NewsNotes - Summer 2018

NEWSNOTES CHILDREN’S DIABETES FOUNDATION — SUMMER 2018

SPRING BRASS RING Christina & Lori Finch

Photo: © Broxton Art

BRASS RING LUNCHEON

THE SPRING BRASS RING

SPRING BRASS RING LUNCHEON RAISES $400K FOR THE CHILDREN’S DIABETES FOUNDATION The 40th annual Spring Brass Ring Luncheon & Fashion

Show raised an astounding $400,000 for The Guild of the Children’s Diabetes Foundation, breaking all previous records for the event. The event, chaired by Lori Finch, was held on Friday, April 13th at the Hilton Denver City Center and drew 775 attendees together for a morning of support and awareness for the heroes living with type 1 diabetes.

Barb Oberfeld, President of The Guild of the Children’s Diabetes Foundation, opened the event, saying, “Today we celebrate the strength and courage of type 1 children and their families, as well as the extraordinary advances made in the field of diabetic care and treatment. Advances in research give us hope that a cure is within reach.”

Lori Finch, the 2018 Brass Ring Luncheon Chair put an incredible amount of love and commitment into the event, largely inspired by her daughter who has type 1 diabetes, saying, “My family continues to give me endless love and support and for that I am eternally grateful. I am especially thankful to my daughter, Christina, for showing me that you become strong in the moments when you think you can’t go on, but you keep going anyway.”

Attendees heard personal stories from kids and teens about their worst day with type 1 diabetes – ranging from dangerous lows to the social stigmas of the disease. After learning what life with this disease is like, the audience erupted into a standing ovation as the type 1 heroes walked the runway.

The Luncheon featured a stunning runway fashion show presented by Mariel Boutique, featuring designs by Nicole Bakti.

The beautiful gowns and flattering silhouettes were 3 exciting to see from start to finish. A special thank you to Joshua Schmitz and the Unlife Creative Agency for 1

producing the show and Gina Comminello and The Look Salon for providing hair and makeup for the models.

Additional highlights from the afternoon included a heartwarming prayer from Margot Rea, a 9 year-old patient with type 1 diabetes, and seeing artist Allison Wickey’s painting come to life throughout the event to later be sold in the live auction. CBS4’s Dave Aguilera served as the Master of Ceremonies, and during the live auction, attendees bid on exciting travel packages and more. Attendees raised their paddles to donate an unprecedented $162,500 to the Children’s Diabetes Foundation.

“This year’s Brass Ring Luncheon was a smashing success,” said Susie Hummell, Guild Program Manager for the Children’s Diabetes Foundation. “We set a new all-time record for fundraising thanks to the unwavering support of the Denver community, the amazing team at the Children’s Diabetes Foundation, our wonderful Event Chair and esteemed fashion stylists. But more importantly, we continued to educate our community about what the Barbara Davis Center is doing to prevent and, ultimately, find a cure for diabetes.”

Proceeds benefit The Guild of the Children’s Diabetes Foundation whose mission is to raise funds to support programs of education, awareness and research, and treatment. These programs include: Helping Hand, an assistance program for families in need, a scholarship program for young people with type 1 diabetes, the Diabetes Awareness and Education Program, and clinic and research programs at the Barbara Davis Center for Diabetes.

To stay up-to-date for future Children’s Diabetes Foundation events, visit www.ChildrensDiabetesFoundation.org and follow us on social media!

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BRASS RING LUNCHEON

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PHOTOS LEFT: 1. Live auction 2. Fashion Show 3. Lisa Corley & Dana Davis 4. Margot Rea, Prayer Child 5. Dave Aguilera of CBS4 PHOTOS RIGHT: 1. Type 1 Heroes 2. Jewels for Hope Team 3. Denise Snyder & Aida Gharakhani 4. Hailey & Kate Kiker 5. The Deatherage Family 6. Neil & Barb Oberfeld 7. Judy & Charlie McNeil 8. Susie Hummell & Rick Rolph 9. Type 1 Heroes walk the runway

Photo: © Janssen Photography

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Saturday, October 6, 2018 The Beverly Hilton Hotel in Beverly Hills, CA Benefiting the Barbara Davis Center and the Children’s Diabetes Foundation

Honoring with the Brass Ring Award Chairman: Mrs. Barbara Davis Co-Chairman: Ms. Dana Davis Master of Ceremonies: Jay Leno Music Director: David Foster Producer: George Schlatter Music Chairmen: Clive Davis & Quincy Jones Auctioneer: Sharon Stone

The 2018 Carousel of Hope Ball is generously sponsored by American Airlines, The Beverly Hilton, Tina & Rick Caruso, Marlyn and Robert Day, and Dexcom.

Learn more about The 2018 Carousel of Hope sponsorships, auction donations, program advertising, and more at

www.ChildrensDiabetesFoundation.org #CarouselofHope 4

THE CAROUSEL OF HOPE KICKOFF PARTY

Mrs. Barbara Davis and Mr. Bruce Bozzi, Jr. co-hosted an elegant cocktail party at The Palm in Beverly Hills, California on Monday, May 21st to kickoff a wonderful year of support for The Carousel of Hope. Attendees came from California and Colorado to hear from Barbara Davis about the exciting details of the upcoming gala, stem cell research from the Barbara Davis Center’s (BDC) Lori Sussel, PhD, and life with type 1 diabetes from 8-year-old BDC patient, Keaton Isakson. Visit www.ChildrensDiabetesFoundation.org to learn more about The Carousel of Hope on October 6th in Beverly Hills, CA. 4

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PHOTOS: 1. Ann Turkel, Dana Davis, Barbara Davis, Alana Collins Stewart 2. Robin Plunket & Nikki Haskell 3. Jolene & George Schlatter 4. Whitney Davis, John Davis & Richard Weitz 5. Keaton Isakson, Dana Davis, Barbara Davis, Lori Sussel, PhD 6. Bruce Bozzi, Jr. & Barbara Davis

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DIABETES NEWS

YOUR IDENTITY WHEN TYPE 1 DIABETES IS IN THE MIX

By Cheryl Lebsock

Just so you know, Frank is a jerk.

Dealing with type 1 diabetes is hard. Really hard. Counting carbs, monitoring blood sugars, giving insulin and being prepared for every curveball that is thrown can be exhausting. Being a parent of a child who has had type 1 for 13 years has been quite a ride. A ride that can be startlingly fast, painfully slow, and sometimes make us want to pull over and get sick. But still we persevere. We are ever grateful for the “gold standard” of diabetes care and the knowledge that our kids with type 1 can and do live a long life with the latest medical advances.

My son Jordon and I were blessed to enter into the FL3X study when he was 14. The FL3X study was counseling for the child with type 1 and also included the parent. In each session, Jordon was asked to identify a struggle he was having with his diabetes and we would help find solutions together. After working through the usual struggles, i.e. testing during school, remembering to bolus and generally keeping him alive – Jordon sat back and just sighed. He said, “I get tired of always talking about my diabetes.

Sometimes I just want to talk about me. My life. Who I am apart from diabetes.” At that moment, Frank was born.

Frank is the name Jordon gave the “monster” that is his diabetes. And, believe me, Frank is a jerk.

Frank is unpredictable. He can act up at the worst time.

He can cause problems with planning and logistics. He can raise a ruckus on sleepovers, P.E. class and in the middle of the night.

Photos: © JensenSutta.com

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Being able to separate Jordon’s diabetes from Jordon has taken so much pressure off of our relationship. It has allowed us to get mad at type 1 diabetes, and not at Jordon.

It has allowed us to work together to fight the battle against diabetes, instead of battling against each other. It has also given us a target for our anger that is separate from Jordon.

Being able to name the beast allowed us to be on the same side of the battle against the daily struggles of type 1 diabetes instead of the opposite sides.

Until the day when medical advances allow us to permanently get Frank out of our household, we can work together to keep him from throwing his “tantrums”. We can make sure we deal with Frank’s curveballs – then we can make sure to make time for the person behind the Frank.

Anyone with type 1 diabetes can apply for a free lifetime access pass to US national parks! You can obtain your pass through the

DIABETES NEWS

But together, WE ARE STRONGER THAN FRANK. The best part? We can talk about Frank, what he did today, the havoc he raised, problem solve on how we can defeat him, then WE CAN BE DONE TALKING ABOUT FRANK and focus on Jordon. How Jordon’s day was – his ups and downs and his personal achievements and struggles apart from Frank. Sometimes Frank is pretty quiet that day and lets us focus on the other aspects of life. Sometimes Frank is pretty big and demands a lot of attention. There are lots of days we can get pretty mad at Frank. But we get over it, because we know we are stronger than Frank.

mail, which involves a $10 fee for processing, or you can get it in person to avoid the processing fee.

Either way, the pass itself is free and lasts a lifetime.

Go to ChildrensDiabetesFoundation.org/ National-Park-Pass for more details.

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DIABETES NEWS

MEET ABBEY SMOLEN CDF Advocate and Barbara Davis Center Patient

What do you to do for fun?

I love to play soccer! I have been playing with some of the same girls since I was five. I also like hanging out with friends and seeing movies.

How long have you had type 1 diabetes?

I have been type 1 for almost 2 years. I was diagnosed on the first day of school on August 22, 2016.

What devices do you wear?

I wear a CGM and T Slim pump. I usually wear these on my stomach and thighs. Sometimes I will put them on my arms, but it usually comes off when I sleep.

What is your biggest challenge with type 1 diabetes?

My biggest challenge with type 1 would be explaining to people what it is. I know that may not seem like a really big challenge‌ but it is for me when nobody really knows what it is or they think I can control it by just eating a certain way.

Some adults will even comment and say things like maybe if you go get acupuncture, you can make it go away.

What do you wish people understood about T1D? I wish people knew how much time, organization and responsibility it is to manage this disease. How much it takes to control. I also wish people could see the daily struggles we go through as diabetics.

What is something positive that has come from your diabetes?

Something positive would be being able to have my phone in class when nobody else gets their phone.

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Andrea Gerard Gonzalez, MD Assistant Professor Barbara Davis Center for Diabetes Director Latino Program

What is caffeine?

Caffeine is a bitter substance that occurs naturally in more than 60 plants including: Coffee beans.

Tea leaves.

Kola nuts, which are used to flavor soft drink colas.

Cacao pods, which are used to make chocolate products.

There is also synthetic (man-made) caffeine, which is added to some medicines, foods and drinks. Most people consume caffeine from drinks. The amount of caffeine in different drinks can vary a lot but it is generally: an 8-ounce cup of coffee: 95-200mg, a 12-ounce can of cola: 35-45mg, an 8 ounce cup of tea: 14-60mg.

What are caffeine’s effects on the body?

Caffeine has many effects on your body’s metabolism, it: • • • • •

Stimulates your central nervous system, which can make you more awake and give you a boost of energy.

Is a diuretic, meaning that it helps your body to get rid of extra salt and water by urinating more.

Increases the release of acid in your stomach, sometimes leading to an upset stomach or heartburn.

May interfere with the absorption of calcium in the body.

Increases your blood pressure.

Caffeine supplementation has become increasingly more popular as an ergogenic aid for athletes and considerable evidence supports its effectiveness.

What are the effects of caffeine on glucose metabolism?

It appears that coffee intake acutely impairs insulin sensitivity and glucose metabolism in individuals with type 2 diabetes. Numerous studies have focused on the effects of caffeine on performance however few have studies the effects of caffeine on glucose metabolism, especially in type 1 diabetes, in which hypoglycemia and hyperglycemia are a major concern during exercise. Overall, glucose balance appears to be impaired, as caffeine supplementation causes elevated blood glucose levels compared with the fasting condition. In a study by Thong et al. found that caffeine caused approximately 50% reduction in glucose uptake in both rested and exercised muscle.

Caffeine enhances the release of epinephrine and this has been shown to impair peripheral glucose uptake because this hormone has the opposite effects than insulin. A number of studies have reported that blood glucose concentrations are increased with caffeine ingestion during activity. These physiological actions may make caffeine intake particularly useful for individuals with type 1 diabetes that suffers from exercise associated hypoglycemia. More recent literature showed that caffeine specifically affects postprandial blood glucose concentrations in individuals with type 2 diabetes, causing greater hyperglycemia and potentially higher A1C over time.

DIABETES NEWS

CAFFEINE AND BLOOD SUGARS

There is limited amount of research on caffeine or coffee intake and their effects on glucose balance in individuals with type 1 diabetes. Interestingly caffeine intake has been shown to improve patient recognition and counter regulatory hormone responses to hypoglycemia induced at rest in patients with type 1 diabetes (Debrah et al.). Caffeine intake has also been shown to reduce risk of nocturnal hypoglycemia with type 1 diabetes (Richardson et al.) and increase heart rate variability, which should lower their risk for sudden death caused by autonomic dysfunction (Richardson et al.).Modest caffeine ingestion (200mg) enhanced the intensity of hypoglycemic warning symptoms in patients with type 1 diabetes, but did not alter glycemic control. It should be pointed out however that caffeine consumption during the first trimester of pregnancy in women with type 1 diabetes increases the risk of spontaneous abortion and thus should be avoided (Khoury et al.). More research should be done evaluating further the effects of caffeine in diabetic patients both at rest and during exercise.

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H. Peter Chase, MD was recently told the BDC had changed their Q: Irecommendations for target blood sugar values. Can

you tell me the new targets and why the changes were made?

physicians at the Barbara Davis Center recently A: Yes, agreed on new target ranges as shown in the Table below.

The new targets make reaching the desired HbA1c level (<7.5 for all children) more realistic, particularly for children <6 years old. The values during the night for the <6 year old group are still higher than the ADA recommendations (90-150 mg/dL for all children). This is for safety purposes. It is important to note that diabetes management recommendations always need to be tailored to the individual. Higher targets may be considered in the following situations: a history of hypoglycemic unawareness/severe hypoglycemia, use of NPH at bedtime, poor access to test strips or CGM, very low insulin requirements, athletes, and infants or toddlers. In young children, use of CGM and insulin pumps may be necessary to reach goals safely.

The new target ranges are in the 14th edition of the “First Book for Understanding Diabetes” (The Pink Panther Synopsis Book) available at www.ChildrensDiabetesFoundation.org/books. The book goes to 14,000 of the 17,000 newly diagnosed children with type 1 diabetes in the U.S. each year. Thus, the new values will be used throughout the U.S. TABLE: Blood Glucose/CGM Target Range Goals

<6 years: 6-17 years: ages 18 and up:

DAY BEDTIME/OVERNIGHT 70-150 100-180 70-130 90-150 70-130 90-150

Do you have questions you would like to submit to the Q & A? Contact Mattie Peck at Mattie@ChildrensDiabetesFoundation.org Photos: © JensenSutta.com

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UPCOMING EVENTS

JUNE 29

AUGUST 13

JULY 9

OCTOBER 6

Building the Future Furniture makers create designs for this silent auction event complete with live entertainment, hors d'oeuvres, and cocktails. Register at DamoreInteriors.Eventbrite.com

Tied to a Cure Denver Golf Tournament Pinehurst Country Club Enjoy a beautiful day on the green to support the Children’s Diabetes Foundation

JULY 12-15 ATDC Keystone Conference A conference for healthcare providers for the most up-todate information about diabetes care and research

High Hopes Golf Tournament Columbine Country Club Come enjoy a day on the course to support The Guild of the Children’s Diabetes Foundation

The Carousel of Hope The Beverly Hilton in Beverly Hills, CA A star-studded gala to raise funds and awareness for type 1 diabetes

OCTOBER 25 V& 26

Tied to a Cure Las Vegas Golf Flyaway Las Vegas, Nevada An overnight getaway to Las Vegas to play at exclusive Shadow Creek Golf Course

AUGUST 4

Run for the Ring 5K & Kids Fun Run to honor Type 1 Heroes on the beautiful Anschutz Medical Campus

FOR EVENT DETAILS AND REGISTRATION, VISIT WWW.CHILDRENSDIABETESFOUNDATION.ORG

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New Features of the 14th Edition of “A First Book for Understanding Diabetes”

Information about new insulins, including Basaglar (generic Lantus) and Tresiba (a new basal insulin with reduced hypoglycemia) A new “Universal Standard of Care” in school and new Individualized Health Plans (IHPs) for students using injections or insulin pumps The latest information on Continuous Glucose Monitors (CGMs) – an area of much improvement Recent FDA approval for the use of CGM glucose values for insulin dosing in place of finger stick blood sugars and incorporating this at school The use of Intranasal Glucagon rather than injections (to be available soon) Updates on new insulin pumps The latest information on the artificial pancreas/hybrid closed loop system New goals for blood or CGM glucose values for children of different ages Expansion of information for toddlers/preschoolers New research information on diabetes prevention - now extended to the general population

Order Your Copy at: www.ChildrensDiabetesFoundation.org/books 12

A CONTINUING MEDICAL EDUCATION CONFERENCE FOR DIABETES HEALTHCARE PROVIDERS

10th Annual

HIGH HOPES GOLF TOURNAMENT Presented by

Monday, August 13, 2018 July 12-15, 2018

This conference is for: Certified diabetes educators, internists, pediatricians, family physicians, physician assistants, nurse practitioners, nurses, dietitians and all healthcare providers interested in receiving the most up-to-date type 1 and type 2 diabetes information from world-renowned diabetes experts.

Benefiting The Guild of the Children’s Diabetes Foundation Proceeds from this event benefit The Guild of the Children’s Diabetes Foundation to fund programs that assist families in need, promote diabetes awareness and education, provide scholarships, sponsor activities for children and their families, and conduct research to prevent and ultimately cure type 1 diabetes.

For more information visit www.ChildrensDiabetesFoundation.org

The four-day conference will emphasize the challenges in dayto-day management of diabetes and practical ways to overcome those hurdles, specifically using new technologies. The discussions will also focus on glucose control, lipids, and CVD; combination treatments for best glucose control; diabetes in special populations (eg: cystic fibrosis and pregnancy); NASH, NAFLD, and diabetes; managing diabetes in the extremes (eg: the very young, teenagers, the elderly, and the underserved youth); and CGM and AP system.

Participants will have an opportunity to be involved in an intimate Meet the Peers session (MD’s, RN’s, and educators) and ask questions to a patient panel. For type 1 diabetes, there will be a plenary on adjunctive therapies. For type 2 diabetes, there will be a plenary on hepatic steatosis. The FDA will give the keynote on Saturday morning.

REGISTRATION DETAILS: View program details and registration information at: www.regonline/atdc.com

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SATURDAY, AUGUST 4, 2018 REGISTER AT

5K RUN/WALK

KIDS ZONE + FUN RUN

CREATE A FUNDRAISER TO RAISE MONEY FOR CDF IN CONNECTION WITH YOUR RUN! IF YOU RAISE $200 OR MORE, REGISTRATION Photos: ©YOUR www.JensenSutta.com FEE WILL BE WAIVED!

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NewsNotes will be published quarterly by the Children’s Diabetes Foundation. We welcome your comments.

If you would like to submit an article or a letter to NewsNotes, send information to: Mattie@ childrensdiabetesfoundation.org Zachary Reece Graphic Designer Mattie Peck Dana Davis Editors

Children’s Diabetes Foundation Board Members and Guild Presidents EXECUTIVE BOARD: Mrs. Barbara Davis, Chairman Dana Davis, Executive Director Richard S. Abrams, M.D. Mr. Peter Culshaw Stephen Daniels, M.D., Ph.D. Chairman of Pediatrics, The Children’s Hospital, Denver Mrs. Nancy Davis Rickel Steven Farber, Esq. Daniel Feiten, M.D. Mr. Shane Hendryson Mrs. Arlene Hirschfeld Mrs. Deidre Hunter Mr. Shawn Hunter Mrs. Tracy van Orman Mr. Cameron van Orman Mr. Ken Rickel John J. Reilly, Jr., M.D. Vice Chancellor for Health Affairs & Dean, School of Medicine, University of Colorado Denver Mrs. Stacy Mendelson Robinson Marian Rewers, M.D., Ph.D. Ex-Officio Member SCIENTIFIC ADVISORY BOARD: Richard S. Abrams, M.D. Director, Colorado Preventive Medicine, Rose Medical Center; Clinical Professor of Medicine UCD Mark Atkinson, Ph.D. Professor of Pathology & Pediatrics, Director, University of Florida Diabetes Institute Ezio Bonifacio, Ph.D. Professor for Preclinical Approaches to Stem Cell Therapy, Center for Regenerative Therapies, Dresden, Germany Robert Eckel, MD Professor of Medicine, Physiology and Biophysics, University of Colorado School of Medicine

Steven Kahn, MB, Ch.B. Professor of Medicine, Director of the Diabetes Research Center, University of Washington Rudolph Leibel, MD Professor of Pediatrics and Medicine, Co-Director, Naomi Berrie Diabetes Center, Columbia University Alvin Powers, MD Professor of Medicine, Molecular Physiology/Biophysics, Division Director, Vanderbilt University William Tamborlane, MD Professor of Pediatrics, Yale University School of Medicine ADVISORY BOARD: Sir Michael Caine Mr. and Mrs. Robert A. Daly The Honorable Diana DeGette, U.S. House of Representatives, Colorado Mr. Neil Diamond Mr. Placido Domingo Mr. John Elway Mr. David Foster Mr. Kenny G Mr. David Geffen Mr. Magic Johnson Mr. Quincy Jones Ms. Sherry Lansing Mr. Jay Leno Mr. Paul Marciano Mr. Mo Ostin Sir Sidney Poitier Mr. Lionel Richie Mr. George Schlatter Ms. Maria Shriver Mr. Steven Spielberg and Ms. Kate Capshaw Ms. Brenda Richie Ms. Barbera Thornhill Miss Joan van Ark Mr. Gary L. Wilson Mr. Stevie Wonder

THE GUILD PRESIDENTS: Founding President, Amy Davis Mrs. Gina Abou-Jaoude Mrs. Christy Alberts Mrs. Jamie Angelich Mrs. Karen Aylsworth Mrs. Linda Broughton Mrs. Tangy Buchanan Mrs. Joy Burns Dr. Bonita Carson Mrs. Nancy Cowee Mrs. Dalyla Creaghe Mrs. Margy Epke Mrs. Chris Foster Mrs. Helenn Franzgrote Mrs. Sally Frerichs Mrs. Debbie Gradishar Mrs. Helen Hanks Mrs. Marty Jensen Mrs. Gail Johnson Mrs. Sharon Kamen Mrs. Janet Knisely Mrs. Shelley Lucas Mrs. Suzy Love Mrs. Judy McNeil Mrs. Sally Newcomb Mrs. Barb Oberfeld Mrs. Gretchen Pope Mrs. Carol Roger Mrs. Kay Stewart Mrs. Diane Sweat Mrs. Loretta Tucker Mrs. Jane Weingarten

Matthias Hebrok, Ph.D. Professor in Residence and Director, Diabetes Center, University of California, San Francisco

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Nonprofit Org. U.S. POSTAGE

PAID Denver, CO Permit No. 1752

Childrenâ&#x20AC;&#x2122;s Diabetes Foundation 4380 South Syracuse Street Suite 430 Denver, CO 80237

Change Service Requested

Saturday, October, 6, 2018 The Beverly Hilton Hotel in Beverly Hills, CA Benefiting the Barbara Davis Center and the Childrenâ&#x20AC;&#x2122;s Diabetes Foundation

July 9

Pinehurst Country Club Denver, CO

Honoring

with the Brass Ring Award

www.ChildrensDiabetesFoundation.org #CarouselofHope

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Sponsorship Opportunities Available!

More details at ChildrensDiabetesFoundation.org