Chemokine Signaling Pathways Chemokine Receptor
Chemokine
PIP2
PKC
FAK P
P
Gα
Gγ
p101
P
P
P
RhoA
P
GTP
Rheb ROCK
P
CALM PPP3CA
MEK1/2
Crk
P
Rho PAK
RhoA PYK2 BCAR1
CDC42
P
FOXO
MLC P
NFKB
BCAR1
PXN
Vav
RAC
IKK
P
LIMK Regulation of Actin mTORC1 Cytoskeleton Cell Migration P p70 S6k Proteasomal P Degradation
P
P
NFKBIB P
P
FAK
p38
CASP9
P
Raf
ITK
P
P
JNK
PAK Arp2/3 P
ELMO1 DOCK2
Bad P
NFKBIB
NFKB
P
P
WASP
STAT Dimer
GDP Ras Ras GTP
P
TSC1/2
P
SOS
Src Shc
GSK3B
CDC42
JNK
P
PDK1
Akt PKB
P
P STAT
GRB2
PI3K
P
Vav
RAC
p38
Gβ Gγ
cAMP p110
p85
PI3K P
P
ADCY
GTP Gα
GTP
p110
ITK
PXN Crk
IKK
P P
GRK
Jak
ATP
PREX1
BCAR1
PYK2
Gβ
BCAR1 Crk
PXN
Recruitment
G Protein
IP3
Chemokine Receptor Receptor Desensitization Internalization Degradation
ARRB
GDP
PLCβ
DAG
Chemokine
ERK1/2
P
MLC
WASP
PXN Crk P
LIMK
p90 RSK Arp2/3
P
4EFP1 eIF4E
RPS6 Protein Synthesis eIF4E
P
Actin/Focal Adhesion Assembly/Disassembly Cell Migration
4EBP1
P
Ca2+
NFATC Cell Survival
IP3R
FOXO cFos cJUN ELK1
NFATC CREB NFKB Cell Motility Cell Survival Proliferation Adhesion
P
STAT Dimer Cell Survival Proliferation Migration Cell Proliferation Chemotactic Response
βγ β