Greater Birmingham Life Sciences 2017

G R E AT E R B I R M I N G H A M LIFE SCIENCES

MAKING IT HAPPEN

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LIFE SCIENCES Greater Birmingham is a dynamic and ambitious region perfect for expanding companies in the Life Sciences sector. It is the rising star in world-wide life science destinations and an ideal location for small and large enterprises alike. Driven by the established biomedical and medtech community, the region encompasses cutting edge research, world-leading healthcare and investment opportunity.

Business Birmingham and Solihull for Success are inward investment agencies working together to attract foreign direct investment, and promote development in the area, as part of the European Regional Development Fund City Region Project and on behalf of the Greater Birmingham and Solihull Local Enterprise Partnership.

The region is going through an unprecedented period of transformation, and leading post-recession national growth and development trends.

With record levels of infrastructure investment, increasing international recognition, and countless opportunities for companies to thrive in the region, there has never been a better time to invest in Greater Birmingham.

Collaboration has been the catalyst for its success; with public and private sector creating pioneering partnerships to drive innovative research programmes and deliver innovative treatments in personalised healthcare and precision medicine. One of Europe’s largest, most diverse and stable patient populations has also helped this region become a global leader in Big Data.

THE UK CURRENTLY HAS

77 NOBEL PRIZES FOR CONTRIBUTIONS TO BIOMEDICAL SCIENCE

The BioHub BirminghamÂŽ

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KEY STRENGTHS "Birmingham's life sciences sector is a major growth opportunity to drive forward the regional economy; improving health, creating employment and stimulating investment"

There has never been a better time to be based in Greater Birmingham.

Global cluster of excellence

Waheed Nazir, Birmingham City Council Director of Planning and Regeneration, and Strategic Director for Economy.

Our life sciences cluster attracts international investment, talent and corporates, including AstraZeneca, Celgene, Eli Lilly, GlaxoSmithKline, Novartis and UCB Celltech. Birmingham Health Partners, a strategic alliance of three major teaching hospitals - University Hospitals Birmingham NHS Foundation Trust, Birmingham Children's Hospital and Birmingham Women's Hospital - and the University of Birmingham is the driving force for the Birmingham Life Sciences Engine.

Progress built on partnerships Pioneering partnerships between Greater Birmingham's academic institutions and its business community underpin our fast-growing healthcare ecosystem. Exceptional population diversity and scale, plus state-of-the-art facilities for R&D and clinical delivery, put us at the leading edge of medical technology and global healthcare - giving our innovative life sciences community a clear competitive advantage over other clusters in the UK and overseas.

Space to grow and prosper Birmingham's Life Sciences Park will deliver 400,000 sq ft in the Edgbaston Medical Quarter for start-ups, growing businesses and R&D labs in a science park environment. The ÂŁ8m iCentrum is Birmingham's first incubator dedicated to early-stage tech companies and developing digital solutions, with 42,000 sq ft of specialist space in the city centre.

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WHY INVEST IN GREATER BIRMINGHAM?

The Queen Elizabeth Hospital Birmingham is home to the largest solid organ transplant programme in Europe, the largest renal transplant programme in the UK, the Royal Centre for Defence Medicine.

Queen Elizabeth Hospital Birmingham

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INVESTMENT Big Pharma recognise the investment potential of Greater Birmingham’s life sciences cluster, not least for its track record to harness the research capabilities of its universities and the NHS to deliver innovative drugs, diagnostics and devices.

The Edgbaston Medical Quarter already provides an internationally-recognised centre of scientific excellence, with an array of hospitals, medical organisations, specialist care centres, GP clinics and routine care facilities.

Global giants such as AstraZeneca, Celgene, Eli Lilly, GlaxoSmithKline, Novartis and UCB Celltech have all supported research projects at the University of Birmingham (UoB). Aston University collaborators include The Wellcome Trust and Spectrum Thea.

The powerful combination of a rapidly-expanding healthcare cluster, world-leading research, one of Europe’s largest portfolios of clinical trials, and access to an ethnically-diverse and stable population of over five million, makes life sciences a major driver of the regional economy.

Investors are also attracted by the presence of Birmingham Health Partners; a strategic alliance between three major teaching hospitals University Hospitals Birmingham NHS Foundation Trust, Birmingham Children’s Hospital and Birmingham Women’s Hospital - and the UoB.

Steve Hollis, GBSLEP Chair and Deputy Head of Strategy - is a former regional chairman of KPMG and specialist in corporate finance. He believes the Greater Birmingham cluster now competes with established healthcare locations such as Boston and Singapore.

There is a clear strategic focus to ensure ample space for ventures of all sizes; from start-ups and SMEs, to fast-growing companies and corporate giants - and their supply chains.

“Our Life Sciences Commission has identified huge potential for this area to become a 21st century life sciences hub; leveraging major investment from global pharma and driving growth, whilst accelerating patient access to new treatments,” he says.

Birmingham City Council is working closely with the University of Birmingham and Greater Birmingham and Solihull Local Enterprise Partnership (GBSLEP) to bring forward the ambitious £171m Life Sciences Park, to deliver 400,000 sq ft of Grade A office space and laboratories in a science Campus environment.

The Life Science Park is located within the cluster’s clinical academic community, and provides the ideal environment for R&D, clinical trials, pharma manufacturers, regional headquarters, and expanding SMEs from across the globe.

“Greater Birmingham’s attractiveness to the life sciences industry is increasingly apparent; from growing interest by global pharma in our world-leading clinical trials infrastructure to the success of home-grown companies, such as the Birmingham-based diagnostics specialist, Binding Site”.

Research by the global real estate specialist, Cushman & Wakefield, predicted that healthcare assets will become increasingly popular for capital investment in 2017, compared to more traditional property sectors.

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TRAINING & RECRUITMENT More than 10,000 students receive life sciences education in Greater Birmingham’s academic institutions annually in such disciplines such as biomedical sciences, dental science, healthcare management, medicine and neuroscience.

The University of Birmingham has the UK’s second largest medical school, founded in 1825 and is now called the College of Medical and Dental Sciences (MDS). The largest of the university’s five colleges, with more than 1,000 staff and researchers, and £60m new research funding each year, MDS has become a major international centre for biomedical research.

The college trains some 370 medical and 400 research students and teaches around 450 post-graduates. The new £50m Birmingham Dental Hospital and School - the first such project to be delivered in the UK for almost 40 years - opened in April 2016, and will provide learning and research facilities to over 600 students a year.

Based at Pebble Mill, in the Edgbaston Medical Quarter, its clinical services will include emergency dental care, oral surgery and medicine, orthodontics, paediatric and restorative dentistry. There are also two major regional initiatives designed to ensure that the talent pool for STEM (Science, Technology, Engineering Mathematics) subjects continues to grow.

The University of Birmingham has established a specialist STEM Education Centre, which delivers a wide range of STEM enhancement and enrichment activities.

University of Birmingham Medical School

Aston University is establishing a medical school - to build upon its pioneering health research in such fields as dementia, diabetes and optometry - with around 100 undergraduates each year when fully operational, focusing on cardiovascular diseases, and issues concerning maternity and child health. The University 6

is also home to the Aston Brain Centre, which specialises in research on AHDH, autism, epilepsy, dyslexia and sleeping disorders.

Birmingham City University (BCU) is the region’s largest provider of nursing and healthcare education, and has expanded its City South (Edgbaston) campus to create a School of Life Sciences, offering courses in health, nutrition and biomedicine, with specialist laboratories, and research space.

The Academy Cube’s UK headquarters is located within BCU’s Centre for Enterprise Systems. Developed by leading international companies, this organisation aims to build the next generation of talent by addressing the challenges of employability and skills, and offering apprenticeship opportunities.

Business Birmingham also works with a small group of recruitment agencies, who specialise in sourcing talent across a diverse range of business sectors, including healthcare and life sciences.

Grad Central is the region’s only agency dedicated to graduate recruitment; whether employers are seeking newly-qualified graduates, or those with years of industry experience.

Lord Search & Selection has specialised in identifying candidates for SME clients for more than 20 years, specialising in life sciences, advanced engineering, information, technology and electronics.

SF Group supplies professional services staff, on a permanent or interim basis. Founded in 1997, it has placed over 33,000 people into 11,000 SME and international clients.

INCUBATORS & BUSINESS SPACE

The rapid growth of Greater Birmingham’s life sciences and healthcare cluster has been underpinned by the ready availability of new hi-tech business space.

quality biomedical lab equipment and desk space at a fraction of commercial rates. Tenants benefit from access to the expertise, facilities and equipment of UoB, and its wholly-owned commercialisation company, Alta Innovations.

Within the Edgbaston Medical Quarter and nearby city centre, public sector bodies and their private sector partners have delivered an array of options; for start-ups, SMEs needing ‘growth’ room, established companies and even virtual businesses.

The BRP is also home to the BizzInn incubator, which offers in-house and independent local specialist support to entrepreneurs and hi-tech companies (from start-ups to established SMEs) with high-growth ambitions.

Access to hot desk space is 24/7, and assistance is provided on all areas of business activity; from strategy and business planning to IP (intellectual property) and access to finance. There is also exhibition and presentation space, where companies, stakeholders and the university can showcase research, products and services.

Birmingham Research Park (BRP), located close to the University of Birmingham (UoB) and the £545m Queen Elizabeth Hospital is ideal for young high-growth companies that need access to world-class research teams and major markets. The site is at the heart of one of the most significant life sciences and healthcare opportunities for public or private investment outside London.

In the city centre, the Innovation Birmingham Campus is a major location for innovators, entrepreneurs and investors looking to develop, or fund, their start-up.

Park tenants have built successful businesses based upon UoB’s reputation in biotech, medical diagnostics, scientific instruments and ICT systems. The site has 24-hour access, ample and secure car parking, CCTV, reception services and space for meetings, and events. BRP, which offers virtual tenancies to early-stage businesses not yet ready for office premises, is also home to The BioHub.

Its £8m iCentrum scheme, with 42,000 sq ft of space, is Birmingham’s first incubator dedicated to early-stage tech companies working in the health sector and developing digital solutions.It houses the Serendip Smart City Incubator, which aims to accelerate the growth of digital start-ups by colocating them with large and existing commercial partners.

The BioHub Birmingham® is Greater Birmingham’s specialist life sciences growth hub, offering a range of facilities to help fledgling companies become commercially competitive. It was designed to act as an incubator for start-up ventures and a location for growing SMEs.

The programme is delivered by the West Midlands Academic Health Science Network, West Midlands Combined Authority, the Transport Systems Catapult and Barclays, across four key sectors; the Internet of Things, intelligent mobility, digital health and empowering digital communities.

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Birmingham Health Partners has a unique co-located life

science infrastructure that is unrivalled in the UK. 5 16 29 11 26

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ECOSYSTEM

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The core of Greater Birmingham’s life sciences cluster, and almost all its centres of academic and clinical excellence, are in a compact location within minutes of the city centre and easily reached by public or private transport.

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The organisations identified here demonstrate the scope and scale of the area’s life sciences ecosystem, but provide only a snapshot. For more information on them and other members of the healthcare community, please contact Business Birmingham or visit www.businessbirmingham.com 8

MAP KEY 1. Advanced Therapies Facility and Human Biomaterials Resource Centre 2. The BioHub Birmingham® (Research Park) 3. Birmingham Children’s Hospital 4. Birmingham Clinical Trails Unit 5. Birmingham Dental Hospital and School of Dentistry 6. Birmingham Life Sciences Park 7. Birmingham University Imaging Centre (BUIC) 8. Birmingham Women’s Hospital 9. Centre for Clinical Haematology 10. Centre for Computational Biology

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11. Centre for Human Brain Health (under construction) 12. Centre for Rare Diseases 13. Centre for Translational Inflammation Research (including MRC/Arthritis Research UK Centre for Musculoskeletal Ageing Research) 14. Clinical Immunology Service 15. CRUK Clinical Trails Unit 16. Health Services Management Centre 17. Henry Wellcome Nuclear Magnetic Resonance Facility 18. Institute of Translational Medicine (ITM) 19. NHS Blood and Transplant Service 20. NIHR Biomedical Research Centre in Inflammatory Diseases 21. NIHR Experimental Cancer Medicine Centre

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22. NIHR Liver Biomedical Research Unit

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23. NIHR Surgical Reconstruction and Microbiology Research Centre 24. NIHR Trauma Management Healthcare Technology Co-operative 25. NIHR/Wellcome Trust Birmingham Clinical Research Facility 26. Phenome Centre Birmingham 27. Queen Elizabeth Hospital Birmingham (QEHB) 28. Tommy’s National Centre for Miscarriage Research 29. University of Birmingham (UoB) 30. University of Birmingham Medical School

Image courtesy of Commission Air. 9

31. West Midlands Regional Genetics Laboratory

ACADEMIC CENTRES OF EXCELLENCE Greater Birmingham is truly at the leading edge of medical technology and global healthcare. The presence of centres of excellence - for both clinical research and trials, and life sciences - enable today’s international challenges to be explored and addressed by specialists from healthcare, academia and industry.

University of Birmingham

Birmingham City University

The University of Birmingham (UoB) consists of five colleges, of which four provide major contributions to life sciences research and education; the Colleges of Medical and Dental Sciences, Life and Environmental Sciences, Social Sciences, Engineering and Physical Sciences. Together they push back the boundaries of translational research, with the aim of finding solutions to big issues affecting society.

Birmingham City University is the second largest of five universities in the city with over 7,000 students. The university recently invested £20 million in facilities, which will be a major influence on nursing and healthcare education in Greater Birmingham.

The five principal thematic Life Sciences research areas, which bring together researchers from UoB and the wider Birmingham life sciences campus, are cancer and genomic sciences, environment, health and wellbeing, immunity and infection, inflammation and chronic diseases, and bioengineering, regeneration and rehabilitation.

The expansion of the Edgbaston campus features specialist laboratories for a new School of Life Sciences, offering a range of courses in health, nutrition and biomedicine. The 10,000m² building will reinforce BCU as the region’s largest provider of qualified health and social care professionals to the NHS, and provide a new home to its School of Education, supporting the development of the next generation of teachers.

Aston University

Institute of Digital Health

The School of Life & Health Sciences pursues interdisciplinary research extending from the laboratory to the clinic. Work ranges from molecular and cellular, through neural systems and human behaviour, to the restoration of health, the study of individuals in healthcare and societal settings.

The Institute of Digital Health (IDH) is hosted by Warwick Manufacturing Group, in partnership with the Warwick Medical School, and supported by the NHS. IDH aims to improve people’s health and wellbeing through the development, evaluation and use of innovative digital technologies and services.

With funding from research councils, prestigious research foundations, charities, the European Union and industry, world-class research here is housed within four state of the art centres of excellence: Aston Research Centre for Heath Ageing, Aston Brain Centre, Centre for Vision and Hearing Research, and Aston Research Centre for Children and Young People’s Health. Significant investment has recently been made into well-equipped laboratories providing excellent (teaching and research) facilities.

The IDH model of research-led innovation works by ascertaining real problems, understanding them by ascertaining relevant theories, selecting appropriate technologies and developing new solutions. Each solution is rigorously evaluated for safety, effectiveness and cost implications, before promotion to healthcare systems. The IDH works closely with industry, the NHS and across disciplinary boundaries, and employs specialists in biomedical and information engineering, health psychologists, statisticians and clinicians with public health, hospital medicine and community health backgrounds.

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CLINICAL CENTRES OF EXCELLENCE

Greater Birmingham’s life sciences community has established a clear competitive advantage within the UK and overseas through its outstanding clinical research capabilities and a unique infrastructure for accelerated trials. Innovative partnerships between the NHS and private research are supported by world-class programmes at its universities.

Greater Birmingham has one of the largest, most diverse and stable populations in Europe, providing an unrivalled patient catchment area, Birmingham itself has the youngest population of any UK city and is one of the most ethnically diverse.

University Hospitals Birmingham NHS Foundation Trust

Birmingham Health Partners

One of Europe’s leading hospital trusts, its state-of-the-art facilities include the £545m Queen Elizabeth Hospital, home to the largest solid organ transplantation programme in Europe, the UK’s largest renal transport programme and the world’s largest single-floor critical care unit.

Birmingham Health Partners (BHP) is a strategic alliance between University Hospitals Birmingham NHS Foundation Trust, the University of Birmingham and Birmingham Children’s Hospital NHS Foundation Trust bringing together clinical, scientific and academic excellence across an integrated medical and life sciences campus.

The hospital houses the world-renowned Royal Centre for Defence Medicine (RCDM), which brings together military and civilian trauma surgeons and scientists to share medical innovations and advances in severe trauma treatment.

The objectives of BHP are to improve healthcare, contribute to the local economy through job creation and inward investment into the biomedical sector, and increase public engagement and education about biomedicine and clinical research, through increased enrolment into early and late phase clinical trials.

The RCDM, built on the strong relationship between the Ministry of Defence and the Department of Health, plays a key role in gathering scientific evidence from injuries sustained in military and civilian environments.

Patients benefit as new treatments are developed and shared across the NHS and the military. The centre also gives SMEs the opportunity to interact at the leading edge of trauma treatment innovation.

Its short-term objectives focus on the identification, adoption and spread of innovation and best practice, through the alignment of healthcare delivery, research and training.

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Edgbaston Medical Quarter

WMAHSN and MedilLink WM

The Edgbaston Medical Quarter (EMQ) was conceived and delivered by Calthorpe Estates; a family-owned property investment and development company. Home to two-thirds of the city’s healthcare economy, the EMQ boasts over 180 medical organisations, 23 training facilities, 44 GP clinics and routine care facilities and 80 hospitals and specialist care centres.

The West Midlands Academic Health Science Network (WMAHSN) leads, drives and acts as a catalyst for co-operation, collaboration and increased productivity, between academia, industry, health and care providers and commissioners, and citizens. It accelerates the adoption of innovation to generate continuous improvement in the region’s health and wealth.

The area has developed an international reputation for medical excellence, and attracts leading practitioners and researchers from many of the UK’s key medical institutions.

WMAHSN’s mission is to deliver improved healthcare outcomes, and create economic growth, by the spread of proven innovations at scale and pace, regionally, nationally and internationally. It is one of 15 AHSNs in England, and is located within the Institute of Translational Medicine.

Close to Birmingham’s city centre, the EMQ is in a thriving commercial and residential district, which incorporates one of the UK’s largest urban conservation areas. The area is an ideal location for SMEs needing to access a clinical base for product development, clinical trials or procurement routes. Calthorpe is also developing the Pebble Mill scheme, located close to the University of Birmingham, the Queen Elizabeth Hospital and the Life Sciences Park.

MediLinkWM, a membership organisation with a remit to stimulate growth and innovation in the medical and health technology sectors, operates as the industry gateway for WMAHSN.

Pebble Mill At the heart of the fast-growing healthcare cluster, this 27-acre site includes the new £50m Birmingham Dental Hospital and School of Dentistry with over 150 senior academic positions, alongside research and learning facilities for more than 600 students a year BUPA care home and a new Circle Health private hospital, it will bring industry and academic into a hub of collaboration to share the. best practice across clinical and medical platforms.

Institute of Translational Medicine The Institute of Translational Medicine (ITM), is the jewel in the crown of Greater Birmingham’s life sciences cluster, a world-class research centre representing investment of £24m.

Delivered by Birmingham Health Partners, it will help progress the latest scientific research from the University of Birmingham into enhanced treatments, across a range of major health issues, including cancer and liver disease.

Midland Metropolitan Hospital.

Due to open in October 2018, this super-hospital will deliver advanced treatment and care to 500,000 adults and children across the region.

Commissioned by Sandwell and West Birmingham Hospitals NHS Trust, the ‘Midland Met’ involves £340m of public and private investment, generating significant opportunities for medical technology, staffing, sub-contracting and research.

A central meeting point and working hub, the ITM will allow clinicians, academics, bioinformaticians, patient groups and industry leaders to maximise their interactions, and develop productive collaborative networks.

It will also build on Birmingham’s excellent track record in clinical trials, by increasing capacity and enabling more patients to be co-located alongside clinicians and researchers.

On a 16-acre site, the hospital has been designed to offer 669 acute care beds, and 13 operating theatre suites. It will expand the services available in the area, and the concentration of acute specialist care is expected to retain and attract highly-skilled clinicians.

The ITM will make it easier for SME and larger pharma and biotech firms to work more closely with clinicians and academics, bringing additional investment into the Greater Birmingham cluster.

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SUCCESS STORIES A network of entrepreneurs, start-ups and established ventures has rapidly developed within the core of Greater Birmingham’s life sciences cluster. Companies looking to join this fast-growing community should contact Business Birmingham’s experienced team of advisers who can offer relocation services, detailed guidance and a host of contacts. Business Birmingham’s connections and commercial partnerships provide multiple opportunities for funding advice and financial package options.

The company provides specialist diagnostic products to clinicians and laboratory professionals worldwide; devising, manufacturing and delivering innovative medical solutions which improve the diagnosis and management of blood cancers and immune system disorders, with a particular focus on myeloma.

Binding Site now employs some 700 people worldwide, with 500 in Birmingham, and its products are sold in more than 100 countries. It has also won four Queen’s Awards; two for Export, another for Innovation, and the most recent (April 2016) for Enterprise in the international trade category.It’s testament to the strength and international profile of Greater Birmingham’s life sciences cluster that Binding Site’s CEO, Charles de Rohan, has kept the group’s corporate headquarters in the Edgbaston

Some of the newest cluster members are featured on the following pages as case studies, and an inspiration to them all is Binding Site, which began life as a research spin-out from the University of Birmingham in 1983, and has become a global success.

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Clinigen Group plc is a global speciality pharmaceutical and services company, and one of Europe’s fastest-growing healthcare businesses, which distributes to hospital pharmacists and clinicians in more than 120 countries. The group has five divisions, focused on three areas of medicine; clinical trial, unlicensed and licensed medicines, and employs 500 people, with a market cap of £840m, and annual turnover to the end of June 2016 of almost £340m.

Board member and former CEO, Peter George says, Greater Birmingham’s excellent connectivity to Europe and its specialist pharmaceutical expertise makes it an ideal base for this fast-growing company.

Kaido Group Ltd is a pioneering digital health company based in Birmingham’s iCentrum. Its Artificially Intelligent Insights platform, created with partners at Microsoft, takes advantage of the huge opportunity data and technology is providing to revolutionise healthcare.

Kaido works with Big Data aggregators, clinical research groups and pharmaceuticals to allow clinicians to better understand the behaviour of their patients, and to empower patients to self-manage their health from home. Its aim is to create predictive, preventative and more personalised models of care, leading to increased efficiencies and massive savings for healthcare systems.

SME CASE STUDIES

Abingdon Health is a medical diagnostics group, focused on developing, manufacturing and commercialising point-of-care immunoassay tests for disorders of the immune system Its initial focus is on developing rapid tests for haematology, oncology and particularly, B cell dyscrasias.

Safe Patient Systems solves clinical problems by creating simple and patient-centric mobile health (mHealth) solutions - using familiar mobile and cloud-based technology - designed by clinicians, to enable more efficient healthcare and improved patient outcomes. Born out of the R&D department of one of the UK’s leading NHS Trusts, Heart of England NHS Foundation Trust, the company still shares many of the values of the NHS, around how it prioritises patients, listens, learns and develops evidence-based solutions.

The business, which is located in Birmingham’s The BioHub, launched the world’s first rapid diagnostic device in multiple myeloma, Seralite FLC, in 2015. Abingdon’s contract services team provides assay development and manufacturing services, for customers looking to transfer existing laboratory-based assays to a lateral flow format, and they take projects from initial concept through to transfer to production.

Based on the Blythe Valley Business Park, close to J4 of the M42, Safe Patient Systems chose that location for easy access to the SouthEast, where a large number of its technology partners are based.

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Over 550 medical technology companies, more than any other UK region.

Source: Department For Business, Innovation & Skills 2016

The University of Birmingham is one of the two largest centres for clinical trials in the UK

Ready access to Life Sciences infrastructure through new

£545 million Queen Elizabeth Hospital

£24 million Institute of

829 jobs created from 28

Translation Medicine is in the centre of the Life Sciences campus

Foreign Direct Investment projects in the Life Sciences sector in the last 10 years

2000 regional biological science graduates

5,000 regional medicine graduates

£353 million investment in the state-of-the-art Midland Metropolitan Hospital

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Want to know how we can make Life Sciences happen?

Get in touch with our Invest Team quoting ‘Making it happen’ T: +44 (0)121 202 5022 E: invest@marketingbirmingham.com Join in the conversation #Makingithappen business_bham BusinessBirmingham BusinessBirmingham To download a digital version of this brochure please log on to businessbirmingham.com/lifesciences 16