Cambridge Rights Medicine Guide Spring 2012

Medicine titles Spring 2012

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Contents

Anesthesia. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Entomology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Public health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 General medicine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Radiology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Medical law and ethics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Mental health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 Neurology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 Reproductive medicine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 Pathology and laboratory science . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 Plasma medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45

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Anesthesia

Core Topics in Cardiac Anesthesia Second edition

Edited by Jonathan H. Mackay Papworth Hospital NHS Foundation Trust

Core Topics in

Cardiac Anesthesia Edited by Jonathan H. Mackay and Joseph E. Arrowsmith

and Joseph E. Arrowsmith

Papworth Hospital NHS Foundation Trust

Description Since the publication of the first edition of Core Topics in Cardiac Anesthesia, the clinical Second edition landscape has undergone significant change. Recent developments include the increased use of electrophysiology, the resurgence of primary percutaneous intervention in acute coronary syndromes, the use of percutaneous devices in patients previously considered inoperable, and the withdrawal of aprotinin. Against this landscape, this invaluable resource has been fully updated. New chapters are dedicated to right heart valves, pulmonary vascular disease, cardiac tumours and cardiac trauma.

All other chapters have been updated according to the latest international guidelines. Written and edited by an international author team with a wealth of expertise in all aspects of the perioperative care of cardiac patients, topics are presented in an easy to digest and a readily accessible manner. Core Topics in Cardiac Anesthesia, Second Edition is essential reading for residents and fellows in anesthesia and cardiac surgery and clinical perfusionists.

Key Features • Reviews all aspects of patient care, from relevant anatomy, pharmacology and pre-op assessment to cardiac OR procedures and cardiac critical care • Concise chapters give readers essential information without repetition, making this an invaluable quick reference resource • An international team of contributors give a broad spectrum of best practice

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Anesthesia

Contents

Preface; Foreword; Abbreviations; Part I. Anatomy and Physiology: 1. Cardiac embryology and anatomy; 2. Cardiac electrophysiology; 3. Cardiac excitation–contraction coupling; 4. Ventricular performance; 5. Coronary physiology; 6. Cardiovascular control mechanisms; 7. Anesthesia and the cardiovascular system; Part II. Cardiac Pharmacology: 8. Cardiac receptors; 9. Inotropes and vasoactive drugs; 10. Anti-dysrhythmic drugs; 11. Anticoagulants and procoagulants; 12. Effects of CPB on drug pharmacokinetics; Part III. Diagnosis of Cardiac Disease: 13. Symptoms and signs of cardiac disease; 14. Non-invasive diagnostic tests; 15. Cardiac radiological imaging; 16. Invasive diagnostic techniques; Part IV. Cardiac Surgery for Anesthetists: 17. Patient selection and risk stratification; 18. Basic principles of cardiac surgery; 19. Myocardial protection; 20. Myocardial stunning, hibernation and preconditioning; 21. Prosthetic heart valves; Part V. Monitoring: 22. Routine clinical monitoring;

23. Invasive hemodynamic monitoring; 24. Transesophageal echocardiography; 25. Intraoperative assessment of left ventricular function; 26. Neurological monitoring; Part VI. Routine Coronary Heart Surgery: 27. Premedication, induction and maintenance; 28. Conduct of cardiopulmonary bypass; 29. Routine early postoperative care; 30. Off-pump coronary artery bypass surgery; Part VII. Anesthetic Management of Specific Conditions: 31. Aortic valve disease; 32. Mitral valve disease; 33. Tricuspid and pulmonary valve disease; 34. Minimally invasive cardiac surgery; 35. Redo surgery; 36. Aortic dissection; 37. Aortic arch surgery; 38. Descending thoracic aorta surgery; 39. Permanent pacemakers and implantable defibrillators; 40. Anesthesia and electrophysiological disorders; 41. Acute myocardial ischemia and infarction; 42. Miscellaneous catheter laboratory procedures; 43. Cardiomyopathies and constrictive pericarditis; 44. Cardiac transplantation; 45. Pulmonary vascular disease; 46. Cardiac tumors; 47. Cardiac trauma; 48. Pregnancy and cardiac surgery; Part VIII. Pediatric Cardiac Anesthesia: 49. General principles;

Additional Information Level: specialist medical trainees, medical specialists/consultants February 2012 246 x 189 mm 480pp 248 b/w illus. 91 colour illus.

978-0-521-19685-7 Hardback c. £65.00

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50. Conduct of anesthesia; 51. Common congenital heart lesions; 52. Common congenital heart operations; 53. Postoperative care; 54. Adult congenital heart disease; Part IX. Cardiopulmonary Bypass: 55. Cardiopulmonary equipment; 56. Failure to wean from bypass; 57. Advanced mechanical support; 58. Coagulopathy and blood conservation; 59. Inflammatory response to cardiopulmonary bypass; 60. Temperature control, hypothermia and rewarming; 61. Deep hypothermic circulatory arrest; 62. Cardiopulmonary bypass emergencies; 63. Controversies of cardiopulmonary bypass; 64. Non-cardiac applications of cardiopulmonary bypass; Part X. Cardiac Intensive Care: 65. Cardiovascular problems in the cardiac intensive care unit; 66. Resuscitation after adult cardiac surgery; 67. Respiratory complications; 68. Gastrointestinal complications; 69. Renal complications; 70. Neurological complications; Part XI. Miscellaneous Topics: 71. Microbiology and infective complications; 72. Regional anesthesia; 73. Pain management; 74. Hematologic problems; 75. Cardiovascular disease and non-cardiac surgery; Index.

Anesthesia

5

Anesthesia for Spine Surgery Edited by Ehab Farag Cleveland Clinic Foundation

Anesthesia for Spine

Description

Surgery

The increased complexity of spinal surgical procedures in recent years has required more EDITED BY sophisticated anesthetic management of patients undergoing these procedures. Spine Ehab Farag surgery anesthesia is now recognized as a distinct sub-specialty, increasingly undertaken by general anesthesiologists as well as neuroanesthesiologists. Anesthesia for Spine Surgery describes the anesthetic management and surgical procedures at every vertebral level in both adult and pediatric patients. The most important related considerations are covered, including: • Postoperative pain management • One lung ventilation during anterior thoracic spine surgery • Intraoperative neuromonitoring • Fluid management Additional chapters review the radiological features of normal and abnormal spines, common complications of spine surgery and ASA closed claims relating to spine surgery anesthesia. Written by highly experienced neuroanesthesiologists and spine surgeons, Anesthesia for Spine Surgery is essential reading for trainee and practising anesthesiologists, neuroanesthesiologists and spine surgeons.

Key Features • The first comprehensive review of spine surgery anesthesia available • Highly illustrated with black and white and color images • Anesthetic management of both the pediatric patient and the adult patient • Written by world-renowned clinicians ensuring an up-to-date, authoritative text

Contents

Preface; Part I. General Considerations: 1. Preoperative assessment of the adult patient; 2. Fluid management; 3. Blood conservation; 4. Upper airway management; 5. Spine imaging; 6. Evoked potential monitoring; 7. Pharmacology of adjunct anesthetic drugs; Part II. Spine Surgery for Adult Patients: 8. Surgical techniques: 8.1. Anterior cervical surgery; 8.2. Posterior cervical surgery; 8.3. Intraoperative neurophysiologic monitoring: surgeon point-of-view;

8.4. An overview of minimally invasive spine surgery; 8.5. Posterior lumbar interbody fusion; 8.6. Minimally invasive procedures for vertebral compression fractures; 8.7. Endoscopic surgery for Chiari type I malformation; 8.8. Posterior and anterior thoracic surgery; 8.9. Surgery for intermedullary spinal cord tumors; 8.10. Avoiding complications: surgeon point-ofview; 9. Anesthsia for cervical spine surgery; 10. Anesthesia for thoracic spine surgery; 11. Lung isolation during thoracic spine surgery; 12. Anesthesia for lumbar spine surgery; 13. Anesthetic management of spinal cord trauma; 14. Anesthesia for patients with spinal cord tumors; Part III. Postoperative Care of the Adult Patient:

Additional Information Level: medical specialists/consultants, specialist medical trainees April 2012 246 x 189 mm 448pp 91 b/w illus. 111 colour illus.

978-1-107-00531-0 Hardback c. £70.00

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15. Complications; 16. Postoperative care in the PACU; 17. Postoperative care in the neuro-intensive care unit; 18. Postoperative acute pain; 19. Postoperative chronic pain management; Part IV. Spine Surgery for Pediatric Patients: 20. Pathophysiology of the pediatric patient; 21. Preoperative evaluation of the pediatric patient; 22. Fluid management and monitoring of the pediatric patient; 23. Surgical techniques in the pediatric patient: 23.1. Scoliosis; 23.2. Tethered cord: surgical release; 24. Spinal surgery for patients with congenital heart disease and other associated conditions; 25. Postoperative pain control in pediatric patients; Index.

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Anesthesia

Adult and Paediatric ALS Self-assessment in Resuscitation

Charles Deakin

Southampton University Hospital Trust

Description Competency in resuscitation is a necessity for most clinical staff, with many attending Advanced Life Support (ALS) courses. Adult and Paediatric ALS: Self-assessment in Resuscitation uses an innovative question-and-answer structure and Resuscitation Council (UK) 2010 Guidelines to provide a complete overview of all aspects of advanced life support and resuscitation in adults and children. Comprising ten chapters of multiple choice questions, diagnostic questions, colour photo questions and comprehensive answers, this resource aids revision of the adult and paediatric ALS syllabus and assists readers in gaining a thorough understanding of all aspects of resuscitation science and practice. Written by a leading resuscitation expert, Adult and Paediatric ALS: Self-assessment in Resuscitation is essential reading for anyone undertaking resuscitation training, beginning training in acute resuscitation specialities or wishing to update their knowledge of advanced life support.

Key Features • Contains the most current recommendations in ALS – the 2010 Resuscitation Council (UK) Guidelines • Colour photos aid learning and enable quick association with the actual practice of ALS • Questions are based on real-life scenarios, making them highly relevant learning tools

Contents

Preface; Acknowledgements; 1. Paper 1; 2. Paper 2; 3. Paper 3; 4. Paper 4;

5. Paper 5; 6. Paper 6; 7. Paper 7; 8. Paper 8; 9. Paper 9; 10. Paper 10; Index.

Additional Information Level: specialist medical trainees, medical specialists/consultants April 2012 246 x 189 mm 144pp 42 b/w illus. 71 colour illus.

978-1-107-61630-1 Paperback c. £29.99

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Anesthesia

7

Essentials of Trauma Anesthesia Edited by Albert J. Varon

University of Miami Miller School of Medicine

and Charles Smith

Case Western Reserve University School of Medicine

Essentials of

Description

Trauma Anesthesia

Essentials of Trauma Anesthesia provides a concise, practical review of the essential elements in the care of the severely injured trauma patient, including emergency airway management, fluid and blood resuscitation, regional and general anesthesia, and Edited by Albert J. Varon perioperative care. Edited by two of the most experienced trauma anesthesiologists in the and Charles E. Smith USA, with chapters written by experts from leading US and Canadian trauma centers with the highest and most varied caseload of critically injured patients, Essentials of Trauma Anesthesia identifies new trends in surgery and anesthesiology practices that impact on the management of trauma patients. Dedicated chapters address the management of special populations including pediatric, geriatric, burn and pregnant patients. Covering the most important topics in trauma anesthesia, Essentials of Trauma Anesthesia provides anesthesiology trainees and practitioners with a practical basis for managing trauma patients.

Key Features • Covers the essential aspects of the care of severely injured patients, guiding anesthesiology trainees and practising anesthesiologists in the best care for these patients • Written and edited by an expert team of anesthesiologists, providing perspectives from major trauma centers in the US and Canada • The concise, practical approach makes this an ideal quick-reference guide to current anesthetic practice in trauma patients

Contents

Preface; Part I. Core Principles in Trauma Anesthesia: 1. Trauma epidemiology, mechanisms of injury, and prehospital care; 2. Initial evaluation and management; 3. Airway management; 4. Shock resuscitation and fluid therapy; 5. Vascular cannulation; 6. Blood component therapy and trauma coagulopathy; 7. General anesthesia for trauma;

8. Regional anesthesia and acute pain management for trauma; 9. Monitoring the trauma patient; 10. Echocardiography in trauma; 11. Postoperative care of the trauma patient; 12. Chemical and other toxic exposures in trauma; Part II. Anesthetic Considerations for Trauma: 13. Anesthetic considerations for head trauma; 14. Anesthetic considerations for spinal cord trauma; 15. Anesthetic considerations for ocular and maxillofacial trauma;

Additional Information Level: medical specialists/consultants, specialist medical trainees May 2012 234 x 156 mm 326pp 75 b/w illus. 20 tables 978-1-107-60256-4 Paperback c. £38.00

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16. Anesthetic considerations for chest trauma; 17. Anesthetic considerations for abdominal trauma; 18. Anesthetic considerations for musculoskeletal trauma; Part III. Anesthetic Management in Special Trauma Populations: 19. Anesthetic management of the burn patient; 20. Anesthetic management of the pediatric trauma patient; 21. Anesthetic management of the geriatric trauma patient; 22. Anesthetic management of the pregnant trauma patient; Index.

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Entomology

Medical Entomology for Students Fifth edition

Mike Service

Liverpool School of Tropical Medicine

Mike Service

MEDICAL ENTOMOLOGY for Students

Description

F IF T H EDI T ION

Despite numerous scientific investigations on vector-borne human infections such as malaria, Lyme disease and typhus these diseases continue to threaten human health. Understanding the role of vectors in disease transmission, and the most appropriate control strategies, is therefore essential. This book provides information on the recognition, biology, ecology and medical importance of the arthropods that affect human health. The fifth edition of this popular textbook is completely updated and incorporates the latest strategies for controlling insects, ticks and mites. Numerous illustrations, with new colour photographs of some of the most important vectors, aid recognition. A glossary of entomological and epidemiological terms is included, along with a list of commonly used insecticides and their trade names.

Clearly presented in a concise style, this text is aimed at students of medical entomology, tropical medicine, parasitology and pest control. It is also essential reading for physicians, health officials and community health workers.

Key Features • Written in plain English and avoids jargon, ideal for students for whom English is a second language • Includes clearly labeled diagrams of all featured insects and arachnids • Glossary of technical terms aids quick and easy understanding

Contents

Preface to the first edition; Preface to the second edition; Preface to the third edition; Preface to the fourth edition; Preface to the fifth edition; Acknowledgements; 1. Introduction to mosquitoes (Culicidae); 2. Anopheline mosquitoes (Anophelinae); 3. Culicine mosquitoes (Culicinae); 4. Black flies (Simuliidae);

5. Phlebotomine sand flies (Phlebotominae); 6. Biting midges (Ceratopogonidae); 7. Horse flies (Tabanidae); 8. Tsetse flies (Glossinidae); 9. House flies and stable flies (Muscidae) and latrine flies (Fanniidae); 10. Flies and myiasis; 11. Fleas (Siphonaptera); 12. Sucking lice (Anoplura); 13. Bedbugs (Cimicidae); 14. Triatomine bugs (Triatominae);

Additional Information Level: undergraduate students, graduate students May 2012 228 x 152 mm 300pp 128 b/w illus. 32 colour illus.

978-1-107-66818-8 Paperback c. £35.00

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15. Cockroaches (Blattaria); 16. Soft ticks (Argasidae); 17. Hard ticks (Ixodidae); 18. Scabies mites (Sarcoptidae); 19. Scrub typhus mites (Trombiculidae); 20. Miscellaneous mites; Appendix: names of some chemicals and microbials used in vector control; Glossary of common terms relevant to medical entomology; Select bibliography; Index.

Public health

Essential Public Health

9

Edited by stephen Gillam, Jan Yates and Padmanabhan Badrinath

Theory and Practice Second edition

Edited by Stephen Gillam

EssEntial

Public Health

University of Cambridge

Jan Yates

theory and Practice

East of England Strategic Health Authority

second Edition

and Padmanabhan Badrinath University of Cambridge

Description How can society most effectively prevent disease and promote health? That is the challenge addressed by this textbook. Public health is the art and science of preventing disease, prolonging life and promoting health through the organised efforts of society. The ‘science’ is concerned with making a diagnosis of a population’s health problems, establishing their cause and determining effective interventions. The ‘art’ lies in creatively addressing these problems. Essential Public Health captures both the art and science of the field. This second edition has been fully updated with contemporary examples and includes new chapters on sustainability and change, management and leadership. Examples are taken from health systems throughout the world, giving readers a wider perspective of the challenges faced. This is essential reading for all trainees in health care, social care and related disciplines. An internet companion includes supplementary information and interactive, self-assessment questions to test understanding and aid learning.

Key Features • Theory is underpinned with practical examples to show what public health specialists aim to achieve in practice • An internet companion featuring self-assessment questions allows readers to test their understanding of key topics • Written for a multidisciplinary audience

Contents

Introduction; Part I. The Public Health Toolkit: 1. Management, leadership and change; 2. Demography; 3. Epidemiology; 4. The health status of the population; 5. Evidence-based health care;

6. Health needs assessment; 7. Decision making in the health care sector – the role of public health; 8. Improving population health; 9. Screening; 10. Health protection and communicable disease control; 11. Improving quality of care; Part II. Contexts for Public Health Practice: Introduction;

Additional Information Level: specialist medical trainees, medical students May 2012 246 x 189 mm 350pp 24 b/w illus. 46 colour illus.

978-1-107-60176-5 Paperback c. £35.00

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12. The health of children and young people; 13. Adult public heath; 14. Public health and ageing; 15. Health inequalities and public health practice; 16. Health policy; 17. International development and public health; 18. Sustainable development – the opportunities and the challenges for the public’s health; Index.

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General medicine

Essential Values-Based Practice Clinical Stories Linking Science with People

K. W. M. Fulford University of Warwick

Edward Peile

University of Warwick

and Heidi Carroll Description This book will help clinicians acquire and develop the processes and skills of values-based practice. The aim of most patient-clinician consultations is to improve health outcomes. Often they succeed, and patients are satisfied and empowered. However, some consultations are unsatisfactory and result in failure to improve health outcomes and dissatisfaction on the part of patients, carers or clinicians. When consultations fail to achieve the desired results, the cause is not usually a failure of evidence-based practice. Today’s clinicians are trained in evidence-based medicine, educated, updated and appraised. The most likely reason why things go wrong is a failure of values-based practice – not ascertaining the relevant values perspectives and acting on them in a coherent and purposeful manner. If you rehearse and practise the elements of values-based practice detailed in this book, you will find your consultations more personally rewarding and your patients are likely to derive more benefit.

Key Features • Describes the principles and the application of values-based practice within the context of real clinical scenarios • Shows how a values-based approach complements an evidence-based approach to optimize clinical outcomes • Is supported by a website containing additional exercises and training resources

Contents

Preface; Foreword – from a patient perspective; Foreword – from a clinician perspective; A bold claim to start this book; Prologue: linking science with people; Part I. Values, Individuals and an Overview of Values-based Practice: Introduction to Part I; 1. ‘It’s my back, Doctor!’ (Episode 1): values in clinical decision making; 2. ‘It’s my back, Doctor!’ (Episode 2): applying the tools already in the clinical toolbox for working with values to individuals; 3. An outline of values-based practice: its point, premise and ten-part process;

Part II. The Clinical Skills for Values-based Practice: Introduction to Part II; 4. Recovery in schizophrenia: a values wake-up call; 5. Teenage acne: widening our values horizons; 6. A smoking enigma: getting (and not getting) the knowledge; 7. Diabetic control and controllers: nothing without communication; Part III. Relationships in Values-based Practice: Introduction to Part III; 8. ‘Best’ in breast cancer: clinician values and person-centred care; 9. Risks in safeguarding children: team values as well as skills; Part IV. Science and Values-based Practice: Introduction to Part IV; 10. The reluctant hypertensive: think evidence, think values too!;

Additional Information Level: specialist medical trainees, medical specialists/consultants Series: Values-Based Medicine March 2012 246 x 189 mm 288pp 43 b/w illus.

978-0-521-53025-5 Paperback c. £35.00

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11. Unexplainable abdominal pain: think values, think evidence too!; 12. Elective fertility: think high-tech, think evidence and values!; Part V. Bringing It All Together: Introduction to Part V; 13. A good (enough) death: dissensus in end of life care; 14. ‘It’s my back, Doctor!’ (Episode 3); Postscript: the small change of care; A bold claim to end this book; VBP glossary; VBP index; Index.

General medicine

11

Principles of Medicine in Africa Fourth edition

Edited by David Mabey

London School of Hygiene and Tropical Medicine

Geoff Gill

University of Liverpool

Chris Whitty

London School of Hygiene and Tropical Medicine

and Martin Weber

World Health Organization, Jakarta

Consultant Editor Eldryd Parry Tropical Health Education Trust

Description Principles of Medicine in Africa combines classical clinical medicine with a rich understanding of the major environmental and cultural influences on health and disease, providing comprehensive guidance for anyone intending to practise medicine in Africa.

Disease is presented in the context of family and culture, and the effects of inequality and problems of limited resources are addressed. The authors have a wealth of experience in front line healthcare and provide practical, evidence-based management guidelines for all the common and less common conditions likely to be encountered. This fourth edition has been thoroughly updated to incorporate the latest research findings and management guidelines. It includes an expanded section on maternal and child health, but careful editing has generated a slimmer volume, whilst retaining all of the essential content. This is the one essential text for medical students and healthcare professionals wanting a complete and up-to-date reference book on medicine in Africa.

Key Features • Focuses on how to cope without the resources taken for granted in other textbooks • Emphasises the authors’ first hand front line experience which they pass on through essential relevant, practical information • Features many colour illustrations to aid understanding and the application of the clinical science presented

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General medicine

Contents

Preface; Part I. Health and Disease: 1. People and their environment; 2. Food and nutrition; 3. Refugees and disasters; 4. Managing a health service; Part II. Mother and Child Health: 5. The pregnant patient; 6. Neonatal care; 7. The integrated management of childhood illness (IMCI); 8. Severe acute malnutrition in childhood; 9. Diarrhoea; 10. Pneumonia and acute lower respiratory tract infections in children; 11. Measles; 12. Pertussis; Part III. Infection: General Principles: 13. The immune response to infection; 14. Approach to the febrile patient; 15. The control and prevention of infection; Part IV. Major Common Infections: 16. Malaria; 17. HIV/AIDS; 18. Tuberculosis; 19. Pneumonia in adults; 20. Meningitis; 21. Sexually transmitted infections; Part V. Bacterial Infections: 22. Typhoid, paratyphoid and non-typhoid salmonella infections; 23. Streptococcus pyogenes and Staphylococcus aureus; 24. Rickettsial infections; 25. Brucellosis;

26. Leptospirosis; 27. Relapsing fever; 28. Plague; 29. Anthrax; 30. Tetanus; 31. Diphtheria; 32. Leprosy; 33. Cholera; Part VI. Viral Infections: 34. Viral haemorrhagic fevers: yellow fever, Lassa fever, Rift Valley fever, Ebola/Marburg fever and Crimean-Congo fever; 35. Dengue; 36. Rabies; 37. Influenza; 38. Poliomyelitis; 39. Varicella (chicken pox), Herpes zoster and monkey pox; 40. Rubella; 41. Mumps; Part VII. Protozoal Infections: 42. Leishmaniasis; 43. Human Africa trypanosomiasis; 44. Amoebiasis; 45. Intestinal protozoa; Part VIII. Helminth Infections: 46. Intestinal helminths; 47. Schistosomiasis; 48. Lymphatic filariasis and Loa Loa; 49. Onchocerciasis; 50. Cysticercosis; 51. Hydatid disease; 52. Paragonimiasis; 53. Trichinosis;

Additional Information Level: specialist medical trainees, medical specialists/consultants August 2012 276 x 219 mm 832pp 296 b/w illus. 440 colour illus.

978-1-107-00251-7 Hardback c. £150.00

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54. Guinea worm; Part IX. Fungal Infections: 55. Fungal infections; Part X. Non-Communicable Diseases: 56. Chronic and non-communicable disease in Africa; 57. Chronic non-communicable disease in health care; 58. Diabetes mellitus; 59. Hypertension; 60. Stroke; 61. Epilepsy; 62. Mental health; 63. Asthma; 64. The disabled patient; Part XI. Diseases of Body Systems: 65. The heart; 66. The lung; 67. Blood disorders; 68. The gut; 69. The liver; 70. The kidney and body fluids; 71. Bones and joints; 72. Endocrinology; 73. The nervous system; 74. The skin; 75. The eye; Part XII. Cancer and Palliative Care: 76. Cancers and lymphomas; 77. Palliative care in Africa; Part XIII. Venoms and Poisons: 78. Venomous and other dangerous animals; 79. Poisoning; Index.

General medicine

Values-Based Commissioning of Health and Social Care

Values-Based PRaCTICe

Values-Based Commissioning of Health and Social Care

Christopher Heginbotham Warwick University Medical School

Description Health and social care commissioning is a values-driven as well as evidence-driven enterprise. However, whereas there has been an expectation that the evidence-base of commissioning should be made fully explicit, the corresponding values-base has been left largely implicit. The book addresses this subject through a detailed discussion of values and values-based practice, illustrated with case examples, and by developing a critique of existing commissioning. This approach enables commissioners to identify and make explicit the often diverse values of all those involved, whether as commissioners, providers or users of services. It provides a skills base and other support processes for working with differences in values held by all those engaged in making commissioning decisions. This will be essential reading for doctors, both experienced and in training, commissioning managers, professional staff in NHS Foundation Trusts and the private sector and all ‘at the sharp’ end of practice.

Christopher Heginbotham

Key Features • Establishes the importance of a values-based approach to commissioning decisions • Illustrates the issues arising with reference to practical case examples • Explains the relevance of values-based commissioning in a wide range of health and social care scenarios

Contents

Foreword; Acknowledgements; Preface; 1. Values-based practice in health and social care; 2. Policy and practice;

3. Health and social care reforms in England; 4. Evidence and outcomes; 5. Patient and public involvement; 6. Values-based commissioning and public health; 7. Integrative commissioning of health and social care; 8. Values in priority setting and resource allocation;

Additional Information Level: primary care physicians/GPs, specialist medical trainees Series: Values-Based Medicine June 2012 234 x 156 mm 176pp 40 b/w illus.

978-1-107-60335-6 Paperback c. £29.99

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9. Values and outcomes; 10. Market stimulation; 11. Management and leadership; Endnote; References and bibliography; Index.

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14

Radiology

Emergency Cross-sectional Radiology Daniel Y. F. Chung

John Radcliffe Hospital, Oxford

Dipanjali Mondal

Emergency Cross-sectional Radiology

John Radcliffe Hospital, Oxford

Erskine J. Holmes

Emergency Medicine Consultant, Wrexham Park Hospital

and Rakesh Misra Consultant Radiologist

Daniel Y. F. Chung, Dipanjali Mondal, Erskine J. Holmes and Rakesh Misra

Description

Cross-sectional imaging plays an ever-increasing role in the management of the acutely ill patient. There is 24/7 demand for radiologists at all levels of training to interpret complex scans, and alongside this an increased expectation that the requesting physician should be able to recognise important cross-sectional anatomy and pathology in order to expedite patient management. Emergency Cross-sectional Radiology addresses both these expectations. Part I demystifies cross-sectional imaging techniques. Part II describes a wide range of emergency conditions in an easy-to-read bullet point format. High quality images reinforce the findings, making this an invaluable rapid reference in everyday clinical practice. Emergency Cross-sectional Radiology is a practical aide-memoire for emergency medicine physicians, surgeons, acute care physicians and radiologists in everyday reporting or emergency on-call environments.

Key Features • Provides different perspectives from a variety of specialty physicians involved in emergency diagnosis • A short introduction explains the basic principles of CT, MRI and ultrasound • Conditions are explained in bullet-point format, providing easy access to salient information

Contents

Preface; Part I. Fundamentals of Cross-sectional Imaging: 1. CT; 2. MRI; 3. Ultrasound;

Part II. Pathology: 4. Head; 5. Chest; 6. Abdomen; 7. Musculoskeletal; Index.

Additional Information Level: specialist medical trainees, medical specialists/consultants March 2012 234 x 156 mm 256pp 200 b/w illus.

978-0-521-27953-6 Paperback c. £34.00

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Medical law and ethics 9780521765206ppc.qxd

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Prenatal and preimplantation testing technologies have offered unprecedented access to information about the genetic and congenital makeup of our

non-intrusive prenatal testing, and more extensive preimplantation testing promise to increase that access further still. The result may be greater reproductive choice, but it also increases the burden on women and men to

University of Technology, Sydney

avail themselves of these technologies in order to avoid having a child with a

and Kristin Savell

so, how to regulate the use of these technologies in the face of compelling but

University of Sydney

disability. The overwhelming question for legislators has been whether and, if

seemingly contradictory claims about the advancement of reproductive choice and the dangers of eugenic or discriminatory effects. This book examines the evolution of this legislative oversight across a number of jurisdictions and explores the tensions and ambiguities that inform these laws.

Isabel Karpin is a Professor in the Faculty of Law at the University of

Description

Technology, Sydney.

Cambridge Disability Law and Policy Series

Perfecting Pregnancy

Isabel Karpin

prospective progeny. Future developments such as preconception testing,

Karpin/Savell

Perfecting Pregnancy Law, Disability, and the Future of Reproduction

15

Perfecting Pregnancy

Prenatal and preimplantation testing technologies have offered unprecedented access to Law, Disability, and the information about the genetic and congenital makeup of our prospective progeny. Future Future of Reproduction developments such as preconception testing, non-intrusive prenatal testing and more extensive preimplantation testing promise to increase that access further still. The result Isabel Karpin and Kristin Savell may be greater reproductive choice, but it also increases the burden on women and men to avail themselves of these technologies in order to avoid having a child with a disability. The overwhelming question for legislators has been whether and, if so, how to regulate the use of these technologies in the face of compelling but seemingly contradictory claims about the advancement of reproductive choice and the dangers of eugenic or discriminatory effects. This book examines the evolution of this legislative oversight across a number of jurisdictions and explores the tensions and ambiguities that inform these laws.

Kristin Savell is a Senior Lecturer in the Faculty of Law, University of Sydney.

Cover art: Louise Bourgeois, The Woven Child, 2002 Photo courtesy of the Worcester Art Museum.

Cover design: Wendy Bedenbaugh

Key Features • Provides a comprehensive comparative legal analysis of laws around prenatal testing and abortion and PGD • Provides a general account of laws regulating prenatal testing and PGD in Canada, the USA, NZ and several European jurisdictions • Draws on original empirical research including interviews with regulators and clinicians in Australia

Contents

1. Disability; 2. Risk; 3. Terminations; 4. De-selections; 5. Interpretations; 6. Futures.

Additional Information Level: graduate students, academic researchers Series: Cambridge Disability Law and Policy Series May 2012 228 x 152 mm 342pp 978-0-521-76520-6 Hardback c. £60.00

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16

Medical law and ethics

The Politics of Blood Ethics, Innovation and the Regulation of Risk

Anne-Maree Farrell

Monash University, Victoria

Description This book examines the relationship between politics, ethics and law in risk governance involving multi-valued human biological materials, such as blood. HIV blood contamination episodes in the USA, England and France are used to examine the emergence of and the consequences resulting from the politicization of risk. The emergence of the phenomenon is examined through a focus on the role of the gift relationship in blood donation, as well as scientific expertise and innovation in risk governance processes involving the blood system. Its consequences are examined through an analysis of legal action taken by aggrieved patient groups, in addition to a critique of the increased use of precautionary and regulatory strategies in dealing with emerging risks to blood safety.

Key Features • Examines the governance of the blood system at both national and supranational (European and global) levels • Provides an insightful analysis that will assist policy-makers, healthcare professionals, regulators and academics interested in political, ethical and legal aspects of governance processes involving human biological materials • Combines a range of perspectives for dealing with risk governance involving multi-valued human biological materials, thereby making the book relevant to a diverse range of academic and non-academic audiences

Contents

1. Introduction; 2. The governance of the blood system; 3. Revisiting the gift relationship; 4. Professional beliefs and scientific expertise;

5. Risk and innovation; 6. The rise of the recipient; 7. The politics of precaution; 8. Regulating risk; 9. Conclusion.

Additional Information Level: academic researchers, graduate students Series: Cambridge Bioethics and Law, 17 May 2012 228 x 152 mm 300pp 1 b/w illus.

978-0-521-19318-4 Hardback c. £55.00

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Medical law and ethics

End-of-Life Decisions in Medical Care

Bioethics and Law

Bioethics and Law

take into account both legal and ethical issues. This book starts with a critical reflection of ethical principles

Y BLK

healthcare professionals, the wider community and

SMITH: End-of-Life Decisions in Medical Care PPC C

Stephen W. Smith

University of Birmingham

Description

STephen W. SmITh is a lecturer in law at the Birmingham Law School, where he teaches Bioethics, Criminal Law and medicine and Jurisprudence.

paternalism. It then explores the practical difficulties of regulating end-of-life decisions, focusing on patients, issues surrounding ‘slippery slope’ arguments. By evaluating the available empirical evidence, the author identifies preferred ways to regulate decisions and minimise abuses at the end of life, and outlines an ethical theory which can provide practical guidance for those engaged in end-of-life decisions.

Those involved in end-of-life decision making must take into account both legal and ethical issues. This book starts with a critical reflection of ethical principles including ideas such as moral status, the value of life, acts and omissions, harm, autonomy, dignity and paternalism. It then explores the practical difficulties of regulating end-of-life decisions, focusing on patients, healthcare professionals, the wider community and issues surrounding ‘slippery slope’ arguments. By evaluating the available empirical evidence, the author identifies preferred ways to regulate decisions and minimise abuses at the end of life, and outlines an ethical theory which can provide practical guidance for those engaged in end-of-life decisions.

End-of-Life Decisions in Medical Care

acts and omissions, harm, autonomy, dignity and

M

including ideas such as moral status, the value of life,

Principles and Policies for Regulating the Dying Process

Smith

Those involved in end-of-life decision making must

End-of-Life Decisions in Medical Care principles and policies for Regulating the Dying process Stephen W. Smith

Cover image: Dog mourning Its Little master, 1866, by A. Archer (fl. 1860–70) / © City of edinburgh museums and Art Galleries, Scotland / The Bridgeman Art Library.

Key Features • Examines end-of-life decisions as a continuum of possible choices, thereby allowing readers to explore the connections and interactions between various types of end-of-life decision • Examines the evidence relating to the practical effects of regulating end-of-life decisions, allowing readers to critically evaluate whether the acceptance of certain end-of-life decisions will have adverse effects upon society • Provides a workable ethical theory for end-of-life decisions that will help readers evaluate the appropriateness of various decisions

Contents

1. Introduction; 2. Moral status; 3. The value of life; 4. Killing versus letting die and moral responsibility; 5. Autonomy and paternalism; 6. Beneficence, non-maleficence and harm; 7. Dignity;

8. A comprehensive ethical approach; 9. Introduction to Part Two; 10. Protection of patients; 11. The impact on health care practitioners; 12. Greater societal issues; 13. Slippery slope arguments; 14. Necessary procedural protections; 15. Conclusions.

Additional Information Level: academic researchers, graduate students Series: Cambridge Bioethics and Law, 18 February 2012 228 x 152 mm 400pp 4 tables 978-1-107-00538-9 Hardback £65.00

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18

Medical law and ethics

Genetic Data and the Law

Bioethics and Law

Genetic Data and the Law

A Critical Perspective on Privacy Protection

Mark Taylor

A Critical Perspective on Privacy Protection

University of Sheffield

Mark Taylor

Description Research using genetic data raises various concerns relating to privacy protection. Many of these concerns can also apply to research that uses other personal data, but not with the same implications for failure. The norms of exclusivity associated with a private life go beyond the current legal concept of personal data to include genetic data that relates to multiple identifiable individuals simultaneously and anonymous data that could be associated with any number of individuals in different, but reasonably foreseeable, contexts. It is the possibilities and implications of association that are significant, and these possibilities can only be assessed if one considers the interpretive potential of data. They are missed if one fixates upon its interpretive pedigree or misunderstands the meaning and significance of identification. This book demonstrates how the public interest in research using genetic data might be reconciled with the public interest in proper privacy protection.

Key Features • Describes a concept of privacy that ensures appropriate research access to genetic data without sacrificing proper privacy protection • Highlights the inability of the legal concept of personal data to protect informational privacy and makes clear the importance of fluid interpretive frameworks to the relationship between data and information • Provides recommendations for reform that suggest how a broader range of privacy interests might be taken into account within a regulatory environment

Contents

1. Introduction; 2. Privacy; 3. Genetic data; 4. The law;

5. Data in common; 6. Anonymity; 7. Human tissue; 8. Genetic discrimination; 9. Potential, promise and possibility.

Additional Information Level: academic researchers, graduate students Series: Cambridge Bioethics and Law, 16 March 2012 228 x 152 mm 264pp 978-1-107-00711-6 Hardback c. £60.00

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Medical law and ethics

Ethical Problems and Genetics Practice Michael Parker University of Oxford

19

Bioethics and Law

Ethical Problems and Genetics Practice Michael Parker

Description Ethical Problems and Genetics Practice provides a rich, case-based account of the ethical issues arising in the genetics clinic and laboratory. By analysing a wide range of evocative and often arresting cases from practice, Michael Parker provides a compelling insight into the complex moral world of the contemporary genetics professional and the challenges they face in the care of patients and their families. This book is essential reading for anyone interested in the ethical issues arising in everyday genetics practice. Ethical Problems and Genetics Practice is also a sustained engagement with the relationships between bioethics and social science. In proposing and exemplifying a new approach to bioethics, it makes a significant contribution to debates on methods and interdisciplinarity and will therefore also appeal to all those concerned with theoretical and methodological approaches to bioethics and social science.

Key Features • Empirically grounded account will appeal to those who are interested in ethical issues arising in genetics for health professionals, policy-makers and family members • Proposes and exemplifies a new approach to bioethics that will appeal to those interested in theoretical and methodological approaches to ethics • Investigation of the relationships between bioethics and social science which makes a significant contribution to debate on methods and interdisciplinarity and to the role of ethics in relation to these two disciplines

Contents

1. Introduction; 2. The patient in the families; 3. Elective affinities; 4. Reproducing ethics; 5. Multi-professional practices; 6. Moral craft; 7. Methodological reflections.

Additional Information Level: academic researchers, graduate students Series: Cambridge Bioethics and Law, 19 April 2012 228 x 152 mm 184pp 1 b/w illus.

978-1-107-02080-1 Hardback c. £55.00

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20

Medical law and ethics

Privacy, Confidentiality, and Health Research William W. Lowrance Description The potential of the e-health revolution, increased data sharing, database linking, biobanks and new techniques such as geolocation and genomics to advance human health is immense. For the full potential to be realized, though, privacy and confidentiality will have to be dealt with carefully. Problematically, many conventional approaches to such pivotal matters as consent, identifiability, and safeguarding and security are inadequate. In many places, research is impeded by an overgrown thicket of laws, regulations, guidance and governance. The challenges are being heightened by the increasing use of biospecimens, and by the globalization of research in a world that has not globalized privacy protection.

Drawing on examples from many developed countries and legal jurisdictions, the book critiques the issues, summarizes various ethics, policy, and legal positions (and revisions underway), describes innovative solutions, provides extensive references and suggests ways forward.

Key Features • Analyzes current problems, reviews practical solutions and proposes new approaches • Reviews and comments in a concise manner • Discusses the intersections between privacy and research

Contents

1. Introduction; 2. Data, biospecimens, and research; 3. Privacy, confidentiality, safeguards; 4. Broad privacy and the data protection regimes; 5. Health care, public health, and research regimes;

6. Consent; 7. Identifiability and person-specific data; 8. Genetics and genomics; 9. Safeguards and responsibilities; 10. Data sharing, access, and transfer; 11. Ways forward.

Additional Information Level: academic researchers, professionals Series: Cambridge Bioethics and Law, 20 June 2012 228 x 152 mm 200pp 1 b/w illus.

978-1-107-02087-0 Hardback c. £55.00

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Medical law and ethics

21

Reproductive Donation Practice, Policy and Bioethics

Edited by Martin Richards University of Cambridge

Guido Pennings

Universiteit Gent, Belgium

and John Appleby

EDI TED BY

MAR T IN R ICHARDS GUIDO PENNINGS JOHN APPLEBY

University of Cambridge

Description

REPRODUC T IVE

Reproductive donation is the most contentious area of assisted reproduction. Even within Europe there are wide variations in what is permitted in each country. This multidisciplinary book takes a fresh look at the practices of egg, sperm and embryo donation and surrogacy, Practice, Policy and Bioethics bringing together ethical analysis and empirical research. New evidence is offered on aspects of assisted reproduction and the families these create, including non-traditional types. One of the key issues addressed is should children be told of their donor origin? If they do learn the identity of their donor, what kinds of relationships may be forged between families, the donor and other donor sibling families? Should donation involve a gift relationship? Is intra-familial donation too close for comfort? How should we understand the growing trend for ‘reproductive tourism’? This lively and informed discussion offers new insights into reproductive donation and the resulting donor families.

DONATION

Key Features • Addresses the new ethical challenges arising from recent changes to legislation and policies on gamete donation around the world • Bridges the gap between empirical research and ethical theory • Encompassing social science, biomedical ethics, philosophy and law, this book offers a genuinely interdisciplinary approach

Contents

1. Introduction; 2. The biology of donation; 3. Ethics for reproductive donation; 4. Parenthood: whose right is it anyway?; 5. Reproductive donation: global perspectives and cultural diversity;

6. UK and USA perspectives on the regulation of reproductive donation; 7. Gamete and embryo donation: a legal view from Spain; 8. The legal and ethical regulation of transnational donation; 9. Balancing ethical criteria for the recruitment of gamete donors; 10. Challenges in intra-family donation; 11. ARTs and the single parent;

Additional Information Level: academic researchers, professionals July 2012 228 x 152 mm 270pp 1 table 978-1-107-00777-2 Hardback c. £60.00

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12. Reproductive donation and justice for gay and lesbian couples; 13. Is disclosure in the best interests of the children conceived by donation?; 14. Identifiable donors and siblings: implications for the future; 15. Ethical issues in embryo donation; 16. Reproduction through surrogacy: the UK and USA experience; 17. Some conclusions regarding the interaction of normative and descriptive elements in reproductive donation.

22

Medical law and ethics

Guidance for Healthcare Ethics Committees Edited by D. Micah Hester

Division of Medical Humanities, University of Arkansas

and Toby Schonfeld

Guidance for Healthcare Ethics Committees EDITED BY

Emory University, Atlanta

D. Micah Hester and Toby Schonfeld

Description Every accredited American hospital is required to have a mechanism for handling ethical concerns; most hospitals satisfy this requirement by constituting an institutional healthcare ethics committee (HEC), a pattern which is repeated in most western countries. This text provides definitive, comprehensive guidance for members of healthcare ethics committees who find themselves confronted with ethically challenging situations. Each chapter includes learning objectives, clinical case studies and questions to stimulate discussion among committee members. Particular emphasis is given to consultation, as this often presents the greatest challenges to committee members. Each chapter stands alone as a teaching module, as well as forming part of a comprehensive volume. Written and edited by nationally and internationally recognized experts in bioethics, this is essential reading for every member of a healthcare ethics committee.

Key Features • Includes conceptual, pragmatic and strategic discussion questions, stimulating individual comprehension and committee discussion • Learning objectives for each chapter clearly identify educational goals • Case studies make the content directly applicable to everyday practice

Contents

Preface; Part I. The Context of Healthcare Ethics Committee Work: 1. Introduction to healthcare ethics committees; 2. Brief introduction to ethics and ethical theory; 3. Ethics committees and the law; 4. Cultural and religious issues in health care; Part II. Consultation: 5. Mission, vision, goals: defining the parameters of the ethics consultation; 6. Ethics consultation process;

7. Informed consent, shared decision making, and the ethics committee; 8. Decision-making capacity; 9. Family dynamics and surrogate decision making; 10. Confidentiality; 11. Advance care planning and end-of-life decision making; 12. Medical futility; 13. Ethical issues in reproduction; 14. Ethical issues in neonatology; 15. Ethical issues in pediatrics;

Additional Information Level: professionals, medical specialists/consultants June 2012 234 x 156 mm 232pp 1 b/w illus. 6 tables 978-0-521-27987-1 Paperback c. £38.00

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Part III. Policy Development and Organizational Issues: 16. Ethics committees and distributive justice; 17. Developing effective ethics policy; 18. Implementing policy to the wider community; 19. Ethics in and for the organization; Part IV. Educating Others: 20. The healthcare ethics committee as educator; 21. Education as prevention; 22. Understanding ethics pedagogy; Index.

Mental health

The Autism Spectrum Scientific Foundations and Treatment

Edited by Mark Reber

Drexel University United States of America

23

The

Autism spectrum scientific Foundations and treatment

Description Written for the wide range of physicians and professionals who treat children and adults with autism spectrum disorders (ASDs), this book reviews the scientific research on the nature and causes of autism, outlines best treatment practices with children and describes a comprehensive assessment and treatment approach for adults.

Topics covered include: edited by mArk reber • Classification, epidemiology and diagnosis • Neurodevelopmental abnormalities • Recommendations for early screening and evaluating at-risk children • Early interventions based on applied behavioral analysis • The critical role of special education, speech-language therapy, occupational therapy and assistive technology in treating children • Pharmacotherapy • Complementary and alternative treatments • Development of individualized and person-centered treatments for adults The Autism Spectrum is an invaluable resource for all those working with ASDs including pediatricians, psychiatrists, behavioral psychologists, special educators, nurses and therapists.

Key Features • Provides clinicians’ perspectives on research which enables practitioners to discern and learn what is relevant to them in latest autism research • Describes treatment approaches in a wide variety of professional disciplines which informs practitioners of best ways to treat autism in own field and that of others • Has separate section devoted to adults with ASDs which offers a comprehensive model for adult assessment and treatment

Contents

Part I. What We Know about Autism and How We Know It: 1. Nosology: definitions and diagnoses; 2. Epidemiology; 3. Phenomenology: the neuropsychology of autism; 4. Pathophysiology: the neuroscience of autism;

5. Etiology: syndromic autism; 6. Etiology: essential autism; Part II. Assessing and Treating Children with Autism: 7. Clinical diagnostic evaluation; 8. Special education;

Additional Information Level: medical specialists/consultants, specialist medical trainees May 2012 234 x 156 mm 300pp 978-0-521-11687-9 Hardback c. £55.00

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9. Habilitation therapies (including speech-language and occupational therapies and assistive technology); 10. Behavioral therapies; 11. Pharmacotherapy and nutritional therapies; Part III. Assessing and Treating Adults with Autism: 12. Clinical assessment of adults; 13. Treatment planning for adults.

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Mental health

Brain Stimulation in Psychiatry ECT, DBS, TMS and Other Modalities

Brain Stimulation in

P S y c h i at r y

Charles H. Kellner

Ect, DBS, tMS and Other Modalities

Mount Sinai School of Medicine, New York

C ha r l e s h. K e llner

Wayne Goodman

Mount Sinai School of Medicine, New York

and Ronald Alterman

Mount Sinai School of Medicine, New York

Description The field of brain stimulation is advancing at rapid pace with a growing number of techniques now approved for the treatment of psychiatric illness. This text acts both as a concise, quick reference for experienced practitioners and a guidebook for residents learning about clinical brain stimulation techniques.

The techniques covered include: • Electroconvulsive therapy (ECT) • Deep brain stimulation (DBS) • Transcranial magnetic stimulation (TMS) • Vagus nerve stimulation (VNS) • Magnetic seizure therapy (MST) • Transcranial direct current stimulation (TDCS) All aspects of these treatments are covered, from patient selection, through the implementation of the technique, to patient aftercare. Potential future applications are discussed and select, up-to-date reference lists guide practitioners to the most important further reading around each technique. Portable, concise and easy to navigate, covering all the need-to-know information, Brain Stimulation in Psychiatry is essential reading for practitioners, residents and medical students in psychiatry and neurology.

Key Features • Provides ‘how-to’ information, functioning as a manual suitable for practitioners at all levels • Clear, easy-to-navigate layout makes the text useful for quick reference in the treatment suite • Includes a theoretical overview of each treatment modality, succinctly summarising the relevant literature

Contents

1. Introduction; 2. Electroconvulsive therapy (ECT): basic concepts; 3. Electroconvulsive therapy (ECT): patient selection and preparation; 4. Electroconvulsive therapy (ECT): technique; 5. Electroconvulsive therapy (ECT): treatment course; 6. Electroconvulsive therapy (ECT): common adverse effects; 7. Electroconvulsive therapy (ECT): the ECT service;

8. Electroconvulsive therapy (ECT): special issues; 9. Deep brain stimulation (DBS); 10. Transcranial magnetic stimulation (rTMS); 11. Magnetic seizure therapy (MST); 12. Vagus nerve stimulation (VNS); 13. Transcranial direct current stimulation (TDCS); Index.

Additional Information Level: medical specialists/consultants, specialist medical trainees June 2012 234 x 156 mm 160pp 16 b/w illus.

978-0-521-17255-4 Paperback c. £35.00

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Mental health

Essential Evidence-Based Psychopharmacology Second edition

Edited by Dan Stein

25

Essential Evidence-Based Psychopharmacology Second Edition

University of Cape Town

Edited by Dan J. Stein, Bernard Lerer, and Stephen M. Stahl

Bernard Lerer

Hadassah-Hebrew Medical Centre

and Stephen Stahl

University of California, San Diego

Description This volume presents up-to-date, comprehensive and high quality reviews of the psychopharmacological evidence-base for each of the major psychiatric disorders, written by expert psychopharmacologists from around the world. Building on the success of the first edition, the volume summarizes the wealth of new developments in the field and sets them within the context of day-to-day clinical practice. All chapters have been fully updated and new contributions on personality disorders and substance dependence added. Each chapter provides information about optimal first line pharmacological interventions, maintenance pharmacotherapy and the management of treatment-refractory patients. The content is organized according to the DSM-V listing of psychiatric disorders, and covers all major conditions including schizophrenia, mood disorders, anxiety disorders, eating disorders and Alzheimer’s disorder. These issues lie at the heart of clinical psychopharmacology, making this book invaluable to all practising and trainee clinicians, in a mental health setting or a less specialized environment.

Key Features • Explains what we know and what we do not know, helping readers to understand the next steps for the field • Focuses on the evidence-base to facilitate informed decision making • Summarizes and clarifies a rapidly expanding literature base

Contents

Preface; Foreword; 1. Evidence-based pharmacotherapy of attention deficit hyperactivity disorder; 2. Evidence-based pharmacotherapy of schizophrenia; 3. Evidence-based pharmacotherapy of bipolar disorder;

4. Evidence-based pharmacotherapy of major depressive disorder; 5. Evidence-based pharmacotherapy of panic disorder; 6. Evidence-based pharmacotherapy of social anxiety disorder; 7. Evidence-based pharmacotherapy of generalised anxiety disorder; 8. Evidence-based pharmacotherapy of obsessivecompulsive disorder; 9. Evidence-based pharmacotherapy of posttraumatic stress disorder;

Additional Information Level: medical specialists/consultants, specialist medical trainees March 2012 234 x 156 mm 336pp 3 b/w illus.

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10. Evidence-based pharmacotherapy of eating disorders; 11. Evidence-based pharmacotherapy of nicotine and alcohol dependence; 12. Evidence-based pharmacotherapy of illicit substance use disorders; 13. Evidence-based pharmacotherapy of Alzheimer’s disease; 14. Evidence-based pharmacotherapy of personality disorders; Index.

26

Mental health

Bipolar II Disorder Modelling, Measuring and Managing Second edition

Edited by Gordon Parker

BIPOLAR II DISORDER MODELLING, MEASURING AND MANAGING

Second Edition

University of New South Wales, Sydney

Description The lifetime risk of developing bipolar II disorder is 5-7%, yet the condition is often poorly detected. Mood elevation states are less extreme than in bipolar I disorder although the depressive episodes are usually severe. When correctly treated, the outcome is positive, but bipolar II is often poorly managed, resulting in a high suicide rate. This is the only academic and clinical management review focusing entirely on bipolar II, scrutinizing Edited by Gordon Parker history, epidemiology, burden and neurobiology and including an extensive clinical debate by international experts about effective management strategies. New chapters cover comorbidity, over-represented personality styles, illness ‘trajectories’ and distinguishing bipolar II from personality-based emotional dysregulation states. Evidence for different clinical management options is reviewed in detail, two clinical management models are presented and then debated. This book is essential reading for all health professionals managing mood disorders and informative to patients seeking information about their condition and treatment options.

Key Features • Chapters feature two voices – academic reviews and clinical management advice from international experts giving two perspectives on the topic • The only book solely focusing on bipolar II disorder and the clinical management of this seriously debilitating condition • New chapters cover comorbidity and personality styles and distinguishing bipolar II disorder from other conditions with similar clinical features • More clinical management models and management commentaries

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Mental health Contents

Introduction to the second edition; 1. Bipolar disorder in historical perspective; 2. The bipolar spectrum; 3. Defining and measuring bipolar II disorder; 4. Bipolar II disorder in context: a review of epidemiology, disability and economic burden; 5. Comorbid conditions associated with bipolar II disorder; 6. Is bipolar II disorder increasing in prevalence?; 7. Personality styles associated with bipolar II disorder; 8. Distinguishing bipolar II disorder from personalitybased states of emotional dysregulation; 9. The neurobiology of bipolar II disorder; 10. The role of antidepressants in managing bipolar II disorder;

11. Current status of mood stabilisers in the management of bipolar II disorder; 12. The use of atypical antipsychotic drugs in bipolar II disorder; 13. The role of fish oil in managing bipolar II disorder; 14. Psychological interventions for bipolar II disorder; 15. The role of wellbeing plans in managing bipolar II disorder; 16. The trajectory of illness experienced by those with bipolar II disorder; 17. Clinical models for managing bipolar II disorder: model one; 18. Clinical models for managing bipolar II disorder: model two; 19. Management commentary 1; 20. Management commentary 2; 21. Management commentary 3;

Additional Information Level: medical specialists/consultants, specialist medical trainees May 2012 234 x 156 mm 304pp 8 b/w illus.

978-1-107-60089-8 Paperback c. £45.00

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22. Management commentary 4; 23. Management commentary 5; 24. Management commentary 6; 25. Management commentary 7; 26. Management commentary 8; 27. Management commentary 9; 28. Management commentary 10; 29. Management commentary 11; 30. Management commentary 12; 31. Management commentary 13; 32. Rounding up and tying down; Index.

27

28

Mental health

Stahl’s Self-Assessment Examination in Psychiatry Multiple Choice Questions for Clinicians

Stephen M. Stahl

University of California, San Diego

Description Dr Stahl’s books occupy a central position as core educational resources in the psychopharmacology literature. Building on Dr Stahl’s exceptional ability to communicate complex principles and make them easily understandable, this book offers 150 self-assessment questions derived from Dr Stahl’s Online Master Psychopharmacology Program. The self-assessment questions will help the reader to identify areas of competence or the need for further study. In addition, the questions themselves are learning exercises: each question is followed by a thorough explanation of the correct and incorrect answer choices. Readers can work through the questions to prepare for formal tests, including American Board of Psychiatry and Neurology examinations and to achieve CME and MoC credits towards ongoing ABPN re-accreditation. The questions are also ideal training tools for those working in related clinical fields and in industry.

Key Features • All questions have been approved by the American Board of Psychiatry and Neurology as being pitched at an appropriate level for re-accreditation purposes • Thorough explanations of the correct and incorrect answer choices for every question demystify complex principles and enable the user to build their knowledge and understanding • The 150 questions are divided into ten sections, reflecting the core areas of psychiatry and providing comprehensive selfassessment for American Board of Psychiatry and Neurology examinations

Contents

1. Basic neuroscience; 2. Unipolar depression; 3. Bipolar disorder; 4. Psychosis; 5. Anxiety;

6. ADHD; 7. Dementia; 8. Pain; 9. Sleep; 10. SUD; Index.

Additional Information Level: specialist medical trainees, medical specialists/consultants May 2012 186 x 123 mm 320pp 978-1-107-68159-0 Paperback c. £28.99

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Neurology

29

Neurogenetics A Guide for Clinicians

Nicholas Wood Description Progress in genetic knowledge is profoundly affecting medical practice, and no clinical specialty has more diseases associated with genetic mutations than neurology. As a more complete picture of the genes which give rise to neurological disease is obtained, trainee and practising neurologists need a guide to basic principles and the more important clinical entities with a genetic component. It is against this background that Neurogenetics: A Guide for Clinicians has been written. The book opens with coverage of genetic testing and counselling. Subsequent chapters discuss genetic factors for all the major neurological diseases, including epilepsy, Alzheimer’s disease, Parkinsonism and muscular dystrophies. No book in this field can hope to be fully up to date with the latest research; rather this work provides a framework on which to add new genetic discoveries. Neurogenetics: A Guide for Clinicians provides a synoptic overview for neurologists, medical geneticists and scientists working in the field.

Key Features • Clinical application of neurogenetics – neurological diseases are cross-referenced to clinical implications • Selected illustrations are used to supplement and enhance the text • Written by international leaders in the field, giving an authoritative and informed perspective

Contents

Preface; 1. The human genome project – what it really means and where next?; 2. Genetic counselling and genetic testing for neurogenetic disorders; 3. Alzheimer’s disease and related dementias; 4. The epilepsies;

5. The ataxias; 6. Huntington’s disease; 7. Parkinsonism; 8. Prion diseases; 9. Channelopathies; 10. Amyotrophic lateral sclerosis and other disorders of the lower motor neuron;

Additional Information Level: medical specialists/consultants, specialist medical trainees April 2012 246 x 189 mm 248pp 28 b/w illus.

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11. The muscular dystrophies; 12. Charcot-Marie-Tooth diseases; 13. Mitochondrial disorders; 14. The neurofibromatoses and related disorders; 15. The future of neurogenetics; Index.

30

Neurology

Clinical Trials in Neurology Design, Conduct, Analysis

Edited by Bernard Ravina

Department of Neurology, University of Rochester School of Medicine

Jeffrey Cummings

Cleveland Clinic, Lou Ruvo Center for Brain Health, Las Vegas

Michael McDermott

Department of Bioststistics and Computational Biology, University of Rochester

Clinical Trials in

Neurology

Design, Conduct, Analysis

and Michael Poole

Wyeth Research, Collegeville, PA

EDITED BY:

Bernard Ravina Jeffrey Cummings Michael McDermott Michael Poole

Description Translating laboratory discoveries into successful therapeutics can be difficult. Clinical Trials in Neurology aims to improve the efficiency of clinical trials and the development of interventions in order to enhance the development of new treatments for neurologic diseases. It introduces the reader to the key concepts underpinning trials in the neurosciences. This volume tackles the challenges of developing therapies for neurologic disorders from measurement of agents in the nervous system to the progression of clinical signs and symptoms through illustrating specific study designs and their applications to different therapeutic areas. Clinical Trials in Neurology covers key issues in Phase I, II and III clinical trials, as well as post-marketing safety surveillance. Topics addressed include regulatory and implementation issues, outcome measures and common problems in drug development. Written by a multidisciplinary team, this comprehensive guide is essential reading for neurologists, psychiatrists, neurosurgeons, neuroscientists, statisticians and clinical researchers in the pharmaceutical industry.

Key Features • Helps readers to understand key regulatory requirements and allows for planning of successful clinical trials • Aims to enhance the development of new treatments for neurological diseases • Definitive single source of information on neurological clinical trials including the basics of clinical trials design and the issue faced when studying neurologic disorders

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Neurology Contents

Preface; Part I. The Role of Clinical Trials in Therapy Development: 1. The impact of clinical trials in neurology; 2. The sequence of clinical development; 3. Unique challenges in the development of therapies for neurological disorders; Part II. Concepts in Biostatistics and Clinical Measurement: 4. Fundamentals of biostatistics; 5. Bias and random error; 6. Approaches to data analysis; 7. Selecting outcome measures; Part III. Special Study Designs and Methods for Data Monitoring: 8. Selection and futility designs;

9. Adaptive designs across stages of therapeutic development; 10. Crossover designs; 11. Two period designs for evaluation of diseasemodifying treatments; 12. Enrichment designs; 13. Non-inferiority trials; 14. Monitoring of clinical trials: interim monitoring, data monitoring committees, and group sequential methods applied to neurology; 15. Clinical approaches to post-marketing drug safety assessment; Part IV. Ethical Issues: 16. Ethics in clinical trials involving the central nervous system: risk, benefit, justice, and integrity; 17. The informed consent process: compliance and beyond; Part V. Regulatory Perspectives: 18. Evidentiary standards for neurologic drugs and biologics approval; 19. Premarket reviews of neurological devices;

Additional Information Level: medical specialists/consultants, specialist medical trainees April 2012 246 x 189 mm 400pp 49 b/w illus.

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31

Part VI. Clinical Trials in Common Neurological Disorders: 20. Parkinson’s disease; 21. Alzheimer’s disease; 22. Acute ischemic stroke; 23. Multiple sclerosis; 24. Amytrophic lateral sclerosis (ALS); 25. Epilepsy; 26. Insomnia; Part VII. Clinical Trial Planning and Implementation: 27. Clinical trial planning: an academic and industry perspective; 28. Clinical trial implementation, analysis and reporting: an academic and industry perspective; 29. Academic-industry collaborations and compliance issues; Index.

32

Neurology

Common Movement Disorders Pitfalls Case-Based Learning

Alberto J. Espay

Department of Neurology, University of Cincinnati Neuroscience Institute

and Anthony Lang

Division of Neurology, University of Toronto

Description Visual observation of patients is crucial in the diagnosis of movement disorders. Such observation can be subject to many pitfalls. The powerful lessons in this case-based book will help the reader appreciate diagnoses missed or wrongly attributed, movements difficult to characterize, tests inappropriately ordered or interpreted, and treatments incorrectly chosen or dosed. The wisdom of hindsight thus generated becomes an invaluable and enduring lesson. Organized in nine chapters according to the categories of errors and oversights, each case conveys a specific set of clinical pearls on diagnostic or therapeutic issues. The text is written in a coaching style, buttressed by the strong pedagogic wisdom of the authors. The ‘hard questions’ after each case are meant to steer the discussion straight into the pitfalls – and how they could have been avoided. Video segments on the accompanying CD-ROM are important complementary data, critical to a field so intimately dependent on phenomenological clues.

Key Features • Includes the most common movement disorders encountered by practising neurologists – will be immediately relevant to all trainees • Case-based approach to learning – allows wide coverage of conditions, highlighting the particular aspect of each condition that commonly causes difficulty • Questions addressed to the reader – maintains interest and heightens the real-life feel of the book • Well-illustrated, including patient material, radiographic studies and video content – will help clinicians detect and identify characteristic abnormalities

Contents

Preface; 1. Missing the diagnosis altogether; 2. Attributing findings to a known or suspected disorder; 3. Clinical findings that are subtle; 4. When movement disorders are difficult to characterize; 5. Over-reliance on negative test results;

6. Failure of pattern recognition; 7. Testing pitfalls of commission or omission; 8. Missing radiographic clues; 9. Management misadventures; Further reading; Appendix: video legends; Index.

Additional Information Level: medical specialists/consultants, specialist medical trainees February 2012 246 x 189 mm 136pp 69 b/w illus. 17 tables 978-0-521-14796-5 Paperback c. £45.00

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Neurology

33

Case Studies in Epilepsy Common and Uncommon Presentations

Edited by Hermann Stefan

Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

Elinor Ben-Menachem

Göteborgs Universitet, Sweden

Patrick Chauvel and Renzo Guerrini

Children’s Hospital A. Meyer-University of Florence

Description Clinical case studies have long been recognized as a useful adjunct to problem-based learning and continuing professional development. They emphasize the need for clinical reasoning, integrative thinking, problem-solving, communication, teamwork and self-directed learning – all desirable generic skills for health care professionals. Epilepsy is amongst the most frequently encountered of neurological disorders. There are important emerging clinical management issues (e.g., first seizure, therapy-resistant seizures, ICU, pregnancy) but also differential diagnosis of non-epileptic seizures (syncopy, pseudo-seizure, paroxysmal dystonic syndromes, sleep disorders, psychosis, inborn errors of metabolism, etc.). This selection of epilepsy case studies will inform and challenge clinicians at all stages in their careers. Including both common and uncommon cases, Case Studies in Epilepsy reinforces the diagnostic skills and treatment decision-making processes necessary to treat epilepsy and other seizures confidently. Written by leading experts, the cases and discussions work through differential diagnoses, treatments and social consequences in pediatric and adult patients.

Key Features • Includes recommended treatment plans which aid quick and accurate treatment of patients • Case studies enable learning from real experiences • Collects experiences from different European countries

Contents

Preface; Introduction; Section 1. Common Presentations of Epilepsy: Cases 1-30; Section 2. Uncommon Presentations: Cases 30-60; Appendix.

Additional Information Level: medical specialists/consultants, medical students Series: Case Studies in Neurology February 2012 247 x 174 mm 288pp 978-0-521-16712-3 Paperback c. £35.00

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34

Neurology

Traumatic Brain and Spinal Cord Injury

Traumatic Brain and Spinal Cord Injury Challenges and Developments

Challenges and Developments

Edited by Cristina Morganti-Kossmann

National Trauma Research Institute, Monash University, Melbourne

Ramesh Raghupathi

Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia

and Andrew Maas

EditEd by:

Cristina Morganti-Kossmann Ramesh Raghupathi Andrew Maas

Department of Neurosurgery, University Hospital Antwerp

Description Traumatic Brain and Spinal Cord Injury comprehensively covers the medical and pathological issues related to neurotrauma and its often devastating consequences. Written by globally renowned experts in the field, both clinicians and researchers will find this book invaluable to update their knowledge. This volume is divided into two sections, one covering the brain, the other the spinal cord. Each section discusses the following topics: • The demographic in the developed and developing world where neurotrauma is witnessing a massive expansion • Major clinical issues including advanced semi-experimental monitoring techniques utilized by neurosurgeons and intensivists and the potential use of identifying markers of tissue injury • Overview of major pathophysiological changes • The development of animal models; successes and limitations • Past, current and future therapeutic strategies including rehabilitative opportunities.

Presenting the most up-to-date clinical and experimental research in neurotrauma, this volume is essential reading for neurologists, neurosurgeons, intensive care physicians and rehabilitative physicians.

Key Features • Advanced knowledge is presented in a manner that will be accessible to trainees as well as experts in the field • The globally renowned contributing authors all write from personal experiences in the clinic and the lab • Each chapter begins with background information on pathophysiology to ensure the fundamentals are clear before new therapeutic methods are presented

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Neurology Contents

Preface; Part I. Traumatic Brain Injury (TBI): 1. Current evaluation of TBI epidemiology in an ageing society with improved preventative measures; 2. Neurotrauma: an emerging epidemic in low and middle income countries; 3. Post-traumatic distress syndrome and blast injury: new challenges in TBI research from the combat zone; 4. Psychological effects of mild TBI: their nature and treatment; 5. Developments of neuroimaging techniques to diagnose and visualize white matter damage; 6. New advances in monitoring the injured brain metabolism; 7. Potential use and limitations of microdialysis for monitoring of neurochemical changes after TBI; 8. Metabolic and therapeutic differences in pediatric and adult TBI;

9. Utility of biomarkers for diagnosis and prognosis of TBI; 10. Animal models of mild and severe TBI: what have we learned in the past 30 years?; 11. Pediatric brain trauma: what do ageappropriate animal models teach us about the age-at-injury?; 12. The complexity of axonal dysfunction following diffuse brain injury; 13. Cerebral inflammation after traumatic injury: regulation of secondary damage, repair or both?; 14. Controversial findings on the role of NMDA receptor in post-traumatic excitotoxicity; 15. Plasticity and recovery of the injured brain; 16. Design and analysis of clinical trials in TBI; 17. Future perspectives for the treatment of TBI patients: decompressive craniectomy, hypothermia and erythropoietin; Part II. Traumatic Spinal Injury (TSI): 18. Global epidemiology of traumatic spinal cord injury;

Additional Information Level: medical specialists/consultants, specialist medical trainees July 2012 246 x 189 mm 384pp 160 b/w illus. 32 colour illus.

978-1-107-00743-7 Hardback c. £75.00

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19. Classification and surgical intervention of spinal injuries; 20. Spinal cord injury: pathophysiology and prospect of decompressive surgical treatment; 21. Modelling the injured spinal cord and developing methods to assess outcomes; 22. Myelin inhibitors of neurite outgrowth in spinal cord injury; 23. Controversies on the role of inflammation in the injured spinal cord; 24. Cell transplantation for spinal cord injury; 25. Combined cell-based and pharmacologic interventions with behavioral training; 26. Chances and limits of locomotor training after damage to the central nervous system; 27. Temperature management and therapeutic hypothermia for the treatment of spinal cord injury; 28. Spinal cord injury clinical trials 1990–2010; Index.

36

Reproductive medicine

Handbook of Human Oocyte Cryopreservation Eleonora Porcu

Reproductive Medicine Unit, University of Bologna

Patrizia Ciotti

Reproductive Medicine Unit, University of Bologna

and Stefano Venturoli

Reproductive Medicine Unit, University of Bologna

Description Human oocyte cryopreservation has undergone rapid growth, with technical improvement and increasing clinical application over the last ten years. Storing eggs is ethical and gives many young women their most realistic chance of conception. Cryopreservation, however, is still considered by many as an experimental technique and conflicting reports are published as to its efficacy. For these reasons, it is necessary to give reproductive researchers and practitioners comprehensive and systematic information about the field. This book describes and analyses the history of human oocyte freezing, the main steps of technical evolution, and the pros and cons of different techniques. In addition, the clinical applications, long-term outcome, efficiency and safety of oocyte cryopreservation are detailed.

The Handbook of Human Oocyte Cryopreservation gives a complete picture of the field today and is a valuable text for embryologists, cryobiologists, reproductive medicine practitioners and anyone involved in researching and implementing the technique.

Key Features • Details of laboratory procedures enable reproductive laboratory staff to learn from the inventors of the technique • Discussion of clinical experience and pregnancy outcome aids clinical management of patients in routine assisted reproduction and fertility preservation • Illustrations help readers to fully understand the content

Contents

Preface; 1. Why freeze human eggs? Clinical and biological indications for human oocyte cryopreservation; 2. Natural history of human oocyte cryopreservation; 3. Clinical management of oocyte cryopreservation; 4. Laboratory management of oocyte cryopreservation; 5. Slow freezing and rapid thawing; 6. Vitrification/warming;

7. Comparison between slow freezing and vitrification: pros and cons; 8. Safety of storage; 9. Database; 10. Physician-embryologists cooperation for optimal management of the oocyte cryopreservation program; 11. Costs; 12. Staff; 13. Secrets and tricks of oocyte cryopreservation; Index.

Additional Information Level: medical specialists/consultants, specialist medical trainees May 2010 234 x 156 mm 256pp 80 b/w illus.

978-0-521-19239-2 Hardback c. £60.00

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Reproductive medicine

Atlas of Oocytes, Zygotes and Embryos in Reproductive Medicine Marc Van den Bergh

Fertility Laboratory, Kantonsspital Baden

Thomas Ebner

Landes- Frauen- und Kinderklinik, Linz

37

Atlas of Oocytes Zygotes and Embryos in Reproductive Medicine Marc Van den Bergh Kay Elder Thomas Ebner

and Kay Elder

Bourn Hall Clinic, Cambridge

Description The assessment and selection of oocytes and embryos is fundamental to the live birth rate data of all IVF units, the parameter that is used to gauge a clinic’s success and credibility. This new atlas contains over 1000 high-quality images of oocytes, zygotes and embryos, presented with accompanying data on indications for treatment, stimulation type and duration, as well as short medical histories of each couple and final outcome of treatment. All images in the book can be downloaded from the accompanying CD-ROM. Structured on a patient-by-patient basis, the atlas describes 100 clinically documented case studies that follow the evolution of oocytes and zygotes between day two and day five. Pronuclear morphology and synchrony as well as embryo morphology are reported and described for each case. Written and produced by experienced embryologists, this practical atlas is an important resource for clinical embryologists and physicians in reproductive medicine.

Key Features • Describes 100 clinically documented case studies, which can facilitate learning from daily practice • High-quality images provide an overview of a complete gamete cohort, showing up to five days of preimplantation development at one glance • Clear descriptions enable the reader to compare their own judgement with the authors’ experiences

Contents

Introduction; Female indications for treatment; Clinical and laboratory protocols; Controlled ovarian hyperstimulation; Sperm preparation; ICSI; In vitro culture system; Oocyte and embryo assessment;

Case histories: Part I. ‘KSB’: Cleavage Stage Transfer (Case Numbers 1–80): 1. No female indication identified (cases 1–33); 2. Tubal infertility (cases 34–40); 3. Cervical hostility/fibroids (cases 41–44); 4. Endometriosis (cases 45–60); 5. Poor responder or ovulatory dysfunction (cases 61–71); 6. Polycystic ovarian disease (cases 72–74); 7. Hyperprolactinaemia/Hypothyroid (cases 75–79);

Additional Information Level: medical specialists/consultants, specialist medical trainees May 2012 276 x 219 mm 262pp 790 colour illus.

978-1-107-00464-1 Mixed media product c. £85.00

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8. Recurrent abortion (case 80); Part II. ‘Linz’: Extended Culture to Blastocyst Stage (Case Numbers 81–111): 9. No female indication identified (cases 81–92); 10. Unexplained, failed IVF (cases 93–94); 11. Tubal infertility (cases 95–98); 12. Endometriosis (cases 99–102); 13. Polycystic ovarian disease (cases 103–109); 14. Premature ovarian failure (case 110); 15. Translocation (case 111).

38

Reproductive medicine

Pregnancy After Assisted Reproductive Technology Edited by Eric Jauniaux

Academic Department of Obstetrics & Gynaecology, University College London Institute for Women’s Health, London

and Botros Rizk

Pregnancy After Assisted Reproductive technology E d i t E d by

Department of Obstetrics & Gynecology, University of South Alabama, Mobile

Eric R. M. Jauniaux and botros R. M. b. Rizk

Description It is estimated that more than 4.5 million couples experience infertility each year, and more than 4 million babies have been born using IVF since 1978. However, assisted reproductive technologies continue to raise many medical, social, ethical, political and religious questions, often leading to controversial and sometimes inaccurate opinions about the outcomes of pregnancies resulting from these techniques. This is the first book dedicated to pregnancies arising from assisted reproductive technologies (ART). Chapters cover the most important management issues, from early pregnancy to outcome of children resulting from ART, including gynaecological, genetic and obstetric complications. Each chapter is written and edited by leading experts in the field of human reproduction. A timely, practical and evidence-based guide to the management of ART pregnancies, based on 30 years of clinical experience, this is essential reading for reproductive and maternal-fetal specialists as well as general obstetricians and gynaecologists.

Key Features • Chapters written by experts in ART pregnancies, providing accurate evidence-based information in a comprehensive and fully integrated way • Includes new techniques such as intracytoplasmic sperm injection (ICSI) • Presents and discusses the risks and complications associated with ART before and during pregnancy such as failure of treatment, ovarian hyperstimulation, risk of multiple pregnancy and possibility of ectopic pregnancy

Contents

1. Introduction; 2. Early pregnancy failure after ART; 3. Gynaecologic problems in early pregnancy after ART; 4. Management of pregnancies following OHSS; 5. Prenatal diagnosis after ART;

6. Pregnancy after IVF: the obstetric perspective; 7. Pregnancy complications of different ART techniques; 8. Multiple pregnancies after ART; 9. Children born after ART; 10. Pregnancy after ICSI;

Additional Information Level: medical specialists/consultants, specialist medical trainees July 2012 246 x 189 mm 240pp 100 b/w illus. 32 colour illus. 20 tables 978-1-107-00647-8 Hardback c. £65.00

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11. Pregnancy outcome after oocyte and embryo cryopreservation; 12. Pregnancy after fertility preservation; 13. Pregnancy after ovarian transplantation; 14. Ethical and legal perspectives of ART pregnancies; 15. ART pregnancies: the historical perspective; Index.

Reproductive medicine

39

Fertility Preservation in Male Cancer Patients Edited by John P. Mulhall

Memorial Sloan-Kettering Cancer Center, New York

Edited in association with Linda D. Applegarth Weill Cornell Medical College of Cornell University

Robert D. Oates

Boston University Medical Center

and Peter N. Schlegel

New York Presbyterian Hospital

fertility preservation in male cancer patients Editor-in-Chief: john p. mulhall Associate Editors: linda d. applegarth,

robert d. oates and petern. schlegel

Description Men with cancer rendered infertile by surgery, chemotherapy, radiation and hormone therapy that are needed to control or cure their disease are increasingly being offered the chance to preserve their reproductive potential through artificial reproductive technologies. Cryopreservation of sperm and testicular tissue have increasingly helped boys and men preserve their fertility. There is a growing subspecialty within reproductive medicine aimed at fertility preservation in this population. Furthermore, strategies are being developed that may in the future revolutionize the approach to such patients. Written by international authorities in the field of fertility preservation, this comprehensive book is aimed at clinicians dealing with male cancer patients, in particular, urologists, andrologists, oncologists, pediatricians, nursing staff as well as clinicians in reproductive endocrinology. The text reviews the impact of cancers and their treatment on male fertility, the available fertility preservation strategies and post-treatment management.

Key Features • Practical commentaries aid in delivering effective patient care • State-of-the-art information is presented in a reader-friendly manner • Resources are clearly listed enabling easy access to further information

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40

Reproductive medicine

Contents

Preface; Part I. Anatomy and Physiology: 1. Functional anatomy of the hypothalamic-pituitarytestis axis and male reproductive tract; 2. Spermatogenesis; 3. The semen analysis; 4. Physiology of ejaculation; Part II. Disorders of Male Fertility: 5. History and physical examination; 6. Abnormalities of semen parameters; 7. Azoospermia; 8. Varicocele; 9. Disorders of ejaculation; 10. Androgen deficiency in the male; 11. Infertility and male sexual dysfunction;

Part III. Impact of Cancers and Treatment of Male Fertility: 12. Radiation effects on spermatogenesis; 13. Chemotherapy: effects on spermatogenesis; 14. Effects of therapy for solid tumors; 15. Lymphoma and leukemia; 16. Stem cell transplantation; 17. Fertility preservation in men with germ cell tumors; 18. Effects of therapy for brain cancer; 19. Male infertility following childhood cancer: special considerations for fertility preservation in children; Part IV. Preservation Strategies: 20. Facilitating discussion about fertility preservation; 21. Development of a program to address fertility preservation and parenthood after cancer treatment; 22. Psychological consultation and assessment; 23. Nutraceuticals in fertility preservation; 24. Application of spermatogenesis suppression therapies for fertility preservation;

Additional Information Level: medical specialists/consultants, specialist medical trainees June 2012 246 x 189 mm 392pp 225 b/w illus. 32 colour illus.

978-1-107-01212-7 Hardback c. £100.00

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25. Semen cryobiology and sperm banking; 26. Ethical and legal considerations of sperm and tissue cryopreservation; 27. The use of ejaculation induction procedures in cancer patients; 28. Sperm extraction in the pre-therapy patient; 29. Fertility preservation in the pediatric population: germ cell culture and transplantation; 30. Exogenous androgens: effect on spermatogenesis; 31. Fertility preservation in the female with cancer; Part V. Post-therapy Considerations: 32. Psychological issues surrounding the use of sperm donation; 33. Medical therapy for male infertility; 34. Management of the varicocele in the treated patient; 35. Sperm extraction in the treated patient; 36. Post-mortem sperm extraction; 37. Fertility following antineoplastic therapy in the male: intrauterine insemination and the assisted reproductive technologies; Index.

Reproductive medicine

Testosterone

41

Fourth Edition

Action, Deficiency, Substitution Fourth edition

Testosterone Action | deficiency | Substitution

Edited by Eberhard Nieschlag

Institute of Reproductive Medicine, University of Munster

and Hermann M. Behre

Reproductive Medicine Unit, Martin Luther University Halle-Wittenberg

EditEd by

Eberhard Nieschlag, and Hermann behre Assistant Editor Susan Nieschlag

Edited in association with Susan Nieschlag Institute of Reproductive Medicine, University of Munster

Description Now in its fourth edition Testosterone: Action, Deficiency, Substitution provides the most up-to-date and comprehensive source of information on testosterone and its role in human physiology and pathology. It covers biosynthesis and mechanisms of action and reviews their effects on brain and behavior, spermatogenesis, hair growth, bones, muscles, erythropoiesis, the cardiovascular system and the prostate. The therapeutic uses of testosterone preparations are carefully evaluated as well as its abuse and detection in competitive sport. This new edition also devotes sections to exploring the effects of testosterone on female physiology and sexual function, and the experimental use of testosterone in male hormonal contraception. Testosterone: Action, Deficiency, Substitution has been written and edited by world experts in the fields of clinical andrology and endocrinology and provides a unique and invaluable guide for andrologists, endocrinologists, urologists, internists and those working in reproductive medicine.

Key Features • Key messages at the end of each chapter provide a quick overview • Physicians benefit from clear instructions on diagnosis and treatment of testosterone deficiency and hypogonadism • Most up-to-date comprehensive source on testosterone on the market

Contents

Preface; 1. The medical and cultural history of testosterone and the testes; 2. Testosterone: biosynthesis, transport, metabolism and (non-genomic) actions; 3. Pathophysiology of the androgen receptor; 4. Methodology for measuring testosterone, DHT and SHBG in a clinical setting; 5. The behavioral correlates of testosterone; 6. The role of testosterone in spermatogenesis; 7. Androgens and hair: a biological paradox with clinical consequences; 8. Testosterone and bone;

9. Androgens effects on the skeletal muscle; 10. Testosterone and cardiovascular disease; 11. Testosterone, obesity, diabetes and the metabolic syndrome; 12. Testosterone and erection; 13. Testosterone and the prostate; 14. Clinical use of testosterone in hypogonadism and other conditions; 15. Testosterone preparations for clinical use in males; 16. Androgens in male senescence; 17. Androgen therapy in non-gonadal disease;

Additional Information Level: medical specialists/consultants July 2012 246 x 189 mm 536pp 101 b/w illus. 6 colour illus.

978-1-107-01290-5 Hardback c. £110.00

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18. Review of guidelines on diagnosis and treatment of testosterone deficiency; 19. Pathophysiology of estrogen action in men; 20. Dehydroepiandrosterone (DHEA) and androstenedione; 21. The state-of-the-art in the development of selective androgen receptor modulators (SARMs); 22. The essential role of testosterone in hormonal male contraception; 23. Testosterone use in women; 24. Detection of illegal use of androgens and SARMs; 25. Clinical effects of doping with anabolic steroids; Index.

42

Reproductive medicine

Colposcopy A Practical Guide Second edition

Mahmood Shafi

Department of Obstetrics & Gynaecology, Addenbrooke’s Hospital, Cambridge

and Saloney Nazeer

University Hospital of Geneva

Description This new, fully revised edition of Colposcopy: A Practical Guide is a state-of-the-art guide to colposcopy, directly applicable to daily clinical practice, and a key text for all those involved in the screening and management of women with cervical cytological abnormalities. All chapters have been updated for this new edition with the latest nomenclature, staging, classification and evidence-based treatment guidelines, as well as important new material on HPV testing and vaccination. Concise text is enhanced by full-colour illustrations and flow-diagrams throughout. Colposcopy: A Practical Guide is essential reading for the British Society for Colposcopy and Cervical Pathology colposcopy training programme and is also an important practical guide for all gynaecologists, nurse colposcopists and gynaecological oncologists.

Key Features • A concise, practical guide, with take-home messages for each chapter • Colour illustrations and flow diagrams aid quick and accurate treatment of patients • Written by leading gynaecologists and gynaecological oncologists, offering a definitive guide based on international experience

Contents

Foreword; Preface; Glossary of terms; 1. Basic principles of colposcopy; 2. The normal cervix and colposcopic appearance; 3. Natural history of cervical carcinoma, HPV and vaccination;

4. Colposcopic appearance of CIN; 5. Colposcopic directed biopsies; 6. Invasive cervical disease; 7. Glandular disease; 8. Inflammatory and infective conditions of the cervix and anogenital tract; 9. Management techniques;

Additional Information Level: specialist medical trainees, medical specialists/consultants April 2012 246 x 189 mm 112pp 12 b/w illus. 120 colour illus. 9 tables 978-1-107-66782-2 Paperback c. £39.00

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10. Follow-up after treatment; 11. Vaginal abnormalities; 12. Vulval disease; 13. Pregnancy and puerperium; 14. Menopause, contraception, immunosuppression, HIV and smoking; Further reading; Index.

Pathology and laboratory science

43

Spencer’s Pathology of the Lung Sixth edition

Edited by Philip Hasleton University of Manchester

and Douglas B. Flieder

Fox Chase Cancer Center, Philadelphia

Description Fully rewritten and updated for the cutting-edge 6th edition, Spencer’s Pathology of the Lung follows in its predecessors’ footsteps as the gold-standard textbook of pulmonary diseases. All recognized diseases of the lungs are discussed and illustrated with extensive, high-quality color images. Each chapter includes practical, clear and concise diagnostic features, including immunohistochemistry, molecular tests and differential diagnoses, while rare entities are discussed and illustrated in detail. This thoroughly reworked edition includes new classification schemes and the latest understanding of the pathophysiology and molecular aspects of a wide range of diseases. Non-neoplastic diseases are presented according to epidemiology, genetics, clinical manifestations, radiographic findings, pathology, cytology, laboratory findings, pathogenesis, differential diagnosis, prognosis and natural history. Neoplasms are discussed according to cell or origin with sections devoted to genetics, molecular findings and clinicopathologic correlations. Written and edited by leading experts in the field, this is an essential resource for practising and trainee pathologists.

Key Features • Authoritative reference text on non-neoplastic and neoplastic lung diseases, written by leading world experts • Extensive high-quality color illustrations aid understanding and diagnosis of common and rare diseases • Thoroughly reworked new edition, including new classification schemes and clinical, radiographic, pathogenetic and molecular coverage of all recognized lung diseases

Contents

Preface; 1. The normal lung: histology, embryology, development, aging and function; 2. Specimen handling and practical considerations; 3. Congenital abnormalities and pediatric lung diseases, including neoplasms; 4. Bacterial infections of the lung; 5. The pathology of respiratory viral infection; 6. Pulmonary mycobacterial infections; 7. Pulmonary mycotic infections; 8. Parasitic lung disease; 9. Acute lung injury; 10. Interstitial lung diseases; 11. Metabolic and connective tissue disorders;

12. Hypersensitivity pneumonitis; 13. Sarcoidosis; 14. Occupational lung disease; 15. Eosinophilic lung disease; 16. Drug and therapy induced lung injury; 17. Chronic obstructive pulmonary disease and diseases of the airways; 18. Vascular pathology in pulmonary hypertension; 19. Pulmonary vasculitis and pulmonary hemorrhage syndromes; 20. The pathology of lung transplantation; 21. The lungs in connective tissue disease; 22. Benign epithelial neoplasms and tumor-like proliferations; 23. Pulmonary preinvasive disease; 24. Epidemiologic and clinical aspects of lung cancer;

Additional Information Level: medical specialists/consultants, specialist medical trainees August 2012 276 x 219 mm 1920pp 215 b/w illus. 2111 colour illus.

978-0-521-50995-4 2 Part Set c. £190.00

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25. Lung cancer staging; 26. Immunoperoxidase in the diagnosis of pulmonary tumors; 27. Adenocarcinoma of the lung; 28. Squamous cell carcinoma; 29. Large cell carcinoma and adenosquamous carcinoma of the lung; 30. Salivary gland neoplasms; 31. Neuroendocrine tumors and other neuroendocrine proliferations; 32. Sarcomatoid carcinomas and variants; 33. Mesenchymal and miscellaneous neoplasms; 34. Pulmonary lymphproliferative diseases; 35. Metastases involving the lungs; 36. Diseases of the pleura; Index.

44

Pathology and laboratory science

Cytohistology of the Serosal Surfaces Edited by Claire W. Michael

University of Michigan School of Medicine

David C. Chhieng

Yale University, Connecticut

and Carlos W. M. Bedrossian Rush Medical College, Chicago

Description Each volume in this richly illustrated series, sponsored by the Papanicolaou Society of Cytopathology, provides an organ-based approach to the cytological and histological diagnosis of small tissue samples. Benign, reactive and malignant entities are presented in a well-organized and standardized format, with high-resolution color photomicrographs, tables, tabulated specific morphologic criteria and ancillary testing algorithms. Example vignettes allow the reader to assimilate the diagnostic principles in a case-based format. This volume provides a comprehensive review of effusion pathology, with extensive color illustrations. Throughout the text cytologic findings are correlated with cell blocks and surgical pathology follow-up. Dedicated chapters provide an update of the biology, immunocytochemistry and molecular diagnostic features utilized in the multimodal approach to serosal pathology, and the utility of core biopsies as a complement to the diagnostic approach. With a CD-ROM offering all images in a downloadable format, this is an important resource for all practising and trainee pathologists.

Key Features • Each chapter concludes with 4-5 vignettes of interesting or unusual cases and a short discussion of special studies, providing a practice-based learning format • Reviews the processing techniques useful for body fluids, helping pathologists understand the advantages and pitfalls of each technique • Bullet points and tables of significant features enable the practising and trainee pathologist to quickly identify important information

Contents

1. Introduction; 2. Benign conditions; 3. Reactive mesothelium; 4. Malignant mesothelioma; 5. Common metastatic epithelial neoplasms; 6. Uncommon metastatic epithelial neoplasms;

7. Rare metastatic tumors of nonepithelial origin; 8. Primary and metastatic hematopoietic diseases; 9. Chemical and histochemical studies in effusions; 10. Immunocytochemical studies in effusions; 11. In search of a primary in malignant effusions; 12. Molecular studies in effusions; Index.

Additional Information Level: medical specialists/consultants, specialist medical trainees Series: Cytohistology of Small Tissue Samples April 2012 276 x 219 mm 288pp 500 b/w illus. 20 tables 978-0-521-49341-3 Hardback c. £95.00

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Plasma medicine

45

Plasma Medicine Applications of Low Temperature Gas Plasmas in Medicine and Biology

Edited by M. Laroussi

Old Dominion University, Virginia

M. G. Kong

Max-Planck-Institut für Plasmaphysik, Garching, Germany

Plasma Medicine

and W. Stolz

Applications of Low Temperature Gas Plasmas in Medicine and Biology

Loughborough University

G. Morfill

Ludwig-Maximilians-Universität Munchen M. Laroussi, M. Kong, G. Morfill and W. Stolz

Description

The introduction of low temperature plasma technology to medical research and to the healthcare arena in general is set to revolutionise the way we cure diseases. This innovative medium offers a valid and advantageous replacement of traditional chemicalbased medications. Its application in the inactivation of pathogens in particular, avoids the recurrent problem of drug resistant microorganisms. This is the first book dedicated exclusively to the emerging interdisciplinary field of plasma medicine. The opening chapters discuss plasmas and plasma chemistry, the fundamentals of non-equilibrium plasmas and cell biology. The rest of the book is dedicated to current applications, illustrating a plasma-based approach to wound healing, electrosurgery, cancer treatment and even dentistry. The text provides a clear and integrated introduction to plasma technology and has been devised to answer the needs of researchers from different communities. It will appeal to graduate students and physicists, engineers, biologists, medical doctors and biochemists.

Key Features • The first book dedicated exclusively to this emerging field • Presents experimental data without the use of complex maths • Written by a team of leading experts in the field

Contents

Foreword; Part I. Introduction to Non-equilibrium Plasma, Cell Biology, and Contamination: 1. Introduction; 2. Fundamentals of non-equilibrium plasmas; 3. Non-equilibrium plasma sources;

4. Basic cell biology; 5. Contamination; Part II. Plasma Biology and Plasma Medicine: 6. Common healthcare challenges; 7. Plasma decontamination of surfaces;

Additional Information Level: academic researchers, graduate students May 2012 247 x 174 mm 430pp 140 b/w illus. 15 tables 978-1-107-00643-0 Hardback c. £70.00

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8. Plasma decontamination of gases and liquids; 9. Plasma-cell interaction: prokaryotes; 10. Plasma-cell interaction: eukaryotes; 11. Plasma based wound healing; 12. Plasma ablation, surgery, and dental applications; Index.

46

Index

A

H

Adult and Paediatric ALS..........................6 Alterman, Ronald...................................24 Anesthesia for Spine Surgery....................5 Appleby, John.........................................21 Applegarth, Linda D................................40 Arrowsmith, Joseph E...............................4 Atlas of Oocytes, Zygotes and Embryos in Reproductive Medicine.....................37 Autism Spectrum, The.............................23

Handbook of Human Oocyte Cryopreservation.................................36 Hasleton, Philip......................................43 Heginbotham, Christopher......................13 Hester, D. Micah.....................................22 Holmes, Erskine J....................................14

B Badrinath, Padmanabhan.........................9 Bedrossian, Carlos W. M.........................44 Behre, Hermann M.................................41 Ben-Menachem, Elinor...........................33 Bipolar II Disorder..................................27 Brain Stimulation in Psychiatry................24

C Carroll, Heidi..........................................10 Case Studies in Epilepsy.........................33 Chauvel, Patrick.....................................33 Chhieng, David C....................................44 Chung, Daniel Y. F...................................14 Ciotti, Patrizia........................................36 Clinical Trials in Neurology......................31 Colposcopy............................................42 Common Movement Disorders Pitfalls.....32 Core Topics in Cardiac Anaesthesia...........4 Cummings, Jeffrey..................................31 Cytohistology of the Serosal Surfaces......44

D Deakin, Charles........................................6

E Ebner, Thomas........................................37 Elder, Kay...............................................37 Emergency Cross-sectional Radiology.....14 End-of-Life Decisions in Medical Care.....17 Espay, Alberto J......................................32 Essential Evidence-Based Psychopharmacology...........................25 Essential Public Health.............................9 Essential Values-Based Practice...............10 Essentials of Trauma Anesthesia................7 Ethical Problems and Genetics Practice...19

F Farag, Ehab..............................................5 Farrell, Anne-Maree................................16 Fertility Preservation in Male Cancer Patients...............................................40 Flieder, Douglas B...................................43 Fulford, K. W. M......................................10

G Genetic Data and the Law......................18 Gill, Geoff..............................................12 Gillam, Stephen........................................9 Goodman, Wayne...................................24 Guerrini, Renzo......................................33 Guidance for Healthcare Ethics Committees.........................................22

J Jauniaux, Eric.........................................38

K Karpin, Isabel.........................................15 Kellner, Charles H...................................24 Kong, M. G.............................................45

L Lang, Anthony........................................32 Laroussi, M............................................45 Lerer, Bernard.........................................25 Lowrance, William W...............................20

M Maas, Andrew........................................35 Mabey, David.........................................12 Mackay, Jonathan H.................................4 McDermott, Michael...............................31 Medical Entomology for Students.............8 Michael, Claire W....................................44 Misra, Rakesh.........................................14 Mondal, Dipanjali...................................14 Morfill, G................................................45 Morganti-Kossmann, Cristina..................35 Mulhall, John P.......................................40

N Nazeer, Saloney......................................42 Neurogenetics........................................29 Nieschlag, Eberhard...............................41 Nieschlag, Susan....................................41

O Oates, Robert D......................................40

P Parker, Gordon.......................................27 Parker, Michael.......................................19 Parry, Eldryd...........................................12 Peile, Edward.........................................10 Pennings, Guido.....................................21 Perfecting Pregnancy..............................15 Plasma Medicine....................................45 Politics of Blood, The..............................16 Poole, Michael........................................31 Porcu, Eleonora......................................36 Pregnancy After Assisted Reproductive Technology..........................................38 Principles of Medicine in Africa...............12 Privacy, Confidentiality, and Health Research.............................................20

R Raghupathi, Ramesh..............................35 Ravina, Bernard......................................31

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Reber, Mark...........................................23 Reproductive Donation...........................21 Richards, Martin.....................................21 Rizk, Botros............................................38

S Savell, Kristin.........................................15 Schlegel, Peter N....................................40 Schonfeld, Toby......................................22 Service, Mike............................................8 Shafi, Mahmood.....................................42 Smith, Charles..........................................7 Smith, Stephen W...................................17 Spencer’s Pathology of the Lung.............43 Stahl, Stephen........................................25 Stahl, Stephen M....................................28 Stahl’s Self-Assessment Examination in Psychiatry............................................28 Stefan, Hermann....................................33 Stein, Dan..............................................25 Stolz, W..................................................45

T Taylor, Mark...........................................18 Testosterone..........................................41 Traumatic Brain and Spinal Cord Injury....35

V Values-Based Commissioning of Health and Social Care...................................13 Van den Bergh, Marc..............................37 Varon, Albert J..........................................7 Venturoli, Stefano...................................36

W Weber, Martin........................................12 Whitty, Chris..........................................12 Wood, Nicholas......................................29

Y Yates, Jan.................................................9

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