Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler) is used in the treatment of chronic obstructive pulmonary disease (bronchitis and emphysema) when there is evidence of spasm (narrowing) of the airways (bronchi).

These two medicines work together to help open the airways in the lungs. Ipratropium Bromide and Albuterol Sulfate is used to help treat airway narrowing (bronchospasm) that happens with chronic obstructive pulmonary disease (COPD) in adult patients who need to use more than one bronchodilator medicine. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Active Ingredient

The active ingredients present in Duolin Inhaler are Ipratropium Bromide And Levalbuterol Tartarate. Each puff contains 50 mcg of Levalbuterol Tartarate (Levosalbutamol Tartarate) and 20 mcg Ipratropium Bromide.

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Chemical Structure The structure of Ipratropium Bromide is given below:

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Chemical Structure The structure of Levalbuterol Tartarate (Levosalbutamol Tartarate) is given below:

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Duolin Inhaler is manufactured by Cipla Limited, India and is available as a canister containing 200 metered doses.

Each measured dose contains 50 mcg of Levosalbutamol Tartarate ( Levalbuterol Tartarate) and 20 mcg Ipratropium Bromide.

(Website: https://www.cipla.com/ )

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Ipratropium Bromide and Levalbuterol (Levosalbutamol) Inhaler – Brand Names

Ipratropium Bromide And Levalbuterol (Levosalbutamol) Inhaler is available under various drug trade names that include Combivent, Duolin, Aeromist, Combimist Inhaler, Iprazest, Salbair-I and Ventipra. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Uses of Duolin Inhaler Ipratropium Bromide and Levalbuterol Tartarate combination Inhaler is used to help control the symptoms of lung diseases, such as asthma, chronic bronchitis, and emphysema. It is also used to treat air flow blockage and prevent the worsening of chronic obstructive pulmonary disease (COPD) in patients who need another medicine.

Ipratropium and Levalbuterol belong to the family of medicines known as bronchodilators. Bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs.

Duolin Inhaler is a combination of Ipratropium Bromide and Levalbuterol Tartarate.

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Uses of Duolin Inhaler Duolin Inhaler is a combination of Ipratropium Bromide and Levalbuterol Tartarate.

Ipratropium bromide is an anticholinergic (parasympatholytic) agent, which inhibits vagally-mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released from the vagus nerve.

Levosalbutamol tartarate is a relatively selective beta2-adrenergic agonist, whose activation leads to an increase in intracellular adenyl cyclase, the enzyme which catalyses the conversion of adenosine triphosphate (ATP) to cyclic-3', 5'- adenosine monophosphate (cAMP).

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Duolin Inhaler Dosage The dosage of Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Tartarate Inhaler) is given below:

The dosage of Duolin Inhaler is 2 inhalations, four times a day. Patients may take additional inhalations as required; however, the total number of inhalations should not exceed 12 in 24 hours. It is recommended to “test-spray” three times before using for the first time and in cases where the aerosol has not been used for more than 24 hours. Avoid spraying into eyes.

Duolin Inhaler may be used with a Zerostat VT Spacer device in patients who find it difficult to synchronize aerosol actuation with inspiration of breath.

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Duolin Inhaler Contraindications Duolin Inhaler is contraindicated in patients with a hypersensitivity to Ipratropium Bromide, Levalbuterol Tartarate (Levosalbutamol Tartarate) or any other component of this medication. Reactions have included urticaria, angioedema, rash, bronchospasm, anaphylaxis, and oropharyngeal edema.

Ipratropium Bromide is contraindicated in patients who are hypersensitive to Atropine or its derivatives.

Duolin Inhaler is contraindicated in patients with a history of hypersensitivity to soya lecithin or related food products such as soybean and peanut.

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Storage Instructions

Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Tartarate Inhaler) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F).

Keep this as well as all other medicines away from children and pets.

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Warnings Paradoxical Bronchospasm: Duolin Inhaler could produce paradoxical bronchospasm that can be life-threatening. In case it occurs, this medicine should be stopped immediately and alternative therapy instituted.

Cardiovascular Effect: The Levalbuterol Tartarate (Levosalbutamol Tartarate) contained in Duolin Inhaler, like other beta-adrenergic agonists, can produce a clinically significant cardiovascular effect in some patients, as measured by pulse rate, blood pressure and/or symptoms. In case any of these symptoms occur, discontinuation of the medication may be indicated.

Do Not Exceed Recommended Dose: Fatalities have been reported in association with excessive use of inhaled sympathomimetic medicines, in patients with asthma. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Warnings Immediate Hypersensitivity Reactions: Immediate hypersensitivity reactions may occur after administration of Ipratropium Bromide or Levosalbutamol Tartarate (Levalbuterol Tartarate), as demonstrated by urticaria, angioedema, rash, bronchospasm, anaphylaxis, and oropharyngeal edema. If such a reaction occurs, treatment with Duolin Inhaler should be stopped at once and alternative therapy should be considered.

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Duolin Inhaler Side Effects The common Duolin Inhaler (Ipratropium Bromide and Levalbuterol Tartarate Inhaler) side effects include: Body as a Whole-General Disorders: Headache, Pain, Influenza, Chest Pain; Gastrointestinal System Disorders : Nausea; Respiratory System Disorders (Lower): Bronchitis, Dyspnea, Coughing, Respiratory Disorders, Pneumonia, Bronchospasm; Respiratory System Disorders (Upper): Upper Respiratory Tract Infection, Pharyngitis, Sinusitis Rhinitis.

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Duolin Inhaler Side Effects Additional side effects, reported in less than two percent of the patients in the Duolin Inhaler (Ipratropium Bromide and Levalbuterol Tartarate Inhaler) treatment group include edema, fatigue, hypertension, dizziness, nervousness, paresthesia, tremor, dysphonia, insomnia, diarrhea, dry mouth, dyspepsia, vomiting, arrhythmia, palpitation, tachycardia, arthralgia, angina, increased sputum, taste perversion, and urinary tract infection/dysuria.

Allergic-type reactions such as skin reactions including rash, pruritus, and urticaria (including giant urticaria), angioedema including that of tongue, lips and face, laryngospasm and anaphylactic reaction have been reported with Ipratropium Bromide And Albuterol Sulfate Inhaler, with positive rechallenge in some cases. Many of these patients had a history of allergies to other medicines and/or foods including soybean.

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Overdose The effects of overdosage are expected to be related primarily to Levalbuterol Tartarate. Acute overdosage with Ipratropium Bromide by inhalation is unlikely since Ipratropium Bromide is not well absorbed systemically after aerosol or oral administration.

Symptoms of overdosage with albuterol may include seizures, anginal pain, hypertension or hypotension, hypokalemia, tachycardia with rates up to 200 beats per minute, metabolic acidosis, arrhythmias, nervousness, headache, tremor, dry mouth, palpitation, nausea, dizziness, fatigue, malaise, and sleeplessness and exaggeration of the pharmacologic effects listed in side effects. As with all sympathomimetic aerosol medications, cardiac arrest and even death may be associated with abuse of Levosalbutamol.

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Overdose Treatment consists of discontinuation of Duolin Inhaler (Ipratropium Bromide and Levalbuterol Tartarate Inhaler) together with appropriate symptomatic therapy. The judicious use of a cardioselective betareceptor blocker may be considered, bearing in mind that such medication can produce bronchospasm.

There is insufficient evidence to determine if dialysis is beneficial in treating overdosage of Levosalbutamol.

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

Duolin Inhaler During Pregnancy Ipratropium Bromide and Levalbuterol Tartarate Inhaler (Duolin Inhaler) has been classified by the US FDA as Pregnancy Category C.

There are no adequate and well-controlled studies of Ipratropium Bromide and Levalbuterol Tartarate Inhaler (Duolin Inhaler), Ipratropium Bromide Or Albuterol Sulfate, in pregnant women. Animal reproduction studies have not been conducted with this medicine. However, Albuterol Sulfate has been shown to be teratogenic in mice and rabbits.

Duolin Inhaler (Ipratropium Bromide and Levalbuterol Tartarate Inhaler) can be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Because of the potential for beta-agonist interference with uterine contractility, use of Duolin Inhaler for the treatment of COPD during labor should be restricted to those patients in whom the benefits clearly outweigh the risk.

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Sulphate Inhaler)

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Duolin Inhaler (Generic Ipratropium Bromide and Levalbuterol Tartarate Inhaler) by Cipla Limited, India.

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