Although 2017 and 2018 were full of challenges for Puerto Rico, they were also full of opportunities and examples of strength and resilience that reinforced our commitment to empower and serve. This report is a testimony of all we can achieve when we place science at the service of Puerto Rico. During 2017-2018, CienciaPR embarked on a more focused strategic direction; we created new educational programs that have impacted more than 150 teachers and 1,800 students in Puerto Rico; we supported the scientific community during the recovery of hurricanes Irma and María; we trained 80 young scientific leaders from 50 institutions in the United States and Puerto Rico; we launched an action network to encourage the participation of scientists in decision-making and public policy; and we were recognized as Science Defenders. We hope you enjoy learning about the fruits of our labor.