Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Lamivir HBV Tablets (Generic Lamivudine HBV Tablets) are used for the treatment of chronic hepatitis B in adults associated with evidence of hepatitis B viral replication and active liver inflammation.

It is not a cure for hepatitis B and does not prevent the passing of hepatitis B to others. This medication is a nucleoside reverse transcriptase inhibitor (NRTI) that works by slowing the growth of the virus, thereby decreasing liver damage caused by the virus.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Active Ingredient

The active ingredient present in Lamivir HBV is Lamivudine. Each Lamivir-HBV tablet contains 100 mg of Lamivudine.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Chemical Structure The structure of Lamivudine

is given below:

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Lamivir HBV tablets are manufactured by Cipla Limited, India in the strengths of 100 mg. ( Website: https://www.cipla.com/ )

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Lamivudine Tablets – Brand Names

Lamivudine tablets are available under various drug trade names that include Epivir-HBV, Epivir, Lamivir HBV, Lamivir, Hepitec, Hepavud, Lamda, Lami, Lamidac, Lamuvid, Retrolam, Viramid and Virolam.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Uses of Lamivir HBV Tablets

Lamivudine HBV tablets (Lamivir HBV Tablets) are indicated for the treatment of chronic hepatitis B virus (HBV) infection associated with evidence of hepatitis B viral replication and active liver inflammation The following points should be considered when initiating therapy with Lamivudine HBV tablets : Due to high rates of resistance development in treated patients, initiation of treatment with Lamivudine HBV tablets should only be considered when the use of an alternative antiviral agent with a higher genetic barrier to resistance is not available or appropriate.

Lamivudine HBV tablets have not been evaluated in patients co-infected with HIV, hepatitis C virus (HCV), or hepatitis delta virus.

Lamivudine HBV tablets have not been evaluated in liver transplant recipients or in patients with chronic hepatitis B virus infection with decompensated liver disease.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Lamivir HBV Tablets Dosage The recommended oral dose of Lamivir- HBV (Generic Lamivudine HBV Tablets) for treatment of chronic hepatitis B in adults is 100 mg once daily.

Safety and effectiveness of treatment beyond 1 year has not been established and the optimum duration of treatment is not known.

The formulation and dosage of Lamivudine in Lamivir-HBV Tablets are not appropriate for patients dually infected with hepatitis B virus (HBV) and HIV. If Lamivudine is administered to such patients, the higher dosage indicated for HIV therapy should be used as part of an appropriate combination regimen.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Contraindications Lamivir- HBV is contraindicated in patients with a hypersensitivity to Lamivudine or any other component of this medication.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Storage Instructions

Lamivir- HBV (Generic Lamivudine HBV Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F).

Keep this as well as all other medicines away from children and pets.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Warnings Severe acute exacerbations of hepatitis B have been reported in patients who have discontinued anti-hepatitis B therapy (including LamivudineHBV). Monitor hepatic function closely in these patients and, if appropriate, initiate anti-hepatitis B treatment.

Lamivudine-HBV tablets and oral solution contain a lower dose of the same active ingredient (Lamivudine) as Lamivudine tablets (Lamivir) and oral solution used to treat HIV-1 infection. HIV-1 resistance may emerge in chronic hepatitis B patients with unrecognized or untreated HIV-1 infection because the lamivudine dosage in Lamivudine-HBV is subtherapeutic and monotherapy is inappropriate for the treatment of HIV-1 infection.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Warnings Emergence of Resistance-Associated HBV Substitutions: Consider a switch to an alternative regimen if serum HBV DNA remains detectable after 24 weeks of treatment.

Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Side Effects The most common reported side effects in those receiving Lamivudine-HBV (Lamivir- HBV) with an incidence greater than or equal to 10% and reported at a rate greater than placebo were ear, nose, and throat infections; sore throat; and diarrhea.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Side Effects

The following side effects have been identified during post-approval use of Lamivudine 100 mg tablets.

Blood and Lymphatic: Anemia (including pure red cell aplasia and severe anemias progressing on therapy), lymphadenopathy, splenomegaly, thrombocytopenia.

Digestive: Stomatitis.

Ear and Labyrinth Disorders:Hearing loss Endocrine and Metabolic: Hyperglycemia. General Weakness.

Hepatic and Pancreatic: Lactic acidosis and steatosis , posttreatment exacerbations of hepatitis , pancreatitis.

Hypersensitivity: Anaphylaxis, urticaria.

Musculoskeletal: Cramps, rhabdomyolysis.

Nervous: Paresthesia, peripheral neuropathy.

Respiratory: Abnormal breath sounds/wheezing.

Skin: Alopecia, pruritus, rash.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Lamivir- HBV Overdose There is no known specific treatment for overdose with Lamivudine Tablets (Lamivir HBV).

In case overdose occurs, the patient should be monitored and standard supportive treatment applied as necessary.

Since a negligible amount of Lamivudine was removed via (4-hour) hemodialysis, continuous ambulatory peritoneal dialysis, and automated peritoneal dialysis, it is not known if continuous hemodialysis would provide clinical benefit in a Lamivudine overdose event.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

Lamivir- HBV Tablets During Pregnancy Lamivudine (Lamivir HBV Tablets) has been classified by the US FDA as Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies of Lamivudine Tablets in pregnant women.

This medicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

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Lamivir HBV Tablets (Generic Lamivudine HBV Tablets)

For more details on Lamivir HBV Tablets click here

Lamivir HBV Tablets (Generic Lamivudine HBV Tablets) by Cipla Limited, India.

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