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PEARLS AND PITFALLS

Anaesthesia, Intensive Care & Pain Management Emergency Medicine Haematology Medical Imaging Neurology and Clinical Neuroscience Obstetrics and Gynaecology, Reproductive Medicine Oncology Pathology and Laboratory Science Surgery

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PEARLS AND PITFALLS

Pearls and Pitfalls in Emergency Radiology Variants and Other Difficult Diagnoses Edited by Martin L. Gunn

Rapid recognition of life-threatening illnesses and injuries expedites appropriate management and improves clinical outcomes. False-positive interpretations in radiology have been identified as a significant cause of error, leading to unnecessary investigation and treatment, increased healthcare costs, and delays in appropriate management. Moreover, it is important that radiologists do not miss important subtle diagnoses that need urgent intervention. Pearls and Pitfalls in Emergency Radiology provides an outline of common imaging artefacts, anatomic variants and critical diagnoses that the radiologist must master in order to guide appropriate care and avoid malpractice lawsuits. One hundred selected cases – illustrated with several hundred images from MRI, MDCT, PET, ultrasound and radiographs – are presented in a succinct and structured format, highlighting key pearls and potential diagnostic pitfalls. The text focuses on emergent presentations of diseases in all body regions in both adults and children. Contents Part I. Brain, Head, and Neck; Part II. Spine; Part III. Thorax; Part IV. Cardiovascular; Part V. Abdomen; Part IV. Pelvis; Part VII. Musculoskeletal; Part VIII. Pediatrics. Contributors Michael J. Modica, Robert B. Carr, Claire K. Sandstrom, Ken F. Linnau, Matthew H. Nett, Joel A. Gross, Randy K. Lau, Martin L. Gunn, Ramesh S. Iyer

HB | 9781107021914 | £75.00 Pages | 387 792 b/w illustrations 25 colour illustrations

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WHY IT WILL SELL • The structured format and key points provide a quick reference point for the emergency department • Over 100 cases provide a fully illustrated compendium of what to look for and what to dismiss • Describes important diagnoses that are commonly missed or misinterpreted

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PEARLS AND PITFALLS

Pearls and Pitfalls in Abdominal Imaging Pseudotumors, Variants and Other Difficult Diagnoses Fergus V. Coakley Research consistently suggests that 1.0 to 2.6% of radiology reports contain serious errors, many of which are avoidable, and it is clear that all radiologists can struggle with the basic questions as to whether a study is normal or abnormal. Pearls and Pitfalls in Abdominal Imaging presents over 100 conditions in the abdomen and pelvis which can commonly cause confusion and mismanagement in daily radiological practice, providing a focused textbook that can be readily used to avoid wrong diagnoses and prevent incorrect management or even malpractice litigation. It includes 700 figures and covers all the major modalities including CT, PET/CT and MRI. The pearls and pitfalls include artifacts, anatomic variants, mimics, and a miscellany of diagnoses that are under-recognized or only recently described. Conditions are presented in anatomic order from diaphragm to the symphysis pubis, with grouping by location and organ system.

PB | 9780521513777 | £58.00 pages | 376 714 b/w illustrations 28 colour illustrations Publication | October 2010

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Pearls and Pitfalls in Musculoskeletal Imaging Variants and Other Difficult Diagnoses Edited by D. Lee Bennett, Georges Y. El-Khoury When a radiological image includes unfamiliar features, how do you decide whether it is normal variation or pathological abnormality? If you decide an abnormality is present, can you make a diagnosis from the image alone? Pearls and Pitfalls in Musculoskeletal Imaging differentiates less common findings or normal variant mimickers from the more common similar appearing diseases, helping you make a quick and accurate diagnosis. Musculoskeletal disorders of the shoulder, upper extremity, pelvis, and lower extremity are described in over 90 cases, highly illustrated with over 300 radiographic, CT, MRI and ultrasound images. Each case follows a standard format: imaging description, importance, typical clinical scenario, differential diagnosis and teaching point, enabling you to locate key information quickly. Pearls and Pitfalls in Musculoskeletal Imaging will help you spot artifacts, mimics and other unusual conditions, enabling you to avoid misdiagnosis and prevent mismanagement. An essential diagnostic tool for radiologists at every level.

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HB | 9780521196321 | £70.00 Pages 268 425 b/w illustrations 4 colour illustrations Publication | May 2013

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Anaesthesia, Intensive Care & Pain Management

Handbook of Drugs in Intensive Care An A-Z Guide 5th edition Henry Paw and Rob Shulman Praise for Edition 4: 'The book is particularly strong on newer medicines … and is stuffed full of useful pearls and snippets of information … an excellent book that can act as a touchstone for front-line clinical pharmacists in critical care.' The Pharmaceutical Journal

NEW EDITION

PB | 9781107696839 | £35.00 Pages | 304 5 b/w illustrations 1 colour illustration

PUBLICATION | SEPT 2013

A thoroughly updated edition of this wellestablished guide to drugs and prescribing for intensive care. The book is split into two sections: an A–Z guide to the drugs available, and concise notes on the key topics and situations faced on a daily basis. The A–Z section provides succinct information on each drug including uses, limitations, administration directions and adverse effects. The second section details complications that may arise in patients with particular conditions such as diabetes, epilepsy and renal failure, and other factors that may affect drug prescribing. This revised edition includes eleven new drug monographs and covers several new topics, including sepsis and drugs for organ donation. Inside the back cover is a colour fold-out chart showing drug compatibility for intravenous administration. Presented in a concise, compact format, this book is an invaluable resource for doctors, nurses, pharmacists and other healthcare professionals caring for critically ill patients.

WHY IT WILL SELL • Provides an A–Z of drugs allowing quick access for the reader • Includes a fold-out chart showing drug compatibility for IV administration • Features 11 new drug monographs and covers new topics including sepsis and drugs for organ donation

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Anaesthesia, Intensive Care & Pain Management

Contents Introduction; How to use this book; Abbreviations; Drugs: an A–Z guide; Short notes: routes of administration; Loading dose; Drug metabolism; Enzyme systems; Drug excretion; Drug tolerance; Drug interactions; Therapeutic drug monitoring; Pharmacology in the critically ill; Cardiopulmonary resuscitation; Management of acute major anaphylaxis; Management of severe hyperkalaemia; Management of malignant hyperthermia; Sedation, analgesia and neuromuscular blockade; Management of status epilepticus; Management of delirium tremens and alcohol withdrawal syndrome; Anti-arrhythmic drugs; Inotropes and vasopressors; Bronchospasm; Antiulcer drugs; Immunonutrition in the ICU; Corticosteroids; Short synacthen test; Bone marrow rescue following nitrous oxide; Antioxidants; Prophylaxis following splenectomy; Anti-microbial drugs; Renal replacement therapy; Appendices: Appendix A. Creatinine clearance; Appendix B. Weight conversion (stones/lb to kg); Appendix C. BMI calculator; Appendix D. Lean body weight charts; Appendix E. Infusion rate/dose calculation; Appendix F. Drug compatibility chart; Appendix G. Omeprazole administration record; Appendix H. Sodium content of oral medications; Appendix I. Drug management of the brain-stem dead donor; Appendix J. Continuous vancomycin infusion; Appendix K. Child-Pugh score; Appendix L. Severe sepsis algorithm; Drug index.

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Anaesthesia, Intensive Care & Pain Management

Brain Disorders in Critical Illness Mechanisms, Diagnosis, and Treatment Edited by Robert D. Stevens, Tarek Sharshar, E. Wesley Ely

HB | 9781107029194 | £75.00 Pages | 432 113 b/w illustrations 8 colour illustrations 64 tables

PUBLICATION | SEPT 2013

WHY IT WILL SELL Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and postdischarge cognitive dysfunction are now recognized as major healthcare burdens. This comprehensive clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.

• Written and edited by scientists and clinicians at the forefront of biomedical research into the causes, prevention and management of brain dysfunction in the ICU • Content is presented in concise chapters, with numerous illustrations, executive summaries and a glossary of terms • Provides a detailed presentation of the dynamic and cutting-edge work in neuroscience and neurobiology which is unravelling the mechanisms and treatments of ICU-acquired brain dysfunction

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Anaesthesia, Intensive Care & Pain Management

Contents Foreword; Introduction; Glossary; Part I. Epidemiology and Outcomes: 1. The epidemiology of critical illness brain dysfunction; 2. Cognitive dysfunction following critical illness; 3. Psychiatric disorders following critical illnesses; 4. Functional status and quality of life after critical illness; 5. Delirium and dementia: unraveling the complex relationship; Part II. Behavioral Neurology in the ICU: 6. Cognitive reserve; 7. Neurology of consciousness impairments; 8. Mechanisms of attention and attentional impairment; 9. Neurology of sleep and sleep disorders; 10. Neural basis of fear and anxiety; Part III. Biological Mechanisms: 11. Experimental models of cognitive dysfunction in infection and critical illness; 12. Neurobiological effects of systemic physiological and metabolic insults; 13. Cerebral ischemia and reperfusion; 14. Brain perfusion and autoregulation in systemic critical illness; 15. Delirium and neurotransmitter dysfunction; 16. Neuromodulatory and neurotoxic effects of sedative agents; 17. Neuroimmunological crosstalk in critical illness; 18. Inflammatory mechanisms in chronic neurodegenerative disease: the impact of microglia priming; 19. The neuroendocrine response to critical illness; 20. Autonomic dysfunction in SIRS and sepsis; 21. Sepsis-induced neuronal dysfunction and death; 22. Neuroimmunomodulation in sepsis; Part IV. Diagnosis of Brain Dysfunction: 23. Clinical neurological assessment of the critically ill patient; 24. Bedside assessment of delirium in critically ill patients; 25. Electroencephalography and evoked potentials in critically ill patients; 26. Neuroimaging of delirium; Part V. Preventative and Therapeutic Interventions: 27. Environmental modification; 28. New paradigms in sedation of the critically ill patient; 29. Pharmacological management of delirium; 30. Pharmacogenomics and cerebral dysfunction; 31. Early physical and occupational therapy; 32. Rehabilitation after critical illness; Part VI. Clinical Encephalopathy Syndromes: 33. Drug-induced encephalopathy; 34. Metabolic encephalopathies: inborn errors of metabolism causing encephalopathies in adults; 35. Encephalopathy associated with alcohol or drug withdrawal; 36. Posterior reversible encephalopathy syndrome (PRES): the essential elements; 37. Hypoxic ischemic encephalopathy; 38. Sepsis-associated encephalopathy; 39. Seizures and status epilepticus in critical illness; 40. Encephalopathy and coma in acute liver failure and chronic liver failure; 41. Neurologic complications of cardiac surgery: stroke, encephalopathy, and cognitive decline; Index. Contributors Raoul Sutter, Robert D. Stevens, Ramona O. Hopkins, James C. Jackson, Dimitry S. Davydow, Sanjay V. Desai, Nathan E. Brummel, Dale M. Needham, Margaret Pisani, Richard E. Temes, Robert S. Wilson, Lisa L. Barnes, David A. Bennett, Benjamin Rohaut, Frédéric Faugeras, Lionel Naccache, Paolo Bartolomeo, Robert D. Sanders, Stefan G. Gurney, Jamie W. Sleigh, Mervyn Maze, Odile Viltart, Christel C. Vanbesien, Colm Cunningham, Jean-Francois Payen, Gérard Audibert, Nicolas Bruder, Raymond C. Koehler, Martin Siegemund, Luzius A. Steiner, Willem A. van Gool, Jean Mantz, Souhayl Dahmani, Robert Dantzer, Keith W. Kelley, V. Hugh Perry, David Luis, Djillali Annane, Jeremy D. Scheff, Panteleimon D. Mavroudis, Steve E. Calvano, Stephen F. Lowry, Ioannis P. Androulakis, S. Gaikwad, C. Widmann, Michael T. Heneka, Marion Griton, Jan Pieter Konsman, Tarek Sharshar, Alawi Luetz, Claudia Spies, Matthew A. Koenig, Peter W. Kaplan, Karen J. Ferguson, Alasdair M. J. MacLullich, Yoanna Skrobik, Christopher G. Hughes, Pratik P. Pandharipande, Dustin M. Hipp, E. Wesley Ely, John P. Kress, R. D. Griffiths, Christina Jones, Bruno Mégarbane, Frederic Sedel, Felix Kork, Walter S. Bartynski, Hebah M. Hefzy, Fabio Silvio Taccone, Alain Cariou, Romain Sonneville, C. Rauturier, F. Verdonk, F. Chretien, Brandon Foreman, Jan Claassen, Julia Wendon, Jennifer Ryan, Rebecca F. Gottesman, Maura A. Grega, Guy M. McKhann, Ola A. Selnes

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Anaesthesia, Intensive Care & Pain Management

Problem-Based Pain Management Eric S. Hsu, Charles Argoff, Katherine E. Galluzzi, Raphael J. Leo, Andrew Dubin

PB | 9781107606104 | £50.00 Pages | 400 30 tables

PUBLICATION | SEPT 2013

Pain management is an essential part of clinical practice for all healthcare providers from trainees and nurse practitioners through to practising physicians. Problem-Based Pain Management is a collaboration between experts in anesthesiology, geriatric medicine, neurology, psychiatry and rehabilitation which presents a multidisciplinary management strategy. Over 60 chapters follow a standard, easy-to-read, quick access format on: clinical presentation, signs and symptoms, lab tests, imaging studies, differential diagnosis, pharmacotherapy, non-pharmacologic approach, interventional procedure, follow-up and prognosis. The broad spectrum of topics include headache, neck and back pain, bursitis, phantom limb pain, sickle cell disease and palliative care. Unlike other large, cumbersome texts currently available, this book serves as a quick, concise and pertinent reference in the diagnosis and management of common pain syndromes.

WHY IT WILL SELL • The concise and easy-to-read format aids quick diagnosis and accurate treatment • Includes most common pain conditions making it a valuable reference for everyday use • Written by a team of experts from a diverse range of specialities

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Anaesthesia, Intensive Care & Pain Management

Contents Preface; Part I. Headache: 1. Migraine headache; 2. Cluster headache; 3. Tension headache; 4. Chronic daily headache; 5. Post-dural puncture headache; Part II. Head Pain: 6. Trigeminal neuralgia; 7. Temporomandibular joint syndrome and orofacial pain; 8. Occipital neuralgia; Part III. Neck and Shoulder: 9. Neck strain and sprain; 10. Cervical radiculopathy; 11. Cervical facet (zygapophyseal) joint syndrome; 12. Cervicobrachial pain syndrome, cervical dystonia and spastic torticollis; 13. Brachial plexopathy; 14. Thoracic outlet syndrome; 15. Shoulder arthritis; 16. Shoulder bursitis and tendinitis; 17. Rotator cuff tear; Part IV. Upper Limb: 18. Elbow DJD and elbow bursitis; 19. Tennis and Golfer's Elbow – lateral and medial epicondylitis; 20. Nerve entrapments at the elbow; 21. Hand and wrist arthritis; 22. Carpal tunnel syndrome; Part V. Thorax: 23. Costosternal, costochondritis, and costovertebral syndromes; 24. Intercostal neuralgia; 25. Post-thoracotomy, post-mastectomy, and post-cardiac surgery pain syndrome; 26. Thoracic spinal pain; Part VI. Abdomen and Pelvis: 27. Acute and chronic pancreatitis; 28. Functional abdominal pain; 29. Groin pain, ilioinguinal, iliohypogastric and genitofemoral neuralgia; 30. Coccydynia; 31. Interstitial cystitis; 32. Pelvic pain and endometriosis; Part VII. Spine: 33. Acute and chronic back pain, back strain and sprain; 34. Compression fracture; 35. Lumbar radiculopathy Jeffrey Loh; 36. Sciatica and piriformis syndrome; 37. Lumbar spinal stenosis; 38. Lumbar facet syndrome; 39. Sacroiliac pain; 40. Lumbar post-laminectomy pain syndrome Christine Lee and Talin Evazyan; Part VIII. Hip and Lower Limb: 41. Hip arthritis and bursitis pain; 42. Meralgia paresthetica; 43. Knee arthritis and bursitis pain; 44. Knee sprain and tendinitis; 45. Degenerative joint disease pain of the ankle, foot and toe; Part IX. Pain Syndromes and Special Topics: 46. Myofascial pain syndrome; 47. Fibromyalgia pain syndrome; 48. Pain in rheumatism; 49. Herpes zoster and postherpetic neuralgia; 50. Complex regional pain syndrome I (RSD) and II (causalgia); 51. Painful polyneuropathy; 52. Pain in human immunodeficiency virus-related neuropathy; 53. Central pain and neurologic disorders; 54. Phantom limb pain; 55. Burn pain; 56. Acute postoperative pain management; 57. Pain during pregnancy and lactation; 58. Sickle cell disease; 59. Pain in critical care; 60. Pediatric pain; 61. Geriatric pain; 62. Cancer pain, palliative and end of life care (includes chemo-induced neuropathy and cancer-related bony pain); 63. Opioid tolerance, physical dependence and addiction; Index. Contributors Jeffrey Loh, Christine Lee, Talin Evazyan

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Emergency Medicine

Case Studies in Pediatric Emergency and Critical Care Ultrasound Edited by David J. McLario, John L. Kendall

PB | 9781107609242 | £60.00 Pages | 320 358 b/w illustrations 84 colour illustrations

PUBLICATION | SEPT 2013

Clinician-performed bedside ultrasound is an exciting new development in medicine. Numerous diagnostic and procedural applications show great promise for improving the care of children. Many pediatric providers, however, remain unaware of its potential and ultrasound continues to be underutilized in both the investigation and management of ill and injured children. Case Studies in Pediatric Emergency and Critical Care Ultrasound illustrates the utility of bedside ultrasound in a variety of scenarios, including the emergency setting and critical care unit. A wide range of diagnostic and procedural applications are covered in fifty-nine cases, recreating real-life experiences of expert practitioners. The cases are concise and readable, with teaching points that highlight how ultrasound can be used to expedite and focus pediatric care. With hundreds of high-quality images, and video content accompanying many cases, this text is essential reading for pediatricians, emergency physicians, pediatric anesthesiologists and critical care physicians.

WHY IT WILL SELL • Accompanying videos illustrate key techniques • Hundreds of high-quality images enable learning from real examples • Key points are pulled out of each case to give readers the essential take-home messages in an accessible format

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Emergency Medicine

Contents Preface; Part I. Diagnostic Applications: 1. Right-upper-quadrant pain in a 10-year-old female; 2. Motor vehicle accident evaluation in a 5-year-old male; 3. Fall from a height in a 5-year-old male; 4. Left flank pain following a fall in an 8-year-old female; 5. Chest trauma in a 14-year-old male; 6. Chest trauma in an 8-year-old male; 7. Multiple trauma in a 7-year-old female; 8. Fall from a tree in a 6-year-old female and 10-year-old male; 9. A pale and poorly responsive 6-year-old female; 10. Sudden desaturation in an 8-year-old male; 11. Poorly responsive and apneic 2-week-old male; 12. Cardiac arrest in a 10-year-old male; 13. Apnea, pallor and leg-stiffening in a 1-week-old female; 14. Headache in a 16-year-old female; 15. A ventriculoperitoneal shunt in a 6-year-old male; 16. Fall from the couch in a 3-month-old male; 17. Visual acuity changes in a 6-year-old male; 18. Periorbital swelling in a 5-year-old female; 19. Neck mass in a 3-year-old female; 20. Sore throat in a 15-year-old female; 21. Difficulty breathing in a 7-week-old male; 22. Cough, fever and rales in a 4-year-old female; 23. Dyspnea with feeding in a 5-month-old female; 24. Syncope in a 16-year-old female; 25. Abdominal pain in a 14-year-old female; 26. Paroxysmal abdominal pain and vomiting in a 7-month-old male; 27. Projectile vomiting in a 4-week-old male; 28. Right upper quadrant pain in 15-year-old female; 29. Vomiting and diarrhea in a 3-year-old male; 30. Rectal bleeding in a 6day-old male; 31. Inguinal mass in an 18-month-old male; 32. Left upper quadrant pain in a 13year-old male; 33. Acute hemiscrotal pain in a 16-year-old male; 34. Severe pelvic pain in a 15-yearold female; 35. Lower abdominal pain and vaginal bleeding in a 14-year-old female; 36. Limping in a 10-year-old female; 37. Forearm pain in a 7-year-old female; 38. Post-traumatic elbow pain in a 7year-old male; 39. Posterior ankle pain in a 16-year-old male; 40. Red and swollen thigh in a 6-yearold female; 41. Suspected finger foreign-body in a 15-year-old male; Part II. Procedural Applications: 42. Acute desaturation after intubation in a 15-month-old female; 43. Urosepsis and no IV access in a 5-year-old male; 44. Dehydration and difficult IV access in a 10-month-old male; 45. Severe dehydration in a 12-month-old male; 46. Cough and dyspnea in a 5-year-old male; 47. Abdominal distention in a 9-year-old male; 48. Labial fusion in a 3-month-old female; 49. Painful leg trauma in a 14-year-old male; 50. Plantar foreign-body in a 5-year-old female; 51. Right shoulder pain in a 16-year-old male; 52. Foreign body in the hand of a 16-year-old male; 53. Spontaneous pneumothorax in a 14-year-old male; 54. Leg pain and swelling in a 16-year-old male; 55. Fall on broken glass in an 8-year-old female; 56. Limp in a 5-year-old male; 57. Post-traumatic forearm deformity in a 7-year-old male; 58. Seizure and fever in a 2-month-old male; 59. Abscess in an uncooperative 12-year-old autistic male; Index. Contributors Marla Levine, Eitan Dickman, Alex Arroyo, Annie Heffernan Rominger, David J. McLario, Brooks T. LaSelle, Nicole Hurst, Conor McKaigney, Matthew Buchanan, Troy Dean, Lisa Mills, Russ Horowitz, In Kim, Brunhild Halm, Jennifer Marin, Timothy Jang, Andrew French, Laura Nolting, Thomas Cook, Amanda Kao, Swathi Nadindla Doyle, James W. Tsung, Katherine Bakes, Jeffrey Darst, Amanda Hauck, Cliff Rice, Christopher C. Raio, Veena A. Modayil, Daniel J. Kim, Molly Thiessen, Jerusha Lev, Matthew Monson, Zachary Soucy, Lisa Mills, Jon Theoret, Geoff Sanz, Srikar Adhikari, Lorraine Ng, Resa E. Lewiss, Brandon Backlund, Keith Cross, Lekha Shah, Pradeep Padmanhaban, Joni Rabiner, Andrew French, Catherine Erickson, Richard Gordon, Matthew Lyon, Fred Warkentine, Thomas Costantino, Alexa Bisinger, Nathan Tiesmann, Raj Geria, Nicole Seleno, Tanya Solano, Jason W. Fischer, Michael B. Stone, Mikaela Chilstrom, Leonard Bunting, Beatrice Hoffman, John L. Kendall, Charisse Kwan

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Emergency Medicine

Orthopedic Emergencies Expert Management for the Emergency Physician Edited by Michael C. Bond, Andrew D. Perron, Michael K. Abraham

Acute care physicians are frequently faced with diagnosing and treating orthopedic emergencies with limited resources and without immediate specialist availability. Orthopedic Emergencies focuses on the acute management and stabilization of orthopedic injuries with specific recommendations on procedures and the stabilization of fractures and dislocation. The topics are organized anatomically with additional chapters on Procedures, Reduction Techniques, and Immobilization and Splinting. The information needed for a rapid diagnosis is available instantly through the bullet-pointstyle text, diagrams, images, pearls and pitfalls. There are specific recommendations on which splint to apply and how to position the affected limb, as well as advice on when to arrange follow up with an orthopedist or sports medicine physician. The spiral binding allows the book to lay flat for easy use at the bedside, making Orthopedic Emergencies the ideal companion for all emergency medicine providers including emergency department physicians, sports clinics, family medicine practitioners and mid-level providers. Contents List of contributors; Preface; 1. Hand and wrist emergencies Carl A. Germann; 2. Shoulder and elbow emergencies Sanjeev Malik, Molly Weiner and George Chiampas; 3. Pelvic emergencies Michael C. Bond; 4. Knee and leg emergencies Arun Sayal; 5. Foot and ankle emergencies Brian Tscholl; 6. Spine emergencies Kelley Banagan; 7. Pediatric orthopedic emergencies Nathan W. Mick and Amy E. Valasek; 8. Orthopedic infections and other complications Stephen Y. Liang, Michael C. Bond and Michael K. Abraham; 9. Procedures for orthopedic emergencies Moira Davenport, Dennis Hanlon and Ryan Friedberg; 10. Immobilization and splinting Michael C. Bond and Michael K. Abraham; Index. Contributors Carl A. Germann, Sanjeev Malik, Molly Weiner, George Chiampas, Michael C. Bond, Arun Sayal, Brian Tscholl, Kelley Banagan, Nathan W. Mick, Amy E. Valasek, Stephen Y. Liang, Michael K. Abraham, Moira Davenport, Dennis Hanlon, Ryan Friedberg

HB | 9781107696617 | £45.00 Pages | 294 167 b/w illustrations 8 tables

PUBLICATION | OCT 2013

WHY IT WILL SELL • Spiral bound to allow for easy use at the bedside • Each chapter highlights key points and provides common pitfalls to avoid and pearls to help you provide the best care possible • Detailed guide on how to perform the most common orthopedic reductions and procedures

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Emergency Medicine

Practical Emergency Resuscitation and Critical Care Edited by Kaushal Shah, Jarone Lee, Kamal Medlej, Scott D. Weingart

PB | 9781107626850 | £45.00 Pages | 482 44 b/w illustrations 138 tables

PUBLICATION | OCT 2013

Acute resuscitation and care of unstable and critically ill patients can be a daunting experience for all trainees in the emergency department or the intensive care unit. The practical, easy-to-read and evidence-based information in Practical Emergency Resuscitation and Critical Care will help all physicians understand and begin management of these patients. This book offers the collaborative expertise of dozens of critical care physicians from different specialities, including but not limited to: emergency medicine, surgery, medicine and anaesthesia. Divided into sections by medical entities, it covers essential topics that are likely to be encountered in the emergency department where critical care often begins. The portable format and bullet point style content allows all practitioners instant access to the principle information that is necessary for the diagnosis and management of critical care patients.

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WHY IT WILL SELL • Provides portable access to the 'nuts and bolts' management of the critically ill patient • Bullet point format renders content easy to read and remember •Offers accurate, evidence-based and clinically relevant material

Emergency Medicine

Contents Preface; Part I. General Critical Care: 1. Shock; 2. Monitoring; 3. Airway management; 4. Mechanical ventilation; 5. The boarding ICU patient in the Emergency Department; Part II. Trauma: 6. General trauma principles; 7. Severe traumatic brain injury; 8. Spinal cord trauma; 9. Neck trauma; 10. Thoracic trauma; 11. Solid organ abdominal trauma; 12. Severe pelvic trauma; 13. Compartment syndrome; 14. Soft tissue injury: crush injury, arterial injury, and open fractures; 15. Burns; Part III. Neurologic Emergencies: 16. Ischemic strokes; 17. Intracranial hemorrhage; 18. Status epilepticus; 19. Acute spinal cord compression; Part IV. Cardiovascular Emergencies: 20. Acute coronary syndrome; 21. Tachyarrhythmias; 22. Bradyarrhythmias; 23. Post cardiac arrest; 24. Acute decompensated heart failure; 25. Aortic dissection; 26. Pericarditis and myocarditis; 27. Hypertensive emergencies; 28. Valvular diseases; Part V. Respiratory Emergencies: 29. Upper airway emergencies; 30. Asthma; 31. Chronic obstructive pulmonary disease (COPD); 32. Acute respiratory distress syndrome; 33. Massive hemoptysis; 34. Pulmonary embolism; Part VI. Gastrointestinal Emergencies: 35. Gastrointestinal bleeding; 36. Abdominal aortic aneurysms; 37. Acute pancreatitis; 38. Fulminant hepatic failure; 39. Acute mesenteric; 40. The surgical abdomen; 41. Abdominal compartment syndrome; 42. Esophageal perforation and mediastinitis; 43. Small bowel obstruction; Part VII. Renal Emergencies: 44. Acid-base interpretation; 45. Common electrolyte disorders (Na, K, Ca, Mg); 46. Acute kidney injury and emergent dialysis; 47. Rhabdomyolysis; Part VIII. Hematology-Oncology Emergencies: 48. Reversal of anticoagulation; 49. Disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS); 50. Neutropenic fever; 51. Tumor lysis syndrome; 52. Sickle cell emergencies; Part IX. Infectious Disease Emergencies: 53. Severe sepsis and septic shock; 54. Pneumonia; 55. Meningitis and encephalitis; 56. Infective endocarditis; 57. Necrotizing soft tissue skin infections; 58. Complications of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS); Part X. Endocrine Emergencies: 59. Diabetic ketoacidosis and hyperglycemic hyperosmolar; 60. Thyroid storm; 61. Adrenal crisis; 62. Pheochromocytoma; Part XI. Environmental Emergencies: 63. Anaphylaxis; 64. Hyperthermia; 65. Hypothermia; 66. Overdoses; Part XII. End of Life: 67. Care of the dying patient; Index. Contributors Raghu Seethala, Ken Bernard, Brandy Ferguson, Seth Trueger, Nelson Wong, Robert L. Sherwin, Bram Dolcourt, Julie Mayglothing, Benjamin Schnapp, Jacob Isserman, Ani Aydin, Vishal Demla, Samantha Wood, Jayaram Chelluri, Jeffrey Pepin, Katrina Harper, Kaushal Shah, Jonathan Friedstat, Jeremy Goverman, Shawn Fagan, Michael N. Cocchi, Joshua W. Joseph, Ashley L. Greiner, Jonathan C. Roberts, Timothy C. Peck, Matthew L. Wong, John W. Hardin, Cristal Cristia, Todd Seigel, Steven Rougas, Joshua Jauregui, Chad Van Ginkel, Stephen Hendriksen, Brandon Maughan, Gregory Hayward, Jennifer Carey, Nadine Himelfarb, Elena Kapilevich, Susan Wilcox, Brian Geyer, Andrew Eyre, Elisabeth Lessenich, Karen Kinnaman, Liza Gonen Smith, Ruth Lamm, Bina Vasantharam, Joel Moll, Carmelle Tabuteau, Payal Modi, Ted Stettner, John Woodruff, Abigail Hankin, Heather Meissen, Matthew Nicholls, Carolyn Maher Overman, Jeffrey N. Siegelman, Sarah Fisher, Carla Haack, Kathryn A. Seal, Sam Kini, Byron Pitts, John Lemos, John E. Arbo, Chanu Rhee, Feras Khan, Jeremy Gonda, Graham Walker, Calvin Hwang, Joseph E. Tonna, Nolan Caldwell, Casey Grover, Charles Lei, Syed S. Ali, Laura Medford-Davis, Navdeep Sekhon, Calvin Lee, Nathan Allen, Sandra Williams, Jennifer Carnell, Lindsay Oelze, Zubaid Rafique, Candace Pettigrew, Brandon Godbout, Benjamin Zabar, Kirill Shishlov, Daniel Rolston, Jolene Nakoa, Jarone Lee, Kamal Medlej, Sebastian Siadecki, Amy Caggiula, Daniel Herbert-Cohen, Viral Patel, Daniel Lepp, Ashley Shreves

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Haematology

Lymphoma Pathology, Diagnosis and Treatment

2nd edition Edited by Robert Marcus, John W. Sweetenham, Michael E. Williams

HB | 9781107010598 | £85.00 Pages | 352 44 b/w illustrations 70 colour illustrations

PUBLICATION | NOV 2013

Major advances have occurred in the diagnosis and treatment of lymphoma in recent years. Our understanding of the molecular biology and genetics of the disease has increased exponentially, and significant imaging developments have resulted in earlier and more accurate diagnosis. The new edition of this landmark text places these advances in the context of daily clinical practice. Each chapter has been updated to reflect recent developments, including new treatment agents such as immunomodulatory drugs and the next generation of antibodies, and the increasing prognostic role of PET scanning. Results from recent large-scale clinical trials are presented, and pathology and cytogenetics are integrated into discussion of each disease entity, enabling the reader to review all the key diagnostic information in one place. Featuring many color illustrations, and written and edited by leading authorities in the field, Lymphoma provides all the information you need to diagnose and manage these complex disorders.

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WHY IT WILL SELL • Treatment algorithms for each lymphoma subtype guide you through the decision-making process for first- and second-line treatment • Integrated pathology and cytogenetic information enable readers to review all of the key diagnostic information of each entity in a single place • Highly illustrated in colour throughout

Haematology

Contents Preface; 1. Epidemiology Eve Roman and Alexandra G. Smith; 2. Prognostic factors for lymphomas Guillaume Cartron and Philippe Solal-Céligny; 3. Imaging Heok K. Cheow and Ashley S. Shaw; 4. Clinical trials in lymphoma Thomas M. Habermann and Matthew Maurer; 5. Hodgkin lymphoma Stephanie Sasse and Andreas Engert; 6. Follicular lymphoma Kristian Bowles; 7. MALT and other marginal zone lymphomas Emanuele Zucca and Francesco Bertoni; 8. Small lymphocytic lymphoma/chronic lymphocytic leukemia Peter Hillmen, with contributions from Andrew Wotherspoon, Andreas Rosenwald and German Ott; 9. Waldenstrom's macroglobinemia/lymphoplasmacytic lymphoma Steven P. Treon and Giampaolo Merlini; 10. Mantle cell lymphoma Martin Dreyling and Michael E. Williams; 11. Burkitt and lymphoblastic lymphoma: clinical therapy and outcome Nirali N. Shah, Alan S. Wayne and Wyndham H. Wilson; 12. Therapy of diffuse large B-cell lymphoma John W. Sweetenham; 13. Central nervous system lymphomas Andrés J. M. Ferreri and Lisa M. DeAngelis; 14. T-cell non-Hodgkin lymphoma Sheetal M. Kircher, Beverly P. Nelson, Steven T. Rosen and Andrew M. Evens; 15. Primary cutaneous lymphoma Sean Whittaker; 16. Lymphoma in the immunosuppressed Michele Spinaa, Robert Marcus, Shireen Kassam and Umberto Tirellia; 17. Atypical lymphoproliferative, histiocytic and dendritic cell disorders Matthew S. Davids and Jennifer R. Brown; Index. Contributors Eve Roman, Alexandra G. Smith, Guillaume Cartron, Philippe Solal-Céligny, Heok K. Cheow, Ashley S. Shaw, Thomas M. Habermann, Matthew Maurer, Stephanie Sasse, Andreas Engert, Kristian Bowles, Emanuele Zucca, Francesco Bertoni, Peter Hillmen, Andrew Wotherspoon, Andreas Rosenwald, German Ott, Steven P. Treon, Giampaolo Merlini, Martin Dreyling, Michael E. Williams, Nirali N. Shah, Alan S. Wayne, Wyndham H. Wilson, John W. Sweetenham, Andrés J. M. Ferreri, Lisa M. DeAngelis, Sheetal M. Kircher, Beverly P. Nelson, Steven T. Rosen, Andrew M. Evens, Sean Whittaker, Michele Spinaa, Robert Marcus, Shireen Kassam, Umberto Tirellia, Matthew S. Davids, Jennifer R. Brown

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Haematology

Manual of Stem Cell and Bone Marrow Transplantation 2nd edition Joseph H. Antin, Deborah Yolin Raley

NEW EDITION Fully revised throughout, the second edition of Manual of Stem Cell and Bone Marrow Transplantation is based on the in-house handbook used at the world-renowned Dana-Farber Cancer Institute. It is a practical pocket manual for all members of the stem cell and bone marrow transplant team. Written by experts at Dana-Farber, the contents are handily arranged in outline format for maximum usefulness and convenience. This essential and user-friendly manual covers all aspects of the transplantation process, from stem cell processing through management of transplant-related complications. Topics discussed thoroughly include evaluation and counselling of patients and donors, preventative care, graft-versus-host disease and conditioning regimens. A new extensive chapter on oral health in stem cell transplantation has been added. These features make the Manual of Stem Cell and Bone Marrow Transplantation an ideal resource for the entire transplant team. Contents Acknowledgements; 1. Rationale for transplantation; 2. Types of transplantation; 3. HLA matching in allogeneic transplantation; 4. Stem cell source; 5. Pre-transplant evaluation and counselling of patient and donor; 6. Conditioning regimens; 7. Stem cell infusion; 8. ABO compatibility; 9. Engraftment; 10. Preventative care; 11. Transplant-related complications; 12. Overview of acute and chronic graft-versus-host disease; 13. Acute graftversus-host disease and staging; 14. Graft-versus-host prophylactic regimens; 15. Treatment guidelines for acute graft-versus-host disease; 16. Chronic graft-versus-host disease; 17. Engraftment syndrome; 18. Infectious disease; 19. Graft rejection and failure; 20. Gastrointestinal complications; 21. Oral health in stem cell transplantation; 22. Pulmonary complications; 23. Veno-occlusive disease; 24. Special transfusion-related situations; 25. Cardiovascular complications; 26. Neurologic complications; 27. Cystitis; 28. Donor lymphocyte infusion; 29. Transplantation: regulation and accreditation; Index.

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HB | 9781107661547 | £35.00 Pages | 200 29 b/w illustrations 26 tables

PUBLICATION | OCT 2013

WHY IT WILL SELL • Based on the handbook used at Dana-Farber Cancer Institute, offering advice from leading experts at one of the world's leading centres for the treatment of cancer • Contents are arranged in outline format, making this a valuable resource for quick reference • Fully revised throughout, with new vaccine and drug schedules

Medical Imaging

Core Radiology A Visual Approach to Diagnostic Imaging Jacob Mandell

Combining over 1200 clinical images, 300 color illustrations and concise, bulleted text, Core Radiology is a comprehensive, up-to-date resource for learning, reference and board review. The clearly-formatted design integrates the images and accompanying text, facilitating streamlined and efficient learning. All subjects covered by the American Board of Radiology Core Exam are included: • Breast imaging, including interventions and MRI • Neuroimaging, including brain, head and neck, and spine • Musculoskeletal imaging, including knee and shoulder MRI • Genitourinary imaging, including pelvic MRI • Gastrointestinal imaging, including MRI and MRCP • General, vascular, gynecological and obstetrical ultrasound • Nuclear imaging, including PET-CT and nuclear cardiology • Thoracic imaging • Cardiovascular imaging, including cardiac CT and MRI • Pediatric imaging • Interventional radiology • Radiological physics review, contrast media and reactions. Essential reading for radiology residents reviewing for boards, as well as practicing radiologists seeking a practical up-to-date guide to the field. Contents

1. Thoracic imaging; 2. Gastrointestinal imaging; 3. Genitourinary imaging; 4. Neuroimaging; 5. Musculoskeletal imaging; 6. Ultrasound; 7. Nuclear imaging; 8. Breast imaging; 9. Cardiovascular imaging; 10. Interventional radiology; 11. Pediatric imaging; Index.

PB | 9781107679689 | £85.00 Pages | 880 1200 b/w illustrations 300 colour illustrations

PUBLICATION | AUG 2013

WHY IT WILL SELL • Fully reviewed by subspecialty faculty affiliated with Harvard Medical School at Brigham and Women's Hospital, Boston Children's Hospital and Massachusetts Eye and Ear Infirmary to ensure information is accurate, up to date and expert • Correlates to the new format of the American Board of Radiology Core Exam allowing readers to learn and review from a single source • Clearly formatted design integrates all images in line with the accompanying text, enabling the reader to focus on learning rather than locating content

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Neurology and Clinical Neuroscience

Common Epilepsy Pitfalls Case-Based Learning Dieter Schmidt, Steven Schachter

PB | 9780521279710 | £45.00 Pages | 224 50 b/w illustrations 20 tables Epilepsy is amongst the most frequently encountered of neurological disorders, yet its diagnosis and management is fraught with pitfalls. Issues surrounding differential diagnosis, seizure type, underlying causes, EEG interpretations, treatment options and prognoses can often trip-up clinicians. Common Epilepsy Pitfalls: CaseBased Learning, is a comprehensive guide to anticipating and managing the pitfalls in the diagnosis and management of epilepsy. Real-life cases are presented along with pragmatic recommendations for courses of action that guide the reader through accurate and effective epilepsy diagnosis and treatment. Cases have been chosen to answer key questions such as: the first seizure – is it epilepsy? Which drug? When should stopping treatment be considered? What to do in an epileptic emergency? Containing detailed coverage of psychiatric, social and family issues – and authored by world experts in epilepsy management – this text is invaluable for neurologists, internists, family practitioners and advanced medical students. Contents Preface; Introduction; 1. Mistaking non-epileptic events for epilepsy; 2. Mistaking EEG changes for epilepsy; 3. Radiographic errors in epilepsy; 4. The first seizure: is it epilepsy?; 5. When to start treatment?; 6. Which drug is best?; 7. How to optimize treatment?; 8. What to do if drugs don't work?; 9. When to stop treatment; 10. Women with epilepsy; 11. Management of psychiatric issues in epilepsy; 12. Management of emergencies in epilepsy; 13. Management of social issues; Index.

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PUBLICATION | FEB 2014

WHY IT WILL SELL • Case-based approach to learning – experienced authors highlight 'pitfalls' in diagnosis and management of epilepsy • Questions addressed to the reader - maintains interest and heightens the real-life feel of the book • Well-illustrated - will help clinicians detect and identify characteristic problems in epilepsy management • Each case will stand alone as a complete story so that the book can be read either as a whole, or 'dipped-into'

Neurology and Clinical Neuroscience

Magnetic Resonance Imaging in Movement Disorders A Guide for Clinicians and Scientists Edited by Paul Tuite, Alain Dagher

HB | 9781107026360 | £95.00 Pages | 296 19 b/w illustrations 135 colour illustrations

PUBLICATION | SEPT 2013

Magnetic Resonance Imaging in Movement Disorders is the first book to focus in detail on MRI in a range of movement disorders. Since MRI was first employed in imaging Parkinson's disease, the number of imaging techniques and their application in diagnosis and management has extended widely. The book shows various imaging strategies ranging from functional, structural and chemical methods as they relate to both motor and non-motor aspects of Parkinson's disease and other conditions such as Huntington's disease and dystonia. Chapters on MRI in surgery and using MRI as a potential outcome measure in clinical trials show the clinical relevance of methods. Novel methods including DTI, tractography and resting case studies are described in detail. The book also summarises the relevance of fMRI to various aspects of movement disorders. Magnetic Resonance Imaging in Movement Disorders is essential reading for neurologists, radiologists and movement disorder specialists.

WHY IT WILL SELL • Contains colour atlas of clinically relevant images • Most up-to-date review of both standard and novel MRI methods • Only book which highlights the use of MRI across all movement disorders

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Neurology and Clinical Neuroscience

Contents 1. Magnetic resonance imaging (MRI) methods in Parkinson's disease Silvia Mangia, Shalom Michaeli and Paul J. Tuite; 2. Imaging iron in Parkinson's disease W. R. Wayne Martin; 3. Motor Parkinson's disease and structure Stephane Lehericy, Cyril Poupon and Cecile Gallea; 4. MR imaging of Parkinson's disease with cognitive impairment and dementia Richard Camicioli; 5. fMRI of motor signs in Parkinson's disease Tobias Wächter; 6. Functional MRI of cognition and mood in Parkinson's disease Alison Simioni and Alain Dagher; 7. Networks and resting-state in Parkinson's disease Nazanin Baradaran and Martin J. McKeown; 8. MRI for targeting in surgical treatment of movement disorders Aviva Abosch and Noam Harel; 9. MR imaging and spectroscopy in Huntington's disease Isabelle Iltis and Janet Dubinsky; 10. Neuroimaging of Tourette's syndrome Yulia Worbe and Andreas Hartmann; 11. Dystonia Bernhard Haslinger; 12. Tauopathies Jennifer L. Whitwell and Keith A. Josephs; 13. Magnetic resonance imaging of multiple system atrophy Klaus Seppi, Christoph Mueller, Gregor K. Wenning and Michael Schocke; 14. Ataxia Kathrin Reetz and Ferdinand Binkofski; 15. Magnetic resonance spectroscopy in Parkinson's disease Uzay E. Emir and Gülin Öz; 16. The image of essential tremor: current neuroimaging and clues to disease localization, pathogenesis and diagnosis Hiral Shah and Elan D. Louis; 17. Adult clinical applications Michael Samuel and Jozef Jarosz; 18. MRI in clinical trials Norbert Schuff; Index. Contributors Silvia Mangia, Shalom Michaeli, Paul J. Tuite, W. R. Wayne Martin, Stephane Lehericy, Cyril Poupon, Cecile Gallea, Richard Camicioli, Tobias Wächter, Alison Simioni, Alain Dagher, Nazanin Baradaran, Martin J. McKeown, Aviva Abosch, Noam Harel, Isabelle Iltis, Janet Dubinsky, Yulia Worbe, Andreas Hartmann, Bernhard Haslinger, Jennifer L. Whitwell, Keith A. Josephs, Klaus Seppi, Christoph Mueller, Gregor K. Wenning, Michael Schocke, Kathrin Reetz, Ferdinand Binkofski, Uzay E. Emir, Gülin Öz, Hiral Shah, Elan D. Louis, Michael Samuel, Jozef Jarosz, Norbert Schuff

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Neurology and Clinical Neuroscience

Manual of Botulinum Toxin Therapy 2nd edition Edited by Daniel Truong, Dirk Dressler, Mark Hallett, Christopher B. Zachary

NEW EDITION

HB | 9781107025356 | £60.00 Pages | 304 388 b/w illustrations

PUBLICATION | NOV 2013

Fully updated throughout, the second edition of the Manual of Botulinum Toxin Therapy provides practical guidance on the use of Botox in a wide variety of disorders. New chapters have been added on the use of botulinum toxin in wound healing, in focal hand dystonia and in thoracic outlet syndrome, as well as others. There are new chapters on the use of botulinum toxins in conjunction with ultrasound guidance. Using clear linedrawings the Manual describes the relevant injection sites for each condition and gives comparative dosage tables for the various formulations of toxins used in different muscle groups. Throughout the emphasis is on technique and the book can be used as both a teaching aid and in bedside guidance. The manual will be of use to neurologists, otolaryngologists, urologists, ophthalmologists, dermatologists, internists, pain management specialists, rehabilitation specialists and plastic surgeons, and any other clinicians discovering the potential of botulinum toxin.

WHY IT WILL SELL • Fully updated version of successful manual • Botulinum toxin therapy is rapidly expanding • Editors are leaders in the field

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Neurology and Clinical Neuroscience

Contents Preface; 1. The pretherapeutic history of botulinum toxin Frank J. Erbguth; 2. Botulinum toxin: history of clinical development Daniel Truong and Mark Hallett; 3. Pharmacology of botulinum neurotoxins Daniel Truong and Mark Hallett; 4. Immunological properties of botulinum neurotoxins Hans Bigalke, Dirk Dressler and Jürgen Frevert; 5. Treatment of cervical dystonia Daniel Truong, Karen Frei and Cynthia L. Comella; 6. Examination and treatment of complex cervical dystonia Gerhard Reichel; 7. Ultrasound guidance for botulinim toxin therapy: cervical dystonia Katharine E. Alter; 8. Treatment of blepharospasm Carlo Colosimo, Dorina Tiple and Alfredo Berardelli; 9. Botulinum toxin in oromandibular dystonia Roongroj Bhidayasiri, Francisco Cardoso and Daniel Truong; 10. Treatment of focal hand dystonia Barbara Illowsky Karp, Chandi Prasad Das, Daniel Truong and Mark Hallett; 11. Botulinum toxin therapy of laryngeal muscle hyperactivity syndromes Daniel Truong, Arno Olthoff and Rainer Laskawi; 12. The use of botulinum toxin in otorhinolaryngology Ranier Laskawi, Arno Olthoff and Oleg Olegovich Ivanov; 13. Treatment of hemifacial spasm Karen Frei; 14. Spasticity Mayank S. Pathak and Allison Brashear; 15. The use of botulinum toxin in spastic infantile cerebral palsy Ann Tilton and H. Kerr Graham; 16. The use of botulinum toxin in spasticity using ultrasound guidance Andrea Santamato, Franco Molteni and Pietro Fiore; 17. The use of botulinum toxin in tic disorders and essential hand and head tremor Joseph Jankovic; 18. Treatment of stiff-person syndrome with botulinum toxin Diana Richardson and Bahman Jabbari; 19. Botulinum toxin applications in ophthalmology Peter Roggenkamper and Allan Scott; 20. Cosmetic uses of botulinum toxins Joshua Spanogle, Christopher Zachary and Dee Anna Glaser; 21. Hyperhidrosis Henning Hamm and Markus K. Naumann; 22. Botulinum toxin-A treatment for ischemic digits and chronic pain Michael W. Neumeister and Kelli Webb; 23. Botulinum toxin in wound healing Holger G. Gassner; 24. Use of botulinum toxin in neuropathic pain Szu-Kuan Yang and Chaur-Jongh Hu; 25. The use of botulinum toxin in the management of headache disorders Stephen D. Silberstein; 26. The use of botulinum toxin in musculoskeletal pain and arthritis Jasvinder A. Singh; 27. Treatment of plantar fasciitis with botulinum neurotoxins Bahman Jabbari and Shivam Om Mittal; 28. Use of botulinum toxin in the treatment of low back pain José De Andrés and Gustavo Fabregat; 29. Use of botulinum toxin in the treatment of piriformis syndrome Loren M. Fishman and Sarah B. Schmidhofer; 30. Ultrasound guided botulinum toxin injections for thoracic outlet syndrome Katharine E. Alter; 31. Botulinum toxin in the gastrointestinal tract Vito Annese and Daniele Gui; 32. Botulinum toxin application in urological disorders Stefano Carda and Brigitte Schurch; Index. Contributors Frank J. Erbguth, Daniel Truong, Mark Hallett, Hans Bigalke, Dirk Dressler, Jürgen Frevert, Karen Frei, Cynthia L. Comella, Gerhard Reichel, Katharine E. Alter, Carlo Colosimo, Dorina Tiple, Alfredo Berardelli, Roongroj Bhidayasiri, Francisco Cardoso, Barbara Illowsky Karp, Chandi Prasad Das, Arno Olthoff, Rainer Laskawi, Oleg Olegovich Ivanov, Karen Frei, Mayank S. Pathak, Allison Brashear, Ann Tilton, H. Kerr Graham, Andrea Santamato, Franco Molteni, Pietro Fiore, Joseph Jankovic, Diana Richardson, Bahman Jabbari, Peter Roggenkamper, Allan Scott, Joshua Spanogle, Christopher Zachary, Dee Anna Glaser, Henning Hamm, Markus K. Naumann, Michael W. Neumeister, Kelli Webb, Holger G. Gassner, Szu-Kuan Yang, Chaur-Jongh Hu, Stephen D. Silberstein, Jasvinder A. Singh, Bahman Jabbari, Shivam Om Mittal, José De Andrés, Gustavo Fabregat, Loren M. Fishman, Sarah B. Schmidhofer, Vito Annese, Daniele Gui, Brigitte Schurch, Stefano Carda

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Neurology and Clinical Neuroscience

Neurologic Differential Diagnosis A Case-Based Approach Edited by Alan B. Ettinger, Deborah M. Weisbrot

HB | 9781107014558 | £65.00 Pages | 656 111 b/w illustrations 175 tables

PUBLICATION | NOV 2013

The increasing pressure upon clinicians to see more and more patients generates great concern as to how to offer a comprehensive and thorough diagnostic approach and yet maintain efficiency. Neurologic Differential Diagnosis is the answer. Unlike other texts which are divided into disease entities, this book uses a case study approach to focus on the patients' symptoms. Each chapter is dedicated to a specific presenting symptom or sign and includes a comprehensive, yet succinct table of clinical features to aid clarification of the broad list of diagnostic possibilities. This allows the clinician to quickly reference specific symptoms such as dizziness, mental status change or diplopia; or signs such as foot drop or psychotic behavior, and then immediately generate diagnostic possibilities. Written from the authors' extensive clinical experience, Neurologic Differential Diagnosis is an invaluable text for neurologists and psychiatrists at all stages of training.

WHY IT WILL SELL • Succinct descriptions allow the clinician to make a quick but comprehensive differential diagnosis • Each chapter lists the essential key features and, where indicated, anatomical guides to facilitate understanding • Each chapter includes a case vignette to aid understanding

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Neurology and Clinical Neuroscience

Contents Foreword; Preface; Part I. Differential Diagnosis of Abnormal Symptoms and Signs: 1. Introduction: localization and differential diagnosis in neurology; 2. Agitation and aggressive behavior in patients with dementia or developmental disability; 3. Agnosias; 4. Anxiety and panic; 5. Aphasia; 6. Apraxia; 7. Ataxia: subacute or chronic; 8. Ataxia, acute, or subacute; 9. Attentional problems; 10. Autonomic failure or syndromes; 11. Bulbar, pseudobulbar; 12. Catatoniclike states; 13. Chorea; 14. Coma; 15. Dementia; 16. Depression and suicidal ideation; 17. Diplopia; 18. Dissociative disorder; 19. Dizziness; 20. Drop attacks; 21. Dysarthria; 22. Dysphagia; 23. Dystonia; 24. Eating disorders; 25. Eye movements, abnormal; 26. Falls; 27. Foot drop; 28. Gait abnormalities; 29. Hallucinations, visual; 30. Headache; 31. Hearing deficit; 32. Hypersomnolence; 33. Incontinence; 34. Mania and bipolar symptoms; 35. Medically unexplained symptoms; 36. Memory loss and cognitive decline, acute and subacute, amnesia; 37. Mental status change, acute [and delirium]; 38. Movement disorders in psychiatric disorders; 39. Movement abnormalities in the face; 40. Movements, focal, clonic; 41. Movements, complex motor activity; 42. Movements during sleep; 43. Movements, tonic-clonic type; 44. Mutism; 45. Myalgia, cramps; 46. Myoclonus; 47. Myotonia; 48. Nystagmus; 49. Ophthalmoparesis, gaze conjugate lateral deficit and conjugate vertical deficit; 50. Pain, eye; 51. Pain, neck; 52. Pain, arm; 53. Pain, back; 54. Pain, face; 55. Papilledema; 56. Paresthesias; 57. Parkinson's Disease and related extrapyramidal syndromes; 58. Proptosis [exophthalmos]; 59. Psychosis, thought disorder; 60. Ptosis; 61. Pupil constriction and Horner's syndrome; 62. Pupil dilatation; 63. Respiratory difficulties, neurologic causes; 64. Retardation, mental; 65. Seizure; 66. Sensory deficits and abnormal sensations; 67. Sensory deficits in the face; 68. Smell deficit; 69. Spasm, hemifacial; 70. Stroke and hemorrhage syndromes; 71. Stroke in adults, etiologies; 72. Stroke in the young, etiologies; 73. Syncope; 74. Tinnitus; 75. Tremor; 76. Vertigo; 77. Visual loss, acute bilateral; 78. Visual loss, monocular; 79. Visual field deficits; 80. Weakness, generalized acute; 81. Weakness, hemiparesis; 82. Weakness, proximal; 83. Weakness, monomelic; 84. Weakness, neck; 85. Weakness, paraparesis; 86. Weakness in ICU; Part II. Differential Diagnosis within Specific Localizations: 87. Cavernous sinus syndrome; 88. Facial nerve palsy; 89. Fourth nerve palsy; 90. Myelopathy; 91. Nerve, cranial: multiple deficit; 92. Neuropathy, tibial; 93. Neuropathy, femoral; 94. Neuropathy, radial; 95. Neuropathy, sciatic; 96. Neuropathy, axonal versus demyelinating; 97. Neuropathy, median and carpal tunnel; 98. Neuropathy, ulnar; 99. Plexopathy, brachial; 100. Plexopathy, lumbar; 101. Radiculopathy; 102. Sixth nerve palsy; 103. Third nerve palsy; Index. Contributors Alan B. Ettinger, Deborah M. Weisbrot, Angela Scicutella, Durga Roy, Marlene Behrmann, Maxim D. Hammer, Kenneth R. Kaufman, Gad E. Klein, Dragana Micic, Jasvindar Chawla, A. Thompson, Subramony H. Subramony, Jay Elliot Yasen, Lenard A. Adler, Rajpaul Singh, Joe Colombo, Eric R. Eggenberger, David Clark, Edward Firouztale, Ruth H. Walker, Galen V. Henderson, Howard Crystal, Diana Rojas-Soto, John J. Barry, Deborah I. Friedman, Danielle G. Koby, W. Curt LaFrance, Jr, Martin Gizzi, Manpreet Multani, Lourdes Bello-Espinosa, David B. Rosenfield, Jessica A. Shields, Anne L. Foundas, Ritesh A. Ramdhani, Steven J. Frucht, Nina Kirz, Vandana Aspen, Heather E. Moss, Christyn M. Edmundson, Steven A. Sparr, Pinky Agarwal, Ryan J. Zehnder, Michael A. Williams, Scott E. Brown, Victoria S. Pelak, Ira M. Turner, Richard B. Lipton, David A. Gudis, Michael J. Ruckenstein, Jeffrey S. Durmer, Heidi D. Riney, Cara Tannenbaum, Niloofar (Nelly) Faghani, Christopher P. Kogut, James L. Levenson, Eve G. Spratt, Ryan R. Byrne, Max C. Rudansky, Jacques Winter, Alan Mazurek, Fawaz Almufti, G. Bryan Young, Teneille Gofton, Gregory M. Pontone, Kevin M. Biglan, Annie Killoran, Daniel J. Luciano, Siddhartha Nadkarni, Michael J. Thorpy, Gaia Donata Oggioni, Alberto J. Espay, Gary P. Kaplan, Rina Caprarella, Venkat Ramani, David Elliott Friedman, Mehri Songhorian, Beth Stein, Steven Herskovitz, Sarita B. Dave, Patrick J. M. Lavin, Matthew J. Thurtell, Mark Beyer, Deepak Grover, Louis J. Goodrich, Ajay Berdia, Robert Duarte, Michael Ronthal, Egilius L. H. Spierings, Don C. Bienfang, George D. Baquis, Anant Shenoy, Oded Gerber, Fawaz AlMufti, Luis J. Mejico, Laryssa A. Huryn, Ramses Ribot, Andres M. Kanner, Andrew R. Harrison, Robert C. Sergott, Scott Uretsky, J. Schiffman, Rosa Ana Tang, Anastas F. Pass, Anne Hayman, Wan-Tsu W. Chang, Paul Nyquist, Varda Gross-Tsur, Tal Gilboa, Rolla Nuoman, David J. Anschel, Paul W. Brazis, Jeffrey A. Brown, Richard L. Doty, Hakan Tekeli, Jagga Rao Alluri, George C. Newman, Aparna Prabhu, Susan W. Law, Daniel M. Rosenbaum, Walter J. Molofsky, Todd Cohen, Eric E. Smouha, Grace M. Charles, Odi Oguh, Esther Baldinger, Tanya Simuni, Maroun T. Semaan, Robert M. Mallery, Misha Pless, Jeff Peterson, Rehan Ahmed, Rod Foroozan, Denis Ostrovsky, Amit M. Shelat, Shicong Ye, Malcolm H. Gottesman, Glenn Lopate, Georgios Manousakis, Casey A. Chamberlain, Michael Andary, Sindhu Ramachandran, Aashit K. Shah, Friedhelm Sandbrink, John J. Halperin, Vladimir Dadashev, Jonathan L. Brisman, John PileSpellman, Phillip Ragone, Kristina Y. Pao, Mark L. Moster, Amanda R. Bedford, Randall J. Wright, David Solomon, Jee Bang, Reema Maindiratta, Eva Sahay, Padmaja Aradhya, Julius Bazan, Pedro J. Torrico, Michael T. Pulley, Alan R. Berger, Hiuying Yu, Steven Ender, Michael Amoashiy, Prajwal Rajappa, Caitlin Hoffman, Jean Robert Desrouleaux, Amtul Farheen, Bashar Katirji, Claire A. Sheldon, Jason J. S. Barton

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Neurology and Clinical Neuroscience

Neuropathic Pain Causes, Management and Understanding Edited by Cory Toth, Dwight Moulin

HB | 9781107023710 | £60.00 Pages | 384 53 b/w illustrations 12 colour illustrations 58 tables

PUBLICATION | OCT 2013

Central or peripheral neuropathic pain can be caused by a wide range of injuries, infections and diseases such as: spinal cord injury, multiple sclerosis, stroke, herpes zoster, diabetes and cancer. Many of these pain syndromes are difficult to treat, representing a challenge for many neurologists not routinely trained in pain management. Written by an international team of experts in the field, Neuropathic Pain: Causes, Management and Understanding gives readers an in-depth understanding of the multitude of conditions causing neuropathic pain. Epidemiology, clinical diagnosis, pathophysiology, outcome measurement and the best evidence-based management of individual and general neuropathic pain conditions are also described in depth. A unique chapter, written from a patient's viewpoint, gives new insight into how chronic neuropathic pain affects the lives of those patients with the condition. This book is essential reading for all pain specialists, neurologists, psychiatrists and anesthesiologists who wish to better understand their patients' neuropathic pain.

WHY IT WILL SELL • Describes all classes of neuropathic pain medication aiding effective pharmacological management • Up-to-date and recommended treatment plans for different causes of neuropathic pain • Written by an international team of experts, bringing together the leading opinions in the field into a single volume

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Neurology and Clinical Neuroscience

Contents Preface; Part I. The Clinical Presentation of Neuropathic Pain: 1. History and physical examination Pam Squire and John Xavier Pereira; 2. Diagnostic testing in chronic neuropathic pain patients Vishal Gupta and Michael Serpell; 3. Epidemiological considerations in neuropathic pain Didier Bouhassira and Nadine Attal; Part II. The Condition of Neuropathic Pain: 4. An overview of animal models for neuropathic pain Patrick L. Stemkowski and Peter A. Smith; 5. Peripheral and central sensitization Cory Toth; 6. Pathophysiology of neuropathic pain: voltage-gated sodium and calcium channels Robyn Flynn and Christophe Altier; 7. Pathophysiology of neuropathic pain: inflammatory mediators Paul J. Austin and Gila Moalem-Taylor; 8. Pathophysiology of neuropathic pain: signaling pathways and their magnification – the role of neuronal toll-like receptors Michael R. Due, Yohance M. Allete and Fletcher A. White; Part III. The Specific Condition: Peripheral Neuropathic Pain: 9. Diabetic and other peripheral neuropathies Cory Toth; 10. Postherpetic neuralgia: the prevention of a scourge C. Peter N. Watson; 11. Painful conditions affecting the nerve roots and plexus Kristine M. Chapman and Amanda Sherwin; Part IV. The Specific Condition: Central Neuropathic Pain: 12. Neuropathic pain following spinal cord injury Jan H. Vranken; 13. Central pain symptoms in multiple sclerosis Scott Jarvis and Bradley J. Kerr; 14. Central poststroke pain Maan Kattan and Dwight E. Moulin; Part V. The Specific Condition: Other Causes of Neuropathic Pain: 15. The complex regional pain syndromes and post-traumatic neuralgias Anne Louise Oaklander and Steven H. Horowitz; 16. The management of neuropathic pain in cancer patients Wojciech Leppert; 17. Fibromyalgia Mary-Ann Fitzcharles and Peter Ste-Marie; Part VI. The Management of Neuropathic Pain: 18. Antidepressants: TCA and SNRIs Maija Haanpää; 19. Gabapentinoids and other anticonvulsants Howard S. Smith, Charles E. Argoff, Manpreet Kaur and Harsha Nagaraja; 20. Opioids Andrea D. Furlan and Angela Mailis-Gagnon; 21. Cannabinoids Mark A. Ware; 22. Local anesthetics and other interventional approaches Ian Carroll; 23. Spinal cord stimulation and other neuromodulation Krishna Kumar and Syed Rizvi; 24. Drug synergy and therapeutic combinations Stephan A. Schug; 25. The person with pain perspective and participation – an essential component of successfully managing chronic neuropathic pain Lynn Kerene Cooper; Part VII. The Prognosis of Neuropathic Pain: 26. Measuring outcomes in chronic neuropathic pain Nadine Attal; 27. Impact of chronic pain upon anxiety, sleep, and mood dimensions Scott Jarvis and Cory Toth; 28. Impact upon related conditions and quality of life Bharati Vyawahare and John Hughes; 29. The future: new concepts and potential therapies Nicole M. Sumracki, Lauren Nicotra, Yuen Kwok, Liang Liu, Krista van Steeg, Linda R. Watkins and Mark R. Hutchinson; Index. Contributors Pam Squire, John Xavier Pereira, Vishal Gupta, Michael Serpell, Didier Bouhassira, Nadine Attal, Patrick L. Stemkowski, Peter A. Smith, Cory Toth, Robyn Flynn, Christophe Altier, Paul J. Austin, Gila Moalem-Taylor, Michael R. Due, Yohance M. Allete, Fletcher A. White, C. Peter N. Watson, Kristine M. Chapman, Amanda Sherwin, Jan H. Vranken, Scott Jarvis, Bradley J. Kerr, Maan Kattan, Dwight E. Moulin, Anne Louise Oaklander, Steven H. Horowitz, Wojciech Leppert, MaryAnn Fitzcharles, Peter Ste-Marie, Maija Haanpää, Howard S. Smith, Charles E. Argoff, Manpreet Kaur, Harsha Nagaraja, Andrea D. Furlan, Angela Mailis-Gagnon, Mark A. Ware, Ian Carroll, Krishna Kumar, Syed Rizvi, Stephan A. Schug, Lynn Kerene Cooper, Scott Jarvis, Bharati Vyawahare, John Hughes, Nicole M. Sumracki, Lauren Nicotra, Yuen Kwok, Liang Liu, Krista van Steeg, Linda R. Watkins, Mark R. Hutchinson

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Neurology and Clinical Neuroscience

Neuropsychiatric and Cognitive Changes in Parkinson’s Disease and Related Movement Disorders Diagnosis and Management Edited by Dag Aarsland, Jeffrey Cummings, Daniel Weintraub, K. Ray Chaudhuri

HB | 9781107039223 | £70.00 Pages | 298 25 b/w illustrations 5 colour illustrations 51 tables

PUBLICATION | AUG 2013

Psychiatric and cognitive changes are common in patients with Parkinson's disease and have key clinical consequences but, despite this, these symptoms are often under-diagnosed and under-treated, leading to increased morbidity and costs. With chapters focused on the major neuropsychiatric features, Neuropsychiatric and Cognitive Changes in Parkinson's Disease and Related Movement Disorders rectifies this deficit. Written by experts in the field, with a consistent focus on relevant clinical knowledge, it provides a comprehensive overview including all the major behavioral changes associated with movement disorders. The book provides broad, indepth, accurate and up-to-date scientific information as well as crucial understanding and practical tools to help patients. The book is essential reading for clinicians working in neurology, psychiatry and geriatric medicine.

WHY IT WILL SELL • Brings to light often underdiagnosed issues • Has a consistent focus on relevant clinical knowledge • The only up-to-date book covering all behavioural problems related to movement diseases

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Neurology and Clinical Neuroscience

Contents Preface; Part I. General Aspects: 1. Overview of Parkinson's disease: epidemiology, diagnosis, course, medical and surgical management Sheila S. Rane and Christopher G. Goetz; 2. Parkinson's disease: pathology, anatomy, and behavior James B. Leverenz and Daniel J. Burdick; 3. Genetics and behavior and cognition in Parkinson's disease Caroline H. Williams-Gray and Roger A. Barker; 4. The boundaries of Parkinson's disease dementia and dementia with Lewy bodies Elisabet Londos; Part II. Diagnosis and Biomarkers: 5. Cognitive assessment in Parkinson's disease Jaime Kulisevsky, Saül Martínez-Horta and Javier Pagonabarraga; 6. Clinical assessment: mood and motivation Albert F. G. Leentjens; 7. Imaging and behavior in Parkinson's disease: structural imaging Mona K. Beyer, Turi O. Dalaker and Liana G. Apostolova; 8. Imaging and behavior in Parkinson's disease: functional imaging Agneta Nordberg; 9. Diagnosis and biomarkers: CSF Brit Mollenhauer and Henrik Zetterberg; Part III. Specific Neuropsychiatric Disorders: 10. Depression Per Svenningsson and Dag Aarsland; 11. Anxiety Laura Marsh and Jessica Calleo; 12. Apathy Kathy Dujardin; 13. Impulse control disorder Daniel Weintraub and Irena Rektorova; 14. Hallucinations and psychosis Oscar Bernal-Pacheco and Hubert H. Fernandez; 15. Early cognitive impairment Alexander I. Tröster and Dag Aarsland; 16. Parkinson's disease dementia: features and management Başar Bilgiç, Haşmet A. Hanağasi and Murat Emre; 17. Sleep disturbances Pouya Movahed, Kristina Røkenes Karlsen and K. Ray Chaudhuri; Part IV. Management: 18. Parkinson's disease: drug treatment and behavior Jaime Kulisevsky, Javier Pagonabarraga and Carolina VillaBonomo; 19. Surgical treatments and behavior Jens Volkmann and Christine Daniels; 20. Clinical trials for psychotropic agents in Parkinson's diesase using psychosis as a model Ryan R. Walsh and Jeffrey Cummings; Part V. Other Issues: 21. Clinical implications of neuropsychiatric symptoms in Parkinson's disease Angelo Antonini and Pablo Martinez-Martin; 22. Neuropsychiatric and cognitive disorders in other Parkinsonian disorders Adam Gerstenecker, Benjamin T. Mast and Irene Litvan; 23. Neuropsychiatric aspects of the on-off phenomenon Irene Rektorova and Marek Balaz; 24. Treatment of neuropsychiatric disturbances in Parkinson's disease: future prospects and strategies Jeffery Cummings and Dag Aarsland; Index. Contributors Sheila S. Rane, Christopher G. Goetz, James B. Leverenz, Daniel J. Burdick, Caroline H. WilliamsGray, Roger A. Barker, Elisabet Londos, Jaime Kulisevsky, Saül Martínez-Horta, Javier Pagonabarraga, Albert F. G. Leentjens, Mona K. Beyer, Turi O. Dalaker, Liana G. Apostolova, Agneta Nordberg, Brit Mollenhauer, Henrik Zetterberg, Per Svenningsson, Dag Aarsland, Laura Marsh, Jessica Calleo, Kathy Dujardin, Daniel Weintraub, Irena Rektorova, Oscar Bernal-Pacheco, Hubert H. Fernandez, Alexander I. Tröster, Başar Bilgiç, Haşmet A. Hanağasi, Murat Emre, Pouya Movahed, Kristina Røkenes Karlsen, K. Ray Chaudhuri, Carolina Villa-Bonomo, Jens Volkmann, Christine Daniels, Ryan R. Walsh, Jeffrey Cummings, Angelo Antonini, Pablo Martinez-Martin, Adam Gerstenecker, Benjamin T. Mast, Irene Litvan, Marek Balaz

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Neurology and Clinical Neuroscience

The Genetic Basis of Sleep and Sleep Disorders Edited by Paul Shaw, Mehdi Tafti, Michael Thorpy

HB | 9781107041257 | £85.00 Pages | 432 63 b/w illustrations 24 colour illustrations

PUBLICATION | SEPT 2013

The first comprehensive book on the subject, The Genetic Basis of Sleep and Sleep Disorders covers detailed reviews of the general principles of genetics and genetic techniques in the study of sleep and sleep disorders. The book contains sections on the genetics of circadian rhythms, of normal sleep and wake states and of sleep homeostasis. There are also sections discussing the role of genetics in the understanding of insomnias, hypersomnias including narcolepsy, parasomnias and sleep-related movement disorders. The final chapter highlights the use of gene therapy in sleep disorders. Written by genetic experts and sleep specialists from around the world, the book is up to date and geared specifically to the needs of both researchers and clinicians with an interest in sleep medicine. This book will be an invaluable resource for sleep specialists, neurologists, geneticists, psychiatrists and psychologists.

WHY IT WILL SELL • Summarizes research into the genetic basis of sleep disorders and applies results to the clinical setting – accessible to clinicians • Focuses on the most important sleep disorders – useful in everyday practice, including counselling patients • Internationally renowned contributors give the content authority and make it applicable to a worldwide market

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Neurology and Clinical Neuroscience

Contents Preface; Part I. General Principles of Genetics and Genomics: 1. Methods in complex trait analysis: mapping the genetic basis of sleep using model organisms Amelie Baud and Jonathan Flint; 2. Linkage and associations Elizabeth J. Rossin and Benjamin M. Neale; 3. Genome-wide association study approaches to sleep phenotypes Patrick Sleiman, Michael March and Hakon Hakonanson; Part II. Genetics of Sleep and Circadian Rhythms: 4. Genetic epidemiology of sleep and sleep disorders Christer Hublin and Jaakko Kaprio; 5. Drosophlia model systems for genetic sleep research Stephane Dissel and Paul J. Shaw; 6. Caenorhabditis elegans and zebrafish in sleep research David A. Prober and David M. Raizen; 7. Optogenetic control of arousal neurons Antoine Adamantidis, Matthew E. Carter and Luis De Lecea; 8. Prostaglandin D2 in the regulation of sleep Yoshihiro Urade and Michael Lazarus; 9. Astroglial regulation of sleep Marcos G. Frank; 10. The role of metabolic genes in sleep regulation Matthew S. Thimgan and Karen D. Schilli; 11. A systems biology approach for uncovering the genetic landscape for multiple sleep-wake traits Peng Jiang, Andrew Kasarskis, Christopher J. Winrow, John J. Renger and Fred W. Turek; 12. Genetic control of the circadian pacemaker Ethan Buhr and Joseph S. Takahashi; 13. Epigenetic basis of circadian rhythms and sleep disorders Irfan A. Qureshi and Mark F. Mehler; Part III. Sleep Physiology and Homeostasis: 14. Genetics of sleep and EEG Thomas Curie and Mehdi Tafti; 15. Genetic interaction between circadian and homeostatic regulation of sleep Valérie Mongrain and Paul Franken; 16. Genetic approaches to understanding circadian entrainment Till Roenneberg and Karla V. Allebrandt; 17. Animal models for cognitive deficits induced by sleep deprivation Laurent Seugnet and Paul Salin; 18. Individual differences in sleep duration and responses to sleep loss Devon A. Grant and Hans P. A. Van Dongen; 19. Clock polymorphisms associated with human diurnal preference Simon N. Archer and Derk-Jan Dijk; 20. Sleep and long-term memory storage Jennifer H. K. Choi and Ted Abel; 21. Sleep and synaptic homeostasis Chiara Cirelli and Giulio Tononi; Part IV. Insomnias: 22. Heritability and genetic factors in chronic insomnia Yves Dauvilliers and Charles M. Morin; Part V. Narcolepsy and Hypersomnias: 23. HLA and narcolepsy Katsushi Tokunaga and Makoto Honda; 24. Orexin (hypocretin) and narcolepsy Takeshi Sakurai and Seiji Nishino; 25. Gene-wide association studies in narcolepsy Hyun Hor; 26. Genetic disorders producing symptomaric narcolepsy Seiji Nishino and Takashi Kanbayashi; 27. Genetics of recurrent hypersomnia Michael Billiard, Rosa Periata-Adrados and Mehdi Tafti; Part VI. Sleep-related Breathing Disorders: 28. Linkage and candidate gene studies of obstructive sleep apnea Annette C. Fedson, Thorarinn Gislason and Allan I. Pack; 29. Genomic mutations and genotype-phenotype in pediatric sleep-related breathing disorders Leila Kheirandish-Gozal and David Gozal; Part VII. Circadian Rhythm Sleep Disorders: 30. Genetic of familial advanced sleep phase Suet Ying Chong, Louis J. Ptacek and Ying-Hui Fu; 31. Delayed sleep phase disorder, circadian genes, sleep homeostasis and light sensitivity Simon N. Archer and Derk-Jan Dijk; Part VIII. Parasomnias and Sleep-related Movement Disorders: 32. Family and genome-wide association studies of restless legs syndrome Eva C. Schulte and Juliane Winkelmann; Part IX. Psychiatric and Medical Disorders: 33. Circadian clock genes and psychiatric disorders Marc Cuesta, Nicholas Cermakian and Diane B. Boivin; 34. Genetics of autosomnal dominant nocturnal frontal lobe epilepsy Keivan Kaveh Moghadam and Giuseppe Plazzi; Part X. Medication Effects: 35. Gene therapy for sleep disorders Dheeraj Pelluru, RodaRani Konadhode, Carlos Blanco-Centurion, Meng Liu and Priyattam J. Shiromani; Index. Contributors Amelie Baud, Jonathan Flint, Elizabeth J. Rossin, Benjamin M. Neale, Patrick Sleiman, Michael March, Hakon Hakonanson, Christer Hublin, Jaakko Kaprio, Stephane Dissel, Paul J. Shaw, David A. Prober, David M. Raizen, Antoine Adamantidis, Matthew E. Carter, Luis De Lecea, Yoshihiro Urade, Michael Lazarus, Marcos G. Frank, Matthew S. Thimgan, Karen D. Schilli, Peng Jiang, Andrew Kasarskis, Christopher J. Winrow, John J. Renger, Fred W. Turek, Ethan Buhr, Joseph S. Takahashi, Irfan A. Qureshi, Mark F. Mehler, Thomas Curie, Mehdi Tafti, Valérie Mongrain, Paul Franken,Till Roenneberg, Karla V. Allebrandt, Laurent Seugnet, Paul Salin, Devon A. Grant, Hans P. A. Van Dongen, Simon N. Archer, Derk-Jan Dijk, Jennifer H. K. Choi, Ted Abel, Chiara Cirelli, Giulio Tononi, Yves Dauvilliers, Charles M. Morin, Katsushi Tokunaga, Makoto Honda, Takeshi Sakurai, Seiji Nishino, Hyun Hor, Seiji Nishino, Takashi Kanbayashi, Michael Billiard, Rosa Periata-Adrados, Annette C. Fedson, Thorarinn Gislason, Allan I. Pack, Leila Kheirandish-Gozal, David Gozal, Suet Ying Chong, Louis J. Ptacek, Ying-Hui Fu, Eva C. Schulte, Juliane Winkelmann, Marc Cuesta, Nicholas Cermakian, Diane B. Boivin, Keivan Kaveh Moghadam, Giuseppe Plazzi, Dheeraj Pelluru, RodaRani Konadhode, Carlos Blanco-Centurion, Meng Liu, Priyattam J. Shiromani

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Neurology and Clinical Neuroscience

The Stroke Book 2nd edition Edited by Michel T. Torbey, Magdy H. Selim

NEW EDITION

HB | 9781107634725 | £38.00 Pages | 400 101 b/w illustrations 17 colour illustrations 58 tables

PUBLICATION | JUL 2013

Designed for use by busy professionals who need quick answers, this revised and updated second edition of The Stroke Book is a concise and practical reference for anyone involved in managing critically ill cerebrovascular patients. Features of this new edition: • Covers a wide range of common conditions such as ischemic and hemorrhagic strokes, subarachnoid hemorrhages and intracranial aneurysms • Provides focused protocols for assessing and treating stroke patients in the emergency room, intensive care unit or general hospital setting • A new chapter summarizes key clinical trials for stroke therapies • User-friendly format • Packed with algorithms, tables and summary boxes for immediate access to key information • A color plate section illustrates key pathology and diagnostic imaging Written by experienced contributors from leading stroke centers, this is an essential companion for navigating stroke-related clinical situations successfully and making informed decisions about treatment.

WHY IT WILL SELL • Algorithms, tables and summary boxes give immediate easy access to recommended management strategies • A color plate section illustrates key pathology and diagnostic imaging • The results of major clinical trials are summarized, facilitating evidence-supported practice

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Neurology and Clinical Neuroscience

Contents Foreword; Preface; Part I. Assessment of Stroke Patients: 1. Emergency medical services (EMS): first line of defense against stroke Noah Grose and Michel Torbey; 2. Initial assessment of patients with stroke-like symptoms Martinson K. Arnan and Rafael H. Llinas; 3. Clinical stroke syndromes and localization Richard P. Goddeau, Jr; Part II. The Hunt for a Stroke Etiology: 4. The hunt for a stroke etiology: ischemic stroke Alex Perchuk and Réza Behrouz; 5. The hunt for a stroke etiology: hemorrhagic stroke Angelos Katramados and Panayiotis Varelas; 6. Uncommon causes of stroke and stroke mimics Andrew W. Tarulli; Part III. Acute Stroke Imaging: 7. Computed tomography in acute stroke Jason M. Johnson and Michael H. Lev; 8. Magnetic resonance imaging in acute stroke Magdy Selim; 9. Neurosonology in acute ischemic stroke Maher Saqqur, Vijay Sharma and Andrei V. Alexandrov; Part IV. Management of Stroke Patients: 10. Ischemic stroke in the first 24 hours Magdy Selim; 11. Management of the acute ischemic stroke patient beyond 24 hours Eric Bershad and Jose I. Suarez; 12. Intracerebral hemorrhage Katja Elfriede Wartenberg and Stephan A. Mayer; 13. Subarachnoid hemorrhage and its medical management Susan Yeager and Diana GreeneChandos; 14. Dural and cerebral venous thrombosis Joshua Kornbluth and Romergryko G. Geocadin; Part V. Stroke in Consultation: 15. Perioperative stroke Hardik Amin and David M. Greer; 16. Stroke on OB/Gyn wards Ann K. Helms; 17. Stroke on pediatric wards Catherine AmlieLefond; Part VI. Prevention of First and Recurrent Stroke: 18. Antithrombotic therapies Sarah Adriance and Michel Torbey; 19. Surgical and endovascular therapies Ciaran Powers and Eric Sauvageau; 20. Stroke risk factors: impact and management Laura Pedelty and Philip B. Gorelick; 21. Synopsis of landmark studies in ischemic stroke Magdy Selim; Index. Contributors Noah Grose, Michel Torbey, Martinson K. Arnan, Rafael H. Llinas, Richard P. Goddeau, Jr, Alex Perchuk, Réza Behrouz, Angelos Katramados, Panayiotis Varelas, Andrew W. Tarulli, Jason M. Johnson, Michael H. Lev, Maher Saqqur, Vijay Sharma, Andrei V. Alexandrov, Eric Bershad, Jose I. Suarez, Katja Elfriede Wartenberg, Stephan A. Mayer, Susan Yeager, Diana Greene-Chandos, Joshua Kornbluth, Romergryko G. Geocadin, Hardik Amin, David M. Greer, Ann K. Helms, Catherine Amlie-Lefond, Sarah Adriance, Ciaran Powers, Eric Sauvageau, Laura Pedelty, Philip B. Gorelick

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Obstetrics & Gynaecology, Reproductive Medicine

Biology and Pathology of the Oocyte 2nd edition Role in Fertility, Medicine and Nuclear Reprograming Edited by Alan Trounson, Roger Gosden, Ursula Eichenlaub-Ritter

NEW EDITION HB | 9781107021907 | £95.00 Pages | 464 46 b/w illustrations 71 colour illustrations

PUBLICATION | OCT 2013

The human egg - the rarest and most rapidly aging cell in the body - is a topic of intense scientific study. Assisted reproduction clinics are constantly vying to improve success rates - choosing the best gametes is a key step in this process. This new edition of what one reviewer of the first edition described as 'possibly the definitive work on the oocyte' covers the development, biology and pathology of the oocyte, and technologies to manipulate, enhance and control fertility. These technologies are used to overcome infertility, avoid inherited diseases, and create genetically engineered embryos from stem cells and cloning. This progress would have been impossible without the myriad of scientific and technical developments covered in this book. The new edition is thoroughly updated and includes major new research on reprogramming, oocyte molecular development, cryopreservation and viability. We are in exciting times for the egg.

WHY IT WILL SELL • Covers an area of reproductive medicine with huge commercial implications – strong incentive for purchase to improve a clinic's outcomes • Professor Trounson's name is synonymous with research on oocytes and stem cells • Expanded content with major new focus on molecular processes

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Obstetrics & Gynaecology, Reproductive Medicine

Contents Preface; Part I. Historical Perspective: 1. Insights into the amphibian egg to understand the mammalian oocyte Kei Miyamoto and John B. Gurdon; Part II. Life Cycle: 2. Otogeny of the mammalian oocyte Anne Grete Byskov and Majken Nielsen; 3. Gene networks in oocyte meiosis Paula Cohen and Swapna Mohan; 4. Follicle formation and oocyte death Melissa E. Pepling; 5. The early stages of follicular growth Alain Gougeon; 6. Follicle and oocyte developmental dynamics Aaron J. W. Hsueh and Kazuhiro Kawamura; 7. Mouse models to identify genes throughout oogenesis Jia Peng, Qinglei Li and Martin M. Matzuk; Part III. Developmental Biology: 8. Structural basis for oocyte-granulosa cell interactions Ursula Eichenlaub-Ritter and Carlos Plancha; 9. Differential gene expression mediated by oocyte/granulosa cell communication Saiichi Furukawa and Koji Sugiura; 10. Hormones and growth factors in the regulation of oocyte maturation Marco Conti; 11. Getting into and out of oocyte maturation Hayden Homer; 12. Chromosome behavior and spindle formation in mammalian oocytes Heide Schatten and QingYuan Sun; 13. Transcription, accumulation, storage, recruitment, and degradation of maternal mRNA in mammalian oocytes Santhi Potireddy, Dasari Amarnath and Keith E. Latham; 14. Setting the stage for fertilization: transcriptome and maternal factors Scott Coonrod; 15. Egg activation: initiation and decoding of Ca2+ signalling John Carroll and Karl Swann; 16. In vitro growth and differentiation of oocytes Hang Yin and Roger Gosden; 17. Metabolism of the follicle and oocyte in vivo and in vitro Helen M. Picton and Karen E. Hemmings; 18. Improving oocyte maturation in vitro Jeremy G. Thompson and Robert B. Gilchrist; Part IV. Imprinting and Reprogramming: 19. Human genes modulating primordial germ-cell and haploid gamete formation Valerie L. Baker, Ruth Lathi and Renee A. Reijo Pera; 20. In vitro differentiation of germ cells from stem cells Fumihiro Sugawa, Karin Hübner and Hans R. Schöler; 21. Parthenogenesis and parthenogenetic stem cells Tiziana A. L. Brevini and Fulvio Gandolfi; 22. Epigenetic consequences of stomatic cell nuclear transfer and induced pluripotent stem cell reprogramming Jose Cibelli, Victoria L. Mascetti and Roger A. Pedersen; 23. Primate and human somatic cell nuclear transfer Rita P. Cervera and Shoukhrat Mitalipov; Part V. Pathology: 24. Gene expression in human oocytes Gayle M. Jones and David S. Cram; 25. Omics as tools for oocyte selection Marc-André Sirard and Isabelle Gilbert; 26. The legacy of mitocondrial DNA Helen A. L. Tuppen, Mary Herbert and Doug M. Turnbull; 27. Relative contribution of advanced age and reduced follicle pool size on reproductive success: the quantity-quality enigma Frank Broekmans and Madeleine Dólleman; 28. Cellular origin of age-related aneuploidy in mammalian oocytes Ursula Eichenlaub-Ritter and Roger Gosden; 29. Alterations in the gene expression of aneuploid oocytes and associated cumulus cells Dagan Wells; 30. Transgenerational risks by exposure in utero Miguel A. Velazquez and Tom P. Fleming; 31. Obesity and oocyte quality Rebecca L. Robker and Robert J. Norman; 32. Safety of ovarian stimulation Dominic Stoop, Ellen Anckaert and Johan Smitz; 33. Oocyte epigenetics and the risks for imprinting disorders associated with assisted reproduction Serge McGraw and Jacquetta Trasler; 34. Genetic basis for primary ovarian insufficiency Luca Persani, Stephanie Sherman and Lawrence Nelson; Part VI. Technology and Clinical Medicine: 35. Polar body screening for aneuploidy in human oocytes Luca Gianaroli, M. Christina Magli and Anna P. Ferraretti; 36. Cytopreservation of oocytes Alan Trounson and Laura Rienzi; 37. Transplantation of ovarian tissue or immature oocytes to preserve and restore fertility in humans Sherman Silber, Natalie Barbey and David Silber; Index. Contributors Kei Miyamoto, John B. Gurdon, Anne Grete Byskov, Majken Nielsen, Paula Cohen, Swapna Mohan, Melissa E. Pepling, Alain Gougeon, Aaron J. W. Hsueh, Kazuhiro Kawamura, Jia Peng, Qinglei Li, Martin M. Matzuk, Ursula Eichenlaub-Ritter, Carlos Plancha, Saiichi Furukawa, Koji Sugiura, Marco Conti, Hayden Homer, Heide Schatten, Qing-Yuan Sun, Santhi Potireddy, Dasari Amarnath, Keith E. Latham, Scott Coonrod, John Carroll, Karl Swann, Hang Yin, Roger Gosden, Helen M. Picton, Karen E. Hemmings, Jeremy G. Thompson, Robert B. Gilchrist, Valerie L. Baker, Ruth Lathi, Renee A. Reijo Pera, Fumihiro Sugawa, Karin Hübner, Hans R. Schöler, Tiziana A. L. Brevini, Fulvio Gandolfi, Jose Cibelli, Victoria L. Mascetti, Roger A. Pedersen, Rita P. Cervera, Shoukhrat Mitalipov, Gayle M. Jones, David S. Cram, Marc-André Sirard, Isabelle Gilbert, Helen A. L. Tuppen, Mary Herbert, Doug M. Turnbull, Frank Broekmans, Madeleine Dólleman, Dagan Wells, Miguel A. Velazquez, Tom P. Fleming, Rebecca L. Robker, Robert J. Norman, Dominic Stoop, Ellen Anckaert, Johan Smitz, Serge McGraw, Jacquetta Trasler, Luca Persani, Stephanie Sherman, Lawrence Nelson, Luca Gianaroli, M. Christina Magli, Anna P. Ferraretti, Alan Trounson, Laura Rienzi, Sherman Silber, Natalie Barbey, David Silber

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Obstetrics & Gynaecology, Reproductive Medicine

Contraception A Casebook from Menarche to Menopause Edited by Paula Briggs, Gabor Kovacs, in consultation with John Guillebaud

PB | 9781107614666 | £40.00 Pages | 272 25 b/w illustrations Publication | July 2013

REVIEW COPIES AVAILABLE

Planned parenthood - and its associated reproductive and sexual healthcare issues - has massive socioeconomic and demographic consequences worldwide. Modern contraception played a major role in the emancipation of women and has huge potential for a sustainable future world population. Yet it is a medical topic which always raises controversy, with serious ethical, religious and cultural overtones. This is an authoritative guide for all those working in reproductive healthcare. Highly practical, evidencebased, with enough detail to inform effective clinical practice, the book is structured on a lifestage approach, mirroring everyday experience of practitioners. All forms of contraceptives are covered in detail, with guidance on prescribing, the advantages and disadvantages of various techniques, and possible complications. The wider field of reproductive healthcare including subfertility and sexual assault are also covered. An ideal guide to contraception for trainees in obstetrics and gynaecology, primary care physicians and nurse-practitioners.

WHY IT WILL SELL • Takes a lifestage approach, recommending effective contraception for different age groups – mirrors everyday practice in the clinic • All forms of contraception covered, including barrier methods and vasectomy • Places contraception in a wider healthcare perspective, whilst recognizing relevant ethical, religious and cultural issues

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Obstetrics & Gynaecology, Reproductive Medicine

Contents Foreword; Preface; 1. What do women want from their contraceptives … and what we can offer Johannes Bitzer; 2. Myths and misconceptions about sex and con(tra)ception Rik H. W. van Lunsen; 3. The history of contraception Lesley Smith; 4. Physiology of the menstrual cycle, and natural family planning Gabor Kovacs and Paula Briggs; 5. The oestrogen component of currentlyused steroidal contraceptives David Crook; 6. The risk of oestrogens in contraceptives Sven O. Skouby; 7. Progestogens used in contraceptives Susanna Hall and Ailsa Gebbie; 8. The contraceptive consultation Caroline Harvey, Kathleen Mcnamee and Deborah Bateman; 9. Menarche and associated problems Mary Hernon and Vicky Sephton; 10. Adolescence – contraception in the teenage years Kathy French; 11. The twentysomething Paula Briggs; 12. Contraception in the thirtysomethings Anne Szarewski; 13. Contraception in the fortysomethings Sunanda Gupta and Ali A. Kubba; 14. The fiftysomething Marie-Odile Gerval, Nicholas Panay and Paula Briggs; 15. What is the risk of cancer with hormonal contraception? Philip C. Hannaford and Lisa Iversen; 16. New developments in female sterilisation Gabor Kovacs and Paula Briggs; 17. Male sterilisation Tina Peers and Tony Feltblower; 18. Emergency contraception Anne Connolly and Lynne Garforth; 19. Sexually transmissible infections and pelvic pain, what you really need to know Mike Abbott; 20. Medical termination of pregnancy Kristina Gemzell-Danielsson; 21. Surgical termination of pregnancy Kate Guthrie; 22. Primary care treatment of subfertility, and what every health professional needs to know about Assisted Reproductive Technology Gabor Kovacs; 23. Sexual assault Catherine White; 24. Future developments in contraception Jean-Jacques Amy; Index. Contributors Johannes Bitzer, Rik H. W. van Lunsen, Lesley Smith, Gabor Kovacs, Paula Briggs, David Crook, Sven O. Skouby, Susanna Hall, Ailsa Gebbie, Caroline Harvey, Kathleen Mcnamee, Deborah Bateman, Mary Hernon, Vicky Sephton, Kathy French, Anne Szarewsk, Sunanda Gupta, Ali A. Kubba, Marie-Odile Gerval, Nicholas Panay, Philip C. Hannaford, Lisa Iversen, Tina Peers, Tony Feltblower, Anne Connolly, Lynne Garforth, Mike Abbott, Kristina Gemzell-Danielsson, Kate Guthrie, Catherine White, Jean-Jacques Amy

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Obstetrics & Gynaecology, Reproductive Medicine

Stem Cells in Reproductive Medicine Basic Science and Therapeutic Potential 3rd edition Edited by Carlos Simón, Antonio Pellicer, Renee Reijo Pera

HB | 9781107034471 | £85.00 Pages | 195 12 b/w illustrations 56 colour illustrations 11 tables Publication | July 2013

REVIEW COPIES AVAILABLE

Stem cell science has the potential to impact human reproductive medicine significantly – cutting edge technologies allow the production and regeneration of viable gametes from human stem cells offering potential to preciously infertile patients. Written by leading experts in the field Stem Cells in Reproductive Medicine brings together chapters on the genetics and epigenetics of both the male and female gametes as well as advice on the production and regeneration of gene cells in men and women, trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a section on new developments in stem cell research. The book is essential reading for reproductive medicine clinicians, gynaecologists and embryologists who want to keep abreast of practical developments in this rapidly developing field.

WHY IT WILL SELL • Up-to-date practical information in a rapidly developing field • New edition of a highly respected book - this is the first edition published by Cambridge University Press • Due to the rapid developments in the field the market for this book is increasing

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Obstetrics & Gynaecology, Reproductive Medicine

Contents Preface; Foreword: views from a pioneer Alan Trounson; Part I. Female Gamete: 1. Genetics of the germline formation Orkan Ilbay and Emre Seli; 2. Germ cell differentiation from pluripotent cells Jose V. Medrano, Ana M. Martínez-Arroyo, Carlos Simón and Renee A. Reijo Pera; Part II. Male Gamete: 3. The male gamete Nicolás Garrido, Rocío Rivera and Marcos Meseguer; 4. In vitro production of functional sperm from neonatal mouse testes Takehiko Ogawa; 5. Adult stem cell population in the human testis Ellen Goossens and Herman Tournaye; Part III. The Embryo/Blastomere: 6. Meiotic recombination in human oocytes Jennifer R. Gruhn, Karl W. Broman, Patricia A. Hunt and Terry J. Hassold; 7. Gene expression dynamics during human embryonic development Carlos Simón and Renee A. Reijo Pera; 8. Embryonic stem cells from blastomeres maintaining embryo viability Irina Klimanskaya; 9. Gamete generation from stem cells to avoid gamete donation and customized hESC from blastomeres as the cellular insurance for the newborn: will it ever be ethically acceptable? Heidi Mertes and Guido Pennings; Part IV. Trophoblast, Amniotic Fluid, Endometrium and Bone Marrow: 10. Amniotic fluid and placental membranes: unexpected sources of highly multipotent cells Sean Vincent Murphy and Anthony Atala; 11. Adult stem cells in the human endometrium Caroline E. Gargett, Irene Cervelló, Hong P. T. Nguyen and Carlos Simón; 12. In utero hematopoietic cell transplantation Amar Nijagal and Tippi C. MacKenzie; 13. Bone marrow stroma: a source of mesenchymal stem cells for cell therapy Agustín G. Zapata; Part V. New Developments in Stem Cell Research: 14. Dedifferentiation, transdifferentiation and reprogramming Sergio Mora and Angel Raya; 15. The metabolic framework of pluripotent stem cells and potential mechanisms of regulation Alexandra J. Harvey, Joy Rathjen and David K. Gardner; Index. Contributors Alan Trounson, Orkan Ilbay, Emre Seli, Jose V. Medrano, Ana M. Martínez-Arroyo, Carlos Simón, Renee A. Reijo Pera, Nicolás Garrido, Rocío Rivera, Marcos Meseguer, Takehiko Ogawa, Ellen Goossens, Herman Tournaye, Jennifer R. Gruhn, Karl W. Broman, Patricia A. Hunt, Terry J. Hassold, Irina Klimanskaya, Heidi Mertes, Guido Pennings, Sean Vincent Murphy, Anthony Atala, Caroline E. Gargett, Irene Cervelló, Hong P. T. Nguyen, Amar Nijagal, Tippi C. MacKenzie, Agustín G. Zapata, Sergio Mora, Angel Raya, Alexandra J. Harvey, Joy Rathjen, David K. Gardner

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Oncology

Molecular Oncology Causes of Cancer and Targets for Treatment Edward P. Gelmann, Charles L. Sawyers, Frank J. Rauscher III

HB | 9780521876629 | £125.00 Pages | 796 48 b/w illustrations 317 colour illustrations

PUBLICATION | DEC 2013

The genomic era has allowed enormous strides in our understanding of the molecular changes that underlie malignant transformation. Mutations have been discovered that are critical drivers of large cross-sections of human cancers. These discoveries have allowed us to find drugs that target these drivers and make important strides in treatment. Genomics and high-throughput technologies have illuminated the complexity of cancer and the facility with which cancers adapt during their natural history. The field is evolving rapidly with new discoveries and new drugs reported monthly. This book is a timely foundation for understanding in context the origins of molecular oncology and its future directions. The content reviews available technologies for the analysis of cancer tissues and genes; summaries of key oncogenic pathways from a molecular perspective; the technologies, pathways and targeted therapies of a wide range of human malignancies; and new pharmacologic therapies that have a common mechanistic target.

WHY IT WILL SELL • Fully comprehensive: covers molecular changes in a wide range of human cancers, how these are analysed, and molecular therapeutic approaches • Demonstrates how basic research informs clinical practice and pharmacologic developments • High-quality team of editors and contributors recruited from some of the leading cancer centers worldwide

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Oncology

Contents Part I; Part II; Part III; Part IV. Pharmacologic Targeting of Oncogenic Pathways. Contributors Abizar Lakdawalla, Jeffrey Fisher, Mostafa Ronaghi, Jian-Bing Fan, Zsofia K. Stadler, Sohela Shah, Kenneth Offit, Donna G. Albertson, Daniel Pinkel, Thomas Ried, Marsha Reyngold, Timothy A. Chan, Edward P. Gelmann, S. Hanash, A. Taguchi, Paramita Ghosh, Yun Qiu, Ling-Yu Wang, Hsing-Jien Kung, Valsamo K. Anagnostou, David L. Rimm, Wolfgang J. Köstler, Yosef Yarden, Michael Pollak, Ying Li, Lopa Mishra, Arne Östman, Carl Henrik Heldin, Soheil Meshinchi, Derek L. Stirewalt, Karen Pulford, Fen Wang, Yongde Luo, Wallace L. McKeehan, Fabiola Cecchi, Young H. Lee, Donald P. Bottaro, Kevin D. Courtney, Lewis C. Cantley, Rosalyn B. Irby, Timothy J. Yeatman, Masura Katoh, Adrienne D. Cox, Molly J. DeCristo, Moriah H. Nissan, David B. Solit, Vikas Sehdev, Altaf A. Dar, Wael El-Rifai, Alexandra K. Gardino, Michael B. Yaffe, Hua Yu, Richard Jove, Michael D. Cole, Shira Anzi, Eitan Shaulian, Chuay-Yeng Koo, Kyle W. Muir, Eric W. F. Lam, Willscott E. Naugler, Michael Karin, Xinchen Teng, J. Marie Hardwick, Jody White, Nicole L. Moore, Margaret M. Centenera, Lisa M. Butler, Theresa E. Hickey, Wayne D. Tilley, Chenguang Wang, Xuemin Zhang, Richard G. Pestell, Yosef Shiloh, Byungchan Ahn, Tinna Stevnsner, Vilhelm A. Bohr, Errol C. Friedberg, Roger A. Schultz, Jerry W. Shay, Woodring E. Wright, Erik S. Knudsen, Ryan J. Bourgo, Elizabeth L. Gosnell, Jeffry L. Dean, A. Kathleen McClendon, Shun J. Lee, Benjamin F. O'Connor, Scott A. Stuart, Jean Y. J. Wang, Robert C. A. M. van Waardenburg, MaryAnn Bjornsti, Milena S. Nicoloso, George A. Calin, Kelly Quesnelle, Jennifer Grandis, Karl Munger, Marshall R. Posner, Jill E. Larsen, John D. Minna, DuyKhanh Pham, Thomas A. D'Amico, Yoshiaki Ito, Yeoh Khay Guan, Allan Spigelman, Janindra Warusavitarne, Erin M. Perchiniak, Joanna Groden, Siong-Seng Liau, David A. Tuveson, Augusto Villanueva, Yujin Hoshida, Derek Y. Chiang, Josep M. Llovet, Kyle A. Furge, Bin T. Teh, Robert S. Svatek, Colin P. Dinney, Kaustubh Datta, Donald J. Tindall, Nancy E. Hynes, Gwen MacDonald, Grace K. Suh, Bryan T. Hennessy, Roeland Verhaak, Ji-Yeon Yang, Gordon B. Mills, Robert C. Bast, Jr, J. Wolter Oosterhuis, John Doorbar, Chang-Hyuk Kwon, Dennis K. Burns, Luis F. Parada, Shereen Ezzat, Sylvia L. Asa, Vandana Batra, Rebecca J. Deyell, John M. Maris, Rachel S. Darken, David H. Gutmann, Carter Van Waes, Yansong Bian, Clint T. Allen, John C. Morris, Zhong Chen, Ervin H. Epstein, Jr, Adina Vultur, Keiran Smalley, Meenhard Herlyn, James A. Fagin, Julio C. Ricarte Filho, Edward M. Brown, Andrew Arnold, Jo W. M. Höppener, C. J. M Lips, Koen Dreijerink, Lee Helman, Christof Schneider, Laura Pasqualucci, Riccardo Dalla-Favera, Kim L. Rice, Monica Buzzai, Jessica Altman, Jonathan D. Licht, Valérie Lallemand-Breittenbach, Hugues de Thé, Ido Paz-Priel, Alan D. Friedman, Francesco Bertoni, Francesco Forconi, Michele Dal-Bo, Antonella Zucchetto, Riccardo Bomben, Giovanni Del Poeta, Valter Gattei, Charles L. Sawyers, W. Michael Kuehl, P. Leif Bergsagel, Donald H. C. Macdonald, Andreas Reiter, Nicholas C. P. Cross, Ross L. Levine, Jeffrey A. Toretsky, Aerang Kim, Bryan C. Barnhart, Marco M. Gottardis, Matthew V. Lorenzi, Siyuan Zhang, Dihua Yu, Antonio Gualberto, Timothy Hla, Nasser Altorki, Vivek Mittal, Anne S. Tsao, Vassiliki Papadimitrakopoulou, Roy Herbst, Ping Fan, V. Craig Jordan, A. Robert MacLeod, C. Frank Bennett, Dario C. Altieri, Jean-Pierre Issa, Paul A. Marks, Tito Fojo, Susan M. Henshall, Andrew V. Biankin, Brian M. Alexander, Alan D. D'Andrea

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Pathology and Laboratory Science

Breast Cytohistology Joan Cangiarella, Aylin Simsir, Sana O. Tabbara Each volume in this richly illustrated series, published in association with the Papanicolaou Society of Cytopathology, provides an organ-based approach to the cytological and histological diagnosis of small tissue samples. Benign, pre-malignant and malignant entities are presented in a well-organized and standardized format, with high-resolution color photomicrographs, tables, and lists of key specific morphologic criteria. Example vignettes allow the reader to assimilate the diagnostic principles in a case-based format. This volume provides comprehensive coverage of both surgical pathology and cytopathology of breast lesions. With a focus on malignant tumors, the full spectrum of inflammatory disorders, benign lesions, and hyperplasias are also covered in detail. Advantages and disadvantages of aspiration and core biopsy are discussed, as well as ancillary testing such as hormonal and molecular markers. With over 200 printed photomicrographs and a CD-ROM offering all images in a downloadable format, this is an important resource for all anatomic pathologists. Contents 1. Minimally invasive breast biopsy: the breast imager's perspective Jessica Torrente, Allison Yingling and Rachel F. Brem; 2. Advantages and disadvantages of FNA and core biopsies: diagnostic accuracy and precision for aspiration biopsy in the diagnosis of lesions of the breast Joan Cangiarella and Aylin Simsir; 3. Utility of aspiration and core biopsy of breast lesions and sentinel lymph nodes Abeer Tabbarah and Sana O. Tabbara; 4. Benign entities Pascale Levine and Joan Cangiarella; 5. Epithelial lesions: benign and premalignant lesions Samantha Easley; 6. Epithelial lesions: invasive tumors M. Katayoon Rezaei; 7. Fibroepithelial lesions Aylin Simsir and Alexander Finkelstein; 8. Myoepithelial neoplasms Joan Cangiarella; 9. Mesenchymal lesions Osvaldo Hernandez and Xiao Jun Wei; 10. Hematopoetic lesions Kasturi Das and Wei Sun; 11. Metastases to the breast Xiaosong Li and Aylin Simsir; 12. Ancillary testing Alejandro Luiña Contreras; Index. Contributors Jessica Torrente, Allison Yingling, Rachel F. Brem, Joan Cangiarella, Aylin Simsir, Abeer Tabbarah, Sana O. Tabbara, Pascale Levine, Samantha Easley, M. Katayoon Rezaei, Alexander Finkelstein, Osvaldo Hernandez, Xiao Jun Wei, Kasturi Das, Wei Sun, Xiaosong Li, Alejandro Luiña Contreras

HB | 9780521515535 | £110.00 Pages | 257 18 b/w illustrations 279 colour illustrations

PUBLICATION | AUG 2013

WHY IT WILL SELL • Bridges cytologic and surgical diagnoses in lesions of the breast • Richly illustrated with over 500 high-quality colour images and a CD-ROM containing all images in a downloadable format • Includes numerous clinical vignettes, offering a valuable case-based approach to diagnosis

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Surgery

Medical Management of the Surgical Patient A Textbook of Perioperative Medicine

5th edition Edited by Michael F. Lubin, Thomas F. Dodson, Neil H. Winawer

NEW EDITION

HB | 9781107009165 | £120.00 Pages | 840 30 b/w illustrations

PUBLICATION | AUG 2013

Now in its fifth edition, Medical Management of the Surgical Patient: A Textbook of Perioperative Medicine has been fully revised and updated and continues to provide an authoritative account of all aspects of perioperative care for surgical patients. Including recommended plans which aid accurate treatment of patients, it provides an evidence-based approach for consulting physicians to care for patients with underlying medical conditions that will affect their surgical management. The latest minimally invasive surgical techniques are included, with new chapters on thoracic aortic disease, reconstruction after cancer ablation, lung transplantation, esophagomyotomy, vasectomy and thyroid malignancies, amongst others. With detailed descriptions of nearly one-hundred operations, highlighting their usual course as well as their common complications, the book encourages learning from experience. This definitive account includes numerous contributions from leading experts at national centers of excellence. It will continue to serve as a significant reference work for internists, hospitalists, anesthesiologists and surgeons.

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WHY IT WILL SELL • Definitive account of perioperative care for a wide range of surgical patients • A significant reference work for all healthcare professionals dealing with surgical patients • New minimally invasive surgical procedures are covered highlighting their usual course and common complications

Surgery

Contents Part I. Medical Management; Part II. Surgical Procedures and their Complications; Section 1. General Surgery. Contributors L. Reuven Pasterna, Vivian M. Zhao, Thomas R. Ziegler, Eva Rimler, Danielle Jones, Nathan Spell, J. Richard Pittman, Jason Lesandrini, Carl C. Hug, Kathleen Kinlaw, Anne Marie Mckenzie-Brown, Michael F. Lubin, Niels Engberding, Howard Weitz, Taki Galanis, Geno J. Merli, Craig R. Keenan, Alvaro Velasquez, Michelle V. Conde, Valarie A. Lawrence, Annette Esper, Raja-Elie E. Abdulnour, Bruce D. Levy, Carter G. Co, David A. Quintero, Eric G. Honig, Michael A. Poles, Frederick Gandolfo, Kristina Chacko, Lorenzo Rossaro, Sooraj Tejaswi, Andrew Boxer, James R. Eckman, Mrinal Dutia, Eve Rodler, Ted Wun, Julie Katz Karp, Christopher D. Hillyer, Beth H. Shaz, Stuart Cohen, Jennifer Brown, Jeffrey L. Lennox, James P. Steinberg, Shanta M. Zimmer, Andrew I. Chin, Jane Y. Yeun, Burl R. Don, Steven M. Gorbatkin, Pamela T. Prescott, Ronald Mackenzie, John Axford, Kumiko Owada, Duncan Borland, Michael Frankel, Monica W. Parker, James J. Lah, Allan I. Levey, Jaffar Khan, Christine Esper, Jorge L. Juncos, Neil H. Winawer, Yelena Melvakova, Madhuri Rao, John G. Kral, Sudha Tata, Remzi Bag, Ram Subramanian, Kathleen Nilles, Stephen Pastan, Nisha N. Shah, Charles L. Raison, Ted Parran, Jr, Stacy Higgins, Jyotirmay Sharma, David V. Feliciano, Jahnavi K. Srinivasan, Edward Lin, John F. Sweeney, Kevin W. McConnell, Rebecca L. Coefield, W. Brent Keeling, Vinod H. Thourani, Omar M. Lattouf, Bryon J. Boulton, William A. Cooper, Duc Q. Nguyen, J. David Vega, Bradley G. Leshnower, Edward P. Chen, Adil Sadiq, Felix G. Fernandez, Radu F. Neamu, David C. Neujahr, Seth D. Force, Kamal A. Mansour, Kumari N. Adams, Allan Pickens, Harrell Lightfoot, Jayer Chung, Thomas F. Dodson, Naren Gupta, James G. Reeves, Ravi K. Veeraswamy, Luke P. Brewster, Matthew A. Corriere, Paul J. Riesenman, Karthikeshwar Kasirajan, Atef A. Salam, Wright A. Jones, Grant W. Carlson, Kimberly A. Singh, John H. Culbertson, Benjamin L. Moosavi, Albert Losken, J. Nicolas Mclean, Neil D. Saunders, Mark D. Walsh, Garrett Harper, Walter Ingram, Cyril O. Spann, Erica C. Dun, S. Robert Kovac, Gina M. Northington, Carla P. Roberts, Leda Gattoc, Sharmila Makhija, Ira R. Horowitz, Kenneth L. Hill, Jr, Jeffrey J. Olson, Mark J. Dannenbaum, Sung Bae Lee, C. Michael Cawley, Daniel L. Barrow, Anthony Sribnick, Sanjay Singh Dhall, Osama N. Kashlan, David V. LaBorde, Robert E. Gross, Vladimir Dadashev, Nelson Oyesiku, Gerald E. Rodts, Jr, Maxwell Boakye, Regis W. Haid, Jr, John F. Payne, G. Baker Hubbard, Timothy W. Olsen, Rupa Shah, Joung Y. Kim, Yuri McKee, Hassan T. Rahman, Bonnie B. Germain, Anastasios P. Costarides, J. Bradley Randleman, Natario L. Couser, Amy K. Hutchinson, Jill R. Wells, Michael S. Sridhar, John W. Xerogeanes,Greg Erens, Thomas Bradbury, James Roberson, William M. Reisman, Thomas J. Moore, Michael B. Gottschalk, Dheera Ananthakrishnan, John G. Heller, John M. Rhee, William C. Horton, Samuel M. Davis, A. Labib, John Louis-Ugbo, James C. Black, Shervin V. Oskouei, Alonzo T. Sexton, Lamar L. Fleming, Gary R. McGillivary, Adrienne M. Laury, Douglas E. Mattox, N. Wendell Todd, Katherine L. Hayes, Michael Baddour Jr, Melissa M. Statham, Eric E. Berg, John M. DelGaudio, Sarah K. Wise, A. Yellin, William G. Grist, Candice C. Colby, J. Trad Wadsworth, Amy Y. Chen, Charles E. Moore, Francis X. Creighton, Michael M. Johns, John G. Pattaras, Muta M. Issa, Adam B. Shrewsberry, J. De Caro, Kenneth Ogan, Peter T. Nieh, Niall T. M. Galloway, Jordan Angell, S. Mohammad A. Jafri, Chad M. W. Ritenour

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Surgery

Practical Procedures in Orthopaedic Trauma Surgery 2nd edition Edited by Peter V. Giannoudis, Hans-Christoph Pape

NEW EDITION HB | 9780521281195 | £60.00 Pages | 496 422 b/w illustrations 672 colour illustrations

PUBLICATION | DEC 2013

This highly illustrated textbook is an essential guide for surgeons in training, providing step-by-step approaches to performing surgical procedures. Practical guidance is given on patient positioning, approach and reduction techniques, which implant to insert, protocols for postoperative mobilisation, possible complications, when the patient should be seen in the outpatient clinic, and whether the implant should be removed. This second edition has been extensively expanded and revised. Additional chapters address fractures of the scapula, fractures around the elbow, around the foot and minimal invasive plate osteosynthesis procedures. All of the other chapters have been expanded and revised to comprehensively cover the range of common trauma procedures performed by surgeons in training. Written by experts in orthopaedics and trauma, the book includes numerous intraoperative colour photographs to help readers visualise the techniques described. This will be an invaluable resource for all surgical trainees in orthopaedics, trauma, and general disciplines.

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WHY IT WILL SELL • Includes over 1000 illustrations helping readers to visualise the techniques described • The concise, practical style ensures information is easy to find and absorb • Written by experts in orthopaedics and trauma from around the world, drawing on decades of collective experience

Surgery

Contents Preface; Part I. Shoulder Girdle: 1. Fractures of the clavicle Peter V. Giannoudis and George M. Kontakis; 2. Fractures of the scapula David Limb; Part II. Upper Extremity: 3.1. Fractures of the proximal humerus David Limb; 3.2. Fractures of the humeral shaft Theodoros I. Tosounidis, Peter V. Giannoudis, Ali Al-Omari, Paige Kendrick and Craig Roberts; 3.3. Fractures of the distal humerus Peter V. Giannoudis, Theodoros I. Tosounidis, Ali Al-Omari, Paige Kendrick, Craig Roberts and Brian W. Scott; 4.1. Fractures around the elbow Roger Hackney and Gertraud Gradl; 4.2. Fractures of the proximal ulna Peter V. Giannoudis, George M. Kontakis and Konstatninos M. Makridis; 4.3. Fractures of the ulnar shaft Nikolaos K. Kanakaris and George M. Kontakis; 4.4. Fractures of the distal ulna Tom Goff and Paul J. Harwood; 5.1. Fractures of the proximal radius Gertraud Gradl; 5.2. Fractures of the radial shaft Peter V. Giannoudis, Christopher Tzioupis and Brian W. Scott; 5.3. Fractures of the distal radius Theodoros I. Tosounidis, Peter V. Giannoudis, Richard Martin Sellei, Reinhard Meier and Hans-Christoph Pape; 6. Fracture of the wrist Doug Campbell; 7.1. Fractures of the first metacarpal Gertraud Gradl, Thomas Pillukat and Robert Farnell; 7.2. Fractures of the metacarpals II-V Gertraud Gradl and Thomas Pillukat; 7.3. Fractures of the phalanx Robert Farnell; Part III. Pelvis and Acetabulum: 8. Fractures of the pelvic ring Peter V. Giannoudis, Nikolaos K. Kanakaris and Theodoros I. Tosounidis; 9.1. Fractures of the acetabulum Peter V. Giannoudis and Theodoros I. Tosounidis; 9.2. Fractures of the femoral head Nikolaos K. Kanakaris and Peter V. Giannoudis; Part IV. Lower Extremity: 10.1. Extracapsular fractures of the hip Peter V. Giannoudis, Christopher Tzioupis and Theodoros I. Tosounidis; 10.2. Intracapsular fractures of the hip Michalis Panteli, Peter V. Giannoudis, Karen L. Shepherd and Paul J. Harwood; 11.1. Fractures of the femoral shaft Christian Weber, Thomas Dienstknech and Brian W. Scott; 11.2. Fractures of the distal femur Miguel Pishnamaz, Christian Weber, HansChristoph Pape, Stefan Hankemeier, Thomas Gosling, Ernesto Guerra, Carles Amat, Pablo Corona and Xavier Flores; 12. Fractures of the patella Miguel Pishnamaz; 13.1. Fractures of the proximal tibia Theodoros I. Tosounidis, Peter V. Giannoudis, Stewart J. Calder, G. Stables, Richard Martin Sellei and John F. Keating; 13.2. Fractures of the tibial shaft Joseph Borrelli, Theodoros I. Tosounidis and Peter V. Giannoudis; 13.3. Fractures of the distal tibia Theodoros I. Tosounidis, Peter V. Giannoudis, Paul Harwood and Evagelos Fragkakis; 14. Fractures of the ankle Peter V. Giannoudis, Theodoros I. Tosounidis and Richard Martin Sellei; 15. Fractures of the foot Matthias Knobe, Theodoros I. Tosounidis and Richard Buckley; Part V. Spine: 16. Spine fractures Peter Millner and Jake Timothy; Part VI. Tendon Injuries: 17. Tendon repair Theodoros I. Tosounidis, Peter V. Giannoudis, Nikolaos K. Kanakaris, Robert Winterton and Robert Farnell; Part VII. Compartments: 18. Compartment decompression Daniel Wilks, Roderick Dunn, Simon Kay, Ali AlOmari and Craig Roberts; Index. Contributors Peter V. Giannoudis, George M. Kontakis, David Limb, Theodoros I. Tosounidis, Ali Al-Omari, Paige Kendrick, Craig Roberts, Brian W. Scott, Roger Hackney, Gertraud Gradl, Konstatninos M. Makridis, Nikolaos K. Kanakaris, Tom Goff, Paul J. Harwood, Christopher Tzioupis, Richard Martin Sellei, Reinhard Meier, Hans-Christoph Pape, Doug Campbell, Thomas Pillukat, Robert Farnell, Michalis Panteli, Karen L. Shepherd, Christian Weber, Thomas Dienstknech, Miguel Pishnamaz, Stefan Hankemeier, Thomas Gosling, Ernesto Guerra, Carles Amat, Pablo Corona, Xavier Flores, Stewart J. Calder, G. Stables, John F. Keating, Joseph Borrelli, Evagelos Fragkakis, Matthias Knobe, Richard Buckley, Peter Millner, Jake Timothy, Robert Winterton, Daniel Wilks, Roderick Dunn, Simon Kay

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Surgery

Wilcox’s Surgical Anatomy of the Heart 4th edition Robert H. Anderson, Diane E. Spicer, Anthony M. Hlavacek, Andrew C. Cook, Carl L. Backer

NEW EDITION

The revised fourth edition of this classic textbook on cardiac anatomy written from the stance of the cardiac surgeon features many new images, including computed tomography angiography. The provision of multiple high quality surgical and pathological photographs makes it essential reading for cardiac surgeons, and of great value to cardiologists, surgical pathologists, radiologists and anaesthetists. The book will also be a valuable reference resource for any healthcare professional or researcher who needs to understand detailed cardiac anatomy. The book begins by describing the surgical approaches to the heart. It goes on to discuss the normal surgical anatomy of the cardiac chambers, the valves, and the systems for circulation and conduction within the heart. This provides the essential anatomical information required to assess and interpret the malformations, lesions and abnormalities discussed in the remainder of the book. Contents Preface; Acknowledgements; 1. Surgical approaches to the heart; 2. Anatomy of the cardiac chambers; 3. Surgical anatomy of the valves of the heart; 4. Surgical anatomy of the coronary circulation; 5. Surgical anatomy of cardiac conduction; 6. Analytic description of congenitally malformed hearts; 7. Lesions with normal segmental connections; 8. Lesions in hearts with abnormal segmental connections; 9. Abnormalities of the great vessels; 10. Positional anomalies of the heart; Index.

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HB | 9781107014480 | £160.00 Pages | 352 2 b/w illustrations 652 colour illustrations Publication | July 2013

REVIEW COPIES AVAILABLE

WHY IT WILL SELL • Written by an expert team of authors who are leading authorities in the field • Featuring many new images, including computed tomography angiography • Detailed colour line diagrams, drawn specifically for the book, help to explain key concepts and simplify complex descriptions

INDEX OF TITLES B Brain Disorders in Critical Illness………………………………………………………….…7 Biology and Pathology of the Oocyte 2e…….…………………………………………….35 Breast Cytohistology…………………………………………………………………………..…43

C Case Studies in Pediatric Emergency and Critical Care Ultrasound……………..11 Common Epilepsy Pitfalls………………………………………………………….……...…..20 Contraception……………………………………………….……………………………………...37 Core Radiology………………………………………………………………..……………………19

G Genetic Basis of Sleep and Sleep Disorders, The……………………………………....31

H Handbook of Drugs in Intensive Care 5e…………………………………………..……..5

L Lymphoma 2e.…………………………………………………………………………………16-17

M Magnetic Resonance Imaging in Movement Disorders…………………………21-22 Manual of Botulinum Toxin Therapy 2e….………………………………………….23-24 Manual of Stem Cell and Bone Marrow Transplantation 2e….……..….…………18 Medical Management of the Surgical Patient 5e…………..……………………...44-45 Molecular Oncology…………………………………………………………………...…….41-42

N Neurologic Differential Diagnosis…………………………………………….….……25-26 Neuropathic Pain…………………………………………………………………………….27-28 Neuropsychiatric and Cognitive Changes in Parkinson's Disease and Related Movement Disorders……………………………………………………..29-30

O Orthopedic Emergencies………………………………………………………………………..13

P Pearls and Pitfalls in Emergency Radiology……………………………………..……….3 Pearls and Pitfalls in Abdominal Imaging………………………………………..……….4 Pearls and Pitfalls in Musculoskeletal Imaging……………………………….…….…..4 Practical Emergency Resuscitation and Critical Care…………………………...14-15 Practical Procedures in Orthopaedic Trauma Surgery 2e……….…………….46-47 Problem-Based Pain Management…………………………………………….…..…….9-10

S Stem Cells in Reproductive Medicine 3e…….…………………..….….…………..39-40 Stroke Book, The 2e………………………………………………………………….……..33-34

W Wilcox's Surgical Anatomy of the Heart 4e………………………….…………….…..48

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NOTES