Creative BioMart Launched a Series of Specially Designed Labeled Proteins for Car-T Therapy

Creative BioMart Launched a Series of Specially Designed Labeled Proteins for Car-T Therapy Creative BioMart, a world leading biotech company specialized in providing protein products and services, recently launched a series of specially designed labeled proteins for Car-T therapy. With a variety of pre-flourescent-conjugated and pre-biotinylated recombinant proteins available, Creative BioMart provides convenience for its customers’ cell separation.

CAR T cell therapy is an immunotherapy that can change the patient's own T cells so that they can recognize and attack cancer. T cells are extracted from the patient's blood. Then, a gene for a special receptor that binds to a protein on a patient's cancer cells is added in the laboratory.

One of the most important steps of CAR-T cell therapy is T cell reconstitution, which produces chimeric antigen receptors (CARs) on the cell surface. These redesigned T cells then need to be selected and collected from other cells. Protein L, anti-Fab, or target antigens are commonly used as detection methods by flow cytometry. Among these common choices, the target antigen is widely considered the best choice because it has high specificity and minimal background staining.

In order to avoid damage to healthy tissues caused by CAR-T cell therapy, the target must be restricted within the tumor cells. However, it is quite difficult to find ideal biomarkers as anti-tumor targets, which are highly expressed on the surface of tumor cells but rarely expressed on healthy cells. In more common cases, the selected biomarkers are expressed in tumor cells and healthy cells with significant differences in expression levels.

Established with the goal to improve people’s life with life technology, Creative BioMart is always endeavoring to develop and bring the latest products, services and technologies for scientists in the biotech field. At present, there are mainly three types of proteins for Car-T therapy: Biotinylated proteins CD19, CD22, CD274, CD276, CD70, EGFR, CEACAM5, EPCAM, IL1RAP, ROR1, TNFRSF17, TNFRSF8 R-PE Labeled Proteins IL3RA, SDC1, CD33, CD55, ULBP1, GPC3, CD40, KDR, ROR2, IL13RA2, MMP2 APC-labeled Proteins CD226, SPN, GPC3, PDCD1, CD79B, FOLR1, L1CAM, VCAM1 To view the whole list of specially designed labeled proteins for Car-T therapy provided by Creative BioMart, please visit https://www.creativebiomart.net/Specially-Designed-Labeled-Protein-forCar-T-Therapy.htm.

About Creative BioMart Starting from a small supplier of proteins and enzymes for academic institutes and biotech companies, Creative BioMart has always been focusing on developing high quality protein products like recombinant proteins, native proteins, GMP proteins, etc. and efficient protein manufacturing services including protein expression, protein labeling, protein interaction etc.