary in such patients.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Warnings

Do not start therapy with Nicardia Retard (Nifedipine Tablets) within 3 days of drinking grapefruit juice or eating grapefruit.

Inform your doctor if you have had grapefruit or grapefruit juice in this time.

Also, do not drink grapefruit juice or eat grapefruit whilst taking Nicardia Retard Tablets. Grapefruit juice has been observed to increase the blood levels of the active ingredient, Nifedipine. This effect can last for at least 3 days.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Side Effects

The most common side effects of Nifedipine (Nicardia Retard Tablets) include Dizziness, lightheadedness, giddiness, Flushing, heat sensation, Headache, Weakness, Nausea, heartburn, Muscle cramps, tremor, Peripheral edema, Nervousness, mood changes, Palpitation, Dyspnea, cough, wheezing, Nasal congestion and sore throat. other side effects include: Incidence Approximately 10% Cardiovascular: peripheral edema Central Nervous System: dizziness or lightheadedness Gastrointestinal: nausea Systemic: headache and flushing, weakness.

Incidence Approximately 5% Cardiovascular: transient hypotension URL: https://www.clearskypharmacy.biz/generic-adalat-cc-procardia-nicardia-by-unique.html

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Side Effects

Incidence 2% or Less Cardiovascular: palpitation Respiratory: nasal and chest congestion, shortness of breath Gastrointestinal: diarrhea, constipation, cramps, flatulence Musculoskeletal: inflammation, joint stiffness, muscle cramps Central Nervous System: shakiness, nervousness, jitteriness, sleep disturbances, blurred vision, difficulties in balance.

Other: dermatitis, pruritus, urticaria, fever, sweating, chills, sexual difficulties.

Incidence Approximately 0.5% Cardiovascular: syncope (mostly with initial dosing and/or an increase in dose), erythromelalgia URL: https://www.clearskypharmacy.biz/generic-adalat-cc-procardia-nicardia-by-unique.html

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Side Effects

Incidence Less Than 0.5% Hematologic: thrombocytopenia, anemia, leukopenia, purpura Gastrointestinal: allergic hepatitis Face and Throat: angioedema (mostly oropharyngeal edema with breathing difficulty in a few patients), gingival hyperplasia CNS: depression, paranoid syndrome Special Senses: transient blindness at the peak of plasma level, tinnitus Urogenital: nocturia, polyuria Other: arthritis with ANA (+), exfoliative dermatitis, gynecomastia Musculoskeletal: myalgia

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Overdose A number of persons have developed toxicity due to acute overdosage with Nifedipine, either accidentally or intentionally, and via either oral or parenteral administration. The adverse effects include heart rhythm disturbances, metabolic acidosis, hypoxia, cardiogenic shock with pulmonary edema, lethargy, bradycardia, marked hypotension (drop in blood pressure) and loss of consciousness.

Usually, Nifedipine overdose leading to pronounced hypotension calls for active cardiovascular support including monitoring of cardiovascular and respiratory function, elevation of extremities, judicious use of calcium infusion, pressor agents (medication that tends to raise reduced blood pressure) as well as fluids.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Overdose After oral ingestion, thorough gastric lavage is recommended, in case necessary in combination with irrigation of the small intestine.

In cases involving overdosage of a slow-release product like Nicardia Retard, removal should be as complete as possible, including from the small intestine, to prevent the subsequent absorption of the active substance.

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

Nicardia Retard Tablets During Pregnancy Nifedipine (Nicardia Retard Tablets) is classified by the US FDA as Pregnancy Category C. During animal studies conducted in rodents, rabbits and monkeys, Nifedipine has been observed to have a variety of embryotoxic, placentotoxic, teratogenic and fetotoxic effects, including including stunted fetuses (rats, mice and rabbits), digital anomalies (rats and rabbits), rib deformities (mice), cleft palate (mice), small placentas and underdeveloped chorionic villi (monkeys), embryonic and fetal deaths (rats, mice and rabbits), prolonged pregnancy (rats; not evaluated in other species), and decreased neonatal survival (rats; not evaluated in other species).

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Nicardia Retard Tablets (Generic Nifedipine Sustained Release Tablets)

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Nicardia Retard Tablets(Generic Nifedipine Sustained Release Tablets) by J B Chemicals and Pharmaceuticals Limited, India.

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