Flt-3 is known as a cell surface receptor for cytokine FLT-3 ligand and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Mutations of Flt-3 that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. Mutations happened would lead to cancer such as leukemia. Signaling through FLT-3 is important for lymphocyte development.
Full Name
fms-related tyrosine kinase 3
Research area
Synonyms
FLT3; CD135; FLK2; STK1; STK-1; CD135 antigen; FLK-2.
Cancer Immunotherapy; Immune Checkpoint; Immunotherapy; Targeted Therapy
Featured Products Cat. No.
Product Name
FLT3-2243H
Recombinant Human FLT3, His tagged
FLT3-303M
Recombinant Mouse FLT3, His-tagged
FLT3-1155R
Recombinant Rhesus Monkey FLT3 Protein, His-tagged
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