Clayco_Life Sciences

LIFE SCIENCES

INTEGRATED DEVELOPMENT, DESIGN, ENGINEERING & CONSTRUCTION SERVICES 2026

Life Sciences Service Offerings

DESIGN, ENGINEERING AND CONSTRUCTION

Life Sciences Leadership Team

+ Site Master Planning & Due Diligence

Leveraging our combined experience in process engineering and operations, cGMP manufacturing, laboratory design, and workplace at various scales – our Enterprise team effectively integrates user requirements and regulatory knowledge into each buildout.

+ Basis of Design (BOD) Development + Front End Loading (FEL) Studies, Peer Evaluations + Strategic Facility Planning, Existing Facility Assessments + Life Safety/Code Reviews + Process Architecture Design + Aseptic Process Design

Ryan Abbott

Paul DePenning

PRESIDENT, SOUTHWEST REGION

SR. VICE PRESIDENT

Life Sciences

Life Sciences

Jose Rivera

John Lagodney

Marc Hanson

SR. VICE PRESIDENT

SR. VICE PRESIDENT

VICE PRESIDENT

Life Sciences

Life Sciences

Life Sciences

+ Consulting (Aseptic Filling, Inspection, Packaging, Lyophilization, Sterilization, OSD) + Regulatory Impact Assessments and Guidance + Manufacturing Process and Logistics Planning + Sustainability Planning and Delivery + Process Engineering, Mechanical, Plumbing, Electrical and Structural Design + Cleanroom Design & Installation

Chris Connelly

Cullen Stewart

Robert Sunukjian

VICE PRESIDENT

SR. PRECONSTRUCTION MANAGER

PROJECT DEVELOPMENT DIRECTOR

+ Hygienic Utility System Analysis & Design

Life Sciences

Life Sciences

Life Sciences

+ Preconstruction Planning and Budgetary Analysis + Laboratory Planning and Design + Workplace & Interior Design

Clayco Safe: Outstanding Results

OSHA VOLUNTARY PROTECTION PROGRAM (VPP) STAR 10-YEAR MEMBER

VPP ACROSS 15 STATES

Clayco takes a proactive approach to safety management, production and quality to provide the owner with a superior final project that is injury and accident free.

0.39

CURRENT EMR (WELL BELOW 1.0 INDUSTRY AVERAGE)

82%

BELOW NATIONAL AVERAGE RECORDABLE RATE

80%

OF ALL PROJECTS HAD ZERO RECORDABLES IN 2025

Region 7 Region 5

EMR 0.54

1.0 Industry Average EMR 0.50

2020 2021

0.52 2022

0.48 2023

0.40

0.39

2024

2025

ENTERPRISE HOURS & RATES total recordable injury rate

88%

total work hours

308%

2.64 TRIR

7.2M Hours

29.4M Hours

0.29 TRIR

2017 2018 2019 2020 2021 2022 2023 2024 2025

OUR COMMITMENT TO

Our Clients & Community

PEOPLE & SAFETY

Safety is foundational to our work, and we are all responsible for creating a safe environment. Through regular trainings and awareness activities we prioritize proactive measures. Addressing physical and psychological well-being is vital, and we foster open dialogue for all employees.

82% below national average recordable rate

80% of all projects had zero recordables in 2025

OSHA VOLUNTARY PROTECTION PROGRAM (VPP) STAR 10-YEAR MEMBER

CLAYCO RISING (CULTURE, EMPOWERMENT, AND INCLUSION) Clayco coordinates social impact efforts through Clayco Rising, a leading CEI program in the industry. With 25 years of experience, Clayco Rising creates opportunities and structural change for employees, our trade partners, and communities.

OUR COMMUNITY

Clayco’s culture extends beyond building structures. We’re committed to long-term partnerships with our communities. A vital part of our identity is dedicating time, energy, and resources to projects and nonprofit organizations in the communities where we live and work.

Clayco consciously meets the needs of today, while empowering future generations. As builders and designers, we are the responsible stewards of the built environment and believe it is our duty to protect and preserve the natural and cultural resources of the communities we serve.

OUR ENVIRONMENT

Clayco prioritizes environmental responsibility, as we meet the needs of employees, clients, and future generations. We design and construct buildings to reduce emissions and enhance energy efficiency. We lead with innovative solutions to minimize embodied carbon and waste. We have 100+ Sustainably Certified Projects and 70+ Sustainability Accredited Professionals.

SBTi Net-Zero Approved

AIA 2030 NetZero Committed AIA Materials Pledge

42 YEARS OF THE

4,000 A FIRM OF THE BEST & BRIGHTEST WITH

+

EMPLOYEES ACROSS THE COUNTRY

0.39

A SAFETY LEADER WITH A CURRENT EMR OF

(1.0 INDUSTRY AVERAGE)

A LOOK AT

Who We Are

$8.1B ACCOMPLISHED 2025 REVENUE

Our team specializes in the “art and science of building,” providing fast-track, efficient solutions. Year after year, we are ranked

by Engineering News Record as a top 5 design-builder and contractor. By embracing the passion, creativity, and ideas of our people, we have been recognized as the Fast Company Best Workplace for Innovators and Brands That Matter.

IN-HOUSE SERVICES

The Power of Integration

Clayco is an unmatched, collaborative team. Financial planners, designers, engineers, programmers, builders, and clients work transparently, sharing knowledge with a common desire to exceed owner expectations. Our vast offering of in-house disciplines allows us to provide the specialized services to meet our client’s individual project needs to deliver unparalleled results.

Develop

Design & Engineering

+ Site Selection

+ Architecture

+ Development

Build + Design-Build

+ Interiors

+ Process & Manufacturing

+ Financing

+ Urban Planning & Design

+ Building Systems

+ Integrated Delivery

+ Asset Management

+ Landscape Architecture

+ Structural

+ CM@Risk

+ Sustainability

+ VDC/BIM

+ EPC

+ Design-Assist

+ Self-Perform Concrete Construction

+ Self-Perform Mechanical, Electrical & Process Systems

+ Self-Perform Building Envelope

+ Procurement Direct Manufacturer Sourcing Nationwide Purchasing Power Delivery Logistics

Project Life Cycle

CLAYCO INTEGRATED SERVICES ARCHITECTURE/ ENGINEERING CONSTRUCTION

CONCRETE CONSTRUCTION MECHANICAL ELECTRICAL & PROCESS SYSTEMS GLASS EXTERIOR CLADDING SYSTEMS PROCUREMENT

= Direct Project Engagement

= Project Support

Preconstruction

At Clayco, competitive pricing, speed-to-market, safety, and quality are paramount.

Our preconstruction approach enables us to deliver highly complex projects within accelerated time frames by collaborating across our full platform of services through communication, lean principles, and technology.

Technology

+ Virtual Design & Construction (VDC)

+ AI & Machine Learning

+ 3D Visualization/Augmented Reality

+ Digital Project Handover

+ Pre-Construction Integration (4D/5D)

+ Generative Design

+ Digital Layout & Reality Capture

+ ACC Common Data Environment

+ Robotics

+ Facility Asset Tracking

+ Digital Jobsite

+ Digital Twin Development

QA/QC

Our Technical Assurance Group (TAG) and Quality Control Team supports all our business and market sectors by meticulously formulating and testing design solutions and ensuring our design processes are of the utmost quality.

COMPREHENSIVE

Capabilities

With these unique services, Clayco delivers a seamless, transparent, and fully integrated delivery experience to our customers.

This is what we do every day. It’s not a segmented endeavor, but a continuum from the initial idea to the project outcome.

Team Experience

OFFICE LOCATIONS

Life Sciences | Biopharmaceutical | R&D Laboratories | API Pharmaceutical | Institutional | Commercial | Industrial

OUR CAPABILITIES

Life Sciences Focus

Aseptic Fill/Finish

Lyophilization

Oral Solid Dosage/Nutraceutical

Syringes

Medical Device

Animal Health

API & Peptides

Cell & Gene Therapy

Oligonucleotides

Packaging

Therapeutic Proteins / ADC

Radiopharmaceutical

Lilly Lebanon Plant 1 (API) Program Lebanon, IN 395,000 SF

Confidential Client Sterilization Facility 90,000 SF

Confidential Agar Plate Production Facility St. Louis, MO 16,000 SF

Image provided courtesy of Eli Lilly

Lilly Medicine Foundry Lebanon, IN 200,000 SF

Benson Hill Biosystems Creve Coeur, MO 160,000 SF

Pfizer Research & Development Facility Chesterfield, MO 295,000 SF

Regeneron B18 Logistics Center – TTCX Tarrytown, NY 137,000 SF

Pfizer Boulder Campus Phase 1 Building Renovation Boulder, CO 20,000 SF

Procurement Perspective

REG ION AL :

$7.6B

2024 REVENUE

0.39

CURRENT EMR

3,800+

LO

• Continuous relationship development, education, and outreach with trade partners and suppliers.

L: 1.5 ho A C

• Maintenance of current trade partners and supplier safety and financials supporting prequalification readiness.

• Direct one-on-one communication and outreach with partners, incrementally building trust.

Strategies for Reducing Procurement Costs 2. Eliminate maverick spending

1. Conduct a spend analysis

4. Leverage your purchase power

3. Develop a cost-reduction strategy

5. Optimize your process & team

6. Monitor supplier performance

7. Evaluate your contracts

VALUED EMPLOYEES

Procurement Success

Clayco consistently achieves COST SAVINGS OF 8-12% on equipment packages.

Conceptual Planning

ABILITY TO INFLUENCE COST & SCHEDULE

Outreach

Procurement

SAFETY THROUGH PROACTIVE n io t c DESIGN u str co

The Art of the Possible

Design

Construction

con f o st

FRONT END LOADING EPC 1 2 3 DESIGN-BUILD

Start Up CMAR

DESIGN-BID-BUILD

mute com ur ho

1984

ESTABLISHED

• Bundling of multiple projects equipment requirements into one purchase order to facilitate outstanding value.

commute ur

Clayco’s team of architects, engineers, and construction professionals are experienced in executing a wide range of state-of-the-art programs across all sectors of the biopharmaceutical industry.

This uniquely positions the delivery of fast-track, complex projects from initial concept to successful turnover which supports the end goal of delivering essential products to patients.

5 4.

• Direct manufacturer contacts, securing product availability and reducing time to market.

Project Trade Partner Procurement ClayExecution co Bidding ProcePlan: ss 11 12 1 2 10 9 3 8 4 7 6 5

1-5 Business Days

*Complete Project

Trade Partner Prequalification

11 12 1 2 10 9 3 8 4 7 6 5

11 12 1 2 10 9 3 8 4 7 6 5

7-14 Business Days Depending on Package Complexity

1-3 Business Days Reconcile 60% Design Estimate for Early Procurement

Specific Front End Documents

Develop Project Specific Set of CWP Bid Package Documents*

Construction Work Package (CWP) Design Package

Complete Scope of Work in Bluebeam & Building Connected

Gather all Bid Package Documents and QA Review for Issuance

Issue Bid Package to Approved Bidders from Project Procurement Plan (PPP)

Yes Complete Design Document List w/ Design Documents

Issue CWP Bid Package for Review in Bluebeam Session

Technical Review & Comment on CWP Bid Package in Bluebeam Session

Complete Bid Leveling and Evaluations

Trade Partner Completes Proposal Based on RFP

Technical Comments Addendum Needed?

Additional Information Needed to Complete Proposals?

No

Complete Proposed Trade Partner Recommendation

Complete Documents for Commercial Review in Bluebeam Session

Yes

No Complete Additional Information Requested from Clayco Procurement

Complete Request for Additional Information

CWP Commercial Review & Contract Issuance 11 12 1 2 10 9 3 8 4 7 6 5

11 12 1 2 10 9 3 8 4 7 6 5

1-3 Business Days

1-5 Business Days CWP Bid Recommendation & Commercial Review in Bluebeam Session

Issue CWP Recommendation & Commercial Approval

Incorporate Recommendation & Commercial Comments and Load Into PM Web

Prepare CWP Subcontract for Issuance to Trade Partner

Prepare CWP Subcontract Package for Signature in Adobe Acrobat Sign

Trade Partner Reviews and Signs Subcontract

Trade Partner

Enroll Trade Partner in OCIP

* Project SpSpecific ecific ConsConstruction truction Work PacWork kage (CPackage WP) Bid Do(CWP) cumentsBid Documents *Project A. Documents A. Project ProjectSpecific SpecificFront-End Front-End Documents 1. Table TableofofContents Contents 2. Invitation Invitation to toBid Bid 3. Instruction Instruction to toBidders Bidders 4. Site Logistics Plan Site Access Accessand Plan 5. Construction ConstructionMilestone MilestoneSchedule Schedule 6. Bid Bid Proposal ProposalForm Form 7. Contract Between Contractor and Subcontractor Contract Between Contractor and Subcontractor 8. Performance Bond Form Performanceand andPayment Payment Bond Form 9. Subcontractor Partial Waiver andand Affidavit Subcontractorand andSupplier SupplierPre-Payment Pre-Payment Partial Waiver Affidavit 10. Subcontractor Partial Waiver andand Affidavit Subcontractorand andSupplier SupplierPost-Payment Post-Payment Partial Waiver Affidavit 11. General GeneralConditions Conditions 12. Specific (E.g., System TOP) Specific Project ProjectRequirements RequirementsDocument Document 13. Insurance Program Specific Project Requirements (Attachment A – Electronic Data Release) 14. Equal Opportunity Specific Project Requirements (Attachment B – Coordination Program) 15. Site Specific Safety Plan Insurance Program B. Scope of Work 16. Equal Opportunity C. Design Documents (Document List, Drawings, Specifications, Other)

Property of Clayco - Copyright 2025

OCIP Rep Contacts Trade Partner to Complete Enrollment

Trade Partner Provides Docs to Complete OCIP Enrollment

Clayco Signs Final Subcontract

Clayco

OCIP Rep Issues OCIP Certificate of Insurance

Accountability Legend Project Director

Project Development

Client

Project Management

Project Engineer

LJC

Field Operations

Safety Safety

Trade Partner/ Supplier

System Info Architecture

Document Control

Document Control

Cost Control Control Cost

Schedule Control

Mission Control

CQV (3rd Party)

Quality

Preconstruction

OCIP (3rd Party)

29JAN2025 rA

PROPERTY OF CLAYCO © 2025 - UPDATED 17 FEBRUARY 2025

We see beyond these walls

to the people and purpose within

DePenning/Sunukjian

we see BEYOND THESE WALLS to a better TOMORROW

CONTACT US Paul DePenning Senior Vice President Clayco e depenningp@claycorp.com p 205.837.3033

CLAYCORP.COM

Jose Rivera Senior Vice President Clayco e riverajo@claycorp.com p 512.406.1815

John Lagodney Senior Vice President Clayco Design & Engineering e lagodneyj@claycorp.com p 484.250.2861

Marc Hanson Vice President Clayco e hansonm@claycorp.com p 531.444.7183

CLAYCORP.COM